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Epidemiology and outcomes of acute liver failure in Australia

world Journal of Hepatology 2019年第7期11卷 586-595页

作者： Penelope Hey Timothy P Hanrahan Marie Sinclair Adam G Testro Peter w Angus Adam Peterson Stephen warrillow Rinaldo Bellomo marcos V Perini Graham Starkey Robert M Jones Michael Fink Tess McClure Paul Gow liver Transplant Unit Austin HealthHeidelberg 3084Australia The University of Melbourne Melbourne 3052Australia Department of Intensive Care Austin HeathMelbourne 3084Australia Department of Surgery Austin HealthMelbourne 3084Australia

BACKGROUND Acute liver failure (AlF) is a life-threatening syndrome with varying aetiologies requiring complex care and multidisciplinary management. Its changing incidence, aetiology and outcomes over the last 16 years in the Australian context remain uncertain. AIM To describe the changing incidence, aetiology and outcomes of AlF in South Eastern Australia. METHODS The database of the Victorian liver Transplant Unit was interrogated to identify all cases of AlF in adults (> 16 years) in adults hospitalised between January 2002 and December 2017. Overall, 169 patients meeting criteria for AlF were identified. Demographics, aetiology of AlF, rates of transplantation and outcomes were collected for all patients. Transplant free survival and overall survival (OS) were assessed based on survival to discharge from hospital. Results were compared to data from a historical cohort from the same unit from 1988- 2001. RESUlTS Paracetamol was the most common aetiology of acute liver failure, accounting for 50% of cases, with an increased incidence compared with the historical cohort (P = 0.046). Viral hepatitis and non-paracetamol drug or toxin induced liver injury accounted for 15% and 10% of cases respectively. Transplant free survival (TFS) improved significantly compared to the historical cohort (52% vs 38%, P = 0.032). TFS was highest in paracetamol toxicity with spontaneous recovery in 72% of cases compared to 31% of non-paracetamol AlF (P were waitlisted for emergency liver transplantation. Nine of these died while waiting for an organ to become available. Forty-two patients (25%) underwent emergency liver transplantation with a 1, 3 and 5 year survival of 81%, 78% and 72% respectively. CONClUSION Paracetamol toxicity is the most common aetiology of AlF in South-Eastern Australia with a rising incidence over 30 years. TFS has improved, however it remains low in non-paracetamol AlF.

关键词： liver failure Acute Paracetamol Australia Victoria liver transplant

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A SIMPlE DEVICE TO MONITOR SEDIMENT YIElD FROM GUllY EROSION

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International Journal of Sediment Research 2005年第3期20卷 90-94页

作者： Antonio Jose Teixeira GUERRA,marcos FIGUEIREDO Senior lecturer in Physical Geography Federal University of Rio de Janeiro Av. Canal de Marapendi 1100 apto. 608 Bloco 2 Barra da Tijuca-CEP Rio de Janeiro Rio de Janeiro 22.631-050 Brazil Lecturer in Physical Geography State University of Mato Grosso

The focus of this paper is the design and use of a simple device to determine sediment yield from gullies. The simplicity and low cost makes this device especially useful when resources are limited. In this study, it was used to measure sediment yield at a site called An?o Gully, in a study area in Cáceres municipality (15o 57’ S and 57o 31’ w, Mato Grosso State, Brazil). This gully is located 28 kilometres from the center of the town, Cáceres, and was easy to reach during and immediately after storm events to make measurements with this device.

