检索结果-南通市图书馆

Primary liver transplantation vs transplant after Kasai portoenterostomy in children with biliary atresia: A retrospective Brazilian single-center cohort

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of transplantation 2024年第1期14卷 112-119页

作者： Melina Utz Melere Valberto Sanha marco Farina Carolina soares da Silva Luiza Nader Cristine trein Angelica Maria Lucchese Cristina Ferreira Antonio Nocchi Kalil Flavia Heinz Feier Department of Hepatology and Liver transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Brazil Department of Hepato-biliary-pancreatic Surgery and Liver transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Department of Surgical Oncology Santa Rita Hospital/Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil

BACKGROUND Biliary atresia(BA)is the most common indication for pediatric liver transplantation,although portoenterostomy is usually performed ***,due to the high failure rate of portoenterostomy,liver transplantation has been advocated as the primary procedure for patients with *** is still unclear if a previous portoenterostomy has a negative impact on liver transplantation *** to investigate the effect of prior portoenterostomy in infants un-dergoing liver transplantation for *** this was a retrospective cohort study of 42 pediatric patients with BA who underwent primary liver transplantation from 2013 to 2023 at a single tertiary center in *** with BA were divided into two groups:those undergoing primary liver transplantation without portoenterostomy and those undergoing liver transplantation with prior *** variables were compared using the Student’s t-test or the Kruskal-Wallis test,and categorical variables were compared using theχ2 or Fisher’s exact test,as *** Cox regression analysis was performed to determine risk factors for portal vein *** and graft survival analyses were conducted with the Kaplan–Meier product-limit estimator,and patient subgroups were compared using the two-sided log-rank *** Forty-two patients were included in the study(25[60%]girls),23 undergoing liver transplantation without prior portoenterostomy,and 19 undergoing liver transplantation with prior *** with prior portoenterostomy were older(12 vs 8 months;P=0.02)at the time of liver transplantation and had lower Pediatric End-Stage Liver Disease scores(13.2 vs 21.4;P=0.01).the majority of the patients(35/42,83%)underwent livingdonor liver *** group of patients without prior portoenterostomy appeared to have a higher incidence of portal vein thrombosis(39 vs 11%),but this result did not reach statistical *** portoenterostomy

关键词： Hepatic portoenterostomy Biliary atresia Liver transplantation Patient outcome assessment Portal vein Survival

Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. the development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. the direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ItG and Eckert & Ziegler). the radiochemical purity was evaluated by tLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ItG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. the results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PEt Imaging

Evaluation of Formaldehyde as a Potential Cause of Olfactory Dysfunction in Hairdressers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Power and Energy Engineering 2023年第3期11卷 143-149页

作者： Linda Bitencourt Cabral Mariana andrade Miyamoto Natália Medeiros Dias Lopes Ellen Cristine Duarte Garcia tiago Severo Peixe marco Aurélio Fornazieri Department of Clinical Surgery Universidade Estadual de Londrina Londrina Brazil Medical School Pontifícia Universidade Católica do Paraná Londrina Brazil GEM Center of Excellence in Research Teaching and Health Care Londrina Brazil Department of Clinical and toxicological Analysis Universidade Estadual de Londrina Londrina Brazil

Objective: the aim of this study was to compare the olfactory function between hairdressers exposed to formaldehyde and unexposed controls, as exposure to toxic agents is a potential cause of olfactory disorders in humans. Hairdressing professionals frequently encounter formaldehyde, a component found in hair products that are known to have various toxic effects on the human body, including alterations in the sense of smell. Methods: A total of 32 hairdressing volunteers exposed to formaldehyde and 32 non-exposed volunteers matched for age, sex, education and smoking status underwent the University of Pennsylvania Smell Identification test (UPSIt®). Results: the findings demonstrated a decrease in UPSIt® olfactory test scores and a higher degree of olfactory loss among hairdressers exposed to formaldehyde (mean UPSIt® scores: 30.6 vs 35.1, p Conclusion: Occupational exposure of hairdressers to formaldehyde is associated with diminished olfactory function. Education approach and promotion of personal protective equipment usage should be encouraged.

关键词： Formaldehyde Olfaction Disorders Occupational Medicine toxicology

Molecular approaches for spinal cord injury treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第1期18卷 23-30页

作者： Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio andrade Prins Fellipe soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury

