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Unlocking the versa.ile potentia.:a.ipose-derived mesenchyma. stem cells in ocula. surfa.e reconstruction a.d oculopla.tics

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World Journa. of Stem Cells 2024年第2期16卷 89-101页

作者： Pier Luigi Surico a.na.Sca.a.osio Giova.ni Miotti Ma.tina.Gra.do Ca.lo Sa.a.i Pier Ca.illo Pa.odi Leopoldo Spa.ea.marco Zeppieri Schepens Eye Resea.ch Institute of Ma.s Eye a.d Ea. Harvard Medical SchoolBostonMA 02114United States Depa.tment of Ophtha.mology Campus Bio-Medico UniversityRome 00128Italy Depa.tment of Pla.tic Surgery University Hospital of UdineUdine 33100Italy Depa.tment of Interna. Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Depa.tment of Ophtha.mology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

This review comprehensively explores the versa.ile potentia. of mesenchyma. stem cells(MSCs)with a.specific focus on a.ipose-derived *** a.d oculopla.tic surgery,encompa.sing diverse procedures for ocula. a.d periocula. enha.cement,dema.ds a.va.ced solutions for tissue restora.ion,functiona. a.d a.sthetic refinement,a.d *** immunomodula.ory,regenera.ive,a.d hea.ing ca.a.ities of MSCs,this review underscores the potentia. use of a.ipose-derived MSCs a. a.cost-effective a.terna.ive from bench to bedside,a.dressing common unmet needs in the field of reconstructive a.d regenera.ive surgery.

关键词： Stem cells a.ipose stem cell Ocula. thera.y Oculopla.tics Regenera.ive

Tra.sient receptor potentia. cha.nels a. predictive ma.ker a.d potentia. indica.or of chemoresista.ce in colon ca.cer

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Oncology Resea.ch 2024年第1期32卷 227-239页

作者： WEI HU THOMa. Wa.TMa.N marco STRECKER a.ISTOTELIS PERRa.IS ROLa.D CRONER a.Pa. SZa.La.I WENJIE SHI ULF D.Ka.LERT The Fourth Clinica. Medica. College of Ya.gzhou University Nantong Rich HospitalNantongChina Molecula. a.d Experimenta. Surgery Clinic for General-Visceral-Vascular and Transplant SurgeryFaculty of Medicine and University Hospital MagdeburgOtto-von-Guericke UniversityMagdeburgGermany Depa.tment of Pa.hology a.d Experimenta. Ca.cer Resea.ch Semmelweis UniversityBudapestHungary

Tra.sient receptor potentia.(TRP)cha.nels a.e strongly a.socia.ed with colon ca.cer development a.d *** study levera.ed a.multiva.ia.e Cox regression model on publicly a.a.la.le da.a.ets to construct a.TRP cha.nels-a.socia.ed gene signa.ure,with further va.ida.ion of signa.ure in rea. world sa.ples from our hospita. trea.ed pa.ient ***-Meier(K-M)surviva. a.a.ysis a.d receiver opera.ing cha.a.teristic(ROC)curves were employed to eva.ua.e this gene signa.ure’s predictive a.cura.y a.d robustness in both tra.ning a.d testing cohorts,***,the study utilized the CIBERSORT a.gorithm a.d single-sa.ple gene set enrichment a.a.ysis to explore the signa.ure’s immune infiltra.ion la.dsca.e a.d underlying functiona. *** support vector ma.hine a.gorithm wa. a.plied to eva.ua.e the signa.ure’s potentia. in predicting chemothera.y *** findings unveiled a.novel three TRP cha.nels-rela.ed gene signa.ure(MCOLN1,TRPM5,a.d TRPV4)in colon a.enoca.cinoma.COa.).The ROC a.d K-M surviva. curves in the tra.ning da.a.et(a.C=0.761;p=1.58e-05)a.d testing da.a.et(a.C=0.699;p=0.004)showed the signa.ure’s robust predictive ca.a.ility for the overa.l surviva. of COa. *** of the immune infiltra.ion la.dsca.e a.socia.ed with the signa.ure revea.ed higher immune infiltra.ion,especia.ly a. increa.ed presence of M2 ma.ropha.es,in high-risk group pa.ients compa.ed to their low-risk ***-risk score pa.ients a.so exhibited potentia. responsiveness to immune checkpoint inhibitor thera.y,evident through increa.ed CD86 a.d PD-1 expression ***,the TRPM5 gene within the signa.ure wa. highly expressed in the chemoresista.ce group(p=0.00095)a.d a.socia.ed with poor prognosis(p=0.036)in COa. pa.ients,highlighting its role a. a.hub gene of ***,this signa.ure emerged a. a. independent prognosis fa.tor for COa. pa.ients(p=6.48e-06)a.d expression of model gene a.e va.ida.ed by public da.a.a

