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Choroidal vascularity index in thyroidassociated ophthalmopathy:a crosssectional study

Eye and Vision 2021年第4期8卷 175-182页

作者： Pasquale Loiudice marco Pellegrini Michele Marinò Barbara Mazzi Ilaria Ionni Giuseppe Covello Michele Figus marco nardi Giamberto Casini Department of Surgical Ophthalmology UnitMedicalMolecular and Critical Area PathologyUniversity of PisaVia Savi1056126 PisaItaly Ophthalmology Unit S.Orsola-Malpighi University HospitalUniversity of BolognaBolognaItaly Department of Clinical and Experimental Medicine Endocrinology Unit IUniversity Hospital of PisaPisaItaly

Background:Hemodynamic changes have been observed in patients with Graves’*** aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index(CVI)in patients with thyroidassociated ophthalmopathy(TAO).Methods:In this cross-sectional observational study,40 patients affected by TAO were *** healthy individuals,matched for age and sex,served as *** enhanced-depth imaging optical coherence tomography scans were obtained from all *** were binarized using the ImageJ software and luminal area(LA)and total choroidal area(TCA)were *** was calculated as the proportion of LA to *** relation between CVI or subfoveal choroidal thickness(SFCT)and clinical activity score,exophthalmometric value,diplopia status,gender,and age was ***:CVI was significantly higher in patients with TAO(P=0.004).No significant difference was observed in SFCT(P=0.200)and TCA(P=0.153)comparing TAO patients and healthy *** was significantly higher in TAO group(P=0.045).On multiple regression analysis,CVI was associated with TCA(P=0.043).No association was found between SFCT or CVI and TCA,clinical activity score,exophthalmometric value,Inami value,diplopia status,gender or age(P>0.05).Conclusions:This is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features.

关键词： Choroidal vascularity index Choroidal vasculature Enhanced depth optical coherence tomography Image binarization Luminal area Subfoveal choroidal thickness Thyroid-associate ophthalmopathy

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Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 423-433页

作者： Paola De nardi Alessandro Giani Giulia Maggi marco Braga Department of Gastrointestinal Surgery IRCCS San Raffaele Scientific InstituteMilano 20132Italy Department of Surgery School of MedicineUniversity of Milano-BicoccaMilan ItalyMonza 20900Italy Department of Oncologic Surgery Policlinico CasilinoRome 00169Italy Department of Surgery San Gerardo HospitalUniversity Milano BicoccaMonza 20900Italy

The prognostic role of body composition indexes,and specifically sarcopenia,has recently been explored in different cancer ***,conflicting results have been *** in cancer type,cancer stage or oncological treatments,as well as different methodology and definition of sarcopenia,could be accounted for different conclusions retrieved from *** focusing on colorectal cancer,it clearly appears that colon and rectal cancers are often treated as a single entity though they have different behaviors and ***,patients with advanced rectal cancer represent a peculiar group of patients that according to current guidelines are treated with neoadjuvant chemotherapy and radiotherapy followed by radical *** review was restricted to a homogeneous group of patients with advanced lower rectal cancer and the aim of exploring whether there is a correlation between skeletal muscle depletion and *** was searched for articles related to patients with advanced rectal cancer undergoing neoadjuvant chemo-radiotherapy(NCRT)followed by radical surgery,in whom muscle mass and/or change in muscle mass during neoadjuvant treatment were *** full-text articles were selected and included in the present *** main findings of our review were:(1)The majority of the studies defined sarcopenia as muscle mass alone over muscle strength or physical performance;(2)There was a great deal of heterogeneity in the definition and measures of sarcopenia,in the definition of cut-off values,and in the method to measure change in muscle mass;(3)There was not full agreement on the association between sarcopenia at baseline and/or after chemoradiotherapy and prognosis,and only few studies found a significance in the multivariate analysis;and(4)It seems that a loss in skeletal muscle mass during NCRT is associated with the worst outcomes in terms of disease-free *** conclusion,analysis of muscle mass might provid

关键词： Advanced rectal cancer Sarcopenia Neoadjuvant treatment Chemoradiotherapy Surgery Muscle mass change Prognosis Survival Review

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A reproducible and sensitive method for generating high-quality transcriptomes from single whitefly salivary glands and other low-input tissues

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Insect Science 2022年第5期29卷 1318-1328页

作者： marco Gebiola Brandon H.le Kerry EMauck Department of Entomology University of California RiversideRiversideCalifornia Department of Botany and Plant Sciences University of California RiversideRiversideCalifornia Institute of Integrative Genome Biology University of California RiversideRiversideCaliforniaUSA

