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Accuracy of a predictive model for severe hepatic fibrosis or cirrhosis in chronic hepatitis C

World Journal of Gastroenterology 2005年第46期11卷 7318-7322页

作者： Agostino Colli Alice Colucci Silvia Paggi Mirella Fraquelli Sara Massironi marco andreoletti Vittorio Michela Dario Conte Department of Internal MedicineOspedale "A.Manzoni" 23900 LeccoItaly Postgraduate School of GastroenterologyIRCCS Ospedale Maggiore 20122 MilanItaly

AIM: To assess the accuracy of a model in diagnosing severe fibrosis/cirrhosis in chronic hepatitis C virus (HCV)***: The model, based on the sequential combination of the Bonacini score (BS: ALT/AST ratio,platelet count and INR) and ultrasonography liver surface characteristics, was applied to 176 patients with chronic HCV infection. Assuming a pre-test probability of 35%,the model defined four levels of post-test probability of severe fibrosis/cirrhosis: 90% (almost absolute).The predicted probabilities were compared with the observed patients' distribution according to the histology (METAVIR).RESULTS: Severe fibrosis/cirrhosis was found in 67 patients (38%). The model discriminated patients in three comparable groups: 34% with a very high (>90%)or low (75%) or low (<10%) probability of cirrhosis, leaving only 33% of the patients still requiring liver biopsy.

关键词： Liver fibrosis Ultrasonography Bonacini score Liver biopsy Hepatitis C

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Measurement of forces generated during distraction of growing-rods in early onset scoliosis

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World Journal of Orthopedics 2012年第2期3卷 15-19页

作者： marco Teli Giuseppe Grava Victor Solomon Giuseppe andreoletti Emanuele Grismondi Jay Meswania Consultant Orthopaedic Surgeon Orthopaedic Spine UnitPoliclinico San MarcoCorso Europa 724040 Osio SottoBergamoItaly Consultant Orthopaedic Surgeon Orthopaedic DepartmentPoliclinico San MarcoCorso Europa 724040 Osio SottoBergamoItaly Staff Grade Surgeon Orthopaedic DepartmentPoliclinico San MarcoCorso Europa 724040 Osio SottoBergamoItaly Biomedical Engineer Royal National Orthopaedic HospitalStanmoreUnited Kingdom

AIM: To measure the forces applied during distraction of growing-rods in early onset scoliosis(EOS), aimed at developing a motorized elongation ***: A consecutive series of measurements were carried out to analyze the forces applied by the surgeon during distraction of single growing-rods in 10 patients affected by EOS(mean age 8.3 years; range 6 to 10 years) undergoing the first distraction 6 months following implantation of the rods. For each measurement, output from the transducer of a dedicated pair of distraction calipers was recorded at zero load status and at every 1 mm of distraction, up to a maximum of 12 mm for each of the two connected ***: Twenty measurements were obtained showing a linear increase of the load with increasing distraction, with a mean peak force of 485 N at 12 mm distraction and a single reading over 500 N. We did not observe bone fractures or ligament disruptions during or after rod elongations. There was one case of superficial wound infection in the ***: The safe peak force carrying capacity of a motorized device for distraction of growing-rods is 500 N.

关键词： Early onset scoliosis Spinal deformity Growing-rods Spinal elongation Force measurement

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