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Chemical Constituents of Pedicularis longiflora var. tubiformis (Orobanchaceae), a Common Hemiparasitic Medicinal Herb from the Qinghai Lake Basin, China

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 1083-1090页

作者： Feng Liu Zilan Ma marcos acaraballo-ortiz Hui Zhang Xu Su Yuping Liu Key Laboratory of Medicinal Animal and Plant Resources of the Qinghai-Tibet Plateau in Qinghai Province School of Life ScienceQinghai Normal UniversityXining810008China Key Laboratory of Physical Geography and Environmental Process in Qinghai Province Qinghai Normal UniversityXining810008China Key Laboratory of Education Ministry of Earth Surface Processes and Ecological Conservation of the Qinghai-Tibet Plateau Qinghai Normal UniversityXining810008China Department of Botany National Museum of Natural HistorySmithsonian InstitutionWashington DC200013-7012USA Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing100093China

Pedicularis longiflora ***(Orobanchaceae)is an abundant parasitic herb mainly found in the Xiaopohu wetland of the Qinghai Lake Basin in Northwestern *** species has an important local medicinal value,and in this study,we evaluated the chemical profile of its stems,leaves and seeds using mass *** samples of stems,leaves and seeds were grinded,weighted,and used for a series of extractions with an ultrasonic device at room *** chemical profiles for each tissue were determined using Gas Chromatography-Mass Spectrometry(GC-MS)and Liquid Chromatography-Mass Spectrometry(LC-MS).Twenty-seven amino acids and organic acids were identified and quantified from stems,leaves and *** content of amino acids detected in leaves and seeds was higher than the amount found in *** fla-vonoids were also detected,including isoorientin,orientin,luteolin-7-O-glucoside,luteolin,apigenin and *** concentrations of luteolin-7-O-glucoside,luteolin and tricin were the highest and more concentrated in leaves,while that of orientin was the lowest and mainly found in *** monosaccharides and oligosaccharides below tetramer were also examined,and our analyses detected the presence of arabitol,fructose,galacturonic acid,glucose,glucuronic acid,inositol,sucrose,and *** is the first study to identify and quantify the main components of amino acids,organic acids,flavonoids and soluble sugars from stems,leaves and seeds of *** *** of the amino acids detected are essential for humans,highlighting the medicinal importance of this *** shown here can be used as a reference case to develop future studies on the chemical constituents of Pedicularis herbs and other medicinal plants from the Tibetan region.

关键词： Amino acid content flavonoids gas chromatography-mass spectrometry(GC-MS) liquid chromatography-mass spectrometry(LC-MS) Qinghai-Tibet Plateau Tibetan medicine

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Effects of dietary Lactobacillus postbiotics and bacitracin on the modulation of mucosaassociated microbiota and pattern recognition receptors affecting immunocompetence of jejunal mucosa in pigs challenged with enterotoxigenic F18^(+)Escherichia coli

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Journal of Animal Science and Biotechnology 2025年第1期16卷 282-299页

作者： marcos Elias Duarte Zixiao Deng Sung Woo Kim Department of Animal Science North Carolina State University116 Polk HallCampus Box 7621RaleighNC 27695USA

Background Enterotoxigenic Escherichia coli(***)is a threat to humans and animals that causes intestinal *** resistance has urged alternatives,including Lactobacillus postbiotics,to mitigate the effects of enterotoxigenic *** Forty-eight newly weaned pigs were allotted to NC:no challenge/no supplement;PC:F18^(+)*** chal-lenge/no supplement;ATB:F18^(+)*** challenge/bacitracin;and LPB:F18^(+)*** challenge/postbiotics and fed diets for 28 *** d 7,pigs were orally inoculated withF18^(+)*** d 28,the mucosa-associated microbiota,immune and oxidative stress status,intestinal morphology,the gene expression of pattern recognition receptors(PRR),and intestinal barrier function were *** were analyzed using the MIXED procedure in SAS *** PC increased(P<0.05)Helicobacter mastomyrinus whereas reduced(P<0.05)Prevotella copri and ***-corea compared to *** LPB increased(P<0.05)*** and Dialister succinatiphilus compared with *** ATB increased(P<0.05)Propionibacterium acnes,Corynebacterium glutamicum,and Sphingomonas pseudosanguinis compared to *** PC tended to reduce(P=0.054)PGLYRP4 and increased(P<0.05)TLR4,CD14,MDA,and crypt cell proliferation compared with *** ATB reduced(P<0.05)NOD1 compared with *** LPB increased(P<0.05)PGLYRP4,and interferon-γand reduced(P<0.05)NOD1 compared with *** ATB and LPB reduced(P<0.05)TNF-αand MDA compared with *** TheF18^(+)*** challenge compromised intestinal *** increased beneficial bacteria show-ing a trend towards increasing the intestinal barrier function,possibly by reducing the expression of PRR ***-tobacillus postbiotics enhanced the immunocompetence of nursery pigs by increasing the expression of interferon-γand PGLYRP4,and by reducing TLR4,NOD1,and CD14.

