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Biliary drainage in inoperable malignant biliary distal obstruction: A systematic review and meta-analysis

World Journal of Gastrointestinal Surgery 2021年第5期13卷 493-506页

作者： Maria Vitória Cury Vieira Scatimburgo Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Vitor Massaro Takamatsu Sagae Bruno Salomão Hirsch Mateus Bond Boghossian Thomas R McCarty marcos EduardoLera dos Santos Tomazo antonio Prince Franzini Wanderley Marques Bernardo Eduardo GuimarãesHourneaux de Moura Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Division of Gasteoenterology Hepatology and EndoscopyBrigham and Women's HospitalBostonMA 02115United States

BACKGROUND Endoscopic drainage remains the treatment of choice for unresectable or inoperable malignant distal biliary obstruction(MDBO).AIM To compare the safety and efficacy of plastic stent(PS)vs self-expanding metal stent(SEMS)placement for treatment of *** This meta-analysis was developed according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.A comprehensive search was performed in MEDLINE,Cochrane,Embase,Latin American and Caribbean Health Sciences Literature,and grey literature to identify randomized clinical trials(RCTs)comparing clinical success,adverse events,stent dysfunction rate,reintervention rate,duration of stent patency,and mean *** difference(RD)and mean difference(MD)were calculated and heterogeneity was assessed with I2 *** analyses were performed by SEMS *** Twelve RCTs were included in this study,totaling 1005 *** was no difference in clinical success(RD=-0.03,95%confidence interval[CI]:-0.01,0.07;I 2=0%),rate of adverse events(RD=-0.03,95%CI:-0.10,0.03;I2=57%),and mean patient survival(MD=-0.63,95%CI:-18.07,19.33;I2=54%)between SEMS vs PS ***,SEMS placement was associated with a lower rate of reintervention(RD=-0.34,95%CI:-0.46,-0.22;I2=57%)and longer duration of stent patency(MD=125.77 d,95%CI:77.5,174.01).Subgroup analyses revealed both covered and uncovered SEMS improved stent patency compared to PS(RD=152.25,95%CI:37.42,267.07;I2=98%and RD=101.5,95%CI:38.91,164.09;I2=98%;respectively).Stent dysfunction was higher in the covered SEMS group(RD=-0.21,95%CI:-0.32,-0.1;I²=205%),with no difference in the uncovered SEMS group(RD=-0.08,95%CI:-0.56,0.39;I²=87%).CONCLUSION While both stent types possessed a similar clinical success rate,complication rate,and patient-associated mean survival for treatment of MDBO,SEMS were associated with a longer duration of stent patency compared to PS.

关键词： Biliary tract neoplasms Stents Protheses Malignancy Biliary system Cancer

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Leaf Essential Oil from Three Exotic Mytaceae Species Growing in the Botanical Garden of Rio de Janeiro, Brazil

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American Journal of Plant Sciences 2016年第6期7卷 834-840页

作者： antonio C. Siani marcos J. Nakamura Gabrielle P. das Neves Sérgio da S. Monteiro Mônica Freiman S. Ramos Departamento de Química de Produtos Naturais Instituto de Tecnologia em Fármacos Fundacao Oswaldo Cruz Rio de Janeiro Brazil Fórum Itaboraí de Política Ciência e Cultura na Saúde Fundacao Oswaldo Cruz Palácio Itaboraí Petrópolis Brazil Departamento de Medicamentos Faculdade de Farmácia Faculdade de Farmácia Universidade Federal do Rio de Janeiro CCS Bloco K Cidade Universitária Rio de Janeiro Brazil

