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Measurement of vibration frequencies of ties in masonry arches by means of a robotic total station

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 489-500页

作者： marco Gatti Dipartimento di Ingegneria University of Ferraravia Saragat 144123 FerraraItaly

Measurement of the vibration frequencies of eight ties set in masonry arches of a church by means of a robotic total station is described.The instrument made continuous recordings(up to ten per second)of the three-dimensional positions of a reflector situated at 1/2 or 1/4 of the length of the tie during vertical oscillation induced by an impulsive load.The recording slips,vibration amplitudes(and their accuracy),hourly diagram and experimental spectra of vibrations,and the corresponding frequencies were calculated.The results were verified by comparing them with the vibration frequencies and indirectly the tension and fixed support constraint calculated from accelerometric measurements.The study provides interesting information on the accuracies of the reflector′s three-dimensional coordinates,but highlighted certain limits in the application of robotized total stations for measuring vibration frequencies of ties in masonry arches.

关键词： RTS frequency vibrations ties arches

Overlapping approach Proton Pump Inhibitors/Nux vomica-Heel as new intervention for gastro-esophageal reflux management:Delphi consensus study

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World Journal of Gastroenterology 2024年第18期30卷 2467-2478页

作者： Edda Battaglia Luciano Bertolusso marco Del Prete marco Monzani marco Astegiano Gastroenterology Unit ASLTO4Ivrea 10015TurinItaly General Practitioner ASL CN2Alba-Bra 12051CuneoItaly Specialist in Nephrology International Academy of Physiological Regulating Medicine Milan 20100Italy Specialist in Endocrinology Territorial Social and Health Authority of BrianzaMonza 20900Italy Gastroenterology Specialist Retired from Gastroenterology and Hepatology UnitAOU Cittàdella Salute e della ScienzaTurin 10123Italy

BACKGROUND Gastro-esophageal reflux disease(GERD)may affect the upper digestive tract;up to 20%of population in Western nations are affected by GERD.Antacids,histamine H2-receptor antagonists,and Proton Pump Inhibitors(PPIs)are considered the referring medications for GERD.Nevertheless,PPIs must be managed carefully because their use,especially chronic,could be linked with some adverse effects.An effective and safe alternative pharmacological tool for GERD is needed.After the identification of potentially new medications to flank PPIs,it is mandatory to revise and improve good clinical practices even through a consensus process.AIM To optimize diagnosis and treatment guidelines for GERD through a consensus based on Delphi method.METHODS The availability of clinical studies describing the action of the multicomponent/multitarget medication Nux vomica-Heel,subject of the consensus,is the basic prerequisite for the consensus itself.A modified Delphi process was used to reach a consensus among a panel of Italian GERD specialists on the overlapping approach PPIs/Nux vomica-Heel as a new intervention model for the management of GERD.The Voting Consensus group was composed of 49 Italian Medical Doctors with different specializations:Gastroenterology,otolaryngology,geriatrics,and general medicine.A scientific committee analyzed the literature,determined areas that required investigation(in agreement with the multiple-choice questionnaire results),and identified two topics of interest:(1)GERD disease;and(2)GERD treatment.Statements for each of these topics were then formulated and validated.The Delphi process involved two rounds of questioning submitted to the panel experts using an online platform.RESULTS According to their routinary GERD practice and current clinical evidence,the panel members provided feedback to each questionnaire statement.The experts evaluated 15 statements and reached consensus on all 15.The statements regarding the GERD disease showed high levels of agreement,with consensus ranging from 70%to 92%.

关键词： Gastro-esophageal reflux disease Proton Pump Inhibitors Consensus Nux vomica-Heel Overlapping Decalage

Microglia out of place—mapping macrophages across the developing human body

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Cellular & Molecular Immunology 2024年第3期21卷 210-212页

作者： Roman Sankowski marco Prinz Institute of Neuropathology Faculty of MedicineUniversity of FreiburgFreiburgGermany Signalling Research Centres BIOsS and CIBSs University of FreiburgFreiburgGermany

Macrophages(MΦs)are versatile cells found in every organ.Throughout the body,they work tirelessly to maintain tissues.To this end,they are instructed by their respective niches to express organ-specific genes and proteins,resulting in a variety of cell morphologies and highly specialized functions across different tissues[1].A recent study by Wang et al.used single-cell RNA sequencing to comprehensively profile human MΦphenotypes across 19 organs between postconception weeks(PCW)4 and 26[2].This study revealed a surprising diversity of these cells and suggests new avenues of research.

