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Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma

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World Journal of Radiology 2017年第5期9卷 245-252页

作者： Giorgio Greco Tommaso Cascella antonio Facciorusso Roberto Nani Rodolfo Lanocita Carlo Morosi Marta Vaiani Giuseppina Calareso Francesca G Greco antonio Ragnanese marco A Bongini Alfonso V Marchianò Vincenzo Mazzaferro Carlo Spreafico Department of Radiology Interventional RadiologyNuclear Medicine and RadiotherapyNational Cancer Institute Gastroenterology Unit Ospedali Riuniti FoggiaUniversity of Foggia Radiology and Interv-entional Radiology Unit Hepato-biliary Surgery and Liver Transplantation Unit National Cancer Institute

AIM To assess the safety and efficacy of transarterial chemoembolization(TACE) of hepatocellular carcinoma(HCC) using a new generation of 40 μm drug eluting beads in patients not eligible for curative *** Drug eluting bead TACE(DEB-TACE) using a new generation of microspheres(embozene tandem,40 μm) preloaded with 100 mg of doxorubicin was performed on 48 early or intermediate HCC patients with *** to therapy was assessed with Response Evaluation Criteria in Solid Tumors(RECIST) and modified RECIST(m RECIST) guidelines applied to computed tomography or magnetic resonance *** out of the 48 treated patients treated progressed on to receive liver orthotopic transplantation(OLT).This allowed for histological analysis on the treated explanted *** DEB-TACE with 40 μm showed a good safety profile without major complications or 30-d *** objective response rate of treated tumors was 72.6% and 26.7% according to m RECIST and RECIST *** examination in 11 patients assigned to OLT showed a necrosis degree > 90% in 78.6% of *** overall time to progression was 13 mo(11-21).CONCLUSION DEB-TACE with 40 μm particles is an effective treatment for the treatment of HCC in early-intermediate patients(Barcelona Clinic Liver Cancer stage A/B) with a good safety profile and good results in term of objective response rate and necrosis.

关键词： Embozene tandem Drug eluting beads Drug eluting bead transarterial chemoembolization Transarterial chemoembolization Hepatocellular carcinoma

Molecular Modeling and Synthesis of Ethyl Benzyl Carbamates as Possible Ixodicide Activity

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Computational Chemistry 2019年第1期7卷 1-26页

作者： Vazquez-Valadez Victor Hugo Hernandez-S.Manuel Alejandro Velazquez-S.Ana Maria Rosales-H.Maria Leyva-R.marco antonio Prado-O.Maria Guadalupe Munoz-G.marco antonio Alba-H.Fernando Abrego Victor Cruz-A.Diego Angeles Enrique Laboratorio de Quimica Medicinal Departamento de Ciencias QuimicasFES-Cuautitlan UNAMEdo.Mex.Mexico Laboratorio de Investigacion Nave 3000 Departamento de Ciencias QuimicasFES-Cuautitlan UNAMEdo.Mex.Mexico Departamento de Quimica CINVESTAVCd.Mx.Mexico Laboratorio 1 de la UIM Departamento de Ciencias BiologicasFES-Cuautitlan UNAMEdo.Mex.Mexico QSAR Analytics S.A.de C.V. Edo.Mex.Mexico

Carbamates are molecules that have different types of biological activities and provide a particular chemical control against ticks. The new structures of the proposed compounds were optimized and synthetized respectively, through a molecular model using the methods:PM3, HF and DFT applying the B3LYP functional, with the basis 6-31+G(d) and 6-311+G(d,p), BVP86 and PBEPBE with 6-31+G(d) and the vibrational frequencies computed. These calculated frequencies were compared with the experimental ones to determine the most accurate level of theory for the prediction of vibrational frequencies of the compounds. The best results were obtained through HF/631+G(d). Additionally, we report a modification to obtain this type of compounds, and based on the amino-dehalogenation of ethyl chloroformate, different benzyl ethyl carbamates were synthesized modifying the base molecule. The performances obtained were compared to others already reported. The methodology used allowed us to synthesize new carbamates using benzylamine derivatives through a modification on the basic catalysis of the addition-elimination reaction.

