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“The red cage”:implementation of pH-responsiveness within a macrobicyclic pyridinium-based molecular host

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Organic Chemistry Frontiers 2022年第1期9卷 81-87页

作者： Pablo Cortón Hongye Wang Iago Neira Arturo Blanco-Gómez Elena Pazos Carlos Peinador Hao Li marcos D.garcía Departamento de Química and Centro de Investigacións Científicas Avanzadas(CICA) Facultade de CienciasUniversidade da Coruña15071 A CoruñaSpain Department of Chemistry Zhejiang UniversityHangzhou 310027China

We present herein the implementation of pH-responsiveness into a new polycationic macrobicyclic structure,namely what we have termed the“red cage”.The hydrolytically-stable cryptand-like compound has been prepared in a relatively high yield in aqueous media by a kinetically-controlled hydrazone-exchange reaction,promoted by the unusual high stability of the new hydrazone CvN bonds *** organic media the macrobicycle was found not able to complex model aromatic *** buffered aqueous solutions,as a comparison,the“red cage”was found able to recognize them,but the binding was observed to be more efficient in acidic form of the cyclophane compared with its conjugate base.

关键词： bonds conjugate media

SARS-CoV-2 infection in children requiring hospitalization: the experience of Navarra, Spain

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World Journal of Pediatrics 2020年第6期16卷 614-622页

作者： Laura Moreno-Galarraga Maria Urretavizcaya-Martinez Josune Alegria Echauri marcos garcia Howard Eva Ruperez garcia Sergio Aguilera-Albesa Valentin Alzina de Aguilar Mercedes Herranz Aguirre Pediatric Pulmonology Department of PediatricsCHNComplejo Hospitalario de NavarraServicio Navarro de SaludC/Irunlarrea 331080 PamplonaSpain IdiSNA.Navarra Institute for Health Research PamplonaSpain Department of Preventive Medicine and Public Health.School of Medicine.University of Navarra Pamplona.wSpain Department of Pediatrics CHNComplejo Hospitalario de NavarraServicio Navarro de Salud.Pamplona.Spain Pediatric Cardiology Department of PediatricsCHN.Complejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain Pediatric Neurology Department of PediatricsCHN.Complejo Hospitalario de NavarraServicio Navarro de SaludPamplonaSpain Department of Pediatrics CUN.Clfnica Universidad de NavarraPamplona.Spain Department of Pediatrics School of MedicineUniversity of NavarraPamplona.Spain

Background Coronavirus disease 2019 in children,or pediatric COVID-19,initially was described as an acute respiratory syndrome similar to the adult presentation but with less severe *** We describe the clinical characteristics,disease presentation,treatments and outcomes of all pediatric cases with COVID-19 admitted to the reference hospitals in Navarra,Spain during the first wave of the COVID-19 outbreak(February-May 2020).Results We found a low number of hospitalized cases in infants and children compared to adults with a hospitalization ratio of 1:*** of these hospitalized cases did not suffer from severe *** 80%of infections reported household contacts,and the mother was the known-contact in 83%of these cases.72%of hospitalized cases were previously healthy *** describe how symptoms in pediatric cases are nonspecific and how COVID-19 can be presented with a wide range and variety of *** symptoms are not always present,and severe neurological and cardiac features can occur in previously healthy *** Epidemiological description and case reports will be key to a better recognition and to adequate treatment of pediatric patients with COVID-19.

关键词： Coronavirus disease 2019 Hospitalization Severe acute respiratory syndrome coronavirus 2

Locoregional therapy and systemic cetuximab to treat colorectal liver metastases

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World Journal of Gastrointestinal Oncology 2015年第6期7卷 47-54页

作者： Giammaria Fiorentini Camillo Aliberti Donatella Sarti Paolo Coschiera Massimo Tilli Luca Mulazzani Paolo Giordani Francesco Graziano Alfonso Marqués Gonzalez Raul garcía marcos Fernando Gómez Mugnoz Maurizio Cantore Stefano Ricci Vincenzo Catalano Andrea Mambrini Oncology Unit Azienda Ospedaliera "Ospedali Riuniti Marche Nord"San Salvatore Hospital Oncology Radiodiagnostics Oncology Institute of VenetoInstitute for the Research and Treatment of Cancer (IRCC) Diagnostics for Images Unit and Interventional Radiology Azienda Ospedaliera "Ospedali Riuniti Marche Nord" Diagnostics for Images and Interventional Radiology Azienda USL of FerraraDelta Hospital Unit of Anestesiology La Fe University Hospital and Polytechnic Medical Imaging and Interventional and Vascular Radiology La Fe University Hospital and Polytechnic Medical Imaging Center (CDIC) Provincial Clinic Hospital Oncology Unit Azienda Ospedaliera "Carlo Poma" Department of Vascular and Interventional Radiology INRCA Hospital-IRCCS Oncology Unit Carrara General Hospital

