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Seismic protection of frame structures via semi-active control:modeling and implementation issues

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 627-645页

作者： Vincenzo Gattulli marco Lepidi Francesco Potenza Dipartimento di Ingegneria delle Strutture delle Acque e del TerrenoUniversità dell'Aquila

Theoretical and practical issues concerning the multi-faceted task of mitigating the latero-torsional seismic response of a prototypal frame structure with asymmetric mass distribution are approached, Chevron braces with embedded magnetorheological dampers acting on the interstory drift are used to ensure additional energy dissipation. The semi-active control strategy employed to govern the modification of the damper characteristics via feedback is based on the selection of optimal forces according to a H2/LQG criterion, with respect to which the actual forces are regulated by a clipped-optimal logic. A dynamic observer is used to estimate the state through a non-collocated placement of the acceleration sensors. Several aspects to be addressed throughout the complex process including the design, modelization, and implementation phases of semi-active protection systems are discussed. Finally, experimental results obtained to mitigate the motion induced by ground excitation in a large-scale laboratory prototype, simulating the seismic response of a two-story building, are summarized.

关键词： seismic protection: flame structures semi-active control magnetorheological damper

EVOKE： A VALUE-DRIVEN CONCEPT SELECTION METHOD FOR EARLY SYSTEM DESIGN

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Journal of Systems Science and Systems Engineering 2018年第1期27卷 46-77页

作者： marco Bertoni Alessandro Bertoni Ola Isaksson GKN Aerospace Sweden AB Trollhättan Sweden

The development of new technologically advanced products requires the contribution from a range of skills and disciplines, which are often difficult to fred within a single company or organization. Requirements establishment practices in Systems Engineering （SE）, while ensuring coordination of activities and tasks across the supply network, fall short when it comes to facilitate knowledge sharing and negotiation during early system design. Empirical observations show that when system-level requirements are not available or not mature enough, engineers dealing with the development of long lead-time sub-systems tend to target local optima, rather than opening up the design space. This phenomenon causes design teams to generate solutions that do not embody the best possible configuration for the overall system. The aim of this paper is to show how methodologies for value-driven design may address this issue, facilitating early stage design iterations and the resolution of early stage design trade-offs. The paper describes how such methodologies may help gathering and dispatching relevant knowledge about the ＇design intent＇ of a system to the cross-functional engineering teams, so to facilitate a more concurrent process for requirement elicitation in SE. The paper also describes EVOKE （Early Value Oriented design exploration with KnowledgE maturity）, a concept selection method that allows benchmarking design options at sub-system level on the base of value-related information communicated by the system integrators. The use of EVOKE is exemplified in an industrial case study related to the design of an aero-engine component. EVOKE＇s ability to raise awareness on the value contribution of early stage design concepts in the SE process has been further verified with industrial practitioners in ad-hoc design episodes.

关键词： Requirements elicitation concept selection systems engineering value-driven design,decision-making knowledge maturity

Inverse design of truss lattice materials with superior buckling resistance

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npj Computational Materials 2022年第1期8卷 2361-2372页

作者： marco Maurizi Chao Gao Filippo Berto Department of Mechanical and Industrial Engineering Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Manipulating the architecture of materials to achieve optimal combinations of properties(inverse design)has always been the dream of materials scientists and *** represent an efficient way to obtain lightweight yet strong materials,providing a high degree of *** massive research has been done on lattice architectures,the inverse design problem of complex phenomena(such as structural instability)has remained *** deep neural network and genetic algorithm,we provide a machine-learning-based approach to inverse-design non-uniformly assembled *** basic building blocks,our approach allows us to independently control the geometry and topology of periodic and aperiodic *** an example,we inverse-design lattice architectures with superior buckling performance,outperforming traditional reinforced grid-like and bio-inspired lattices by~30–90%and 10–30%,*** results provide insights into the buckling behavior of beam-based lattices,opening an avenue for possible applications in modern structures and infrastructures.

