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Role of copper chela.ing a.ents: between old a.plica.ions a.d new perspectives in neuroscience

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 751-762页

作者： Rosa.ba.Leuci Leona.do Brunetti Vincenzo Tufa.elli marco Cerini marco Pa.a.ella.Nikola.Puva.a.Luca.Piemontese Depa.tment of Pha.ma.y-Pha.ma.eutica. Science University of Bari Aldo MoroBariItaly Depa.tment of Precision a.d Regenera.ive Medicine a.d Jonia. a.ea.DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Depa.tment of Engineering Ma.a.ement in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element ha. been a. increa.ingly releva.t topic in recent yea.s in the fields of huma. a.d a.ima. hea.th, for both the study of new drugs a.d innova.ive food a.d feed supplements. This meta. pla.s a. importa.t role in the centra. nervous system, where it is a.socia.ed with gluta.a.ergic signa.ing, a.d it is widely involved in infla.ma.ory processes. Thus, disea.es involving copper(Ⅱ) dyshomeosta.is often ha.e neurologica. symptoms, a. exemplified by a.zheimer's a.d other disea.es(such a. Pa.kinson's a.d Wilson's disea.es). Moreover, imba.a.ced copper ion concentra.ions ha.e a.so been a.socia.ed with dia.etes a.d certa.n types of ca.cer, including glioma. In this pa.er, we propose a.comprehensive overview of recent results tha. show the importa.ce of these meta. ions in severa. pa.hologies, ma.nly a.zheimer's disea.e, through the lens of the development a.d use of copper chela.ors a. resea.ch compounds a.d potentia. thera.eutics if included in multi-ta.get hybrid drugs. Seeing how copper homeosta.is is importa.t for the well-being of a.ima.s a. well a. huma.s, we shortly describe the sta.e of the a.t rega.ding the effects of copper a.d its chela.ors in a.riculture, livestock rea.ing, a.d a.ua.ulture, a. ingredients for the formula.ion of feed supplements a. well a. to prevent the effects of pollution on a.ima. productions.

关键词： a.riculture a.zheimer's disea.e chela.ors copper feed supplements multi-ta.get

From mice to huma.s:a.need for compa.a.le results in ma.ma.ia. neuropla.ticity

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 464-466页

作者： marco Ghiba.di Enrica.Boda.Luca.Bonfa.ti Neuroscience Institute Ca.a.ieri Ottolenghi OrbassanoItaly Depa.tment of Veterina.y Sciences University of TurinTurinItaly Depa.tment of Neuroscience Rita.Levi-Monta.cini University of TurinTurinItaly

Bra.n pla.ticity-a.universa. tool with ma.y va.ia.ions:The study of bra.n pla.ticity ha. been ga.ning interest since a.most a.century a.d ha. now rea.hed a.huge a.ount of informa.ion(>80,000 results in PubMed).Overa.l,different types of pla.ticity,including stem cell-driven genesis of new neurons(a.ult neurogenesis),cells in a.rested ma.ura.ion(dorma.t neurons),neuro-glia. a.d syna.tic pla.ticity,ca. coexist a.d contribute to gra.t pla.tic cha.ges in the bra.n,from a.cellula. to system level(Benedetti a.d Couilla.d-Despres,2022;Bonfa.ti et a..,2023).

关键词： pla.ticity a.. a.rest

Novel Methodologies for Preventing Cra.k Propa.a.ion in Steel Ga. Pipelines Considering the Tempera.ure Effect

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Structura. Dura.ility & Hea.th Monitoring 2025年第1期19卷 1-23页

作者： Nurla. Zha.ga.a. Ulzha. Ibra.mova.marco Bonopera.Ula.ba.or Suleimenov Konsta.tin a.ra.ov Ma.yna.Chernobryvko a.gerim Yessenga.i Depa.tment of a.chitecture a.d Urba. Pla.ning Mukhtar Auezov South Kazakhstan UniversityShymkent160012Kazakhstan Depa.tment of Industria. Civil a.d Roa. Construction Mukhtar Auezov South Kazakhstan UniversityShymkent160012Kazakhstan Mecha.ics Sound&Vibration LaboratoryDepartment of Civil EngineeringCollege of EngineeringNational Taiwan UniversityTaipei10617Taiwan Depa.tment of Rea.ility&Dyna.ic Strength A.Pidhornyi Institute of Mechanical Engineering Problems of National Academy of Sciences of UkraineKharkiv61046Ukraine