关键词： N-Carbamates Ixodicide Molecular Modeling

Atypical Calcified Ganglioglioma: A Rare Case Report

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Advances in Computed Tomography 2014年第1期3卷 11-13页

作者： Seizo Yamashita Luiz antonio Resende Fernanda M. P. Souza marco Zanini Carlos Clayton André P. Trindade Department of General Surgery Faculty of Medicine UNESP Botucatu Brazil

Considered rare tumors, gangliogliomas account for 0.4% - 0.9% of intracranial neoplasms. The peak of its incidence occurs between 10 and 20 years of age. These tumors are composed of glial and ganglion cells and they are relatively low-grade neoplasms associated with good prognoses. We report a case of an atypical calcified ganglioglioma in an 18-year-old woman with history of four months of stabbing right-sided parietal headache, paroxysmal. On image studies were noted the presence of thick wall calcification in gangliogliomas. Although rare, this atypical ganglioglioma should be included in the differential diagnosis of lesions occurring in this area of the brain.

关键词： Gangliogliomas Brain Calcification Atypical

Process Mineralogy of Lateritic Nickel Ore

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矿物学报 2013年第S1期33卷 17-17页

作者： Daniel Uliana M.Manuela M.Lé Tassinari Henrique Kah marco antonio Angora University of Sao Paulo Polytechnic SchoolMining and Petroleum Engineering Department Av.Prof.Mello Mores2373SAO PAULOSPBrazil Votorantim Metais Nickel Business Unit Av.Dr.José Artur Nova1309SAO PAULOSPBrazil

This paper presents a methodology for studying low grade lateritic nickel ore, which usually presents complex mineralogy, with widespread nickel in several mineral phases. The study is focused on determining the mineralogy and the distribution of nickel in the bearing minerals. Laboratory assays comprise homogenization, sampling and particle size analysis. Chemical analyses by X-ray fluorescence are performed in all fractions sizes, while mineralogical assessments by X-ray diffraction are carried out for head sample. The mineralogical composition of the samples and the partition of main elements in the bearing minerals are assayed by size fraction through automated image analysis software (MLA) coupled to a scanning electron microscope (SEM). The chemical compositions of the several minerals identified in MLA are determined during systematic observations on SEM with energy dispersive spectrometer (EDS).

关键词： nickel ore process mineralogy automated mineralogy image analysis

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遗传学在胆管细胞癌发展中的重要性

中国普通外科杂志 2015年第2期24卷 151-162页

作者： Luca Maroni Irene Pierantonelli Jesus M.Banales antonio Benedetti marco Marzioni 史肖华王强凤意大利马尔凯理工大学胃肠病科安科纳荷兰泰阿姆斯特丹大学学术医疗中心泰加特肝肠病研究所阿姆斯特丹奥地利维也纳医科大学内科学系III胃肠病学与肝脏病学区维也纳西班牙巴斯克大学Biodonostia研究所肝脏病学与胃肠病学系圣塞瓦斯蒂安不详

胆管细胞癌(CCA)是肝脏一种少见的恶性肿瘤,起源于胆管。在过去的30年里,CCA在世界各地的发病率不断的增高,但其预后依然很差,几乎未改变过。尽管已发现几个危险因子与该肿瘤的发生相关,但这些危险因子中没有一个在大多数患者中得以肯... 详细信息

