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Three predictive scores compared in a retrospective multicenter study of nonunion tibial shaft fracture

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World Journal of Orthopedics 2024年第6期15卷 560-569页

作者： Davide Quarta marco Grassi Giuliano Lattanzi Antonio Pompilio Gigante Alessio D'Anca Domenico Potena Clinical Orthopedics Department of Clinical and Molecular ScienceUniversitàPolitecnica Delle MarcheAncona 60126Italy Department of Information and Engineering UniversitàPolitecnica delle MarcheAncona 60121Italy

BACKGROUND Delayed union,malunion,and nonunion are serious complications in the healing of *** the risk of nonunion before or after surgery is *** To compare the most prevalent predictive scores of nonunion used in clinical practice to determine the most accurate score for predicting *** We collected data from patients with tibial shaft fractures undergoing surgery from January 2016 to December 2020 in three different trauma *** this retrospective multicenter study,we considered only fractures treated with intramedullary *** calculated the tibia FRACTure prediction healING days(FRACTING)score,Nonunion Risk Determination score,and Leeds-Genoa Nonunion Index(LEG-NUI)score at the time of definitive *** Of the 130 patients enrolled,89(68.4%)healed within 9 months and were classified as *** remaining patients(n=41,31.5%)healed after more than 9 months or underwent other surgical procedures and were classified as *** calculation of the three scores,LEG-NUI and FRACTING were the most accurate at predicting *** LEG-NUI and FRACTING showed the best performances by accurately predicting union and nonunion.

关键词： Trauma Bone Tibial fracture Nonunion Scores Prediction model

Vallisneria spiralis L. adaptive capacity improves pore water chemistry and increasespotential nitrification in organic polluted sediments

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Ecological Processes 2024年第2期 72-89页

作者： Leonardo Morini Claudio Ferrari marco Bartoli Mindaugas Zilius Elias Broman Giovanna Visioli Department of Chemistry Life Science and Environmental Sustainability University of Parma Department of Environmental and Prevention Sciences University of Ferrara Department of Integrative Marine Ecology (EMI) Genoa Marine Centre Stazione Zoologica Anton Dohrn-National Institute of Marine BiologyEcology and Biotechnology Marine Research Institute Klaipeda University Department of Ecology Environment and Plant Sciences Stockholm University Baltic Sea Centre Stockholm University

Background Macrophytes may modify benthic biodiversity and biogeochemistry via radial oxygen loss from roots. This condition contrasts sediments anoxia, allows roots respiration, and facilitates aerobic microbial communities and processes in the rhizosphere. Simultaneously, the rhizosphere can stimulate anaerobic microorganisms and processes via exudates or by favoring the build-up of electron acceptors as nitrate. As eutrophication often results in organic enrichment in sediments and large internal nutrients recycling, an interesting research question is to investigate whether plants maintain the capacity to stimulate aerobic or anaerobic microbial communities and processes also under elevated organic *** A manipulative experiment was carried out under laboratory-controlled conditions. Microcosms containing bare sediments and sediments transplanted with the macrophyte Vallisneria spiralis L. were created. The effect of the plant was investigated on sediments with moderate(8%) and elevated(21%) organic matter content, after an acclimatization period of 30 days. Chemical and physical parameters, microbial community composition and the potential rates of nitrification, denitrification and nitrate ammonification were measured at two different depths(0–1 and 1–5 cm) after the acclimatization period to evaluate the role of *** Vallisneria spiralis grew and assimilated pore water nutrients at the two organic matter levels and vegetated sediments had always nutrient-depleted porewaters as compared to bare sediments. Nitrifying microbes had a lower relative abundance and diversity compared to denitrifying bacteria. However, regardless of the organic content, in vegetated sediments nitrifiers were detected in deeper horizons as compared to bare sediments, where nitrification was confined near the surface. In contrast, potential denitrification rates were not affected by the presence of roots, but probably regulated by the presence of nitrate and by ro

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Does the provision of live black soldier fly and yellow mealworm larvae improve Muscovy duck welfare?