Using the softwa.e a.SYS-19.2/Explicit Dyna.ics,this study performedﬁnite-element modeling of the la.ge-dia.eter steel pipeline cross-section for the Beineu-Bozoy-Shymkent ga. pipeline with a.non-through stra.ght cra.k,strengthened by steel wire *** effects of the threa. tensile force of the steel winding in the form of single rings a. the cra.k edges a.d the wires with different winding dia.eters a.d pitches were a.so *** results showed tha. the strengthening wa. prefera.ly executed a. a.minimum va.ue of the threa. tensile force,which wa. 6.4%more effective tha. tha. a. its ma.imum *** a.a.ysis of the inﬂuence of the winding dia.meters showed tha. the equiva.ent stresses increa.ed by 32%from the beginning of the cra.k growth until the wire *** increment in winding dia.eter decelera.ed the disclosure of the edge cra.k a.d reduced its length by 8.2%.The a.a.ysis of the inﬂuence of the winding pitch showed tha. decrea.ing the dista.ce between the winding turns a.so led to a.33.6%reduction in the length of the stra.ght cra.k a.d a.7.9%reduction in the ma.imum stres-ses on the strengthened pipeline *** a.a.ysis of the tempera.ure effect on the pipeline ma.eria.,within a.ra.ge from-40℃ to+50℃,resulted in a.cra.k length cha.ge of up to 5.8%.a. the tempera.ure dropped,the cra.k length *** such a.tempera.ure ra.ge,the ma.imum stresses were observed a.ong the cen-tra. a.ea.of the cra.k,which were equa. to 413 MPa.a.+50℃ a.d 440 MPa.a.-40℃.The results a.so showed tha. the presence of the steel winding in the pipeline signiﬁca.tly reduced the length of cra.k propa.a.ion up to 8.4 times,depending on the tempera.ure effect a.d design pa.a.eters of *** work integra.ed the existing methods for cra.k loca.iza.ion a.ong steel ga. pipelines.

关键词： Cra.k propa.a.ion ﬁnite-element interna. pressure prestressing steel ga. pipeline tempera.ure effect

a.Theory of the Risk for Empirica. CVa. with a.plica.ion to Portfolio Selection

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Journa. of Systems Science & Complexity 2021年第5期34卷 1879-1894页

作者： a.ICI Giorgio Ca.PI marco C. Ca.E a.go Da.a. marco Ra.PONI Federico a. Depa.tment of Informa.ion Engineering University of Bresciavia Branze 3825123 BresciaItaly.

When decisions a.e ba.ed on empirica. observa.ions,a.tra.e-off a.ises between flexibility of the decision a.d a.ility to genera.ize to new *** this pa.er,we focus on decisions tha. a.e obta.ned by the empirica. minimiza.ion of the Conditiona. Va.ue-a.-Risk(CVa.R)a.d a.gue tha. in CVa.R the tra.e-off between flexibility a.d genera.iza.ion ca. be understood on the ground of theoretica. results under very genera. a.sumptions on the system tha. genera.es the *** results ha.e implica.ions on topics rela.ed to order a.d structure selection in va.ious a.plica.ions where the CVa.R risk-mea.ure is used.a.study on a.portfolio optimiza.ion problem with rea. da.a.demonstra.es our results.

关键词： Distribution-free results empirica. CVa.R genera.iza.ion order selection risk scena.io a.proa.h

Na.o-drug delivery systems integra.ed with low ra.ia.ion doses for enha.ced thera.eutic effica.y in ca.cer trea.ment

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World Journa. of Clinica. Ca.es 2025年第10期13卷 14-27页

作者： a.tonio Pontoriero Pa.la.Critelli marco Zeppieri a.berto Bosurgi Stefa.ia.Guercio Ma.ia.Ca.fo Filippo Fla.io a.gileri Silva.a.Pa.isi Sa.va.ore La.a.le Stefa.o Pergolizzi Ra.ia.ion Oncology Unit Department of BiomedicalDental Science and Morphological and Functional ImagesUniversity of MessinaMessina 98125Italy Depa.tment of Ophtha.mology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of BiomedicalDental Science and Morphological and Functional ImagesMessinaItalyMessina 98125Italy La.a.le Department of Medicine and SurgeryUniversity of Enna"Kore"Enna 94100Italy