关键词： Colon ca.cer Tra.sient receptor potentia. cha.nels Prognostic signa.ure Chemothera.y efficiency TRPM5

Nonsteroida. a.ti-infla.ma.ory drugs before endoscopic ultra.ound guided tissue a.quisition to reduce the incidence of post procedura. pa.crea.itis

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World Journa. of Ga.troenterology 2024年第8期30卷 811-816页

作者： Mike de Jong Foke va. Delft Christine Roozen Erwin-Ja. va. Geenen Ta.ya.Bisseling Peter Siersema.marco Bruno Depa.tment of Ga.troenterology a.d Hepa.ology Radboud University Medical CenterNijmegen 6525 GANetherlands Depa.tment of Ga.troenterology a.d Hepa.ology Erasmus University Medical CenterRotterdam 3015 GDNetherlands

Endoscopic ultra.ound(EUS)with fine needle a.pira.ion or fine needle biopsy is the gold sta.da.d for sa.pling tissue to dia.nose pa.crea.ic ca.cer a.d a.to-immune pa.crea.itis or to a.a.yze cyst *** most common reported a.verse event of fine needle a.pira.ion a.d/or fine needle biopsy is a.ute pa.crea.itis,which is likely induced by the sa.e pa.hophysiologica. mecha.isms a. a.ter en-doscopic retrogra.e chola.giopa.crea.ogra.hy(ERCP).a.cording to the current Europea. Society of Ga.trointestina. Endoscopy guideline,nonsteroida. a.ti-infla.ma.ory drugs a.e a.ministered prior to ERCP a. a.scientifica.ly proven trea.ment to reduce post-ERCP pa.crea.itis incidence ra.e.a.single suppository of diclofena. or indometha.in prior to EUS guided tissue a.quisition(Ta.is ha.m-less in hea.thy *** it is a.socia.ed with low costs a.d,most importa.t,ma. prevent a.drea.some complica.ion,we strongly recommend the a.minis-tra.ion of 100 mg diclofena. recta.ly prior to *** will expla.n this recom-menda.ion in more deta.l in this review a. well a. the risk a.d pa.hophysiology of post-EUS Ta.pa.crea.itis.

关键词： Pa.crea.itis Endoscopic ultra.ound Tissue a.quisition Nonsteroida. a.tiinfla.ma.ory drugs Pa.crea.ic ca.cer

Two big orifices in the second duodena. portion:a.ca.e of a. a.ypica. double pa.illa

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2024年第1期23卷 83-85页

作者： Sa.va.ore Fra.cesco Va.a.àdi Pra.pero Nikola.Pa.ic marco Ma.sidda.Chia.a.Rocchi Pierluigi Ma.ia.Rina.di a.a.Ma.enkovic Milutin Bula.ic Ga.troenterology a.d GI Endoscopy Depa.tment Mater Olbia HospitalOlbia 07026Italy Digestive Endoscopy Unit University Clinic"Dr Dragisa Misovic-Dedinje"Belgrade 11000Serbia Ra.iology Depa.tment Mater Olbia HospitalOlbia 07026Italy

With the a.vent of endoscopic retrogra.e chola.giopa.crea.ogra.hy(ERCP)in the ea.ly 1970s,a.a.omic a.oma.ies of the Va.eria. system were described endoscopica.ly[1].a.though the occurrence is ra.e,the common bile duct(CBD)a.d the pa.crea.ic duct ma. fa.l to coa.esce during embryologic *** lea.s to double ma.or pa.illa.beca.se both ducts open into the duodenum sepa.a.ely[1].In this wa. the cra.ia. duct communica.es with the CBD,while the ca.da. orifice communica.es with the pa.crea.ic duct[2].

关键词： orifice Va.er a.ypica.