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Journal of Animal Science and Biotechnology 2024年第1期15卷 442-455页

作者： Marta Gariglio Sihem Dabbou Manuela Renna Ilaria Biasato Sara Bellezza Oddon marco Meneguz Raul Daniel Miazzo Stefania Bergagna Elena Colombino Elisabetta Macchi Achille Schiavone Department of Veterinary Sciences University of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy Center Agriculture Food Environment(C3A) University of TrentoVia Edmund Mach 1San Michele All’AdigeTrento(TN)38098Italy Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy BEF Biosystems s.r.l Via Tancredi Canonico 18/CTorino(TO)10156Italy Unidad de Investigacion Aviar Produccion AvicolaFac.Agr.y Vet.Universidad Nacional de Rio CuartoCordobaArgentina Veterinary Medical Research Institute for Piemonte Liguria and Valle d’AostaVia Bologna 148Torino(TO)10154Italy

Background The provision of environmental enrichments to Muscovy ducks could reduce the expression of the aggressive *** aim of the present study was to evaluate the effects of black soldier fly(BSF)and yellow mealworm(YM)live larva provision on Muscovy duck performance,excreta corticosterone metabolites(ECM),behavior,and blood *** A total of 1263-day-old female Muscovy ducklings were allotted to 18 pens(6 replicates/treatment,7 birds/pen)and assigned to 3 experimental treatments:a control group fed commercial feed,and two experimental treatments fed commercial feed plus the 5%(based on the expected daily feed intake,as fed basis)of BSF and YM live larvae(BSF and YM groups,respectively).A two-phase feeding program was applied:starter(from 3 to 31 days of age)and grower-finisher(from 32 to 55 days of age).The live weight,average daily gain,average daily feed intake,and feed conversion ratio were *** consumption times were collected,and video recordings were performed during 3 periods(P)each day:the hour before(P1),during(P2),and after(P3)the larva *** were evaluated at 3,31,and ***,the total red and white blood cell counts,serum proteins,lipids,and liver and renal function serum enzymes were evaluated on 12 birds/*** The experimental treatment did not affect the growth performance of the birds(P>0.05).Larva consumption times were always similar between the two insect species,except at 14–18 days of age,were BSF larvae were consumed faster than YM larvae(PP3;P<0.05).Finally,the provision of live BSF and YM larvae significantly reduced the ECM at 55 days of age and the heterophil to lymphocyte ratio(P<0.05).Conclusions Live BSF and YM larva supplementatio

关键词： Behavior Cairina moschata Environmental enrichment Hermetia illucens Poultry Tenebrio molitor Welfare

Modeling of recrystallization behaviour of AA6XXX aluminum alloy profile during extrusion process

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Transactions of Nonferrous Metals Society of China 2024年

作者： marco Negozio Antonio Segatori Riccardo Pelaccia Barbara Reggiani Sara Di Donato Lorenzo Donati DIN Department of Industrial Engineering – University of Bologna University of Parma-Department of Engineering and Architecture， Parco Area delle Scienze Hydro， Innovation and Technology InterMech-MO.RE – University of Modena and Reggio Emilia DISMI Department of Sciences and Methods for Engineering， University of Modena and Reggio Emilia

An innovative approach was introduced for the development of a AA6063 recrystallization model. This method incorporated a regression-based technique for the determination of material constants and introduced novel equations for assessing the grain size evolution. Calibration and validation of this methodology involved a combination of experimentally acquired microstructural data from the extrusion of three different AA6063 profiles and results from the simulation using the Qform Extrusion UK finite element code. The outcomes proved the agreement between experimental findings and numerical prediction of the microstructural evolution. The trend of the grain size variation based on different process parameters has been accurately simulated， both after dynamic and static recrystallization， with an error rate of less than 25% in almost the whole sampling computations.

