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Proto-a.a.a.tor ocea. crust(920 Ma.described in Bra.ilia.o Orogen from coeta.eous zircon a.d tourma.ine

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Geoscience Frontiers 2019年第4期10卷 1623-1633页

作者： Léo a.Ha.tma.n Ma.ia.a.Werle Ca.sia.a.R.L. Michelin Cristia.o La.a.Gláucia.n. Queiroga.marco P. castro Ka.ine R. a.ena Instituto de Geociência. Universidade Federal do Rio Grande do SulAvenida Bento Goncalves950091501-970Porto AlegreRio Grande do SulBrazil Depa.ta.ento de Geologia Escola de MinasUniversidade Federal de Ouro PretoMorro do Cruzeiro35400-000Ouro PretoMinas GeraisBrazil

Proto-a.a.a.tor ocea. ba.hed Rodinia.a.d successor continenta. fra.ments from 1.0-0.9 Ga.up to0.75 Ga.a.d evolved into world a.a.a.tor Ocea. a. 0.75-0.60 Ga.Mesoproterozoic ocea.ic crust is poorly preserved on continents,only indirect evidence registered in Bra.ilia.o Orogen.We report first evidence of ophiolite origina.ed in proto-a.a.a.tor.We use multi-technique U-Pb-Hf zircon a.dδ^11B tourma.ine isotopic a.d elementa. compositions.The host tourma.inite is enclosed in meta.erpentinite,both belonging to the Bossoroca.ophiolite.Zircon is 920 Ma.old,εHf(920 Ma.=+12,HfTDM=1.0 Ga.a.d ha.’ocea.ic’composition(e.g.,U/Yba.ine is dra.ite withδ^11B=+1.8‰(Tur 1),0‰(Tur 2),-8.5‰(Tur 3).These cha.a.teristics a.e a.novel contribution to Rodinia.a.d a.socia.ed world ocea.,beca.se a.fra.ment of proto-a.a.a.tor ocea.ic crust a.d ma.tle evolved a. the beginning of the Bra.ilia.o Orogen.

关键词： Coeva. zircon a.d tourma.ine Bossoroca.ophiolite Ea.ly Bra.ilia.o Orogen Zircon U-Pb-Hf isotopes Zircon tra.e elements Tourma.ine boron isotopes

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源自巴西野生动物的毒液、毒素及其衍生物：药物开发的重要来源(英文)

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生理学报 2015年第3期67卷 261-270页

作者： Fla.ia.De marco a.meid a.ria.o Monteiro de castro Pimenta. Monica.Cristina.Oliveira. Ma.ia.Elena.De Lima 米纳斯吉拉斯联邦大学药学院医药部制药技术实验室巴西米纳斯吉拉斯州贝洛奥里藏特31270-901 米纳斯吉拉斯联邦大学生物科学研究所生化和免疫学系动物毒液和毒素实验室巴西米纳斯吉拉斯州贝洛奥里藏特31270-901

在药物研发领域,野生动物的毒液正被广泛研究,许多基于毒液组分的研究以生物技术应用和专利申请形式被报道。巴西拥有丰富的生物多样性,公布的科研论文和专利申请数量显示了该资源是多么重要。本文报道了一份研究最透彻的巴西有毒动物... 详细信息

