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Treating children with inflammatory bowel disease: Current and new perspectives

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World Journal of Gastroenterology 2017年第30期23卷 5469-5485页

作者： Graziella Guariso marco Gasparetto University of Padova Department of Paediatric Gastroenterology Cambridge University Hospitals CUH-FT

Inflammatory bowel disease(IBD) is a chronic inflammatory condition of the gut characterised by alternating periods of remission and relapse. Whilst the mechanism underlying this disease is yet to be fully understood, old and newer generation treatments can only target selected pathways of this complex inflammatory process. This narrative review aims to provide an update on the most recent advances in treatment of paediatric IBD. A MEDLINE search was conducted using "paediatric inflammatory bowel disease", "paediatric Crohn's disease", "paediatric ulcerative colitis", "treatment", "therapy", "immunosuppressant", "biologic", "monitoring" and "biomarkers" as key words. Clinical trials, systematic reviews, and meta-analyses published between 2014 and 2016 were selected. Studies referring to earlier periods were also considered in case the data was relevant to our scope. Major advances have been achieved in monitoring the individual metabolism, toxicity and response to relevant medications in IBD including thiopurines and biologics. New biologics acting on novel mechanisms such as selective interference with lymphocyte trafficking are emerging treatment options. Current research is investing in the development of reliable prognostic biomarkers, aiming to move towards personalised treatments targeted to individual patients.

关键词： Paediatric inflammatory bowel disease Crohn’s disease Ulcerative colitis Treatment Therapy Immunosuppressant Biologic Monitoring Biomarker

Left main bifurcation stenting:the impact of strut thickness on long-term outcomes

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Journal of Geriatric Cardiology 2021年第2期18卷 91-93页

作者： Gianluca Rigatelli marco Zuin Cardiovascular Diagnosis and Endoluminal Interventions Unit Rovigo General HospitalRovigoItaly Section of Internal and Cardiopulmonary Medicine University of FerraraFerraraItaly

Over the latest years,both randomized controlled trials(RCTs)and observational studies have provided solid basis for percutaneous coronary intervention as a treatment option for unprotected left main(LM)bifurcation coronary artery disease.A recent meta-analysis comparing the long-term outcome between LM bifurcation disease one-stent technique versus twostent technique,the study has demonstrated that one-stent strategy resulted associated with both major adverse cardiac events and target lesion revascularizations(TLRs)lower rates but resulted equivalent to two-stent strategy in terms of cardiovascular mortality,target lesion failure and stent thrombosis(ST)even at one-year and three-year follow-up.[1]

关键词： stent coronary bifurcation

What are the odds?On the determinants of high residential energy expenditure

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Energy and Built Environment 2020年第3期1卷 288-295页

作者： Giorgio Besagni marco Borgarello Power System Development Department Ricerca sul Sistema Energetico-RSE S.p.A.via Rubattino 5420134 MilanoItaly

A precise understanding of the relationships between the household characteristics and the residential energy consumption is needed to support the implementation of effective top-bottom energy strategies and to improve the prediction of forecasting *** paper contributes to the present-day discussion and analyses the build-ing factors,socio-demographic variables and appliances contributing to high-energy expenditures(viz.,electrical energy expenditure,thermal energy expenditure and total energy expenditure)in the Italian *** proposed study builds on an earlier work proposed by the authors,which identified the determinants of the household energy expenditures,based on a nationally representative survey(the“household Budget Survey:mi-crodata for research purposes-2015”performed by the Italian National Institute of Statistics).In particular,the present paper completes and extends the previous research by applying the odds-ratio analysis to the previously identified determinants,in order to identify the factors that led to high electricity consumption(viz.,electrical energy expenditure,thermal energy expenditure and total energy expenditure).In conclusion,this paper aims to providing a more precise understanding of the factors that certainly affect the energy expenditure.

关键词： Energy expenditure Residential sector Odd-ratio Household variables Determinants

ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: what is the way forward?

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World Journal of Gastroenterology 2018年第29期24卷 3222-3238页

作者： Aleksandra Adamska marco Falasca Metabolic Signalling Group School of Pharmacy and Biomedical Sciences Curtin Health Innovation Research Institute Curtin University

Pancreatic ductal adenocarcinoma(PDAC) is one of the most aggressive diseases and is characterized by high chemoresistance, leading to the lack of effective therapeutic approaches and grim prognosis. Despite increasing understanding of the mechanisms of chemoresistance in cancer and the role of ATPbinding cassette(ABC) transporters in this resistance, the therapeutic potential of their pharmacological inhibition has not been successfully exploited yet. In spite of the discovery of potent pharmacological modulators of ABC transporters, the results obtained in clinical trials have been so far disappointing, with high toxicity levels impairing their successful administration to the patients. Critically, although ABC transporters have been mostly studied for their involvement in development of multidrug resistance(MDR), in recent years the contribution of ABC transporters to cancer initiation and progression has emerged as an important area of research, the understanding of which could significantly influence the development of more specific and efficient therapies. In this review, we explore the role of ABC transporters in the development and progression of malignancies, with focus on PDAC. Their established involvement in development of MDR will be also presented. Moreover, an emerging role for ABC transporters as prognostic tools for patients' survival will be discussed, demonstrating the therapeutic potential of ABC transporters in cancer therapy.

关键词： Pancreatic ductal adenocarcinoma Multidrug resistance ATP-binding cassette transporters Targeted therapies Pancreatic ductal adenocarcinoma prognosis Predictive markers

Gastroesophageal reflux disease:From pathophysiology to treatment

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World Journal of Gastroenterology 2010年第30期16卷 3745-3749页

作者： Fernando A Herbella marco G Patti Department of Surgery University of Chicago Pritzker School of MedicineChicagoIL 60637United States

This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett’s esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD.

