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Retinoprotective compounds,current efficacy,and future prospective

Neural Regeneration Research 2023年第12期18卷 2619-2622页

作者： Rachele Marino Rebecca Sappington marco Feligioni Laboratory of Neuronal Cell Signaling EBRI Rita Levi-Montalcini FoundationRomeItaly Department of Neurobiology and Anatomy Wake Forest School of MedicineAtrium Health Wake Forest Baptist Medical CenterWinston-SalemNCUSA Department of Ophthalmology Wake Forest School of MedicineWinston-SalemNCUSA Department of Neurorehabilitation Sciences Casa di Cura IgeaMilanItaly

Retinal dysfunction is the most common cause of vision loss in several retinal *** has been estimated a great increase in these pathologies that are becoming more globally widespread and numerous over time,also supported by the life expectancy *** different types of retinopathies,we can account some that share causes,symptoms,and treatment including diabetic retinopathy,age-related macular degeneration,glaucoma,and retinitis *** changes,environmental factors,and genetic predisposition might be some of the main causes that drive retinal tissue to chronic inflammation and neurodegeneration in these *** treatments available on the market contain compounds that efficiently ameliorate some of the important clinical features of these pathologies like stabilization of the intraocular pressure,reduction of eye inflammation,control of eye oxidative stress which are considered the major molecular mechanisms related to retinal ***,the most commonly used drugs are antiinflammatories,such as corticosteroids,antioxidant,hypotonic molecules and natural neuroprotective ***,these drugs,which are fundamental to treating disease symptoms,are not capable to cure the pathologies and so they are not life-changing for *** review provided an overview of current treatments on the market,but more interestingly,wants to be a quick window on the new treatments that are now in clinical ***,it has been here highlighted that the recent technical enhancement of the investigation methods to identify the various retinopathies causes might be used as a sort of“precise medicine”approach to tailor the identification of molecular pathways involved and potentially study a dedicated treatment for each *** approach includes the use of cutting-edge technologies like gene therapy and metabolomics.

关键词： age-related macular degeneration anti-inflammatory drugs antioxidants diabetic retinopathy glaucoma neuroprotective compounds retinitis pigmentosa retinopathies vision loss

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New paradigm of oral rehydration in patients affected by irritable bowel syndrome with chronic diarrhea

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第1期15卷 1-4页

作者： marco Chiarelli Matilde De Simone Gerardo Cioffi Ugo Cioffi Department of Emergency and Robotic Surgery A.Manzoni Hospital–ASST LeccoLecco 23900Italy Department of Surgery University of MilanVia F.Sforza 3520122 MilanoMilano 20122Italy Department of Sciences and Technologies UnisannioBenevento 82100Italy Department of Surgery University of MilanMilano 20122Italy

Irritable bowel syndrome with diarrhea is a very frequent clinical condition characterized by disabling intestinal *** disease presents with daily abdominal pain for at least 3 months related to defecation and associated with a change in the frequency of bowel movements and the shape of the *** surveys about this disease report a global prevalence of about 1.5%.A new amino acid based electrolyte solution has recently been commercialized for oral rehydration in *** is composed of water,electrolytes,and five selected amino acids that function as sodium co-transporters without containing *** recent years,some studies explored the effectiveness of the amino acid based electrolyte beverage in oncologic patients with gastrointestinal mucositis,reporting good ***,a prospective study to evaluate the clinical impact of the amino acid based medical beverage was conducted in patients with diarrhea predominant irritable bowel *** research was based on a real-life methodology minimizing the disruption of the routine *** hundred patients suffering from irritable bowel syndrome with diarrhea drank a solution based on selected amino acids twice a day for 2 *** enrolled patient completed the study and showed a significant response rate with regard to stool consistency and pain *** on this data,we can hypothesize that the amino acid based oral rehydration solution could be a valid tool in the treatment of patients affected by irritable bowel syndrome with *** is certainly necessary to plan highquality clinical trials comparing glucose based oral solutions and amino acid based solutions in patients with persisting *** in the near future all oral rehydration solutions will contain amino acids.