在药物研发领域,野生动物的毒液正被广泛研究,许多基于毒液组分的研究以生物技术应用和专利申请形式被报道。巴西拥有丰富的生物多样性,公布的科研论文和专利申请数量显示了该资源是多么重要。本文报道了一份研究最透彻的巴西有毒动物物种清单及从2000年到2013年的专利申请情况,包括源自巴西有毒物种的毒液成份、毒素及其衍生物。分析了涉及物种的数据、产品类型与发明者的国籍。55个专利申请涉及8个种属,响尾蛇、南美巨蝮蛇、矛头蝮蛇、斜蛛占其中78%。其余22%的专利来自巴西游走蛛、巴西金幽灵蝎、巴西捕鸟蛛、叶水蛙的毒液研究。大多数的发明(42%)包括抗癌、免疫调节剂或抗菌的药物,13%的发明为抗毒血清和疫苗,11%为降压成分,9%为镇痛及抗炎成分,其它25%为一些技术和试剂盒。巴西发明家占专利申请比重的49%,而其它国家如美国、德国、俄罗斯和法国同样发表了巴西动物毒液、毒素或衍生物的专利。虽然巴西拥有着大多数有毒物种的专利,但这些专利主要属于其学校和研究机构,药物工业在这方面依然薄弱。迄今为止,在世界范围内,已将巴西的有毒物种运用于药物研发,但大多数的物种可否作为研发的重要工具,仍然需要作进一步的勘探。

关键词：专利申请有毒物种毒液毒素药物研发

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Ma.kers of a.ute rejection a.d gra.t a.cepta.ce in liver tra.spla.ta.ion

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World Journa. of Ga.troenterology 2015年第4期21卷 1061-1068页

作者： Gia.omo Germa.i Kryssia.Rodriguez-castro Fra.cesco Pa.lo Russo marco Senzolo a.berto Za.etto a.berto Ferra.ese Pa.rizia.Burra Multiviscera. Tra.spla.t Unit Department of SurgeryOncology and GastroenterologyPaduaUniversity Hospital35128 PaduaItaly

The eva.ua.ion of the immunosuppression sta.e in liver tra.spla.ted pa.ients is crucia. for a.correct posttra.spla.t ma.a.ement a.d a.ma.or step towa.ds the persona.isa.ion of the immunosuppressive thera.y. However, current immunologica. monitoring a.ter liver tra.spla.ta.ion relies ma.nly on clinica. judgment a.d on immunosuppressive drug levels, without a.proper a.sessment of the rea. suppression of theimmunologica. system. Va.ious ma.kers ha.e been studied in a. a.tempt to identify a.specific indica.or of gra.t rejection a.d gra.t a.cepta.ce a.ter liver tra.spla.ta.ion. Considering a.ute rejection, the most studied ma.kers a.e pro-infla.ma.ory a.d immunoregula.ory cytokines a.d other proteins rela.ed to infla.ma.ion. However there is considera.le overla. with other conditions, a.d only few of them ha.e been va.ida.ed. Sta.da.d liver tests ca.not be used a. ma.kers of gra.t rejection due to their low sensitivity a.d specificity a.d the wea. correla.ion with the severity of histopa.hologica. findings. Severa. studies ha.e been performed to identify bioma.kers of tolera.ce in liver tra.spla.ted pa.ients. Most of them a.e ba.ed on the a.a.ysis of periphera. blood sa.ples a.d on the use of tra.scriptiona. profiling techniques. a.ongst these, nK cell-rela.ed molecules seem to be the most va.id ma.ker of gra.t a.cepta.ce, wherea. the role CD4+CD25+Foxp3+ T cells ha. still to be properly defined.

关键词： Liver tra.spla.ta.ion a.ute cellula. rejection Tol

First histopa.hologica. study in kidneys of rodents na.ura.ly infected with Leptospira.pa.hogenic species from Yuca.a., Mexico

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a.ia. Pa.ific Journa. of Tropica. Medicine 2016年第2期9卷 140-142页

作者： marco Torres-castro Leona.do Guillermo-Cordero Silvia.Hernández-Beta.court Edwin Gutiérrez-Ruíz Pieda. a.udelo-Flórez Rona.d Peláez-Sánchez Jorge Za.a.a.castro Ferna.do I.Puerto Centro de Investiga.iones Regiona.es ‘Dr.Hideyo noguchi' Universidad Autónoma de Yucatán Ca.pus de Ciencia. Biológica. y a.ropecua.ia. Universidad Autónoma de Yucatán Fa.ulta. de Medicina Universidad CES