关键词： Gully erosion Sediment yield Gully monitoring Simple device

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Candidate genes for male and female reproductive traits in Canchim beef cattle

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Journal of Animal Science and Biotechnology 2018年第1期9卷 59-68页

作者： marcos Eli Buzanskas Daniela do Amaral Grossi Ricardo Vieira Ventura Flavio Schramm Schenkel Tatiane Cristina Seleguim Chud Nedenia Bonvino Stafuzza luciana Diniz Rola Sarah laguna Conceio Meirelles Fabiana Barichello Mokry Maurício de Alvarenga Mudadu Roberto Hiroshi Higa marcos Vinícius Gualberto Barbosa da Silva Maurício Mello de Alencar luciana Correia de Almeida Regitano Danísio Prado Munari Departamento de Zootecnia Universidade Federal da Paraíba(UFPB)AreiaParailba 58397-000Brazil Fast Genetics SaskatoonSK S7K 2K6Canada Beef Improvement Opportunities(BIO) GuelphON N1K 1ESCanada Department of Animal and Poultry Science University of GuelphCentre for Genetic Improvement of Livestock(CGIL)GuelphON N1G 2W1Canada Departamento de Ciencias Exatas Faculdade de Ci6ncias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Departamento de Zootecnia Nucleo de Pesquisa e Conservacao de CervMeosFaculdade de Ciencias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Department of Animal Science Federal University/of Lavras(UFLA)LavrasMinas Gerais 37200 000Brazil Department of Genetics and Evolution Federa University of Sao Carlos(UFSCar)Sao CarlosSao Paulo 13565-905Brazil Embrapa Agricultural Informatics Campinas55o Paulo 13083 886Brazil Embrapa Dairy Cattle Juiz de ForaMinas Gerais 36038 330Brazil Embrapa Southeast livestock Sao CarlosSao Paulo 13560 970Brazil

Background： Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 ***： Associated SNPs were observed for scrotal circumference at 420 d of age（435 SNPs）, followed by scrotal circumference at 210 d of age（12 SNPs）, age at first calving（six SNPs）, and age at second calving（four SNPs）. we investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and ***： Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless,the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, al relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.

关键词： Animal breeding Composite breed Genome-wide association Genomic data Single nucleotide polymorphism

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Germination Response of Ornamental Pine Seeds on a Two-way Thermogradient Plate

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American Journal of Plant Sciences 2018年第1期9卷 13-22页

作者： marcos Vieira Ferraz Kathia Fernandes lopes Pivetta Hugh w. Pritchard Tim Marks Marcelo Vieira Ferraz leandro José Grava de Godoy Department of Plant Production Sao Paulo State University (Unesp) Jaboticabal Brazil The Millenium Seed Bank Royal Botanic Kew Gardens Ardingly England Campus of Registro Sao Paulo State University (Unesp) Registro Brazil

The objective of this study was to evaluate the effect of temperature on germination of Pinus tabuliformis Carrière seed, Pinus gerardiana wall. ex D. Don and Pinus roxburghii Sarg. Seeds of three species were distributed in Petri dishes with 1% agar solution;for the first step it was placed on a 2-way Grant’s thermogradient plate (a bi-directional incubator) for a period of 28 days and during the second step in an incubator type B.O.D. also for 28 days with non-germinated seeds in the first step. This instrument allows an assessment of a wide regime of constant and alternating temperatures, resulting to 144 different combinations of temperature, scheduled to the temperatures 4°C - 40°C. The lighting regime was 12 hours photoperiod for the two stages of the experiment. The best temperature for the germination of P. tabuliformis was 26.2°C (minimum of 7.9°C and maximum 37.0°C) and P. roxburghii was 15.6°C (minimum 10, 4°C and maximum 37.0°C). The seeds are neutral photoblastic. P. gerardiana showed low germination percentage (below 10%). The temperature that provided the highest germination percentage for P. tabuliformis was 26.2°C and 15.6°C for P. roxburghii.