关键词： organs instru

Ubiquitination and PARylation cross-talk about immunity

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Molecular Plant 2021年第12期14卷 1976-1978页

作者： marco Trujillo Faculty of Biology Cell BiologyⅡUniversity of Freiburg79104 FreiburgGermany

Post-translational modifications(PTMs)allow organisms to quickly respond and acclimate to environmental changes.The attachment of ubiquitin and its different polymeric forms,act as signals that modulate most aspects of cellular life.Ubiquitination is of key importance to maintain protein homeostasis during the immune response by coordinating the major degradation path-ways,namely proteasomal and vacuolar in plants(Trujillo,2021).Poly(ADP-ribosyl)ation(PARylation),has also been linked to various stress responses and shows many commonalities to ubiquitination(Rissel and Peiter,2019).Yao et al.(2021)have now uncovered a link between these two PTMs.

关键词： maintain translational polymeric

The intriguing giant deer from the Bate cave (Crete): could paleohistological evidence question its taxonomy and nomenclature?

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Integrative Zoology 2022年第1期17卷 54-77页

作者： Maria Rita PALOMBO marco ZEDDA CNR-IGAG c/o Department of Earth Sciences Sapienza UniversityRomaItaly Department of Veterinary Medicine University of SassariItaly

The research describes for the first time a possible case of pituitary gigantism in fossil mammals,precisely in deer.The pathology was detected in 2 long bones(tibia and metatarsus)belonging to an individual of an unusual large size found at the Bate cave(Rethymnon,Northern Crete).It formed the basis of Candiacervus major,the largest among the endemic deer species recorded in the Pleistocene-Early Holocene of Crete.Radiological and histomorphological examinations highlighted a reduction in cortical bone thickness and the presence of wide lacunae inside of the bone tissue.The pathological conditions suggest a pituitary gigantism diagnosis also supported by some morphological evidence,such as the extremely elongated distal part of the metatarsal diaphysis,the proportionally small proximal epiphysis,and some bone gracility.The diagnosis of a case of pituitary gigantism as presumed responsible for the extraordinary elongation of the tibia and the metatarsal bone is intriguing as they are,respectively,the paratype and the holotype of the C.major.The species represents a case of a deviation from the“island rule”in Pleistocene large mammals.The new evidence recommends a taxonomic and nomenclatural revision of this species.The main outcomes of this research are as follows:(i)a case of pituitary gigantism is described for the first time in an extinct mammal;(ii)it is underlined that paleohistology may provide interesting clues for disentangling taxonomic and nomenclatural issues;(iii)one of the very few cases of gigantism in insular mammals is being questioned.

关键词： Candiacervus major Cretan deer island rule paleohistology pituitary gigantism

How physical and motor training affect cognitive performance: lessons from an inflammatory molecule

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Neural Regeneration Research 2022年第12期17卷 2689-2690页

作者： Margherita Maffei marco Mainardi Institute of Clinical Physiology National Research Council(IFC-CNR)and Obesity/Lipodystrophies CenterPisa University HospitalPisaItaly Neuroscience Institute National Research Council(IN-CNR)PisaItaly

Our phenotype includes not only physical features,but also behavioral outputs such as motor schemes and learned skills,and is the result of a complex interaction between genetic background and environment.In fact,a good fraction of last decades’biomedical efforts were dedicated to understanding how different elements(e.g.,genetic polymorphisms,lifestyle components)participate in this interplay,ultimately contributing to affect a given phenotype up to the point of steering it towards pathology.Genetic and epigenetic elements are relatively easy to analyze individually using a reductionist approach,for instance via loss-or gain-of-function studies in cellular and animal models;the effects of nutrients,drugs,pollutants can be similarly tested as single specific stimuli.