胆管细胞癌(CCA)是肝脏一种少见的恶性肿瘤,起源于胆管。在过去的30年里,CCA在世界各地的发病率不断的增高,但其预后依然很差,几乎未改变过。尽管已发现几个危险因子与该肿瘤的发生相关,但这些危险因子中没有一个在大多数患者中得以肯定。由于诊断时多已是晚期以及有限的治疗选择,导致CCA生存率很低。近来对CCA遗传学和表观遗传学上变化的研究结果为重新阐明胆管细胞恶性转化的分子学机制带来了希望。沿着这一方向进一步研究将有助于形成新的诊断、预后和治疗方法。该篇全面概述了CCA的最新进展,描述迄今所报道过的发生在CCA中最重要的基因突变和表观遗传学改变。

关键词：胆管肿瘤/遗传学后成说,遗传

Recent trends in endoscopic management of achalasia

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World Journal of Gastrointestinal Endoscopy 2014年第9期6卷 407-414页

作者： Salvatore Tolone Paolo Limongelli Gianmattia del Genio Luigi Brusciano antonio Russo Lorenzo Cipriano marco Terribile Giovanni Docimo Roberto Ruggiero Ludovico Docimo XI Division of General and Obesity Surgery Second University of Naples

Esophageal achalasia is a chronic and progressive motility disorder characterized by absence of esophageal body peristalsis associated with an impaired relaxation of lower esophageal sphincter(LES) and usually with an elevated LES pressure, leading to an altered passage of bolus through the esophago-gastric junction. A definitive cure for achalasia is currently unavailable. Palliative treatment options provide only food and liquid bolus intake and relief of symptoms. Endoscopic therapy for achalasia aims to disrupt or weaken the lower esophageal sphincter. Intra-sphincteric injection of botulinum toxin is reserved for elderly or severely ill patients. Pneumatic dilation provides superior results than botulinum toxin injection and a similar mediumterm efficacy almost comparable to that attained after surgery. Per oral endoscopic myotomy is a promising option for treating achalasia, but it requires increased experience and further objective and long-term follow up. This article will review different endoscopic treatments in achalasia, and summarize the short-term and long-term outcomes.

关键词： Achalasia Endoscopy Pneumatic dilation Botulinum toxin injection Per oral endoscopic myotomy High resolution manometry Dysphagia

Numerical Model of Ultra-High Molecular Weight Polyethylene Abrasive Wear Tests

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Modeling and Numerical Simulation of Material Science 2020年第1期10卷 1-14页

作者： Tomas De la Mora Ramirez Isaias Hilerio Cruz marco antonio Donu Ruiz Noe Lopez Perrusquia David Garcia Bustos Martin Flores Martinez Autonomous Metropolitan University Azcapotzalco UnitAzcapotzalcoMexico CityMexico Science and Engineering of Materials Technological of Studies of JocotitlanJocotitlan State of MexicoMexico Group of Materials Science and Engineering Polytechnic University of the Valley of MexicoTultitlanMariano EscobedoMexico University of Guadalajara University Center of Exact Sciences and EngineeringGuadalajaraMéxico

Ultra-high molecular weight polyethylene (UHMWPE) has been used in orthopedics as one of the materials for artificial joints in knee, hip and spine prostheses, most of the implanted joints are designed so that the metal of the prosthesis is articulate against a polymeric material, however the main problems is the average life time of the UHMWPE due to wear, and the particles generated by the friction of the metal on the articulation of the polymer are the most common inducer of osteolysis, generating a loosening of the implant leading to an imminent failure resulting in the total replacement of the prosthesis. In this investigation a numerical model of abrasive wear was made using the classic Archard wear equation applied to dynamic simulation of finite element analysis (FEA) of the micro-abrasion test using a subroutine written in Fortran language linked to the finite element software to predict the rate of wear. The results of the numerical model were compared with tests of abrasive wear in the laboratory, obtaining a margin of error below 5%,concluding that the numerical model is feasible for the prediction of the rate of wear and could be applied in knowing the life cycle of joint prostheses or for the tribological analysis in industrial machinery or cutting tools. The wear coefficient (K) was obtained from the grinding tests depending on the depth of stroke of the crater, which was analyzed by 3D profilometry to obtain the wear rate and the wear constant.