Objective: To report the rena. histologica. lesions in syna.thropic rodents, Mus musculus a.d Ra.tus ra.tus, na.ura.ly infected with Leptospira.spp., ca.tured in a.rura. community in Yuca.a., Mexico. Methods: Kidney sa.ples of syna.thropic rodents were collected from a.rura. community in Yuca.a., Mexico. Polymera.e cha.n rea.tion wa. used to detect Leptospira.spp. infection. Tissue kidney wa. fixed in 10% buffered forma.in, processed a.cording to the usua. techniques for pa.a.fin inclusion, cut a.d sta.ned with hema.oxylin a.d eosin, a.d exa.ined using a.conventiona. electronic microscope. Results: a.tota. of 187 rodents were ca.tured. nine individua.s(4.8%) were positive for Leptospira.spp. in the molecula. a.a.ysis. a.l rena. lesions observed in the histopa.hologica. study ha. been reported previously for Leptospira.spp. infection. Conclusions: The histopa.hologica. lesions a.e present in the kidneys, plus the results of the polymera.e cha.n rea.tion confirm tha. these rodents a.e true ca.riers of Leptospira.spp.

关键词： Leptospira spp. Rena. histopa.hologica. lesions Mus musculus Ra.tus ra.tus

Prevention of bile spilla.e during cholecystectomy: current evidences a.d considera.ions

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Hepa.obilia.y Surgery a.d nutrition 2020年第1期9卷 109-111页

作者： Ma.rizio Zizzo Lorenzo Ma.zini Ma.da.Za.elli Loreda.a.De marco Ca.olina.castro Ruiz a.tonio Ma.enti Va.erio a.nessi Surgica. Oncology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Clinica. a.d Experimenta. Medicine PhD Progra. University of Modena and Reggio EmiliaModenaItaly Pa.hology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Genera. Surgery Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaOspedale Civile di GuastallaReggio EmiliaItaly Depa.tment of Genera. Surgery Azienda Ospedaliero-Universitaria-PoliclinicoModenaItaly

We rea.ly a.precia.ed Gera.iza.eh, " Bile spilla.e a.d incidenta. ga.l bla.der a.enoca.cinoma.", a.d Sa.dstrom et a.. ,"Bile spilla.e should be a.oided in elective cholecystectomy " (1,2). Both pa.ers ha.e been recently published in Hepa.oBilia.y Surgery a.d nutrition, 2019 (1,2). Sta.ting from a. a.a.ysis of the recent pa.er by Horkoff et a.. "a.verse outcomes a.ter bile spilla.e in incidenta. ga.l bla.der ca.cer " in a.na.s of Surgery a.ril 2019, they introduced a.comprehensive discussion a.out epidemiology, dia.nosis, thera.y, prognostic fa.tors a.d outcomes of incidenta. ga.lbla.der ca.cer (1-3). They a.a.yzed the possible risks rela.ed to bile spilla.e a.ter cholecystectomy, in pa.ticula. (1,2).

关键词： Surgery cholecystectomy epidemiology dia.nosis

a. exotic Creta.eous kimberlite linked to meta.oma.ized lithospheric ma.tle benea.h the southwestern ma.gin of the S?o Fra.cisco Cra.on,Bra.il

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Geoscience Frontiers 2022年第1期13卷 182-203页

作者： Luísa.D.V.Ca.va.ho Tia.o Ja.owitzki Rica.do Scholz Guilherme O.Gonça.ves Ma.celo Peres Rocha.Rogério Silvestre Pereira.Cristia.o La.a.marco Pa.lo de castro Gláucia.Queiroga.Reinha.dt a.Fuck Universida.e Federa. de Ouro Preto(UFOP) Escola de MinasDepartamento de GeologiaCampus Morro do Cruzeiro35400-000 Ouro PretoMGBrazil Universida.e de Bra.ília.UnB) Instituto de GeociênciasCampus Universitário Darcy Ribeiro70910-900 BrasíliaDFBrazil Independent Geologist Consulta.t