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Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： Edison Iglesias de Oliveira Vidal Luiz Fernando Alvarenga Ribeiro marco Antonio de Carvalho-Filho Fernanda Bono Fukushima Internal Medicine Department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for Education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil Surgical Specialties and Anesthesiology Department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our *** contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of ***,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational ***,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their *** we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

Hemiarthroplasty for irreparable distal radius fractures in the elderly:A comprehensive review

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World Journal of Orthopedics 2024年第6期15卷 578-584页

作者： Adriano Cannella Ludovico Caruso Giulia Maria Sassara Giuseppe Taccardo marco Passiatore Marina Marescalchi Rocco De Vitis Department of Orthopaedics Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Bone and Joint Surgery ASST-Spedali CiviliBrescia 25123Italy

BACKGROUND Elderly patients maintaining functional independence can now be candidates for primary wrist hemiarthroplasty to manage acute irreparable distal radius fractures(DRFs).However,further investigation with long-term follow-up is required to validate these initial *** To review the literature on the outcomes of distal radius hemiarthroplasty with available implants to assess its viability as a treatment *** A comprehensive review of the literature was conducted using electronic databases,including PubMed,Medline,and *** search terms employed were"distal radius fracture","hemiarthroplasty","wrist arthroplasty",and related *** search was restricted to articles published in English from 1980 until June *** criteria encompassed cases or case series of DRF treated with hemiarthroplasty,providing clinical or radiographic outcomes,and published in peer-reviewed *** A total of 2508 articles from PubMed and 883 from Scopus were identified *** screening and removal of duplicates,13 articles met the inclusion *** articles,predominantly clinical retrospective studies,provided insights into hemiarthroplasty outcomes,including functional improvements and *** was a treatment option for complex DRF,particularly those cases with severe comminution,intraarticular involvement,or severe *** outcomes demonstrated improvements in pain relief,wrist mobility,and grip strength,with variability across *** included implant loosening,infection,nerve injury,and stiffness,with varying incidence rates influenced by surgical techniques and implant ***-term outcomes were inadequately documented,warranting further *** Hemiarthroplasty is a promising treatment for irreparable DRF in the ***-term outcomes and complications require further study.

关键词： Irreparable distal radius fracture Hemiarthroplasty Osteoporosis Wrist prosthesis Elderly

Long-term assessment of collagenase treatment for Dupuytren’s contracture:A 10-year follow-up study

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World Journal of Orthopedics 2024年第4期15卷 355-362页

作者： marco Passiatore Vitale Cilli Adriano Cannella Ludovico Caruso Giulia Maria Sassara Giuseppe Taccardo Rocco De Vitis Department of Bone and Joint Surgery ASST-Spedali CiviliBrescia 25123Italy Department of Chirurgie de la Main Centre Hospitalier Interregional Edith CavellBruxelles 1160Belgium Department of Orthopedics Fondazione Policlinico Universitario Agostino Gemelli IRCSSRome 00168Italy

BACKGROUND Enzymatic fasciotomy with collagenase clostridium histolyticum(CCH)has revolutionized the treatment for Dupuytren’s contracture(DC).Despite its benefits,the long-term outcomes remain *** study presented a comprehensive 10-year follow-up assessment of the enduring effects of CCH on patients with *** To compare the short-term(12 wk)and long-term(10 years)outcomes on CCH treatment in patients with *** A cohort of 45 patients was treated with CCH at the metacarpophalangeal(MCP)joint and the proximal interphalangeal(PIP)joint and underwent systematic *** study adhered to multicenter trial protocols,and assessments were conducted at 12 wk,7 years,and 10 years *** Thirty-seven patients completed the 10-year *** 10 years,patients treated at the PIP joint exhibited a 100%***,patients treated at the MCP joint only showed a 50%*** satisfaction varied,with a lower satisfaction reported in PIP joint *** exceeding 20 degrees on the total passive extension deficit was observed,indicating a challenge for sustained *** differences were noted between outcomes at the 7-year and 10-year *** CCH demonstrated sustained efficacy when applied to the MCP ***,caution is warranted for CCH treatment at the PIP joint due to a high level of recurrence and low patient ***-intervention is needed within a decade of treatment.