关键词： Diarrhea Irritable bowel syndrome Diarrhea-predominant irritable bowel syndrome Medical food Amino acid beverage formulation

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中国电动汽车发展之我见

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国际人才交流 2024年第7期 48-52页

作者：马可·洛格里奥张佳艺(译) 不详

2009年8月,一项对电动汽车的长达110多公里的路面测试正在北戴河进行,一些中国政府领导也莅临现场。这是一辆6.9米长的豪华轿车红旗CA7560,充电仅需20分钟便能行驶350多公里。这辆原型样车由雷天能源集团提供,我曾在这家锂电池公司担任... 详细信息

2009年8月,一项对电动汽车的长达110多公里的路面测试正在北戴河进行,一些中国政府领导也莅临现场。这是一辆6.9米长的豪华轿车红旗CA7560,充电仅需20分钟便能行驶350多公里。这辆原型样车由雷天能源集团提供,我曾在这家锂电池公司担任副总裁。度过了我早期在中国电动汽车领域的时光。

关键词：电动汽车副总裁路面测试锂电池北戴河样车之我见

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Biomarkers for targeted rehabilitation strategies after breast cancer: Proposal for the next-generation management of survivorship issues

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BIOCELL 2022年第10期46卷 2221-2223页

作者： marco INVERNIZZI NICOLA FUSCO Translational Medicine Dipartimento AttivitàIntegrate Ricerca e Innovazione(DAIRI)Azienda Ospedaliera SS.Antonio e Biagio e Cesare ArrigoAlessandria15121Italy Physical and Rehabilitation Medicine Department of Health SciencesUniversity of Eastern PiedmontNovara28100Italy Division of Pathology IEOEuropean Institute of Oncology IRCCSMilan20141Italy Department of Oncology and Hemato-Oncology University of MilanMilan20122Italy

Breast cancer(BC)is the most common malignant tumor and one of the top causes of cancer-related death worldwide(Sung et al.,2021).The recent advances in early tumor diagnosis coupled with more effective treatment strategies resulted in a steady increase of long-term survivors(Nardin et al.,2020;Invernizzi et al.,2022).These improved survival rates led to a significantly higher incidence of disabling complications related to breast cancer and/or its treatment(Invernizzi et al.,2020a;D’Egidio et al.,2017;Zhong et al.,2020).

关键词： Breast cancer Biomarkers Survivorship Rehabilitation Precision medicine

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Downwash modelling for three-lifting-surface aircraft configuration design

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Chinese Journal of Aeronautics 2023年第6期36卷 161-173页

作者： Salvatore CORCIONE Giordana BONAVOLONTÃ Agostino DE marco Fabrizio NICOLOSI Department of Industrial Engineering University of Naples“FedericoⅡ”Naples 8125Italy School of Aerospace Transport&Manufacturing Cranfield UniversityBedford MK43 OALUnited Kingdom

This paper introduces a semi-empirical model to predict the downwash gradient at the horizontal tail of a three-lifting-surface *** superposition principle applied to well established formulations valid for two lifting surfaces is not a reasonable approach to calculate the downwash of a canard-wing-tail layout,and this paper demonstrates that such a basic technique leads to incorrect ***,an ad hoc prediction model is proposed that considers the combined nonlinear effects of canard and main wing inductions on tail downwash,being based on a full factorial design sweep of CFD simulations obtained by varying the main geometrical parameters of the three lifting surfaces.A suitable analytical formula for the downwash gradient is established through a process of data analysis and factor *** presented model extends the validity of the available models for traditional two-lifting-surface designs by means of a correction *** engineering estimation method introduced here exhibits an acceptable accuracy,as well as relatively small prediction errors,and it is suitable for conceptual and preliminary studies of threesurface *** value of this methodology is confirmed by the validation with the results of numerical and experimental investigations on a case study aircraft.

关键词： Aerodynamic modelling Aircraft design Design of experiments Downwash Three-lifting-surface

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Erratum to: Born to sing! Song development in a singing primate

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Current Zoology 2024年第2期70卷 276-276页

作者： Chiara De Gregorio Filippo Carugati Vittoria Estienne Daria Valente Teresa Raimondi Valeria Torti Longondraza Miaretsoa Jonah Ratsimbazafy marco Gamba Cristina Giacoma Department of Lifte Sciences and Systems Biology University of Torinovia Accademia Alberina 13Torino 10125Italy Groupe d'Etude et de Recherche sur les Primates de Madagascar(GERP) BP 779-Antananarivo 101Madagascar

The pagination of this article online has been updated to pages 597-608 to match the print *** Publisher sincerely apologizes for introducing this error online.