关键词： Gastroesophageal reflux disease Pathophysiology Acid reflux Non-acid reflux Esophageal manometry Ambulatory pH Barrett’s esophagus Esophageal adenocarcinoma

Image grid display:A study on automatic scrolling presentation

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Visual Informatics 2017年第1期1卷 16-24页

作者： marco Porta Stefania Ricotti Department of Electrical Computer and Biomedical EngineeringUniversity of PaviaPaviaItaly

In this paper we describe a study on image grid display with automatic vertical *** scroll operations are normally carried out manually by the user,in the context of RSVP(Rapid Serial Visual Presentation)techniques this work considers a presentation mode in which the image grid is automati-cally *** experiments carried out with 50 testers,we have investigated user performance while looking for specific target subjects within large collections of *** numbers of columns and scrolling speeds have been *** search task implied both clicking on the identified target pictures and simply vocally stating their visual *** this purpose,and to identify possible specific gaze behaviours,eye tracking technology has been *** obtained results show that number of columns and scroll speed do affect search ***,the user’s gaze tends to focus on different screen areas depending on the values of these two *** it is not possible to definitely find an optimal columns-speed combination that is valid in all cases,the particular context of use can suggest feasible solutions according to one’s *** the best of our knowledge,image grid display with automatic scrolling has never been studied to date.

关键词： Image griddisplay Automatic scrolling Image presentationmodes Image collections Rapid serialvisual presentation

Spontaneous fungal peritonitis: Epidemiology, current evidence and future prospective

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World Journal of Gastroenterology 2016年第34期22卷 7742-7747页

作者： marco Fiore Sebastiano Leone Department of Anesthesiological Surgical and Emergency SciencesSecond University of Naples Division of Infectious Diseases "San Giuseppe Moscati" Hospital

Spontaneous bacterial peritonitis is a complication of ascitic patients with end-stage liver disease(ESLD); spontaneous fungal peritonitis(SFP) is a complication of ESLD less known and described. ESLD is associated to immunodepression and the resulting increased susceptibility to infections. Recent perspectives of the management of the critically ill patient with ESLD do not specify the rate of isolation of fungi in critically ill patients,not even the antifungals used for the prophylaxis,neither optimal treatment. We reviewed,in order to focus the epidemiology,characteristics,and,considering the high mortality rate of SFP,the use of optimal empirical antifungal therapy the current literature.

关键词： Cirrhosis Critically ill patient Spontaneous fungal peritonitis Life-threatening infections Fungal ascitis Nosocomial spontaneous peritonitis

Influence of manufacturing process-induced geometrical defects on the energy absorption capacity of polymer lattice structures

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Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： Alexandre Riot Enrico Panettieri Antonio Cosculluela marco Montemurro Universite de Bordeaux Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance French Atomic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern additive manufacturing processes enable fabricating architected cellular materials of complex shape,which can be used for different *** them,lattice structures are increasingly used in applications requiring a compromise among lightness and suited mechanical properties,like improved energy absorption capacity and specific stiffness-to-weight and strength-to-weight ratios.A dedicated modeling strategy to assess the energy absorption capacity of lattice structures under uni-axial compression loading is presented in this *** numerical model is developed in a non-linear framework accounting for the strain rate effect on the mechanical responses of the lattice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodecahedron and truncated cuboctahedron 2+,are ***,the influence of the relative density of the representative volume element of each geometry,the strain-rate dependency of the bulk material and of the presence of the manufacturing process-induced geometrical imperfections on the energy absorption capacity of the lattice structure is *** main outcome of this study points out the importance of correctly integrating geometrical imperfections into the modeling strategy when shock absorption applications are aimed for.

关键词： Lattice structures Architected cellular materials Dynamic simulation Energy absorption Geometrical imperfection Additive manufacturing

Sensitivity of a solid Eu(Ⅲ) complex towards acetonitrile vapor:Structural and spectroscopic characterization

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Journal of Rare Earths 2020年第5期38卷 571-576页

作者： Fabio Piccinelli Veronica Paterlini Magda Monari marco Bettinelli Luminescent Materials Laboratory DBUniversita di Veronaand INSTMUdR VeronaStrada Le Grazie 1537134VeronaItaly Dipartimento di Chimica"G.Ciamician" Universita di BolognaVia Selmi 240126BolognaItaly

The Eu(Ⅲ)nitrate complex of the meso-N,N’-bis(2-pyridylmethylene)-1,2-(R,S)-cyclohexanediamine ligand was synthesized and characterized by single crystal and powder X-ray *** crystal lattice of the complex is capable of absorbing and desorbing selectively acetonitrile molecules,at 293 K upon an acetonitrile vapor pressure of^0.1×10^5 *** process,which is partially reversible,can be easily followed by both powder X-ray diffraction(P-XRD)and Eu(III)luminescence *** acetonitrile molecule,located in the outer coordination sphere of the metal ion,does not affect the radiative transition probability of 5 D0 level of Eu(Ⅲ)and also it does not activate further non-radiative channels from this *** the other hand,this molecule is capable of affecting the energy position and intensities of the crystal field components of the 5 D0→7 F2 *** complex in solid form can be considered a promising material for the optical sensing of acetonitrile vapors.

关键词： Eu(Ⅲ) X-ray diffraction Crystal structure Luminescence spectroscopy Rare earths