关键词： Abrasive Wear Finite Element Numerical Wear Model UHMWPE

用于电磁炉零压准谐振转换器的ESBT^(TM)晶体管

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家电科技 2005年第10期 30-32页

作者： Simone Buonomo marco D`antonio Giovanni Vitale 意法半导体

ESBTTM是由一个高压双极晶体管与一个低通态电阻的低压功率MOSFET组成,两个器件连接采用共发共基放大器结构(CASCODE)。这个解决方案的最大优点是关断快速和传导过程中压降较低。由于具有这些特性,对于传统的开关而言,ESBTTM系列代表了... 详细信息

ESBTTM是由一个高压双极晶体管与一个低通态电阻的低压功率MOSFET组成,两个器件连接采用共发共基放大器结构(CASCODE)。这个解决方案的最大优点是关断快速和传导过程中压降较低。由于具有这些特性,对于传统的开关而言,ESBTTM系列代表了全谐振或准谐振转换器应用中的一个理想的解决方案。

关键词：双极晶体管准谐振转换器电磁炉功率MOSFET 零压通态电阻放大器 M系列

Big Data Analytics for Earth Sciences:the EarthServer approach

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International Journal of Digital Earth 2016年第1期9卷 3-29页

作者： Peter Baumann Paolo Mazzetti Joachim Ungar Roberto Barbera Damiano Barboni Alan Beccati Lorenzo Bigagli Enrico Boldrini Riccardo Bruno antonio Calanducci Piero Campalani Oliver Clements Alex Dumitrua,Mike Grant Pasquale Herzig George Kakaletris John Laxton Panagiota Koltsida Kinga Lipskoch Alireza Rezaei Mahdiraji Simone Mantovani Vlad Merticariu antonio Messina Dimitar Misev Stefano Natali Stefano Nativi Jelmer Oosthoek marco Pappalardo James Passmore Angelo Pio Rossi Francesco Rundo Marcus Sen Vittorio Sorbera Don Sullivan Mario Torrisi Leonardo Trovato Maria Grazia Veratelli Sebastian Wagner Large-Scale Scientific Information Systems Jacobs UniversityBremenGermany Rasdaman GmbH BremenGermany CNR-IIA National Research Council of ItalyInstitute of Atmospheric Pollution ResearchFlorenceItaly EOX IT Services GmbH ViennaAustria Consorzio COMETA CataniaItaly Division of Catania Italian National Institute for Nuclear PhysicsCataniaItaly Department of Physics and Astronomy University of CataniaCataniaItaly MEEO S.r.l. FerraraItaly Plymouth Marine Laboratory PlymouthUK Fraunhofer IGD DarmstadtGermany Athena Research and Innovation Center in Information Communication&Knowledge Technologies AthensGreece British Geological Survey EdinburghUK Software Engineering Italia S.r.l. CataniaItaly British Geological Survey KeyworthUK NASA Ames Research Center Moffett FieldCAUSA

Big Data Analytics is an emerging field since massive storage and computing capabilities have been made available by advanced *** and Environmental sciences are likely to benefit from Big Data Analytics techniques supporting the processing of the large number of Earth Observation datasets currently acquired and generated through observations and ***,Earth Science data and applications present specificities in terms of relevance of the geospatial information,wide heterogeneity of data models and formats,and complexity of ***,Big Earth Data Analytics requires specifically tailored techniques and *** EarthServer Big Earth Data Analytics engine offers a solution for coverage-type datasets,built around a high performance array database technology,and the adoption and enhancement of standards for service interaction(OGC WCS and WCPS).The EarthServer solution,led by the collection of requirements from scientific communities and international initiatives,provides a holistic approach that ranges from query languages and scalability up to mobile access and *** result is demonstrated and validated through the development of lighthouse applications in the Marine,Geology,Atmospheric,Planetary and Cryospheric science domains.

关键词： big data Big Data Analytics array databases Earth Sciences interoperability standards