关键词： introducing sincerely match

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What Is New in the 2023 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndromes

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Cardiology Discovery 2023年第4期3卷 227-231页

作者： marco Roffi Division of Cardiology University HospitalsGeneva 1211Switzerland

For the first time,European Society of Cardiology(EsC)guidelines have aggregated in 1 single document recommendations for the management of patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS)and ST-elevation myocardial infarction(STEMI).From a clinical perspective,this is coherent,as the spectrum of clinical presentations in acute coronary syndromes(ACS)may range from new onset or progressive troponin-negative angina to STEMl,cardiogenic shock,or cardiac *** addition,the management pathways of NSTE-ACS and STEMI patients are widely *** with previous editions of the guidelines,the extensive document is improved also from a graphic perspective,containing several appealing and easy-to-understand *** or modified recommendations include,among others,the topics of diagnostic work-up,timing of invasive strategy,revascularization in multi-vessel disease,intravascular imaging,cardiac arrest,cardiogenic shock,and antithrombotic *** the first time in the field of ACS,ESC guidelines have incorporated a section on patient perspectives with dedicated *** of the most relevant changes in recommendations impacting clinical practice are discussed inthis article.

关键词： Acute coronary syndromes Guidelines European Society of Cardiology

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Transneuronal delivery of designer cytokines: perspectives for spinal cord injury

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Neural Regeneration Research 2022年第2期17卷 338-340页

作者： Daniel Terheyden-Keighley marco Leibinger Dietmar Fischer Department of Cell Physiology Ruhr University of BochumBochumGermany

We recently achieved significant functional recovery after a complete spinal cord injury,allowing previously paralyzed mice to walk *** was accomplished by a single,unilateral application of an adeno-associated virus(AAV) carrying the cDNA for the designer cytokine hyper-interleukin-6 (hIL-6) into the sensorimotor cortex after spinal cord injury.

关键词： cortex cytokines injury

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Analytical solution to logarithmic spiral trajectories with circumferential thrust and mission applications

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Astrodynamics 2022年第4期6卷 413-427页

作者： marco Bassetto Alessandro A.Quarta Giovanni Mengali Department of Civil and Industrial Engineering University of PisaPisaⅠ-56122Italy

This study made use of a shape-based method to analyze the orbital dynamics of a spacecraft subject to a continuous propulsive acceleration acting along the circumferential *** the assumption of a logarithmic spiral trajectory,an exact solution to the equations of motion exists,which allows the spacecraft state variables and flight time to be expressed as a function of the angular *** is also a case characterized by specific initial conditions in which the time evolution of the state variables may be analytically *** this context,the presented solution is used to analyze circle-to-circle trajectories,where the combination of two impulsive maneuvers and a logarithmic spiral path are used to accomplish the *** determined results are then applied to the achievement of the Earth–Mars and the Earth–Venus transfers using actual data from a recent thruster developed by NASA.

关键词： circumferential thrust logarithmic spiral trajectory circle-to-circle transfer

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Robust state of charge and state of health estimation for batteries using a novel multi model approach

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Control Theory and Technology 2022年第3期20卷 418-438页

作者： Giovanni Guida Davide Faverato marco Colabella Gianluca Buonomo Innovation Department Brain TechnologiesCorso Tazzoli 215/12BTurin10137Italy

Estimation of state-of-charge and state-of-health for batteries is one of the most important feature for modern battery management system(BMS).Robust or adaptive methods are the most investigated because a more intelligent BMS could lead to sensible cost reduction of the entire battery *** propose a new robust method,called ERMES(extendible range multi-model estimator),for determining an estimated state-of-charge(SoC),an estimated state-of-health(SoH)and a prediction of uncertainty of the estimates(state-of-uncertainty—SoU),thanks to which it is possible to monitor the validity of the estimates and adjust it,extending the robustness against a wider range of uncertainty,if ***,a finite number of models in state-space form are considered starting from a modified Thevenin battery *** model is characterized by a hypothesis of SoH *** iterated extended Kalman filter(EKF)is then applied to each model in parallel,estimating for each one the SoC state *** errors are then considered to fuse both the estimated SoC and SoH from the bank of EKF,yielding the overall SoC and SoH estimates,*** addition,a figure of uncertainty of such estimates is also provided.

关键词： Adaptive estimation multiple models Connected embedded systems Extended Kalman filter Nonlinear observability State-of-charge State-of-health State and parameter estimation

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