The leaf essential oils of three Myrtaceae species: Melaleuca leucadendra, Lophostemon confertus and Ugni molinae, non-native to Brazil and growing in the Rio de Janeiro Botanical Garden, were obtained by hydrodistillation and analyzed by GC and GC-MS. Oil yields from fresh leaves were 0.76%, 0.08%, and 0.04%, respectively. Sixty-seven percent of M. leucadendra oil was made up of monoterpenes, wherein 1,8-cineole was largely predominant (49%), followed by α-terpineol (7.6%) and terpinen-4-ol (4.3%). The sesquiterpene profile was characterized by a significant amount of viridiflorol (29%). Oil from L. confertus was 42% monoterpenes;the most predominant constituents being α-pinene (20.8%) and α-thujene (7.1%). Total sesquiterpenes (55.4%) comprised spathulenol (28%), globulol (14%), and aromadendrene derivatives (8.5%) as the main species. U. Molinae oil was exclusively composed of sesquiterpenes, with a predominance of β-elemene (44%) followed by β-caryophyllene (7.1%), and bicyclogermacrene (6.7%);guaiol-type alcohols made up 30% of its profile. To the best of our knowledge, this is the first time U. Molinae leaf oil composition has been described. The composition of M. leucadendra oil corresponded to a chemotype described for a species growing in Cuba, but was different from that produced by M. leucadendra growing in Egypt, Tunisia, and elsewhere in Brazil. The profile of the L. confertus leaf oil showed high similarity with those described for Australian native specimens, in particular in relation to the relevant presence of α-pinene, aromadendrenes, and the guaiol-type alcohols.

关键词： Melaleuca leucadendra Lophostemon confertus Ugni molinae Myrtaceae Essential oil

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Time difference correlation between earthquake lights and seismic ground accelerations

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Applied Geophysics 2021年第1期18卷 9-16,128页

作者： Juan antonio Lira Maurizio Mulas Facultad de Ciencias Físicas Universidad Nacional Mayor de San MarcosLima 1Peru Sección Física Departamento Académico de CienciasPontificia Universidad Católica del PerúLima 32Peru Escuela Superior Politécnica del Litoral ESPOLFacultad de Ingeniería en Ciencias de la TierraCampus Gustavo Galindo Km 30.5 Vía PerimetralP.O.Box 09-01-5863

Although earthquake lights have been known since ancient times,it has not been easy to study *** was not until the 60s that the first photographs of them were *** the Peruvian earthquake in 2007,it was possible to obtain the fi rst fi lm recording on earthquake ***,during the earthquakes in Ecuador in 2016 and in Mexico in 2017,two fi lms of the earthquake lights were *** fi lm recordings have helped in the study of earthquake lights,both for their objectivity and for their informational *** causal mechanisms have been proposed to explain earthquake lights:piezoelectricity,radon emanation,fluid diffusion,friction-vaporization,positive holes and dipole currents,among *** this work a time difference correlation between earthquake lights and seismic ground accelerations was found and we use both seismic data and fi lm recordings of earthquake lights to explain its *** the discussion section it is suggested that fracturing of rocks manifest itself to some extent in the form of static electricity producing earthquake lights through induction The induction model proposed is new and it can explain the formation of EQL,even if the earth’s crust has layers of large electrical *** model also explains the formation of seismic lights without the need for special conditions on the earth’s surface or in the atmosphere.A better understanding of the earthquake lights generation process can improve our understanding of seismicity and help in the prediction of earthquakes.

关键词： time diff erence correlation earthquake lights seismic ground accelerations rock fracturing

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Physical habitat condition as a key tool to maintain freshwater biodiversity in neotropical artificial ponds

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Water Biology and Security 2023年第3期2卷 30-35页

作者： Marden S.Linares Livia B.dos Santos marcos Callisto Jean C.Santos Universidade Federal de Minas Gerais Instituto de Ciencias BiologicasDepartamento de GeneticaEcologia e EvoluçaoLaboratorio de Ecologia de BentosAv.Antonio Carlos 6627CEP 31270-901PampulhaBelo HorizonteMGBrazil Laboratorio de Macroecologia e Conservaçao da Biodiversidade Departamento de Botanica e EcologiaUniversidade Federal do Mato GrossoAv.Fernando Correa da Costa2367Boa EsperançaCuiabaMato GrossoCEP 78060-900Brazil Programa de Pos-Graduaçao em Ciencias Ambientais Instituto de Ciencias NaturaisHumanas e SociaisUniversidade Federal do Mato GrossoAvenida Alexandre Ferronato1200SinopMTCEP 78550-728Brazil Universidade Federal de Sergipe Departamento de EcologiaCampus Sao Cristovao-Cidade Universitaria Prof.Jose Aloísio de CamposCEP 49100-000Sao CristovaoSergipeBrazil