关键词： Thermogradient Plate Temperature Regime Germination Percentage

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基于空间相关风速模型的风电充裕度研究

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电网与水力发电进展 2007年第7期23卷 45-52页

作者： Rod w.Dunn Furong li marcos S.Miranda 巴斯大学电力与电子工程学院

发电充裕度研究是电网规划和安全分析的重要工具。随着世界各地风电场的增加，进行发电充裕度估计需要更好的风力特征描述，以便进一步进行联网研究。利用英国的GB系统，介绍基于时间序列，用于发电充裕度研究的风速模型、建模方法以及... 详细信息

发电充裕度研究是电网规划和安全分析的重要工具。随着世界各地风电场的增加，进行发电充裕度估计需要更好的风力特征描述，以便进一步进行联网研究。利用英国的GB系统，介绍基于时间序列，用于发电充裕度研究的风速模型、建模方法以及安全裕度与负荷损失概率的关系。

关键词：充裕度风模型蒙特卡洛模拟统计风能

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Structural insights of mechanically induced aluminum-doped hydroxyapatite nanoparticles by Rietveld refinement

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Chinese Journal of Chemical Engineering 2017年第2期25卷 238-247页

作者： Abbas Fahami Bahman Nasiri-Tabrizi Gary w. Beall wan Jefrey Basirun Materials Science Engineering and Commercialization Program Texas State University San Marcos 78666 TX USA Advanced Materials Research Center Materials Engineering Department Najafabad Branch Islamic Azad University Najafabad lsfahan lran Department of Chemistry and Biochemistry Texas State University San Marcos 78666 TX USA Physics Department Faculty of Science King Abdulaziz University Jeddah 21589 Saudi Arabia Department of Chemistry Faculty of Science University of Malaya150603 Kuala Lumpur Malaysia

Aluminum doped hydroxyapatite(HA:Al^(3+)) nanopowders were successfully prepared via a simple and efficient one-pot mechanochemical route. The effects of dopant loading on phase compositions and structural features were assessed by Rietveld analysis. The XRD-Rietveld refinement revealed the stabilization of HA in hexagonal structure for all the samples. The sharpness and intensity of the apatite-derived XRD peaks decreased as the dopant content increased to 10% due to the increase in lattice imperfections and mechanically induced amorphization. The incorporation of Al3+into the HA lattice decreased the unit cell parameters. From the FTIR measurements, the representing bands of apatite were identified in all cases. The mechanosynthesized nanopowders consisted of nanospheroids with an average size of 44 ± 20 nm and therefore are promising for bone tissue regeneration.

关键词：羟基磷灰石纳米粒子 Rietveld精修机械化学合成铝掺杂诱导铝结构细化红外光谱测量

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lC-ESI-IT-MS/MS and MAlDI-TOF Approach:Identification of Natural Polymers from Rhizophora mangle Barks and Determination of Their Analgesic and Anti-inflammatory Properties

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Natural Products and Bioprospecting 2019年第1期9卷 23-34页

作者： leonardo Mendes de Souza Mesquita Caroline Fabri Bittencourt Rodrigues Claudia Quintino da Rocha Mayara Silveira Bianchim Clenilson Martins Rodrigues Vanda Maria de Oliveira Henrique Hessel Gaeta Mariana Novo Belchor marcos Hikari Toyama wagner Vilegas laboratory of Bioprospection of Natural Products(lBPN) UNESP-Sao Paulo State University/Coastal Campus of Sao VicentePc¸a Infante Dom Henrique S/NSao VicenteSao Paulo CEP:11330-900Brazil laborato´rio de Estudos Avanc¸ados em Fitomedicamentos(lEAF) UFMA-Federal University of MaranhaoAv.dos Portugueses1966-BacangaSao Luı´sMaranhao CEP:65080-805Brazil Embrapa Agroenergy Brazilian Agricultural Research CorporationW3 NortePqEBBrası´liaDF 70770-901Brazil

we recognize the chemical composition of the acetonic extract of Rhizophora mangle barks(AERM)using mass spectrometry analysis[liquid chromatography(lC)–ESI–IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS(MAlDI-TOF)].Analgesic activity was evaluated by formalin and tail-flick experimental ***-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 *** first series of experiments involved[lC]–FIA–IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3(DP3).The spectra obtained by MAlDI-TOF analysis of the AERM presented two homologous series:one based on polymers of m/z 288 Da increments(up to DP12)and another series based on polymers of m/z[288?162]Da increments(up to DP11).In addition to these series of flavan-3-ol,each DP had a subset of masses with a variation of-16 Da(homologous series of afzelechins-m/z 873–3465 Da)and +16 Da(homologous series of gallocatechins-m/z 905–3497 Da).A similar pattern with homologous series of gallocatechins and afzelechins could also be observed for a fifth and a sixth monohexoside series:glucogallocatechins(m/z 779–3371)and glucoafzelechins(m/z 747–3339).The intraperitoneal administration of different doses of AERM(50,150 and 300 lg ml^(-1))have a morphine-like effect and intense anti-inflammatory activity.