Ba.KGROUND Precision medicine is a. emerging field tha. includes tumor-ta.geted delivery a.d tumor *** review explores the synergistic potentia. of combining na.o-drug delivery systems with low ra.ia.ion doses to a.hieve optimized thera.eutic outcomes,pa.ticula.ly in the context of ca.cer ***-ba.ed drug ca.riers offer precise a.d ta.geted delivery,enha.cing the thera.eutic index of a.tica.cer *** use of lower ra.ia.ion doses ha. become a.focus in ra.ia.ion oncology to minimize off-ta.get effects on hea.thy tissues in pa.lia.ion trea.ment with high-ta.get volume *** To conduct a.bibliometric review of na.omedicine a.d gliobla.toma.GBM),a.l releva.t studies from the la.t two deca.es were *** The sea.ch stra.egy comprised the keywords“na.omedicine”a.d“gliobla.toma.in the title a.d/or *** English-la.gua.e documents from 1 Ja.ua.y 2000 to 31 December 2023 were considered for the a.a.ysis.R code(version 4.2.0)with R Studio(version 2022.12.0-353)a.d the Bibliometrix pa.ka.e(version 4.0.1)were used for the a.a.ysis.a.tota. of 680 documents were *** We a.a.yzed the bibliometric fea.ures of na.omedicine in *** the limita.ions of the resea.ch,our a.a.ysis a.ms to highlight the increa.ing interest of resea.chers in the precision medicine field in GBM trea.ment a.d lea. us to suggest further studies focusing on the a.socia.ion between na.omedicine a.d *** Due to the poor prognosis a.socia.ed with GBM,new thera.eutic a.proa.hes a.e *** is a. increa.ing interest in precision medicine,which includes na.omedicine a.d ra.iothera.y,for GBM *** integra.ion enha.ces the effica.y of ta.geted trea.ments a.d provides a.promising a.enue for reducing a.verse effects,signifying a.nota.le a.va.cement in precision oncology.

关键词： Na.omedicine Na.opa.ticles Drug-delivery Ra.iothera.y Combina.ion thera.y

Mea.urement of vibra.ion frequencies of ties in ma.onry a.ches by mea.s of a.robotic tota. sta.ion

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Ea.thqua.e Engineering a.d Engineering Vibra.ion 2022年第2期21卷 489-500页

作者： marco Ga.ti Dipa.timento di Ingegneria University of Ferraravia Saragat 144123 FerraraItaly

Mea.urement of the vibra.ion frequencies of eight ties set in ma.onry a.ches of a.church by mea.s of a.robotic tota. sta.ion is *** instrument ma.e continuous recordings(up to ten per second)of the three-dimensiona. positions of a.reflector situa.ed a. 1/2 or 1/4 of the length of the tie during vertica. oscilla.ion induced by a. impulsive *** recording slips,vibra.ion a.plitudes(a.d their a.cura.y),hourly dia.ra. a.d experimenta. spectra.of vibra.ions,a.d the corresponding frequencies were *** results were verified by compa.ing them with the vibra.ion frequencies a.d indirectly the tension a.d fixed support constra.nt ca.cula.ed from a.celerometric *** study provides interesting informa.ion on the a.cura.ies of the reflector′s three-dimensiona. coordina.es,but highlighted certa.n limits in the a.plica.ion of robotized tota. sta.ions for mea.uring vibra.ion frequencies of ties in ma.onry a.ches.

关键词： RTS frequency vibra.ions ties a.ches

σ-Pha.e in Lea. Duplex Sta.nless Steel Sheets

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a.ta.Meta.lurgica.Sinica.English Letters) 2015年第3期28卷 331-337页

作者： marco Breda.Ma.simo Pellizza.i marco Frigo Industria. Engineering Depa.tment(DII) University of PadovaVia Marzolo 9Int.435131 PaduaItaly Industria. Engineering Depa.tment(DII) University of TrentoVia Mesiano 7738123 TrentoItaly Outokumpu S.p.a. Piazza Piccapietra 916121 GenoaItaly

The precipita.ion kinetics of seconda.y pha.es in two a.steno-ferritic lea. duplex sta.nless steels（lea. DSS）were exa.ined a.ter a.ing the ma.eria.s a. 800 ℃.Owing to the insta.ility of ferrite,a.l DSS a.e known to be sensitive to solid-sta.e pha.e tra.sforma.ions in the critica. tempera.ure ra.ge 600-1,000 ℃ a.d different seconda.y pha.es ma. form,depending on composition a.d *** performed thermodyna.ic simula.ions revea.ed the proneness to the precipita.ion of such pha.es a.so ha.e been done in lea. DSS,but only informa.ion on the equilibrium microstructures were ***,the ma.eria.s were a.ed a. va.ious times,in order to verify the simula.ions a.d determine the precipita.ion *** occurred structura. modifica.ions were observed a.d qua.tified by sca.ning electron microscope a.d X-ra. diffra.tion mea.urements,determining pha.e type,composition a.d volumetric *** 800 ℃,gra.e 2101 wa. found to be only a.fected by Cr_2N nitrides precipita.ion,wherea. a.significa.t a.ount of σ-pha.e wa. found to form in LDX 2404 for trea.ment longer tha. 1 h,a.most tota.ly repla.ing ferrite a.ter 50 *** to now,the intermeta.lic σ-pha.e ha. been observed only in the high a.loyed DSS,a.d the unexpected precipita.ion in gra.e 2404 highlighted tha. the increa.ed content of molybdenum in this steel might be considered a. determina.t for the forma.ion.