In areas highly affected by anthropogenic disturbances,artificial(human-made)freshwater ecosystems can provide habitat for maintaining and conserving regional freshwater *** assessed how the physical habitat of artificial ponds affected the structure of benthic macroinvertebrate *** do so,we tested two hypotheses.(1)Physical habitat disturbances are not detrimental to the diversity of nearby artificial ponds,and(2)Physical habitat disturbances do not cause significant shifts in taxonomic *** results rejected both null hypotheses,i.e.,macroinvertebrate diversity metrics correlated significantly and positively with Physical Habitat Integrity index scores,and only sites with high habitat condition scores were significantly associated with sensitive indicator *** results highlight the importance of maintaining physical habitat conditions for sustaining the ecological health of artificial ponds.

关键词： Bioindicators Ecosystem management Lentic ecosystems

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Study of a Model Humic Acid-type Polymer by Fluorescence Spectroscopy and Atomic Force Microscopy

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Materials Sciences and Applications 2012年第7期3卷 478-484页

作者： Marcilene Ferrari Barriquello Fábio de Lima Leite Daiana Kotra Deda Sérgio da Costa Saab Nelson Consolin-Filho marcos antonio Piza Ladislau Martin-Neto Universidade Tecnológica Federal do Paraná Campo MouraoBrazil Universidade Federal de Sao Carlos SorocabaBrazil Universidade Estadual de Ponta Grossa Ponta GrossaBrazil Embrapa Instrumentação Agropecuária Sao CarlosBrazil

A model HA-type polymer of para-benzoquinone synthetic humic acid (SHA) and its complexes with copper, iron and manganese metal ions were studied using atomic force microscopy (AFM). Natural humic acids (HA) and synthetic humic acids (SHA) were examined by fluorescence spectroscopy, which indicated similarity of SHA and HA spectra. The AFM images of SHA and its complexes revealed variable morphologies, such as small spheres, aggregates and a sponge-like structure. The SHA complexes displayed morphologies similar to those of natural HA. The presence of copper, iron and manganese ions led to the formation of aggregate-type structures in an apparent arrangement of smaller SHA particles.

关键词： Humic Substances Synthetic Humic Acids Metal Complexes AFM Fluorescence Spectroscopy

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Mesenchymal stem cell enhances chondral defects healing in horses

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Stem Cell Discovery 2013年第4期3卷 218-225页

作者： Ana Lucia Miluzzi Yamada Armando de Mattos Carvalho Andrei Moroz Elenice Deffune marcos Jun Watanabe Carlos Alberto Hussni Celso antonio Rodrigues Ana Liz Garcia Alves Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science(FMVZ)UNESPUniversidade Estadual PaulistaBotucatuBrazil Faculty of Veterinary Medicine Cuiaba UniversityCuiabaBrazil Department of Morphology Institute of BiosciencesUNESPBotucatuBrazil Blood Center School of MedicineUNESPBotucatuBrazil

The purpose of this study was to evaluate the effect of intralesional Mesenchymal Stem Cells (MSC) on the treatment of experimentally induced articular chondral defects in horses, emphasizing the benefits of this application in veterinary medicine. Chondral defects were induced in the medial femoral trochlea of both hind limbs of four horses. Thirty days post induction;the horses were divided into two groups. The G1 was submitted to treatment with MSC and the G2 was the control group. Clinical evaluations, synovial fluid analysis and synovial Prostaglandin E2 (PGE2) assessment were performed prior to defects and fortnightly up to 120 and 150 days. Macroscopic, histopathological and histochemical evaluations were performed at the end of the experiment. The treatment with MSC reduced the intraarticular inflammatory process. The G1 showed lower PGE2 concentrations in the synovial fluid and greater percentage of mononuclear cells and lower percentages of lymphocytes and neutrophils. The treatment improved the macro and microscopic aspects of repair tissue. No difference was observed in the scores of lameness between the G1 and G2. The use of MSC in the treatment of chondral defects minimized joint inflammation, as confirmed by synovial fluid analysis. The treatment resulted in an improved repair tissue, verified by macroscopic examination, histochemical and histopathological analysis.