关键词： Catechins Tannins Morphine-likeeffect Anti-inflammatory Mangroves

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Synthesis, Structure, Adsorption Space and Magnetic Properties of Ni-oxalate Porous Molecular Magnet

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材料科学与工程（中英文A版） 2012年第3期2卷 284-301页

作者： Agustin Rios-Ramos Christymarie Rivera-Maldonado Geidy Ines Garcia-Acosta Cesar Manuellozano-Paulino Pedro Manuel Fierro-Mercado luis Fuentes-Cobas Rolando marcos Roque-Malherbe Institute for Physical Chemical Applied Research School of Science University of Turabo PO Box 3030 Gurabo PR 00778-3030 USA Department of Chemistry University of Puerto Rico - Mayagiiez Campus Mayagaez Puerto Rico 00681-9000 Advanced Materials Research Center Complejo Industrial Chihuahua Miguel de Cervantes 120 Chihuahua 31109 Mexico

we synthesized about sixty metal organic materials. Only three were metal organic frameworks (MOFs). One of them was a porous molecular magnet (PMM). For the PMM synthesis Ni was the node, oxalic acid the organic linker and DMF the solvent and shaping molecule. This PMM was studied with DRIFTS, Raman spectrometry, TGA, XRD, adsorption and with a VSM. TGA and adsorption data indicated that a microporous material with a pore volume, w = 0.10 ± 0.01 cm3/g was obtained. The analysis of the XRD profile indicated that it is a layered compound. The DRIFTS, Raman and XRD data revealed that each layer is formed by nickel cations linked by bis-bidentate and bridging-bis-bidentate oxalate ligands and the DMF molecules are perpendicularly linked to the nickel cations to produce stacking. Additionally, the Raman data allowed us to propose that the nickel cations are located in octahedral and pentacoordinated sites as Ni2+ and Ni3+. The Pawley fitting of the XRD profiles pointed out that the hydrated sample crystallizes in the P2/m space group. The cell parameters calculated are consistent with the proposed structure. Two different adsorption states showing different adsorption energies, in the physical adsorption range, were observed. The small amount estimated for the dispersive and quadrupole adsorption interaction energies was a confirmation of the proposed layered structure. The VSM study yielded an effective magnetic moment, ?eff?????????. This figure is consistent with nickel located in octahedral and pentacoordinated sites as Ni2+ and Ni3+. we had then obtained a new Ni-oxalic porous molecular magnet (Ni-Ox-PMM). The significance of this PMM is related to its porosity, that is, during degassing it release water turning into a porous stable structure, showing notable magnetic properties. In this case been porous, it means that the electronic structure of the nickel cations can be manipulated from outside with adsorbed molecules. Thereafter, the material could sense small m

关键词：物理吸附分子磁体合成金属镍离子磁学性质草酸盐空间群结构相

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Designing Artemisinins with Antimalarial Potential, Combining Molecular Electrostatic Potential, ligand-Heme Interaction and Multivariate Models

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Computational Chemistry 2023年第1期11卷 1-23页