AIM: To investigate efficacy and safety of second-line treatment with irinotecan-loaded drug-eluting beads(DEBIRI) and cetuximab(DEBIRITUX) of unresectable colorectal liver ***: Patients with the following characteristics were included in the study: unresectable hepatic metastases from colorectal carcinoma(CRC-LM), progression after first line chemotherapy(any type of chemotherapeutic drug and combination was allowed), second line treatment(mandatory), which included for each patient(unregarding the KRas status) two cycles of DEBIRI(using 100-300 μm beads loaded with irinotecan at a total dose 200 mg) followed by 12 cycles of cetuximab that was administered weekly at a first dose of 400 mg/m2 and then 250 mg/m2; good performance status(0-2) and liver functionality(alanine aminotransferase and gamma-glutamyl transferase not exceeding three times the upper limit of normal, total bilirubin not exceeding 2.5 mg/m L). Data were collected retrospectively and included: tumor response(evaluated monthly for 6 mo then every 3 mo), overall response rate(ORR), KRas status, type and intensity of adverse events(G according to the Common Terminology Criteria for Adverse Events v3.0, CTCAE), overall survival(OS) and progression free survival(PFS).RESULTS: Forty consecutive cases of CRC hepatic metastases were included in the study. Median duration of DEBIRITUX was 4.4 mo(range, 4.0-6.5). Sixteen patients(40%) received the planned 2 cycles of DEBIRI and an average of 10 cetuximab cycles. ORR of the whole sample was 50%, in particular 4 patients were complete responders(10%) and 16(40%) partial responders. The most observed side effects(G2) were: post-embolization syndrome(30%), diarrhea(25%), skin rushes(38%) and asthenia(35%). The retrospective evaluation of KRas status(24 wild type, 16 mutated) showed that the group of patients with wild type KRas had ORR significantly higher than mutant KRas. Median follow-up was 29 mo(8-48 range); median PFS was 9.8 mo and OS was

关键词： Cetuximab Irinotecan-loaded drug-elutingbeads Hepatic metastases Chemoembolization Colonrectal tumor Irinotecan

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墨西哥哈利斯科别墅

设计 2016年第14期29卷 32-33页

作者： Jacob marcos garcía

这栋别墅坐落在墨西哥瓜达拉哈拉州住宅增长率最高的区域中,别墅的设计理念基于对场址的分析和客户的要求。项目被划分成了两个部分,分别是作为中央轴的门廊和垂直的环流,这样的设计使得空间的分布更加高效,带来了更多的有用区域。在这... 详细信息

这栋别墅坐落在墨西哥瓜达拉哈拉州住宅增长率最高的区域中,别墅的设计理念基于对场址的分析和客户的要求。项目被划分成了两个部分,分别是作为中央轴的门廊和垂直的环流,这样的设计使得空间的分布更加高效,带来了更多的有用区域。在这样的情况下,别墅就像是一个人行漫步道,当你下车或走近别墅的时候就开始了你的散步旅程,你经常会发现自己处于被天井、有顶或无顶阳台、不同的街景、邻近的建筑体量或花园区域包围的地方。

关键词：墨西哥别墅哈利设计理念增长率住宅门廊空间

Percutaneous Ultrasound-Guided Radiofrequency Thermal Ablation for Treatment of Uterine Fibroids

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Open Journal of Obstetrics and Gynecology 2014年第12期4卷 716-724页

作者： Raúl garcía marcos Javier Monleón Alicia Martínez-Varea Fernando Gómez Guillermina Montoliú Jose J. Martínez Luis Martí-Bonmatí Antonio Pellicer Department Obstetrics and Gynecology La Fe University Hospital Valencia Spain Department of Radiology Hospital Clinic Barcelona Spain Department of Radiology La Fe University Hospital Valencia Spain

Purpose: To assess the safety, efficacy and effectiveness of percutaneous radiofrequency (RF) thermal ablation to reduce symptoms of uterine fibroids. Materials and Methods: 17 premenopausal women with symptomatic uterine fibroids despite conventional medical treatment were included. The assessment of symptoms and characteristics of fibroids by vaginal ultrasound, magnetic resonance imaging (MRI) and contrast enhanced ultrasound (CEUS) was performed before starting treatment and 6 months after the procedure. Successful treatment was clinically considered if patients reported a reduction in symptoms 6 months after RF myolysis. Successful treatment was also considered if the necrosis of the fibroid was greater than 50%, 6 months after treatment. Results: The baseline score on visual analogue scale (VAS) for dysmenorrhea and intermenstrual pain was 5.76 ± 3.31 and 3.0 ± 3.4, respectively. According to a score of 0 - 3, baseline bleeding during menstruation was 2.29 ± 0.92. Six months after RF myolysis, the VAS for dysmenorrhea was 2.75 ± 3.32 (p = 0.004), whereas for intermenstrual pain it was 1.38 ± 2.56 (p = 0.02). Menstrual bleeding was reduced to 1.13 ± 0.89 (p = 0.005). Clinical success of the treatment was evident in 11 (64.7%) of the 17 patients with a 95% CI [38.6%, 84.7%]. Fourteen patients underwent MRI monitoring 6 months post-myolysis. Compared to baseline fibroid volume, ultrasound and MRI volume were 57.38% and 79.66% six months after surgery, respectively. A total of 13 patients (92.86%) had radiological success from the treatment (95% CI [64.2%, 99.6%]). Conclusion: Since percutaneous RF myolysis reduces volume and symptoms of uterine fibroids, it may be considered as a valid treatment for symptomatic fibroids.