关键词： Escherichia coli Immunocompetence Intestinal health Pattern recognition receptors Pigs

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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The Camborygma Ichnofacies in a high-resolution sequence-stratigraphic framework for the Eocene palustrine-alluvial depositional interval of the Kutch Basin,India

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Journal of Palaeogeography 2025年第1期14卷 141-156页

作者： Mohuli Das Sudipta Dasgupta Seema Singh marcos Ant?nio Klunk Renzo D'souza Bombay Ichnos Research Group Department of Earth Sciences Indian Institute of Technology Bombay (IIT Bombay) Department of Petroleum Engineering and Earth Sciences Indian Institute of Petroleum and Energy (IIPE) Department of Geology Panjab University Department of Geology Universidade do Vale do Rio dos Sinos (UNISINOS)

The non-marine strata of the Ypresian Naredi Formation have been deposited and intermittently pedogenized after the culmination of the Early Eocene Climatic Optimum(EECO). This continental interval comprises intercalation of laterite and palaeosol horizons developed by cyclic episodes of erosion, subaerial exposure, and deposition. The palaeopedological analyses investigate the morphological and micromorphological features evidencing repeated subaerial exposure and consequently moderate to well-developed palaeosol horizons. The topmost laterite bed records an intensely bioturbated ichnofabric(consisting of the root traces and the composite ichnotaxa of lungfish aestivation burrows, Macanopsis(possible arachnid burrows), and Skolithos. The pedogenized shale horizons contain the paucispecific Camborygma-root trace ichnofabric with highly localized patchy preservation of Camborygma symplokonomos, Camborygma eumekenomos, and rhizoturbation. The ichnospecies variation of Camborygma along with the ichnofabric analyses led to the demarcation of stratigraphic horizons and evaluation of the palaeowater-table fluctuations vis-a-vis the low-order allocyclicity, the ethology of producers, and the depositional setting. The paucispecific suite of trace fossils refers to the Camborygma Ichnofacies, where the substrate is intermittently pedogenized and lateritized with upward increasing thickness of beds and intensity of pedogenesis, lateritization, ichnodiversity, and ***, as an expression of high-frequency(interpreted as 5th-order) stratigraphic fluctuations within an early Falling Stage Systems Tract(FSST), a hot palaeoclimate with seasonality varying between humid inundated to dry desiccated conditions is interpreted with the palaeowater table being the base-level control. It culminates with the driest condition at the top with the thickest laterite development associated with the RAeMaS *** the onset of early transgression as documented in the ove

关键词： Camborygma Lungfish aestivation burrow Macanopsis Skolithos Palaeosol-laterite profile Naredi formation

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Virtual globes for UAV-based data integration:Sputnik GIS and Google Earth^(TM) applications

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International Journal of Digital Earth 2019年第5期12卷 583-593页

作者： marcos Arza-Garci Mariluz Gil-Docampo Juan ortiz-Sanz Santiago Martinez-Rodriguez Agroforestry Engineering Department University of Santiago de CompostelaEscuela Politecnica SuperiorLugoSpain

The integration of local measurements and monitoring via global-scale Earth observations has become a new challenge in digital Earth *** increasing accessibility and ease of use of virtual globes(VGs)represent primary advantages of this integration,and the digital Earth scientific community has adopted this technology as one of the main methods for disseminating the results of scientific *** this study,the best VG software for the dissemination and analysis of highresolution UAV(Unmanned Aerial Vehicle)data is identified for global and continuous geographic scope *** VGs Google Earth and Sputnik Geographic Information System(GIS)are selected and compared for this *** Earth is a free platform and one of the most widely used VGs,and one of its best features its ability to provide users with quality visual *** proprietary software Sputnik GIS more closely approximates the analytical capacity of a traditional GIS and provides outstanding advantages,such as DEM overlapping and visualization for its dissemination.

关键词： Virtual reality geospatial data geographic visualization multiscale DEM

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FANET and MANET, a Support and Composition Relationship

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Computers, Materials & Continua 2025年第2期82卷 1699-1732页

作者： Carlos Andrés Tavera Romero Jesús Hamilton ortiz Luis Carlos Rodríguez Timaná Fernando Vélez Varela Andrés Hernando Aristizábal Montufar Javier Gamboa-Cruzado COMBA R&D Laboratory Faculty of EngineeringUniversidad Santiago de CaliCali76001Colombia Development Department Closemobile R&D Telecommunications LSMadrid28070Spain GIEIAM Research Group Faculty of EngineeringUniversidad Santiago de CaliCali76001Colombia Faculty of Engineering Universidad LibreCali760031Colombia Faculty of Systems and Informatics Engineering Universidad Nacional Mayor de San MarcosLima15001Perú