关键词： instance drugs lesson

Potential and progress of studying mountain biodiversity by means of butterfly genetics and genomics

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Journal of Genetics and Genomics 2024年第3期51卷 292-301页

作者： Shuting Wang marco Girardello Wei Zhang State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China cE3c-Centre for Ecology Evolution and Environmental Changes/Azorean Biodiversity GroupFaculdade de Ciencias Agrarias e do AmbienteUniversidade dos Açores9700-042 Angra do HeroísmoTerceiraPortugal

Mountains are rich in biodiversity,and butterflies are species-rich and have a good ecological and evolutionary research foundation.This review addresses the potential and progress of studying mountain biodiversity using butterflies as a model.We discuss the uniqueness of mountain ecosystems,factors influencing the distribution of mountain butterflies,representative genetic and evolutionary models in butterfly research,and evolutionary studies of mountain biodiversity involving butterfly genetics and genomics.Finally,we demonstrate the necessity of studying mountain butterflies and propose future perspectives.This review provides insights for studying the biodiversity of mountain butterflies as well as a summary of research methods for reference.

关键词： Mountain ecosystem Butterfly Biodiversity Adaptation Genomics Genetics

Retinoprotective compounds,current efficacy,and future prospective

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Neural Regeneration Research 2023年第12期18卷 2619-2622页

作者： Rachele Marino Rebecca Sappington marco Feligioni Laboratory of Neuronal Cell Signaling EBRI Rita Levi-Montalcini FoundationRomeItaly Department of Neurobiology and Anatomy Wake Forest School of MedicineAtrium Health Wake Forest Baptist Medical CenterWinston-SalemNCUSA Department of Ophthalmology Wake Forest School of MedicineWinston-SalemNCUSA Department of Neurorehabilitation Sciences Casa di Cura IgeaMilanItaly

Retinal dysfunction is the most common cause of vision loss in several retinal disorders.It has been estimated a great increase in these pathologies that are becoming more globally widespread and numerous over time,also supported by the life expectancy increment.Among different types of retinopathies,we can account some that share causes,symptoms,and treatment including diabetic retinopathy,age-related macular degeneration,glaucoma,and retinitis pigmentosa.Molecular changes,environmental factors,and genetic predisposition might be some of the main causes that drive retinal tissue to chronic inflammation and neurodegeneration in these retinopathies.The treatments available on the market contain compounds that efficiently ameliorate some of the important clinical features of these pathologies like stabilization of the intraocular pressure,reduction of eye inflammation,control of eye oxidative stress which are considered the major molecular mechanisms related to retinal dysfunction.Indeed,the most commonly used drugs are antiinflammatories,such as corticosteroids,antioxidant,hypotonic molecules and natural neuroprotective compounds.Unfortunately,these drugs,which are fundamental to treating disease symptoms,are not capable to cure the pathologies and so they are not life-changing for patients.This review provided an overview of current treatments on the market,but more interestingly,wants to be a quick window on the new treatments that are now in clinical trials.Additionally,it has been here highlighted that the recent technical enhancement of the investigation methods to identify the various retinopathies causes might be used as a sort of“precise medicine”approach to tailor the identification of molecular pathways involved and potentially study a dedicated treatment for each patient.This approach includes the use of cutting-edge technologies like gene therapy and metabolomics.

关键词： age-related macular degeneration anti-inflammatory drugs antioxidants diabetic retinopathy glaucoma neuroprotective compounds retinitis pigmentosa retinopathies vision loss

What Is New in the 2023 European Society of Cardiology Guidelines for the Management of Acute Coronary Syndromes

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Cardiology Discovery 2023年第4期3卷 227-231页

作者： marco Roffi Division of Cardiology University HospitalsGeneva 1211Switzerland

For the first time,European Society of Cardiology(EsC)guidelines have aggregated in 1 single document recommendations for the management of patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS)and ST-elevation myocardial infarction(STEMI).From a clinical perspective,this is coherent,as the spectrum of clinical presentations in acute coronary syndromes(ACS)may range from new onset or progressive troponin-negative angina to STEMl,cardiogenic shock,or cardiac arrest.In addition,the management pathways of NSTE-ACS and STEMI patients are widely similar.Compared with previous editions of the guidelines,the extensive document is improved also from a graphic perspective,containing several appealing and easy-to-understand figures.New or modified recommendations include,among others,the topics of diagnostic work-up,timing of invasive strategy,revascularization in multi-vessel disease,intravascular imaging,cardiac arrest,cardiogenic shock,and antithrombotic treatment.For the first time in the field of ACS,ESC guidelines have incorporated a section on patient perspectives with dedicated recommendations.Some of the most relevant changes in recommendations impacting clinical practice are discussed inthis article.

关键词： Acute coronary syndromes Guidelines European Society of Cardiology