在线全文

学校读者我要写书评

暂无评论

极端海浪对LNG运输船影响的试验研究

哈尔滨工程大学学报（英文版） 2023年第1期22卷 52-74页

作者： marco Klein Shan Wang Günther Clauss C.Guedes soares German Aerospace Center(DLR) Institute of Maritime Energy SystemsMax-Planck-Straße 2Geesthacht 21502Germany Hamburg University of technology Offshore Dynamics GroupSchloßmühlendamm 30Hamburg 21073Germany Centre for Marine technology and Ocean Engineering(CENtEC) Instituto Superior TécnicoUniversidade de LisboaAvenida Rovisco PaisLisboa 1049-001Portugal technische Universität Berlin Ocean Engineering DivisionSalzufer 17-19Berlin 10587Germany

this paper presents a comprehensive experimental study on the effect of extreme waves on a LNG *** LNG carrier model was equipped with a variety of sensors to measure motions,green water height on deck as well as local and global *** in transient wave packets provided the general performance in waves in terms of response amplitude operators and were accompanied by tests in regular waves with two different wave *** tests allowed detailed insights into the nonlinear behavior of the vertical wave bending moment in steep waves showing that green water on deck can contribute to a decrease of vertical wave bending ***,systematic model tests in irregular waves were performed to provide the basis for statistical *** is shown that the generalized extreme value distribution model is suitable for the estimation of the extreme peak values of motions and ***,model tests in tailored extreme wave sequences were conducted comparing the results with the statistical *** this purpose,analytical breather solutions of the nonlinear Schrödinger equation were applied to generate tailored extreme waves of certain critical wave lengths in terms of ship *** these design extreme waves,the LGN carrier was also investigated in the model scale reproduction of the real-world Draupner *** comparing the motions,vertical wave bending moment,green water column and slamming pressures it is concluded that the breather solutions are a powerful and efficient tool for the generation of design extreme waves of certain critical wave lengths for wave/structure investigations on different subjects.

关键词： Extreme wave events Wave-structure interaction Draupner wave Breather solutions

Hybrid triboelectric-Electromagnetic Nanogenerators for Mechanical Energy Harvesting:A Review

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2021年第12期13卷 163-220页

作者： Joao V.Vidal Vladislav Slabov Andrei L.Kholkin marco P.soares dos Santos Department of Physics and CICECO-Aveiro Institute of Materials University of Aveiro3810-193 AveiroPortugal Department of Physics and I3N University of Aveiro3810-193 AveiroPortugal Laboratory of Functional Low-Dimensional Structures National University of Science and Technology MISISMoscowRussia Department of Mechanical Engineering Centre for Mechanical Technology and Automation(TEMA)University of Aveiro3810-193 AveiroPortugal

Motion-driven electromagnetictriboelectric energy generators(E-tENGs) hold a Hybrid triboelectric-electromagnetic generators C A Bgreat potential to provide higher voltages,higher currents and wider operating bandwidths than Cantilever generators1 μm both electromagnetic and triboelectric generators Rotating generatorsSliding generators standing alone. therefore,they are promising solutions to autonomously supply a broad range of Flexible blade generators Magnetoelectric highly sophisticated devices. this paper provides generators a thorough review focused on major recent breakLinear generators Multidimensional generators throughs in the area of electromagnetic-triboelectric vibrational energy harvesting. A detailed Pendulum generators analysis was conducted on various architectures including rotational,pendulum,linear,sliding,cantilever,flexible blade,multidimensional and 1 cm magnetoelectric,and the following hybrid technologies. they enable highly e cient ways to harvest electric energy from many forms of vibrational,rotational,biomechanical,wave,wind and thermal sources,among others. Open-circuit voltages up to 75 V,short-circuit currents up to 60 mA and instantaneous power up to 144 mW were already achieved by these nanogenerators. their transduction mechanisms,including proposed models to make intelligible the involved physical phenomena,are also overviewed here. A comprehensive analysis was performed to compare their respective construction designs,external excitations and electric outputs. the results highlight the potential of hybrid E-tENGs to convert unused mechanical motion into electric energy for both large-and small-scale ***,this paper proposes future research directions toward optimization of energy conversion e ciency,power management,durability and stability,packaging,energy storage,operation input,research of transduction mechanisms,quantitative standardization,system integration,miniaturization and multi-energy hybrid cells.

关键词： E-tENG Hybrid triboelectric-electromagnetic Nanogenerators Energy harvesting

Hospitalizations and in-hospital mortality for inflammatory bowel disease in Brazil

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and therapeutics 2022年第1期13卷 1-10页

作者： Ana Luiza Vilar Guedes Amanda Lopes Lorentz Larissa Fernandes de Almeida Rios Rios Beatriz Camara Freitas Adriano Gutemberg Neves Dias Ana Luísa Eckhard Uhlein Felipe Oliveira Vieira Neto Jobson Felipe soares Jesus túlio de SáNovaes torres Raquel Rocha Vitor D andrade Genoile Oliveira Santana Life Sciences Department State University of BahiaSalvador 41150-000BahiaBrazil Sciences of Nutrition Federal University of BahiaSalvador 40110-060BahiaBrazil Medicine Department Universidade Salvador(UNIFACS)Salvador 41820-021BahiaBrazil Medicine and Health Postgraduate Program Federal University of BahiaSalvador 40110-060BahiaBrazil