关键词： buckling inverse lattice

A probabilistic model to evaluate the effectiveness of main solutions to COVID-19 spreading in university buildings according to proximity and time-based consolidated criteria

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Building Simulation 2021年第6期14卷 1795-1809页

作者： marco D'Orazio Gabriele Bernardini Enrico Quagliarini Department of Construction Civil Engineering and ArchitectureUniversita Politecnica delle Marchevia Brecce Blanche 60131 AnconaItaly

University buildings are one of the most relevant closed environments in which the COVID-19 event clearly pointed out stakeholders'needs toward safety issues,especially because of the possibility of day-to-day presences of the same users(***,teachers)and overcrowding causing long-lasting contacts with possible"infectors".While waiting for the vaccine,as for other public buildings,policy-makers’measures to limit virus outbreaks combine individual’s strategies(facial masks),occupants,capacity and access ***,up to now,no easy-to-apply tools are available for assessing the punctual effectiveness of such *** fill this gap,this work proposes a quick and probabilistic simulation model based on consolidated proximity and exposure-time-based rules for virus transmission confirmed by international health *** building occupancy is defined according to university scheduling,identifying the main"attraction areas"in the building(classrooms,break-areas).Scenarios are defined in terms of occupants’densities and the above-mentioned mitigation *** model is calibrated on experimental data and applied to a relevant university *** demonstrate the model *** particular,it underlines that if such strategies are not combined,the virus spreading can be limited by only using high protection respiratory devices(***3)by almost every *** the contrary,the combination between access control and building capacity limitation can lead to the adoption of lighter protective devices(*** masks),thus improving the feasibility,users'comfort and favorable *** rules to combine acceptable mask filters-occupants,density are thus provided to help stakeholders in organizing users'presences in the building during the pandemic.

关键词： simulation model closed built environment building occupancy crowd models proximity exposure COVID-19

Spatio-temporal patterns of the Red-footed Falcon's hunting behavior during the nestling period suggest ad hoc conservation policies

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Avian Research 2021年第1期12卷 118-123页

作者： marco Gustin Alessandro Ferrarini Conservation Department BirdLifeLIPU(Lega Italiana Protezione Uccelli)Via Udine 343100 ParmaItaly

The Red-footed Falcon(Falco vespertinus)is a species of high international conservation *** analyzed its hunting behavior at the two largest colonies in Italy during the nestling *** accurate data-loggers,we tracked three adult Red-footed Falcons in June and July,2019 and collected 4703 GPS *** detected clear patterns of hovering and perching activity(HPA)in both time and *** occupied one-third of the Red-footed Falcons’day,and showed two peaks just after sunrise(between 35 and 40%of the monitoring time)and just before sunset(50‒60%)in both June and July,and minimum(20‒30%)at night and during the hottest time interval(10:00 a.m.‒4:00 p.m.).Almost 40%of HPA occurred within 50 m from *** findings,although preliminary,have important implications for the conservation of these two colonies that are located within two Natura 2000 *** detected spatio-temporal patterns of Red-footed Falcons’hunting behavior suggests the creation of two nested protection belts:the inner one is a narrow belt(up to 50 m from the two rows of trees that host the two colonies)with integral conservation,and hopefully increase the alfalfa crops and fallow land,and the outer belt(50 m‒2 km)with optimized agricultural activities.

关键词： Biotelemetry Falco vespertinus Hovering Italy Natura 2000 site Perching

Novel pathomechanistic insights into lysosomal storage disorders:how neuron-intrinsic cGAS-STING signaling drives disease progression

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3548-3549页

作者： Maximilian Frosch marco Prinz Institute of Neuropathology University of FreiburgFaculty of MedicineFreiburgGermany Signalling Research Centres BIOSS and CIBSS University of FreiburgFreiburgGermany

In their recent paper published in Nature Cell Biology,1 Wang and colleagues defined a pathogenetic mechanism among a variety of lysosomal storage disorders(LSDs)mediating neuronal death and disease *** authors observed neuron-intrinsic activated cGAS-STING signaling triggered by accumulating cytosolic dsDNA,and thus,they provide a valuable target for directed therapies.