关键词： Arthroscopy Cartilage Equine Lameness Mesenchymal Stem Cells

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Design of N-11-Azaartemisinins Potentially Active against Plasmodium falciparum by Combined Molecular Electrostatic Potential, Ligand-Receptor Interaction and Models Built with Supervised Machine Learning Methods

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Journal of Biophysical Chemistry 2023年第1期14卷 1-29页

作者： Jeferson Stiver Oliveira de Castro José Ciríaco Pinheiro Sílvia Simone dos Santos de Morais Heriberto Rodrigues Bitencourt antonio Florêncio de Figueiredo marcos antonio Barros dos Santos Fábio dos Santos Gil Ana Cecília Barbosa Pinheiro Instituto de Educação Ciência e Tecnologia do Pará Castanhal PA Brasil Laboratório de Química Teórica e Computacional Universidade Federal do Pará Belém PA Brasil Instituto Amazônia dos Saberes São Luís MA Brasil Universidade do Estado do Amapá Macapá AP Brasil Laboratório de Síntese Universidade Federal do Pará Belém PA Brasil Universidade do Estado do Pará Belém PA Brasil Fundação Santa Casa de Misericórdia do Pará Belém PA Brasil

N-11-azaartemisinins potentially active against Plasmodium falciparum are designed by combining molecular electrostatic potential (MEP), ligand-receptor interaction, and models built with supervised machine learning methods (PCA, HCA, KNN, SIMCA, and SDA). The optimization of molecular structures was performed using the B3LYP/6-31G* approach. MEP maps and ligand-receptor interactions were used to investigate key structural features required for biological activities and likely interactions between N-11-azaartemisinins and heme, respectively. The supervised machine learning methods allowed the separation of the investigated compounds into two classes: cha and cla, with the properties εLUMO+1 (one level above lowest unoccupied molecular orbital energy), d(C6-C5) (distance between C6 and C5 atoms in ligands), and TSA (total surface area) responsible for the classification. The insights extracted from the investigation developed and the chemical intuition enabled the design of sixteen new N-11-azaartemisinins (prediction set), moreover, models built with supervised machine learning methods were applied to this prediction set. The result of this application showed twelve new promising N-11-azaartemisinins for synthesis and biological evaluation.

关键词： Antimalarial Design MEP Ligand-Receptor Interaction Supervised Machine Learning Methods Models Built with Supervised Machine Learning Methods

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Percutaneous Ultrasound-Guided Radiofrequency Thermal Ablation for Treatment of Uterine Fibroids

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Open Journal of Obstetrics and Gynecology 2014年第12期4卷 716-724页

作者： Raúl García marcos Javier Monleón Alicia Martínez-Varea Fernando Gómez Guillermina Montoliú Jose J. Martínez Luis Martí-Bonmatí antonio Pellicer Department Obstetrics and Gynecology La Fe University Hospital Valencia Spain Department of Radiology Hospital Clinic Barcelona Spain Department of Radiology La Fe University Hospital Valencia Spain

Purpose: To assess the safety, efficacy and effectiveness of percutaneous radiofrequency (RF) thermal ablation to reduce symptoms of uterine fibroids. Materials and Methods: 17 premenopausal women with symptomatic uterine fibroids despite conventional medical treatment were included. The assessment of symptoms and characteristics of fibroids by vaginal ultrasound, magnetic resonance imaging (MRI) and contrast enhanced ultrasound (CEUS) was performed before starting treatment and 6 months after the procedure. Successful treatment was clinically considered if patients reported a reduction in symptoms 6 months after RF myolysis. Successful treatment was also considered if the necrosis of the fibroid was greater than 50%, 6 months after treatment. Results: The baseline score on visual analogue scale (VAS) for dysmenorrhea and intermenstrual pain was 5.76 ± 3.31 and 3.0 ± 3.4, respectively. According to a score of 0 - 3, baseline bleeding during menstruation was 2.29 ± 0.92. Six months after RF myolysis, the VAS for dysmenorrhea was 2.75 ± 3.32 (p = 0.004), whereas for intermenstrual pain it was 1.38 ± 2.56 (p = 0.02). Menstrual bleeding was reduced to 1.13 ± 0.89 (p = 0.005). Clinical success of the treatment was evident in 11 (64.7%) of the 17 patients with a 95% CI [38.6%, 84.7%]. Fourteen patients underwent MRI monitoring 6 months post-myolysis. Compared to baseline fibroid volume, ultrasound and MRI volume were 57.38% and 79.66% six months after surgery, respectively. A total of 13 patients (92.86%) had radiological success from the treatment (95% CI [64.2%, 99.6%]). Conclusion: Since percutaneous RF myolysis reduces volume and symptoms of uterine fibroids, it may be considered as a valid treatment for symptomatic fibroids.