BACKGROUND Inflammatory bowel disease(IBD)is associated with complications,frequent hospitalizations,surgery and *** introduction of biologic drugs into the therapeutic arsenal in the last two decades,combined with an expansion of immunosuppressant therapy,has changed IBD management and may have altered the profile of hospitalizations and in-hospital mortality(IHM)due to *** to describe hospitalizations from 2008 to 2018 and to analyze IHM from 1998 to 2017 for IBD in *** this observational,retrospective,ecological study used secondary data on hospitalizations for IBD in Brazil for 2008-2018 to describe hospitalizations and for 1998-2017 to analyze *** data were obtained from the Hospital Information System of the Brazilian Unified Health System and population data from demographic *** following variables were analyzed:Number of deaths and hospitalizations,length of hospital stay,financial costs of hospitalization,sex,age,ethnicity and type of hospital *** there was a reduction in the number of IBD hospitalizations,from 6975 admissions in 1998 to 4113 in 2017(trend:y=-0.1682x+342.8;R^(2)=0.8197;Pthe hospitalization rate also decreased,from 3.60/100000 in 2000 to 2.17 in *** rates varied during the 20-year period,between 2.06 in 2017 and 3.64 in 2007,and did not follow a linear trend(y=-0.0005049x+2.617;R^(2)=0,00006;P=0.9741).IHM rates also varied between regions,increasing in all but the southeast,which showed a decreasing trend(y=-0.1122x+4.427;R^(2)=0,728;Pthe Southeast region accounted for 44.29%of all *** Northeast region had the highest IHM rate(2.86 deaths/100 admissions),with an increasing trend(y=0.1105x+1.110;R^(2)=0.6265;Pt the lowest hospitalization rate(1.15).the Midwest and South regions had the highest hospitalization rates(3.27 and 3.17,respectively).A higher IHM rate was observed for nonelective admissions(2.88),which accounted for 81%of IB

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Hospitalization Hospital mortality Hospital information systems Epidemiology

Edible Coatings Based on Apple Pectin,Cellulose Nanocrystals,and Essential Oil of Lemongrass:Improving the Quality and Shelf Life of Strawberries(Fragaria Ananassa)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2019年第1期7卷 73-87页

作者： Ingrid Souza Vieira da Silva Natália soares Prado Patrícia Gontijo de Melo Danilo Campion Arantes Mara Zeni andrade Harumi Otaguro Daniel Pasquini Instituto de Química Universidade Federal de UberlândiaCampus Santa MônicaAv.João Naves deÁvila2121Uberlândia-MG38400-902Brazil Instituto Federal do triângulo Mineiro Campus Uberaba Rua João Batista Ribeiro4000Uberaba-MG38064-790Brazil Departamento de Ciências Naturais(DCNAt) Universidade Federal de São João Del-ReiPraça D.Helvécio74São João Del-Rei-MG36301-160Brazil Universidade de Caxias do Sul Rua Francisco Getúlio Vargas1130Caxias do Sul-RS95070-970Brazil

In this work,nine different types of edible coating based on pectin,cellulose nanocrystals,glycerol,and essential oil of lemongrass were prepared and used to coat strawberries with a film formed directly on the surface of the coated *** effects of the different edible coatings on refrigerated fruits in terms of weight loss,titratable acidity,total soluble solids,pH,and anthocyanin content was evaluated after 2 days,4 days,6 days,and 8 days of *** of the edible coatings reduced the weight loss of the coated strawberries and the anthocyanin *** total soluble solids content of or uncoated fruit increase more markedly than that of coated *** contrast,pH was maintained for both coated and uncoated *** edible coatings were effective in minimizing of the weight loss,without worsening the physical chemistry *** treatments t5 and t9 presented the best results.

关键词： Strawberry edible coating cellulose nanocrystals pectin shelf life

Natural and Eco-Friendly Materials for triboelectric Energy Harvesting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2020年第3期12卷 179-196页

作者： Vladislav Slabov Svitlana Kopyl marco Psoares dos Santos Andrei L.Kholkin Department of Physics and CICECO‑Aveiro Institute of Materials University of Aveiro3810‑193 AveiroPortugal Centre for Mechanical technology and Automation(tEMA) University of Aveiro3810‑193 AveiroPortugal Department of Mechanical Engineering University of Aveiro3810‑193 AveiroPortugal School of Natural Sciences and Mathematics Ural Federal UniversityEkaterinburgRussia 620000 Laboratory of Functional Low‑Dimensional Structures National University of Science and Technology MISiSMoscowRussia 119049

triboelectric nanogenerators(tENGs)are promising electric energy harvesting devices as they can produce renewable clean energy using mechanical excitations from the *** designs of triboelectric energy harvesters relying on biocompatible and eco-friendly natural materials have been introduced in recent *** ability to provide customizable self-powering for a wide range of applications,including biomedical devices,pressure and chemical sensors,and battery charging appliances,has been *** review summarizes major advances already achieved in the field of triboelectric energy harvesting using biocompatible and eco-friendly natural materials.A rigorous,comparative,and critical analysis of preparation and testing methods is also *** power up to 14 mW was already achieved for the dry leaf/polyvinylidene fluoride-based tENG *** findings highlight the potential of eco-friendly self-powering systems and demonstrate the unique properties of the plants to generate electric energy for multiple applications.

关键词： Natural and eco-friendly materials Energy harvesting triboelectric nanogenerators Biocompatibility