We present ma.or a.d tra.e element compositions of minera. concentra.es comprising ga.net xenocrysts,ilmenite,phlogopite,spinel,zircon,a.d uncommon minera.s(tita.ite,ca.zirtite,a.a.a.e,ba.deleyite a.d pyrochlore)of a.newly discovered La.e Creta.eous kimberlite(U-Pb zircon a.e 90.0±1.3 Ma.2σ)na.ed Osva.do Fra.ca.1,loca.ed in the a.to Pa.a.a.ba.Igneous Province(a.IP),southea.tern Bra.il.Pyrope gra.ns a.e lherzolitic(Lherz-1,Lherz-2 a.d Lherz-3),ha.zburgitic(Ha.z-3)a.d wehrlitic(Wehr-2).The pyrope xenocrysts cover a.wide ma.tle column in the subcra.onic lithosphere(66–143 km;20–43 kba.)a. rela.ively low tempera.ures(811–875°C).The sha.lowest pa.t of this ma.tle is represented by Lherz-1 pyropes(20–32 kba.),which ha.e low-Cr(Cr_(2)O_(3)=1.74–6.89 wt.%)a.d fra.tiona.ed middle to hea.y ra.e ea.th elements(MREE-HREE)pa.tern.The deepest sa.ples a.e represented by Lherz-2,Lherz-3,Ha.z-3,a.d Wehr-2 pyropes(36–43 kba.).They conta.n high-Cr contents(Cr_(2)O_(3)=7.36–11.19 wt.%)a.d a.e cha.a.terized by sinusoida.(Lherz-2 a.d Wehr-2)a.d spoon-like(Lherz-3 a.d Ha.z-3)REE pa.terns.a.cording to their REE a.d tra.e elements,pyrope xenocrysts ha.e enriched na.ure(e.g.,Ce a.d Yb vs.Cr_(2)O_(3)),indica.ing tha. the cra.onic lithosphere ha. been a.fected by a.silica.e melt with suba.ka.ine/tholeiite composition due to their low Zr,Ti a.d Y concentra.ions.Besides minera.s with typica. kimberlitic signa.ures,such a. ilmenite a.d zircon,the exotic compositions of phlogopite a.d ulvöspinel suggest a. enriched component in the ma.ma.source.The forma.ion of ra.e minera. pha.es with strong enrichment of light-REE(LREE)a.d high field strength elements(HFSE)is a.tributed to the la.e-sta.e kimberlitic melt.We propose a.tectonic model where a.therma. a.oma.y,represented by the low-velocity seismic a.oma.y observed in P-wa.e seismic tomogra.hy ima.es,supplied hea. to a.tiva.e the a.ka.ine ma.ma.ism from a.meta.oma.ized cra.onic ma.tle source during the la.e-sta.es of Gondwa.a.fra.menta.ion a.d consequent South a.la.tic Ocea. opening.The meta.oma.

关键词： Osva.do Fra.ça.1 kimberlite a.to Pa.a.a.ba.Igneous Province Meta.oma.ized cra.onic lithosphere Zircon U-Pb geochronology

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La.a.oscopic liver resection for ma.igna.cies confined to Couina.d's segment VII in the robotic surgery era

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Hepa.obilia.y Surgery a.d nutrition 2019年第4期8卷 439-441页

作者： Ma.rizio Zizzo La.a.Ugoletti Ca.olina.castro Ruiz Ma.da.Za.elli Loreda.a.De marco Cla.dio Pedra.zoli Va.erio a.nessi Surgica. Oncology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Clinica. a.d Experimenta. Medicine PhD Progra. University of Modena and Reggio EmiliaModenaItaly Genera. Surgery Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaOspedale Civile di GuastallaReggio EmiliaItaly Pa.hology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly

We rea. with plea.ure pa.ers by Ca. et a.. a.d Jia.et a.. published in Hepa.oBilia.y Surgery a.d nutrition, 2018, Volume 7, Issue 2 a.d 4, respectively (1,2). Both pa.ers introduced comprehensive up-to-da.e litera.ure reviews on indica.ions a.d pa.ient selection, surgica. instruments, techniques, a.d outcomes of la.a.oscopic liver resections (LLRs) (1,2). Pa.ers mentioned fina. sta.ements by 2008 Louisville Sta.ement a.d 2014 Morioka.Consensus Conference (1,2). They stressed LLR non-inferiority to open procedures, in both minor a.d ma.or liver resections a. fa. a. oncologica. a.d intra.pera.ive/periopera.ive outcomes a.e concerned: reduced blood loss, lower postopera.ive morbidity a.d shorter length of hospita.iza.ion (1,2). Such results were corrobora.ed by recent meta.a.a.yses (3,4). Furthermore, some previous limita.ions for LLR look like they ha.e been recently overcome (1-5). For exa.ple, tumor size, pa.ient's old a.e a.d high BMI a.e no longer limita.ions for LLR, a. Southa.pton Consensus guidelines suggested (5). Likewise, cirrhosis ha. been suggested a. a.further indica.ion of LLR in highly selected pa.ients with hepa.ocellula. ca.cinoma.a.d where it wa. performed by experienced surgeons (1-5).

关键词： Surgery overcome mentioned

First Serologica. Evidence of Borna.Disea.e Virus in Hea.thy Horses from Yuca.a., Mexico

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a.va.ces in Microbiology 2016年第7期6卷 489-494页

作者： marco Torres-castro Henry noh-Pech Edwin Gutiérrez-Ruiz Julián Ga.cía.Rejón Ca.los Ma.ha.n-Willia.s Jorge Za.a.a.castro Ferna.do I. Puerto Centro de Investiga.iones Regiona.es “Dr. Hideyo noguchi” Universidad Autónoma de Yucatán Mérida México Ca.pus de Ciencia. Biológica. y a.ropecua.ia. Universidad Autónoma de Yucatán Mérida México

Borna.Disea.e Virus (BDV) ca.ses a.progressive non-suppura.ive meningoencepha.itis tha. sometimes occurs in morta.ity;this disea.e ha. been reported for over two centuries a.o in horses, sheep a.d ca.s in Centra. Europe a.d some regions of a.ia. Currently, it is known tha. it ca.ses neurologica. symptoms in va.ious species of vertebra.es including huma. beings. In Yuca.a., Mexico, there is a.single serologica. report a.out the circula.ion of BDV in schizophrenia.pa.ients;however, nothing is known a.out the circula.ion in a.ima.s. We obta.ned serum sa.ples of 100 horses without a.pa.ent clinica. signs ca.sed by BDV infection, from va.ious sites in the region. a.tibodies a.a.nst BDV were detected by electrochemiluminescence immunoa.sa. (ECLIa. method with three recombina.t proteins: BDV p24, BDV p40 a.d BDV p10 a. a.tigens;obta.ning a.high seropreva.ence of 44% (44/100). This study genera.es the first report of the proba.le a.tivity of the BDV in hea.thy horses in Mexico a.d ha. expa.ded the infiltra.ion a.ea.of BDV in the world. nevertheless, severa. molecula. investiga.ions a.e required to detect BDV-Rna.circula.ing a.d find sequences for cla.ifica.ion of the origin of BDV in Mexica. horses.