关键词： Percutaneous Radiofrequency Thermal Ablation Myolysis Uterine Fibroids

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Common bean SNP alleles and candidate genes affecting photosynthesis under contrasting water regimes

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Horticulture Research 2021年第1期8卷 110-123页

作者： Susana Trindade Leitao Maria Catarina Bicho Priscila Pereira Maria Joao Paulo marcos Malosetti Susana de Sousa Araujo Fred van Eeuwijk Maria Carlota Vaz Patto Instituto de Tecnologia Quimica e Biológica antonio Xavier Universidade Nova de LisboaOeirasPortugal Wageningen University&Research WageningenThe Netherlands Present address:Instituto Superior de Agronomia Universidade de LisboaLisboaPortugal Present address:Nunhems Vegetable Seeds NunhemThe Netherlands Present address:Association BLC3-Technology and Innovation Campus Centre Bio R&D UnitOliveira do HospitalLisboaPortugal

Water deficit is a major worldwide constraint to common bean(Phaseolus vulgaris L.)production,being photosynthesis one of the most affected physiological *** gain insights into the genetic basis of the photosynthetic response of common bean under water-limited conditions,a collection of 158 Portuguese accessions was grown under both well-watered and water-deficit *** gas-exchange parameters were measured and photosynthetic pigments *** same collection was genotyped using SNP arrays,and SNP-trait associations tested considering a linear mixed model accounting for the genetic relatedness among accessions.A total of 133 SNP-trait associations were identified for net CO 2 assimilation rate,transpiration rate,stomatal conductance,and chlorophylls a and b,carotenes,and xanthophyll *** of these associations were detected under water-deficit and 43 under well-watered conditions,with only two associations common to both *** candidate genes revealed that stomatal regulation,protein translocation across membranes,redox mechanisms,hormone,and osmotic stress signaling were the most relevant processes involved in common bean response to water-limited *** candidates are now preferential targets for common bean water-deficit-tolerance ***,new sources of water-deficit tolerance of Andean,Mesoamerican,and admixed origin were detected as accessions valuable for breeding,and not yet explored.

关键词： breeding water assimilation

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Regression of Barrett＇s Esophagus： Is There a Difference between Clinical and Surgical Treatment？

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Journal of Pharmacy and Pharmacology 2017年第12期5卷 928-933页

作者： Ramon Rawache Barbosa Moreira de Lima Fernando antonio Siqueira Pinheiro Joao Odilo Goncalves Pinto marcos Andre Araujo Accioly Filho Mateus Alves de Araujo Paulo Henrique Araujo Parente Department of Digestive Surgery Walter Cantideo University Hospital Federal University of Ceara Fortaleza 60430-380 Brazil

Objective： To evaluate the response to clinical and surgical treatment of Walter Cantidio University Hospital patients who were diagnosed with Barrett＇s esophagus between 2012 and 2016. Methodology： From the database analysis of Walter Cantidio University Hospital＇s pathology service, we identified all patients with a diagnosis of Barrett＇s esophagus between 2012 and 2016. We analyzed the patients＇ medical records and collected epidemiological and clinical data. Results： 22 patients were included in the study, 13 of whom were surgically treated and 9 were clinically treated. The regression was 33.3% in the clinical group and 30.7% in the surgical group, with no statistical difference between these two groups. Conclusions： The results show synchrony with data from the medical literature regarding the response of Barrett＇s esophagus to clinical and surgical treatment.

关键词： Barrett's esophagus treatment regression.

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