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Combined Descemet stripping automated endothelial keratoplasty and intravitreal dexamethasone implant for concomitant pseudophakic bullous keratopathy and cystoid macular edema

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 866-869页

作者： Gabriella Cirigliano marco r pastore Alberto A Perrotta Chiara De Giacinto Daniele Tognetto Eye Clinic Department of Medical Surgical Sciences and HealthUniversity of Trieste

Dear Editor,Endothelial cell density decreases with age and in various ocular conditions,including corneal endotheliitis,uveitis,pseudoexfoliation syndrome,and birth injury(1)The reduction of endothelial cell density is exacerbated over time after intraocular surgery(1)Descemet stripping automated endothelial keratoplasty(DSAEK)is considered the primary procedure for patients with only endothelial dysfunction.

关键词： PBK Figure Combined Descemet stripping automated endothelial keratoplasty and intravitreal dexamethasone implant for concomitant pseudophakic bullous keratopathy and cystoid macular edema IOL IOP

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Spontaneous or secondary to intravitreal injections of anti-angiogenic agents retinal pigment epithelial tears in age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2014年第4期7卷 681-685页

作者： Pia E.Leon Sandro Saviano Andrea Zanei marco r.pastore Elvira Guaglione Alessandro Mangogna Daniele Tognetto University Eye Clinic of Trieste Ospedale Maggiore

·AIM:Toevaluatethevisualfunctionevolutionofretinal pigment epithelial(rPE) tears in patients with age-related macular degeneration(AMD) according to type of occurrence [spontaneous or secondary to anti-vascular endothelial growth factor(anti-VEGF) injection] and the topographic location of the tear after a two-year followup period.·METHODS: A total of 15 eyes of 14 patients with rPE tears in exudative AMD were analyzed retrospectively at the University Eye Clinic of Trieste. Inclusion criteria were: patient age of 50 or older with AMD and rPE tears both spontaneous occurring or post anti-VEGF treatment. Screening included: careful medical history,complete ophthalmological examination, fluorescein angiography(FA), indocyanine green angiography(ICG),autofluorescence and infrared imaging and optical coherence tomography(OCT). Patients were evaluated every month for visual acuity(VA), fundus examination and OCT. Other data reported were: presence of PED,number of injections before the tear, location of the lesion.·rESULTS:Meanfollow-up was24wk(SD±4wk). Atotal of 15 eyes were studied for rPE tear. In 6 cases(40%),the rPE tears occurred within two years of anti-VEGF injections the others occurred spontaneously. In 13cases(86.6%), the rPE tear was associated with pigment epithelial detachment(PED). In 7 cases(46.6%), the rPE tear occurred in the central area of the retina and involved the fovea. Two lesions were found in the parafoveal region, six in the extra-macular area. In all cases visual acuity decreased at the end of the follow-up period(P r the topographical location of the lesion.·CONCLUSION: rPE tear occurs in exudative AMD as a spontaneous complication or in relation to anti-VEGF injections. Visual acuity decreased significantly and gradually in the follow-up period in all cases. No correlation was found between visual loss and the type of onset or the topographic location of the tears.

关键词： retinal pigment epithelial age-related macular degeneration tears visual acuity anti-vascular endothelial growth factor treatment

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Concentrated suspensions of Brownian beads in water: dynamic heterogeneities through a simple experimental technique

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Science China(Physics,Mechanics & Astronomy) 2019年第10期62卷 33-44页

作者： raffaele pastore marco Caggioni Domenico Larobina Luigi Santamaria Amato Francesco Greco Department of Chemical Materials and Production EngineeringUniversity of Naples FedericoⅡNapoli 80125Italy Corporate Engineering The Procter&Gamble CompanyCincinnatiWest Chester OH 45069USA Institute for Polymers Composites and BiomaterialsNational Research Council of ItalyNapoli 80055Italy ASI Agenzia Spaziale ItalianaCentro di Geodesia SpazialeMatera 75100Italy

Concentrated suspensions of Brownian hard-spheres in water are an epitome for understanding the glassy dynamics of both soft materials and supercooled molecular liquids. From an experimental point of view, such systems are especially suited to perform particle tracking easily, and, therefore, are a benchmark for novel optical techniques, applicable when primary particles cannot be resolved. Differential variance analysis（DVA） is one such novel technique that simplifies significantly the characterization of structural relaxation processes of soft glassy materials, since it is directly applicable to digital image sequences of the sample. DVA succeeds in monitoring not only the average dynamics, but also its spatio-temporal fluctuations, known as dynamic heterogeneities. In this work, we study the dynamics of dense suspensions of Brownian beads in water, imaged through digital video-microscopy, by using both DVA and single-particle tracking. We focus on two commonly used signatures of dynamic heterogeneities: the dynamic susceptibility, χ4, and the non-Gaussian parameter, α2. By direct comparison of these two quantities,we are able to highlight similarities and differences. We do confirm that χ4 and α2 provide qualitatively similar information, but we find quantitative discrepancies in the scalings of characteristic time and length scale on approaching the glass transition.

关键词： glass transition structural relaxation dynamic heterogeneities colloidal glasses

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Correction of low corneal astigmatism in cataract surgery

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 719-724页

作者： Pia Leon marco rocco pastore Andrea Zanei Ingrid Umari Meriem Messai Corrado Negro Daniele Tognetto University Eye Clinic of Trieste Ospedale Maggiore University of Trieste

· AIM: To evaluate and compare aspheric toric intraocular lens(IOL) implantation and aspheric monofocal IOL implantation with limbal relaxing incisions(LrI) to manage low corneal astigmatism(1.0-2.0 D) in cataract surgery.· METHODS: A prospective randomized comparative clinical study was performed. There were randomly recruited 102 eyes(102 patients) with cataracts associated with corneal astigmatism and divided into two groups. The first group received toric IOL implantation and the second one monofocal IOL implantation with peripheral corneal relaxing incisions. Outcomes considered were: visual acuity, postoperative residual astigmatism, endothelial cell count, the need for spectacles, and patient satisfaction. To determine the postoperative toric axis, all patients who underwent the toric IOL implantation were further evaluated using an OPD Scan III(Nidek Co, Japan). Follow-up lasted 6mo.· rESULTS: The mean uncorrected distance visual acuity(UCVA) and the best corrected visual acuity(BCVA) demonstrated statistically significant improvement after surgery in both groups. At the end of the follow-up the UCVA was statistically better in the patients with toric IOL implants compared to those patients who underwent implantation of monofocal IOL plus LrI. The mean residual refractive astigmatism was of 0.4 D for the toric IOL group and 1.1 D for the LrI group(P rence was observed in the postoperative endothelial cell count between the two groups.· CONCLUSION: The two surgical procedures demonstrated a significant decrease in refractive astigmatism. Toric IOL implantation was more effective and predictable compared to the limbal relaxing incision.

关键词： low corneal astigmatism toric intraocular lenses limbal relaxing incisions cataract surgery visual acuity

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