Transcriptomic studies are an important tool for understanding the molecular pathways underlying host plant use by agricultural pests,including vectors of damaging plant *** far,bulk RNA-Seq has been the main approach for non-model *** method relies on pooling large numbers of whole organisms or hundreds of individually dissected *** latter approach is logistically challenging,may introduce artifacts of handling and storage,and is not compatible with biological ***,we tested an approach to generate transcriptomes of individual salivary glands and other low-input body tissues from whiteflies(Bemisia tabaci MEAM1),which are major vectors of plant *** comparing our outputs to published bulk RNA-Seq datasets for whole whitefly bodies and pools of salivary glands,we demonstrate that this approach recovers similar numbers of transcripts relative to bulk RNA-Seq in a tissue-specific manner,and for some metrics,exceeds performance of bulk tissue *** generated from individual salivary glands also yielded additional novel transcripts not identified in pooled salivary gland datasets,and had hundreds of enriched transcripts when compared with whole head ***,our study demonstrates that it is feasible to produce high quality,replicated transcriptomes of whitefly salivary glands and other low-input *** anticipate that our approach will expand hypothesis-driven research on salivary glands of whiteflies and other Hemiptera,thus enabling novel control strategies to disrupt feeding and virus transmission.

关键词： Aleyrodidae Bemisia tabaci bulk RNA-Seq insect vectors low-input RNA-Seq plant pathogens

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Telomerase reactivation is associated with hepatobiliary and pancreatic cancers

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 420-428页

作者： Vito Sansone marco le Grazie Jenny Roselli Simone Polvani Andrea Galli Francesco Tovoli Mirko Tarocchi Department of Medical and Surgical Sciences University of BolognaBolognaItaly Department of Experimental and Clinical Biomedical Sciences"Mario Serio" University of Florence50139 FirenzeItaly

Background:Human telomerase reverse transcriptase(hTERT)and its components play a significant role in cancer progression,but recent data demonstrated that telomeres and telomerase alterations could be found in other diseases;increasing evidence suggests a key role of this enzyme in the fields of hepatobiliary and pancreatic *** sources:We performed a PubMed search with the following keywords:telomerase,hepatocellular carcinoma,cholangiocarcinoma,pancreatic adenocarcinoma by December *** reviewed the relevant publications that analyzed the correlation between telomerase activity and hepatobiliary and pancreatic ***:Telomerase reactivation plays a significant role in the development and progression of hepatobiliary and pancreatic tumors and could be used as a diagnostic biomarker for hepatobiliary and pancreatic cancers,as a predictor for prognosis and a promising therapeutic ***:Our review summarized the evidence about the critical role of hTERT in cancerous and precancerous lesions of the alteration and its activity in hepatobiliary and pancreatic diseases.

关键词： Telomerase Telomere Cancer Hepatobiliary and pancreatic disease

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Muscle Loss in Cancer Patients: Pathophysiology and Impact on the Outcome

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Journal of Nutritional Oncology 2016年第1期1卷 15-20页

作者： Maria Chiara Salandini Nicolo Pecorelli Paola De nardi marco Braga Department of Surgery Vita-Salute San Raffaele University Milan 20132 Italy

A generalized loss of skeletal muscle can be associated with malnutrition, cancer, inflammation or neurodegenerative processes. Most cancer patients undergoing surgery are sarcopenic although only a minority of them suffer from severe weight loss. The cancer stage is a major determinant of sarcopenia, while nutritional factors seem to be less important. In cancer patients sarcopenia has been associated with a worse physical performance, a reduced response to chemotherapy and radiotherapy, a higher postoperative morbidity rate, and a reduced life expectancy.

关键词： Cancer Cachexia Sarcopenia Visceral fat Body composition

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Chemotherapy for hepatocellular carcinoma:The present and the future

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World Journal of Hepatology 2017年第21期9卷 907-920页

作者： marco le Grazie Maria Rosa Biagini Mirko Tarocchi Simone Polvani Andrea Galli Gastroenterology Research Unit Department of Experimental and Clinical Biochemical Sciences"Mario Serio"University of Florence50139 FlorenceItaly

Hepatocellular carcinoma(HCC) is the most common primary tumor of the liver. Its relationship to chronic liver diseases, in particular cirrhosis, develops on a background of viral hepatitis, excessive alcohol intake or metabolic steatohepatitis, leads to a high incidence and prevalence of this neoplasia worldwide. Despite the spread of HCC, its treatment it's still a hard challenge, due to high rate of late diagnosis and to lack of therapeutic options for advanced disease. In fact radical surgery and liver transplantation, the most radical therapeutic approaches, are indicated only in case of early diagnosis. Even local therapies, such as transarterial chemoembolization, find limited indications, leading to an important problem regarding treatment of advanced disease. In this situation, until terminal HCC occurs, systemic therapy is the only possible approach, with sorafenib as the only standard treatment available. Anyway, the efficacy of this drug is limited and many efforts are necessary to understand who could benefit more with this treatment. Therefore, other molecules for a targeted therapy were evaluated, but only regorafenib showed promising results. Beside molecular target therapy, also cytotoxic drugs, in particular oxaliplatinand gemcitabine-based regimens, and immune-checkpoint inhibitors were tested with interesting results. The future of the treatment of this neoplasia is linked to our ability to understand its mechanisms of resistance and to find novel therapeutic targets, with the objective to purpose individualized approaches to patients affected by advanced HCC.