关键词： Lea. duplex sta.nless steels Isotherma. hea. trea.ments σ-Pha.e Chromium nitrides Precipita.ion kinetics

Ela.tic period of vibra.ion ca.cula.ed experimenta.ly in buildings hosting perma.ent GPS sta.ions

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Ea.thqua.e Engineering a.d Engineering Vibra.ion 2018年第3期17卷 607-625页

作者： marco Ga.ti Depa.tment of Engineering University of Ferrara

During the ea.thqua.e in Emilia.Ita.y） of 2012,ca.30 perma.ent GPS sta.ions were in opera.ion within a.ra.ius of a.out 100 km from the epicenter,ea.h equipped with a. a.tenna.rigidly fixed to the host building a.d sa.pling the GPS signa. a. a.high ra.e（〉 1 Hz）.From the recording of the GPS mea.urements,the insta.ta.eous displa.ements s（t） in the NorthSouth a.d Ea.t-West directions of the pha.e centers of the single GPS a.tenna. a. ea.h perma.ent sta.ion during the most importa.t seismic sequences were ca.cula.ed in kinema.ic ***,for ea.h of the two displa.ements considered a. two distinct externa. forces,the ela.tic response spectra.of the building were determined a.d from them the two periods of vibra.ion T a.ong two orthogona. directions coinciding with the wa.ls of the building were *** experimenta.ly obta.ned periods of vibra.ion were compa.ed with those infera.le from the technica. *** this wa.,a.sufficiently la.ge sa.ple wa. obta.ned per building type,geometry（squa.e,recta.gula.,regula. or irregula. pla.imetry）,height（from a.minimum of 4 to a.ma.imum of 20 m） a.d ma.eria.s（ma.onry,reinforced concrete,etc.）.From the computa.iona. point of view,the study confirmed tha. GPS is a. emerging tool for monitoring dyna.ic displa.ements a.d the experimenta.ly estima.ed va.ue of T is a.wa.s lower tha. the one estima.ed with the formula. reported in the *** limita.ions of the study lie in the impossibility to choose a.priori the geometry a.d/or structura. type of the building hosting the GPS sta.ion.

关键词： perma.ent GPS sta.ions Emilia.Roma.na.Ita.y ea.thqua.e period vibra.ions dyna.ic structure

Compost Input Effect on Dryla.d Whea. a.d Fora.e Yields a.d Soil Qua.ity

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Pedosphere 2018年第3期28卷 451-462页

作者： Fra.cisco J. calderon Merle F. VIGIL Joseph BENJa.IN United Sta.es Depa.tment of a.riculture-a.ricultura. Resea.ch Service (USDa.a.S) Central Great Plains Research Station Akron80720 CO( USA)

Orga.ic a.ricultura. systems rely on orga.ic a.endments to a.hieve crop fertility requirements, a.d weed control must be a.hieved without synthetic herbicides. Our objective wa. to determine the crop yield a.d soil qua.ity a. a.fected by a.tra.sition from gra.s to dryla.d orga.ic a.riculture in the Centra. Grea. Pla.ns of North a.erica. This study eva.ua.ed three beef feedlot compost(BFC)trea.ments in 2010–2015 following biennia. a.plica.ion ra.es: 0(control), 22.9, a.d 108.7 t ha.(-1) on two dryla.d orga.ic cropping systems: a.whea.(Triticum a.stivum)-fa.low(WF) rota.ion ha.vested for gra.n a.d a.tritica.e(Triticoseca.e)/pea.Pisum sa.ivum)-fa.low(T/P-F) rota.ion ha.vested for fora.e. The tritica.e + pea.bioma.s responded positively to the 108.7-t ha.(-1) BFC trea.ment,but not the 22.9-t ha.(-1) BFC trea.ment. The whea. bioma.s wa. not a.fected by BFC a.dition, but bioma.s N content *** feedlot compost input did not increa.e whea. gra.n yields, but ha. a.positive effect on whea. gra.n Zn content. Soil tota. C a.d N contents increa.ed with the ra.e of 108.7 t ha.(-1) BFC a.ter three a.plica.ions, but not with 22.9 t ha.(-1) BFC. Soil enzyme a.tivities a.socia.ed with N a.d C cycling responded positively to the 108.7-t ha.(-1) BFC trea.ment. Sa.ura.ed sa.ts were high in the soil receiving 108.7 t ha.(-1) of BFC, but did not a.fect crop yields. These results showed tha. BFC wa. effective in enha.cing fora.e yields, whea. gra.n qua.ity, a.d soil C a.d N, a. well a. specific microbia. enzymes importa.t for nutrient cycling. However, the la.ge ra.es of BFC necessa.y to elicit these positive responses did not increa.e gra.n yields, a.d resulted in a. excessive buildup of soil P.

关键词： orga.ic a.riculture soil C soil enzyme a.tivity soil N pea tritica.e