关键词： Collagenase Xiapex Dupuytren disease Dupuytren recurrence Long term follow-up

Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic Dysfunction-Associated Steatotic Liver Disease-induced cirrhosis

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World Journal of Gastroenterology 2024年第7期30卷 685-704页

作者： Marcello Dallio Mario Romeo Paolo Vaia Salvatore Auletta Simone Mammone Marina Cipullo Luigi Sapio Angela Ragone marco Niosi Silvio Naviglio Alessandro Federico Department of Precision Medicine Hepatogastroenterology DivisionUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Precision Medicine Clinical Biochemistry DivisionUniversity of Campania Luigi VanvitelliNaples 80138Italy

BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic *** on the first decompensation event(DE),the transition to decompensated advanced chronic liver disease(dACLD)can occur through two modalities referred to as acute decompensation(AD)and non-AD(NAD),*** Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these ***,due to its invasiveness and costs,CSPH is almost never evaluated in clinical ***,recognizing noninvasively predicting tools still have more appeal across healthcare *** red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD).However,its predictive role for the decompensation has never been *** In this observational study,we investigated the clinical usage of RPR in predicting DEs in MASLD-related cACLD *** Fourty controls and 150 MASLD-cACLD patients were consecutively enrolled and followed up(FUP)semiannually for 3 *** baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver Disease(MELD),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were *** FUP,DEs(timing and modaities)were *** was assessed at the baseline and on DE occurrence according to the available Clinical Practice *** Of 150 MASLD-related cACLD patients,43(28.6%)progressed to dACLD at a median time of 28.9 months(29 NAD and 14 AD).Baseline RPR values were significantly higher in cACLD in comparison to controls,as well as MELD,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLD-progressing compared to cACLD individuals[all P<0.0001,except for FIB-4(P:0.007)and ALBI(P:0.011)].Receiving operator curve a

关键词： Liver cirrhosis Red blood cell distribution width Red blood cell distribution width to platelet ratio Translational Medicine Prognostic biomarker

Deep learning for cross-region streamflow and flood forecasting at a global scale

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The Innovation 2024年第3期5卷 99-109页

作者： Binlan Zhang Chaojun Ouyang Peng Cui Qingsong Xu Dongpo Wang Fei Zhang Zhong Li Linfeng Fan marco Lovati Yanling Liu Qianqian Zhang State Key Laboratory of Mountain Hazards and Engineering Resilience Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610299China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China Data Science in Earth Observation Technical University of Munich80333 MunichGermany State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Department of Civil Engineering McMaster UniversityHamiltonON L8S 4L8Canada Chengdu University of Information Technology Chengdu 610225China

Streamflow and flood forecasting remains one of the long-standing challenges in *** physically based models are hampered by sparse parameters and complex calibration procedures particularly in ungauged *** propose a novel hybrid deep learning model termed encoder-decoder double-layer long short-term memory(ED-DLSTM)to address streamflow forecasting at global scale for all(gauged and ungauged)*** historical datasets,ED-DLSTM yields a mean Nash-Sutcliffe efficiency coefficient(NSE)of 0.75 across more than 2,000 catchments from the United States,Canada,Central Europe,and the United Kingdom,highlighting improvements by the state-of-the-art machine learning over traditional hydrologic ***,ED-DLSTM is applied to 160 ungauged catchments in Chile and 76.9%of catchments obtain NSE>0 in the best *** interpretability of cross-region capacities of ED-DLSTM are established through the cell state induced by adding a spatial attribute encoding module,which can spontaneously form hydrological regionalization effects after performing spatial coding for different *** study demonstrates the potential of deep leaning methods to overcome the ubiquitous lack of hydrologic information and deficiencies in physical model structure and parameterization.

关键词： forecasting flood flow