This study investigates the design and implementation of Flying Ad Hoc Networks(FANETs),a network architec-ture inspired by the Mobile Ad Hoc Network(MANET)model,specifically tailored to support unmanned aerial vehicles(UAVs).As UAVs increasingly contribute to diverse fields,from surveillance to delivery,FANETs have emerged as essential in ensuring stable,dynamic communication channels among drones in *** research adopts a dual approach,combining rigorous theoretical analysis with detailed practical simulations to assess the performance,adaptability,and efficiency of FANETs in varying *** findings emphasize the ability of FANETs to manage network congestion effectively in densely populated areas,a critical feature for maintaining reliable communications in complex ***,FANETs demonstrate high potential to support critical applications,such as emergency response,disaster management,and public safety operations,where quick and coordinated action is *** study also underscores the importance of establishing a hierarchical structure among nodes within the network,which allows for more efficient data exchange and helps optimize the overall network *** this work,significant insights are offered into the design principles that can enhance UAV communication networks,providing a foundation for the development of more resilient,scalable,and efficient technological *** advancements could accelerate the deployment of UAVs across a variety of sectors,including logistics,agriculture,environmental monitoring,and *** such,this study not only contributes to the field of ad hoc networking but also holds potential for transformative impacts across industries where UAVs play an increasingly central role,promoting greater integration and operational success.

关键词： Ad hoc FANET MANET network UAV

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Metal and organo-catalysed asymmetric hydroaminomethylation of styrenes

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催化学报 2015年第1期36卷 106-112页

作者： Barbara Villa-marcos Jianliang Xiao Department of Chemistry University of Liverpool

A new protocol that enables asymmetric hydroaminomethylation of styrenes to afford chiral amines has been developed. Catalysed by an Rh-phosphine species and a chiral phosphoric acid, styrenes are converted into β-chiral amines with good enantioselectivities under syngas in the presence of an amine and Hantzsch ester. The reaction involves two key steps, hydroformylation and reductive amination, with the former catalysed by the Rh species whilst the latter by the phosphoric acid.

关键词：苯乙烯不对称有机催化金属对映选择性加氢甲酰化手性胺酸催化

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Contrasting levels of genotype by environment interaction for life history and morphological traits in invasive populations of Zaprionus indianus(Diptera:Drosophilidae)

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Insect Science 2020年第5期27卷 1090-1100页

作者： Nicolas J.Lavagnino marcos Imberti Victoria E.ortizj Nicolas Flaibani Juan Jose Fanara Laboratorio de Evolucion Departamento de EcologiaGenetica y EvolucidnFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina IEGEBA-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina

It has been demonstrated that phenotypic plasticity and genotype by envi-ronment interaction are important for coping with new and heterogeneous environments during *** indianus Gupta(Diptera:Drosophilidae)is an Afrotropical invasive fly species introduced to the South American continent in *** species is generalist and polyphagous,since it develops and feeds in several different fruit *** characteristics of *** suggest that phenotypic plasticity and genotype by environment interaction may be important in this species invasion *** this sense,our aim was to investigate the role of genetic variation for phenotypic plasticity(geno-type by environment interaction)in *** invasion of the South American ***,we quantified quantitative genetic variation and genotype by environment in-teractions of morphological and life history traits in different developmental environments,that is,host *** was done in different populations in the invasive range of ***-anus in *** showed that *** populations have considerable amounts of quantitative genetic ***,genotype by environment interactions was detected for the different traits analyzed in response to the different developmental ***,the amounts and patterns of these parameters differed between *** interpreled these results as the existence of diferences in evolutionary potential be-tween populations that have an important role in the short-and long-term success of the *** invasion process.

关键词： biological invasion genotype by env ironment interaction invaded range life history traits morphological traits Zaprionus indianus

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Pathogenesis and clinical management of arboviral diseases

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World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich Juan marcos Caram Costa Marina Maria Gomes Leite Oliveira Carlos Eduardo Oliveira Aguiar Luis Guilherme de Oliveira Silva Marcel Silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

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Filtering cylindrical–conical hydrocyclone

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Particuology 2019年第6期17卷 54-62页

作者： Fernanda FSalvador marcos ASBarrozo Luiz GMVieira Federal University of Espírito Santo Center of Agricultural Sciences and EngineeringDepartment of Rural EngineeringZIP Code:29500-000AlegreESBrazil Federal University of Uberlândia Chemical Engineering SchoolBlock 1 KCampus Santa MônicaZIP Code:38400-902UberlândiaMGBrazil

Hydrocyclones have versatile applications in various industrial *** functionn on the principle of centrifugal separation to remove a dispersed phase(particles or drops)from a continuous phase(fluid).In unconventional filtering hydrocyclones,the separation efficiency and energy costs have been improved by combining filtration with centrifugal *** work investigated experimentally the effect of incorporating a cylinder and a porous cone in a conventional *** also evaluated the effects of the main geometric dimensions of the separator on the hydrocyclone performance.A differential-evolution algorithm was applied to optimize the hydrocyclone performance,which was represented as the maximum total efficiency and minimum Euler *** experimental results validated the optimization results and showed that hydrocyclones with optimized geometries exhibited higher total efficiencies(89.59%)and lower Euler numbers(582)than hydrocyclones with other experimental configurations.

关键词： Solid–liquid separation Hydrocyclone Filtration Differential evolution

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