关键词： Percutaneous Radiofrequency Thermal Ablation Myolysis Uterine Fibroids

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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森林里的二重奏

现代装饰（家居） 2015年第2期 12-25页

作者： Elías Rizo Suárez Alejandro Rizo Suarez Kárima Dipp marcos garcía 范嘉苑

本案位于墨西哥的哈利斯科,其业主是两兄弟,因此整个项目包含了两座独立的楼房(A栋与B栋)。由于该项目的占地面积较为庞大,所以给Elias Rizo Arquitectos的设计团队带来了不小的挑战。设计团队在设计之初与业主们进行了详尽的沟通,并了... 详细信息

本案位于墨西哥的哈利斯科,其业主是两兄弟,因此整个项目包含了两座独立的楼房(A栋与B栋)。由于该项目的占地面积较为庞大,所以给Elias Rizo Arquitectos的设计团队带来了不小的挑战。设计团队在设计之初与业主们进行了详尽的沟通,并了解到两位业主的需求较为相似,他们并不介意两座房子的设计风格类似,甚至希望将相同的设计语言运用于两座房屋之中,在此基础上,每栋房子还要保留自己的特色。两座房子的所处地形本身就较为复杂,所以房屋的空间结构也因此富有了多变性和层次感。应业主需求,设计团队在两座房屋采用统一设计风格的前提下。

关键词：哈利斯业主需求语言运用层次感占地面积室内布局 articulate 住宅空间两兄弟 contour

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Soil-vegetation relationships in Mediterranean forests after fire

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Forest Ecosystems 2021年第2期8卷 240-252页

作者： Víctor Fernández-garcía Elena marcos Sara Huerta Leonor Calvo Area of Ecology Department of Biodiversity and Environmental ManagementFaculty of Biological and Environmental SciencesUniversidad de León24071 LeónSpain

Background:Wildfires are one of the major environmental concerns in Mediterranean ***,many studies have addressed wildfire impacts on soil and vegetation in Mediterranean forests,but the linkages between these ecosystem compartments after fire are not well *** aim of this work is to analyze soil-vegetation relationships in Mediterranean burned forests as well as the consistency of these relationships among forests with different environmental conditions,at different times after fire,and among vegetation with different functional ***:Our results indicate that study site conditions play an important role in mediating soil-vegetation ***,we found that the nature of soil-vegetation relationships may vary over time as fire effects are less dominant in both ecosystem *** this,we detected several common soil-vegetation relationships among study sites and times after *** instance,our results revealed that available P content and stoichiometry(C:P and N:P)were closely linked to vegetation growth,and particularly to the growth of *** found that enzymatic activities and microbial biomass were inversely related to vegetation growth rates,whereas the specific activities of soil enzymes were higher in the areas with more vegetation height and ***,our results suggest that resprouters may influence soil properties more than seeders,the growth of seeders being more dependent on soil ***:We provide pioneer insights into how vegetation is influenced by soil,and vice-versa,in Mediterranean burned *** results reflect variability in soil-vegetation relationships among study sites and time after fire,but consistent patterns between soil properties and vegetation were also *** research is highly relevant to advance in forest science and could be useful to achieve efficient post-fire management.

关键词： Wildfires Soil nutrients Enzymatic activities Microbial biomass Growth forms Regenerative strategies

Human-environmental interaction with extreme hydrological events and climate change scenarios as background

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Geography and Sustainability 2022年第3期3卷 232-236页

作者： Carlos Sánchez-garcía marcos Francos PaleoRisk Research Group Geography DepartmentFaculty of Geography and HistoryUniversity of BarcelonaBarcelonaEspaña IPHES Catalan Institute for Human Palaeoecology and Social Evolution TarragonaEspaña Department of Geography Faculty of Geography and HistoryUniversity of SalamancaCervantes s/n37002SalamancaSpain Centro de Investigación de Estudios Avanzados del Maule(CIEAM) Universidad Católica del MauleAv.San Miguel 36053466706TalcaChile

Climate change significantly impacts the lives of all *** change is composed of multiple factors that affect the population differently,having a very significant impact in the Mediterranean *** beings,through their actions,try to mitigate this impact and thus generate a more resilient *** hydro-logical events are affected by this climate change,with torrential rainfall events and severe droughts becoming *** these trends will allow us to better adapt to future *** study aims to analyse catastrophic floods and severe droughts from paleo studies to studies that focus on future *** this purpose,a search for information has been carried out through other studies over the last five years to have a current perspective of this *** point to changes in the dynamics of floods and droughts,not only worsening the extremes but also affecting the average values of the records of *** addition,the studies point out that anthropic action is accelerating the changes,with human beings and their capacity to adapt being infe-rior to the velocity of this global *** is necessary to generate a paradigm shift in terms of global production by trying to adapt to future extreme flood and drought hazards.

关键词： Climate change Flood hazard Human disaster management Historical floods