关键词： disorders intrinsic death

Microglia out of place—mapping macrophages across the developing human body

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Cellular & Molecular Immunology 2024年第3期21卷 210-212页

作者： Roman Sankowski marco Prinz Institute of Neuropathology Faculty of MedicineUniversity of FreiburgFreiburgGermany Signalling Research Centres BIOsS and CIBSs University of FreiburgFreiburgGermany

Macrophages(MΦs)are versatile cells found in every *** the body,they work tirelessly to maintain *** this end,they are instructed by their respective niches to express organ-specific genes and proteins,resulting in a variety of cell morphologies and highly specialized functions across different tissues[1].A recent study by Wang et *** single-cell RNA sequencing to comprehensively profile human MΦphenotypes across 19 organs between postconception weeks(PCW)4 and 26[2].This study revealed a surprising diversity of these cells and suggests new avenues of research.

关键词： organs instru

The intriguing giant deer from the Bate cave (Crete): could paleohistological evidence question its taxonomy and nomenclature?

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Integrative Zoology 2022年第1期17卷 54-77页

作者： Maria Rita PALOMBO marco ZEDDA CNR-IGAG c/o Department of Earth Sciences Sapienza UniversityRomaItaly Department of Veterinary Medicine University of SassariItaly

The research describes for the first time a possible case of pituitary gigantism in fossil mammals,precisely in *** pathology was detected in 2 long bones(tibia and metatarsus)belonging to an individual of an unusual large size found at the Bate cave(Rethymnon,Northern Crete).It formed the basis of Candiacervus major,the largest among the endemic deer species recorded in the Pleistocene-Early Holocene of *** and histomorphological examinations highlighted a reduction in cortical bone thickness and the presence of wide lacunae inside of the bone *** pathological conditions suggest a pituitary gigantism diagnosis also supported by some morphological evidence,such as the extremely elongated distal part of the metatarsal diaphysis,the proportionally small proximal epiphysis,and some bone *** diagnosis of a case of pituitary gigantism as presumed responsible for the extraordinary elongation of the tibia and the metatarsal bone is intriguing as they are,respectively,the paratype and the holotype of the *** species represents a case of a deviation from the“island rule”in Pleistocene large *** new evidence recommends a taxonomic and nomenclatural revision of this *** main outcomes of this research are as follows:(i)a case of pituitary gigantism is described for the first time in an extinct mammal;(ii)it is underlined that paleohistology may provide interesting clues for disentangling taxonomic and nomenclatural issues;(iii)one of the very few cases of gigantism in insular mammals is being questioned.

关键词： Candiacervus major Cretan deer island rule paleohistology pituitary gigantism

Potential application of the Kampo medicine goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy

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Journal of Integrative Medicine 2017年第2期15卷 77-87页

作者： marco Cascella Maria Rosaria Muzio Division of Anesthesia Department of Anesthesia and Pain Medicine Istituto Nazionale Tumori "Fondazione G. Pascale"--IRCCS via Mariano Semmola Naples 80131 Italy Division of Infantile Neuropsychiatry UOMI-Maternal and Infant Health Asl NA 3 SUD Torre del Greco via Marconi Naples 80059 Italy

Chemotherapy-induced peripheral neuropathy （CIPN） is one of the most common and severe adverse effects related to cancer treatment. Unfortunately, although several agents and protocols have been proposed, no prophylactic strategies have yet to be proven useful. Therefore, new alternative therapies have been considered for CIPN prevention. Herbal medicine in Japan, called Kampo medicine, is derived from traditional Chinese medicine. Goshajinkigan （GJG） is a Kampo medicine, that is comprised of ten herbs. The aim of this work is to analyse the results of pre-clinical and clinical studies on the potential applications of GJG in CIPN prevention.

关键词： chemotherapy peripheral neuropathies herbal medicine alternative medicine natural products