关键词： Hepatocellular carcinoma Systemic therapy Chemotherapy Molecular targeted therapy Cytotoxic therapy Immunotherapy Perspectives

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Modeling of Circuits within Networks by fMRI

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Wireless Sensor Network 2010年第3期2卷 208-217页

作者： G. de marco A. le Pellec 不详

In this review, the authors describe the most recent functional imaging approaches used to explore and identify circuits within networks and model spatially and anatomically interconnected regions. After defining the concept of functional and effective connectivity, the authors describe various methods of identification and modeling of circuits within networks. The description of specific circuits in networks should allow a more realistic definition of dynamic functioning of the central nervous system which underlies various brain functions.

关键词： fMRI CNS Modeling Network Effective Connectivity

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Influence of manufacturing process-induced geometrical defects on the energy absorption capacity of polymer lattice structures

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Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： Alexandre Riot Enrico Panettieri Antonio Cosculluela marco Montemurro Universite de Bordeaux Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance French Atomic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern additive manufacturing processes enable fabricating architected cellular materials of complex shape,which can be used for different *** them,lattice structures are increasingly used in applications requiring a compromise among lightness and suited mechanical properties,like improved energy absorption capacity and specific stiffness-to-weight and strength-to-weight ratios.A dedicated modeling strategy to assess the energy absorption capacity of lattice structures under uni-axial compression loading is presented in this *** numerical model is developed in a non-linear framework accounting for the strain rate effect on the mechanical responses of the lattice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodecahedron and truncated cuboctahedron 2+,are ***,the influence of the relative density of the representative volume element of each geometry,the strain-rate dependency of the bulk material and of the presence of the manufacturing process-induced geometrical imperfections on the energy absorption capacity of the lattice structure is *** main outcome of this study points out the importance of correctly integrating geometrical imperfections into the modeling strategy when shock absorption applications are aimed for.

关键词： Lattice structures Architected cellular materials Dynamic simulation Energy absorption Geometrical imperfection Additive manufacturing

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Sensitivity of a solid Eu(Ⅲ) complex towards acetonitrile vapor:Structural and spectroscopic characterization

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Journal of Rare Earths 2020年第5期38卷 571-576页

作者： Fabio Piccinelli Veronica Paterlini Magda Monari marco Bettinelli Luminescent Materials Laboratory DBUniversita di Veronaand INSTMUdR VeronaStrada Le Grazie 1537134VeronaItaly Dipartimento di Chimica"G.Ciamician" Universita di BolognaVia Selmi 240126BolognaItaly

The Eu(Ⅲ)nitrate complex of the meso-N,N’-bis(2-pyridylmethylene)-1,2-(R,S)-cyclohexanediamine ligand was synthesized and characterized by single crystal and powder X-ray *** crystal lattice of the complex is capable of absorbing and desorbing selectively acetonitrile molecules,at 293 K upon an acetonitrile vapor pressure of^0.1×10^5 *** process,which is partially reversible,can be easily followed by both powder X-ray diffraction(P-XRD)and Eu(III)luminescence *** acetonitrile molecule,located in the outer coordination sphere of the metal ion,does not affect the radiative transition probability of 5 D0 level of Eu(Ⅲ)and also it does not activate further non-radiative channels from this *** the other hand,this molecule is capable of affecting the energy position and intensities of the crystal field components of the 5 D0→7 F2 *** complex in solid form can be considered a promising material for the optical sensing of acetonitrile vapors.

关键词： Eu(Ⅲ) X-ray diffraction Crystal structure Luminescence spectroscopy Rare earths

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Impact of Neoadjuvant Therapy on Body Composition and Prognosis in Rectal Cancer Patients

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Journal of Nutritional Oncology 2018年第4期3卷 165-169页

作者： Paola De nardi Mariachiara Salandini Damiano Chiari Nicolo Pecorelli Giulia Cristel Anna Damascelli Monica Ronzoni marco Braga Department of Surgery San Raffaele University Hospital Via Olgettina 60 20132 Milan Italy Department of Radiology San Raffaele University Hospital Via Olgettina 60 20132 Milan Italy Department of Medical Oncology San Raffaele University Hospital Via Olgettina 60 20132 Milan Italy

Objectives The aim of this study was to assess the impact of neoadjuvant chemo-radiotherapy (nCRT) on body composition in patients who subsequently underwent curative surgery for low rectal cancer. Methods Thirty-eight consecutive patients who underwent nCRT and subsequent laparoscopic proctectomy for locally advanced low rectal cancer have been studied. In all patients body composition was measured by computed tomography before and after nCRT. Pathology response on CRT, postoperative short-term outcome, overall and disease-free long-term survival were assessed. Results Twelve patients (31.5%) had skeletal muscle loss 2% after nCRT. No correlation was found between changes in body composition and postoperative complications. Skeletal muscle loss after nCRT significantly correlated with a shorter 5-year disease-free survival. Conclusion Preliminary data suggests that skeletal muscle loss after nCRT negatively impacted on disease-free survival in patients with locally advanced rectal cancer.

关键词： Neoadjuvant Therapy Rectal Cancer

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