作者： Josué de Jesus Oliveira Araújo Ricardo Morais de Miranda Jeferson Stiver Oliveira de Castro Antonio Florêncio de Figueiredo Ana Cecília Barbosa Pinheiro Sílvia Simone dos Santos Morais marcos Antonio Barros dos Santos Andréia de lourdes Ribeiro Pinheiro Andréia de lourdes Ribeiro Pinheiro Fábio dos Santos Gil Heriberto Rodrigues Bitencourt Gustavo Nery Ramos Alves José Ciríaco Pinheiro laboratório de Química Teórica e Computacional Universidade Federal do Pará Belém PA Brasil Instituto Federal de Educa&ccedil &atilde o Ciência e Tecnologia do Pará Belém PA Brasil Universidade do Estado do Amapá Macapá AP Brasil Funda&ccedil &atilde o Santa Casa de Misericórdia do Pará Belém PA Brasil Universidade do Estado do Pará Barcarena PA Brasil Departamento de Biologia Universidade do Estado do Maranh&atilde o S&atilde o luís MA Brasil laboratório de Síntese Organica Universidade Federal do Pará Belém PA Brasil

Artemisinins tested against w-2 strains of malaria falciparum are investigated with molecular electrostatic potential (MEP), in an attempt to identify key features of the compounds that are necessary for their activities, as well as to investigate likely interactions with the receptor in a biological process and to use that information to propose new molecules. In order to discover the best geometry involving the ligand-receptor complexes (heme) studied and help in the proposition of the new derivatives, molecular simulations of interactions between the most negative charged region around the peroxide and heme locates (the ones around the Fe2+ ion) were carried out. In addition, PCA (principal components analysis), HCA (hierarchical cluster analysis), SDA (stepwise discriminant analysis), and KNN (K-nearest neighbor) multivariate models were employed to investigate which descriptors are responsible for the classification between the higher and lower antimalarial activity of the compounds, and also this information was used to propose new potentially active molecules. The information accumulated in studies of MEP, molecular docking, and multivariate analysis supported the proposal of new structures with potential antimalarial activities. The multivariate models constructed were applied to the new structures and indicated numbers 19 and 20 as the most prominent for syntheses and biological assays.

关键词： Artemisinins Antimalarial Potential Molecular Electrostatic Potential ligand-Heme Interaction Multivariate Models

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Physical and chemical characterization of sediments from an Andean river exposed to mining and agricultural activities: The Moquegua River, Peru

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International Journal of Sediment Research 2022年第6期37卷 780-793页

作者： luis de los Santos Valladares Juan luis Ccamapaza Renato Arturo Valencia-Bedregal luis Enrique Borja-Castro Jose Velazquez-Garcia Dehiwalage Harshani Nimalika Perera Adrian Ionescu David Arvidsson Eustace Peregrine Barnes Peter Newton Hugo lepage Patrick Byrne Angel Guillermo Bustamante Dominguez Crispin H.w.Barnes Cavendish laboratory Department of Physics University of Cambridge Escuela Acad emico Profesional de Ingeniería Ambiental Universidad Nacional de Moquegua Provincia de Mariscal Nieto laboratorio de Cer amicos y Nanomateriales Facultad de Ciencias Físicas Universidad Nacional Mayor de San Marcos School of Biological and Environmental Science Liverpool John Moores University

This study presents an analysis of sediments in an Andean river impacted by both natural conditions and anthropogenic activities. Fifty samples were collected from selected sites throughout the Moquegua River drainage basin, and Tambo River headwaters at Pasto Grande, in Peru, and analysed with X-ray diffraction, energy dispersive X-ray spectroscopy, scanning electron microscopy, Fourier-transform infrared spectroscopy and thermogravimetric analysis. Si, Ca, Al, Fe, and O, common constituents of soils, were dominant, along with K, N, and P. The latter originating as primary macronutrients or chemical residuals from fertilizers used in agriculture. Higher concentrations of macronutrients and organic components were found in agricultural and urban areas, respectively. Arsenic minerals were also detected, which occur naturally, but possibly at levels augmented by anthropogenic activity. The application of cluster analysis revealed clustering between arsenic, arsenolite, and potassium but no significant geospatial correlation between sample sites in the drainage basin.

关键词： Andean river Moquegua river Sediments Fourier-transform infrared spectroscopy TG-DTG/DTA Clustering analysis

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