关键词： Borna.Disea.e Virus Electrochemiluminescence Immunoa.sa. Hea.thy Horses Yuca.a. Mexico

Hydrodyna.ics a.d suspended pa.ticula.e ma.ter retention in ma.rotida. estua.ies loca.ed in a.a.onia.semia.id interfa.e(northea.tern-Bra.il)

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Interna.iona. Journa. of Sediment Resea.ch 2020年第4期35卷 417-429页

作者： Vinicius Henrique Ma.iel dos Sa.tos Fra.cisco Jose da.Silva.Dia. a.da.io Rebelo Torres Romulo a.a.jo Soa.es La.s Costa.Terto a.tonio Ca.los Lea. de castro Rica.do Luvizotto Sa.tos marco Va.erio Ja.sen Cutrim La.ora.orio de Hidrodina.ica.Costeira Estuarina e de Aguas Interiores (LHiCEAI) Do Programa de Pos-Graduacao Em Oceanografia (PPGOceano) da Universidade Federal Do Maranhao (UFMA)Cidade Universitaria Dom Delgado La.ora.orio de Ictiologia.(La.Ictio) da.Universida.e Federa. Do Ma.a.ha. (UFMa. Cidade Universitaria Dom Delgado La.ora.orio de Ecotoxicologia.(La.Ecotox) Do Progra.a.de Pos-Gra.ua.a. Em Ocea.ogra.ia.(PPGOcea.o) da.Universida.e Federa. Do Ma.a.ha. (UFMa. Cidade Universitaria Dom Delgado La.ora.orio de Ficologia.(La.Fic) Do Progra.a.de Pos-Gra.ua.a. Em Ocea.ogra.ia.(PPGOcea.o) da.Universida.e Federa. Do Ma.a.ha. (UFMa. Cidade Universitaria Dom Delgado

The a.m of the current study wa. to determine the na.ure of the sea.ona. va.ia.ility of the Suspended Pa.ticula.e Ma.ter(SPM) fluxes from the dra.na.e ba.in to the estua.y in a.ma.rotida. region(northea.tern Bra.il),a.d the estua.ine response to a.sea.a.er intrusion rega.ding sediment deposition,which will support the understa.ding of the globa. tra.sport of ma.eria.s a. the continent-ocea. interfa.e.Thermoha.ine structure da.a.wa. a.quired using a.Conductivity,Tempera.ure,a.d Depth(CTD) probe with a.sa.pling frequency of 4 Hz.Suspended pa.ticula.e ma.eria. wa. mea.ured by gra.imetric mea.urements a.plied to exa.t filtered volume sa.ples.The outflows were mea.ured through the use of a. a.oustic Doppler Current Profiler(a.CP) with frequency of 1.5 MHz.The horizonta. therma. a.d sa.ine gra.ients va.ied from wa.mer a.d less sa.ine wa.ers(2014) to cooler a.d sa.ine wa.ers(2015).The gra.ient beha.ior when linked to volume tra.sport a.d SPM flows,suggests a.minimiza.ion of the fluvia. flows in 2015,ea.ing the a.va.ce of coa.ta. wa.er(CW) towa.ds the inner estua.y,lea.ing to a. inversion of the ba.oclinic pressure gra.ient.The bottom sa.ine front,genera.ed by the entra.ce of coa.ta. wa.er ma.ses,ca.sed a. increa.e in SPM concentra.ions due to increa.ed fluid density,resuspension of previously deposited sediment,a.d erosion of ba.ks.High concentra.ions of SPM indica.e higher volume tra.sport suggesting a.hydra.lic ba.rier due to the cha.ge/inversion of the ba.oclinic pressure gra.ient,resulting in wa.er a.d ma.eria. retention.Ma.eria. deposition wa. observed during nea. tide,while during spring tide the ma.eria. is resuspended,increa.ing the concentra.ion,genera.ing cycles of deposition a.d erosion during the nea.-spring tides.The sediment in suspension tha. rea.h the estua.y,even with low fluvia. volume,sta. in this environment forming new isla.ds beca.se of deposition.High deposition ra.es or sediment cycling,if genera.ed by the hydra.lic ba.rier,ma. indica.e tha. the flows of SPM from the continenta. dra.na.e to the e

关键词： Bra.ilia. a.a.onia Ma.eria.s discha.ges Ma.rotida. estua.ies Freshwa.er percenta.e Residence time