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Selection signatures in Canchim beef cattle

Journal of Animal Science and Biotechnology 2017年第1期8卷 15-23页

作者： Ismael Urbinati Nedenia Bonvino Stafuzza marcos Túlio Oliveira Tatiane Cristina Seleguim Chud Roberto Hiroshi Higa Luciana Correia de Almeida Regitano Maurício Mello de Alencar marcos eli buzanskas Danísio Prado Munari Departamento de Ciencias Exatas Univ Estadual PaulistaFaculdade de Ciencias Agrairias e VeterinairiasjaboticabalSao Paulo 14884-900Brazil Departamento de Tecnologia UNESP-Univ Estadual PaulistaFaculdade de Ciencias Agrarias e VeterinariasJaboticabalSao Paulo 14884-900Brazil Embrapa Agricultural Informatics CampinasSao Paulo 13083-886Brazil Embrapa Southeast Livestock Sao CarlosSao Paulo 13560-970Brazil

Background： Recent technological advances in genomics have allowed the genotyping of cattle through single nucleotide polymorphism（SNP） panels. High-density SNP panels possess greater genome coverage and are useful for the identification of conserved regions of the genome due to selection, known as selection signatures（SS）. The SS are detectable by different methods, such as the extended haplotype homozygosity（EHH）; and the integrated haplotype score（i HS）, which is derived from the EHH. The aim of this study was to identify SS regions in Canchim cattle（composite breed）, genotyped with high-density SNP ***： A total of 687,655 SNP markers and 396 samples remained for SS analysis after the genotype quality control. The i HS statistic for each marker was transformed into pi HS for better interpretation of the *** BTA5 and BTA14 showed pi HS 〉 5, with 39 and nine statistically significant SNPs（P 〈 0.00001）,respectively. For the candidate selection regions, i HS values were computed across the genome and averaged within non-overlapping windows of 500 Kb. We have identified genes that play an important role in metabolism,melanin biosynthesis（pigmentation）, and embryonic and bone ***： The observation of SS indicates that the selection processes performed in Canchim, as well as in the founder breeds（i.e. Charolais）, are maintaining specific genomic regions, particularly on BTA5 and BTA14. These selection signatures regions could be associated with Canchim characterization.

关键词： Composite breed Extended haplotype homozygosity Genomics Single nucleotide polymorphism

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Candidate genes for male and female reproductive traits in Canchim beef cattle

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Journal of Animal Science and Biotechnology 2018年第1期9卷 59-68页

作者： marcos eli buzanskas Daniela do Amaral Grossi Ricardo Vieira Ventura Flavio Schramm Schenkel Tatiane Cristina Seleguim Chud Nedenia Bonvino Stafuzza Luciana Diniz Rola Sarah Laguna Conceio Meirelles Fabiana Barichello Mokry Maurício de Alvarenga Mudadu Roberto Hiroshi Higa marcos Vinícius Gualberto Barbosa da Silva Maurício Mello de Alencar Luciana Correia de Almeida Regitano Danísio Prado Munari Departamento de Zootecnia Universidade Federal da Paraíba(UFPB)AreiaParailba 58397-000Brazil Fast Genetics SaskatoonSK S7K 2K6Canada Beef Improvement Opportunities(BIO) GuelphON N1K 1ESCanada Department of Animal and Poultry Science University of GuelphCentre for Genetic Improvement of Livestock(CGIL)GuelphON N1G 2W1Canada Departamento de Ciencias Exatas Faculdade de Ci6ncias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Departamento de Zootecnia Nucleo de Pesquisa e Conservacao de CervMeosFaculdade de Ciencias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil Department of Animal Science Federal University/of Lavras(UFLA)LavrasMinas Gerais 37200 000Brazil Department of Genetics and Evolution Federa University of Sao Carlos(UFSCar)Sao CarlosSao Paulo 13565-905Brazil Embrapa Agricultural Informatics Campinas55o Paulo 13083 886Brazil Embrapa Dairy Cattle Juiz de ForaMinas Gerais 36038 330Brazil Embrapa Southeast Livestock Sao CarlosSao Paulo 13560 970Brazil

Background： Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 ***： Associated SNPs were observed for scrotal circumference at 420 d of age（435 SNPs）, followed by scrotal circumference at 210 d of age（12 SNPs）, age at first calving（six SNPs）, and age at second calving（four SNPs）. We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and ***： Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless,the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, al relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.

关键词： Animal breeding Composite breed Genome-wide association Genomic data Single nucleotide polymorphism

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Vibration Control of a Gym Floor Using Tuned Mass Dampers: A Numerical Analysis

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Modern Mechanical Engineering 2013年第3期3卷 9-16页

作者： marcos Daniel Souza dos Santos Daniel Valenca Fiuza Lima Jorge eliécer Campuzano Carmona Suzana Moreira Avila Graciela Nora Doz de Carvalho Departamento de Engenharia Civil e Ambiental Faculdade de TecnologiaUniversidade de BrasiliaBrasiliaBrasil

This work presents a study on excessive vibration problem occurring on concrete slabs, usually used on residential and commercial building floors. Even well designed slabs, according to ultimate and serviceability limit states criteria, can be vulnerable to undesirable vibrations that lead to user discomfort. A gym floor, that presented real excessive vibrations, located in a commercial building situated in the city of Brasilia,Brazil, was analyzed via Finite Element Method using ANSYS software. The first step in this analysis was to obtain natural frequencies and vibration modes, the structure presented low natural frequencies representing its flexible behavior. Then it was simulated a dynamic loading of people jumping, characteristic of this type of building occupation. Since it was observed the occurrence of excessive vibrations also in the numerical analysis, a Tuned Mass Damper (TMD) control system was proposed, looking for the best set of dampers to improve the control performance. The parameters for the best vibration reduction were obtained via a parametric study considering four different slabs varying dimensions and support conditions. Different models considering one and more TMDs, varying its placements and parameters, besides the frequency reference value to tune the damper were considered. An efficient control solution to this practical problem is presented to reduce its undesirable vibrations.

关键词： Structural Dynamics Structural Control Concrete Slabs Tuned Mass Damper

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