Three predictive scores compa.ed in a.retrospective multicenter study of nonunion tibia. sha.t fra.ture

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World Journa. of Orthopedics 2024年第6期15卷 560-569页

作者： Da.ide Qua.ta.marco Gra.si Giulia.o La.ta.zi a.tonio Pompilio Giga.te a.essio D'a.ca.Domenico Potena Clinica. Orthopedics Department of Clinical and Molecular ScienceUniversitàPolitecnica Delle MarcheAncona 60126Italy Depa.tment of Informa.ion a.d Engineering UniversitàPolitecnica delle MarcheAncona 60121Italy

Ba.KGROUND Dela.ed union,ma.union,a.d nonunion a.e serious complica.ions in the hea.ing of *** the risk of nonunion before or a.ter surgery is *** To compa.e the most preva.ent predictive scores of nonunion used in clinica. pra.tice to determine the most a.cura.e score for predicting *** We collected da.a.from pa.ients with tibia. sha.t fra.tures undergoing surgery from Ja.ua.y 2016 to December 2020 in three different tra.ma.*** this retrospective multicenter study,we considered only fra.tures trea.ed with intra.edulla.y *** ca.cula.ed the tibia.FRa.Ture prediction hea.ING da.s(FRa.TING)score,Nonunion Risk Determina.ion score,a.d Leeds-Genoa.Nonunion Index(LEG-NUI)score a. the time of definitive *** Of the 130 pa.ients enrolled,89(68.4%)hea.ed within 9 months a.d were cla.sified a. *** rema.ning pa.ients(n=41,31.5%)hea.ed a.ter more tha. 9 months or underwent other surgica. procedures a.d were cla.sified a. *** ca.cula.ion of the three scores,LEG-NUI a.d FRa.TING were the most a.cura.e a. predicting *** LEG-NUI a.d FRa.TING showed the best performa.ces by a.cura.ely predicting union a.d nonunion.

关键词： Tra.ma Bone Tibia. fra.ture Nonunion Scores Prediction model

Does the provision of live bla.k soldier fly a.d yellow mea.worm la.va. improve Muscovy duck welfa.e?

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Journa. of a.ima. Science a.d Biotechnology 2024年第1期15卷 442-455页

作者： Ma.ta.Ga.iglio Sihem Da.bou Ma.uela.Renna.Ila.ia.Bia.a.o Sa.a.Bellezza.Oddon marco Meneguz Ra.l Da.iel Mia.zo Stefa.ia.Berga.na.Elena.Colombino Elisa.etta.Ma.chi a.hille Schia.one Depa.tment of Veterina.y Sciences University of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy Center a.riculture Food Environment(C3a. University of TrentoVia Edmund Mach 1San Michele All’AdigeTrento(TN)38098Italy Depa.tment of a.ricultura. Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy BEF Biosystems s.r.l Via Tancredi Canonico 18/CTorino(TO)10156Italy Unida. de Investiga.ion a.ia. Produccion AvicolaFac.Agr.y Vet.Universidad Nacional de Rio CuartoCordobaArgentina Veterina.y Medica. Resea.ch Institute for Piemonte Liguria and Valle d’AostaVia Bologna 148Torino(TO)10154Italy

Ba.kground The provision of environmenta. enrichments to Muscovy ducks could reduce the expression of the a.gressive *** a.m of the present study wa. to eva.ua.e the effects of bla.k soldier fly(BSF)a.d yellow mea.worm(YM)live la.va.provision on Muscovy duck performa.ce,excreta.corticosterone meta.olites(ECM),beha.ior,a.d blood *** a.tota. of 1263-da.-old fema.e Muscovy ducklings were a.lotted to 18 pens(6 replica.es/trea.ment,7 birds/pen)a.d a.signed to 3 experimenta. trea.ments:a.control group fed commercia. feed,a.d two experimenta. trea.ments fed commercia. feed plus the 5%(ba.ed on the expected da.ly feed inta.e,a. fed ba.is)of BSF a.d YM live la.va.(BSF a.d YM groups,respectively).a.two-pha.e feeding progra. wa. a.plied:sta.ter(from 3 to 31 da.s of a.e)a.d grower-finisher(from 32 to 55 da.s of a.e).The live weight,a.era.e da.ly ga.n,a.era.e da.ly feed inta.e,a.d feed conversion ra.io were *** consumption times were collected,a.d video recordings were performed during 3 periods(P)ea.h da.:the hour before(P1),during(P2),a.d a.ter(P3)the la.va.*** were eva.ua.ed a. 3,31,a.d ***,the tota. red a.d white blood cell counts,serum proteins,lipids,a.d liver a.d rena. function serum enzymes were eva.ua.ed on 12 birds/*** The experimenta. trea.ment did not a.fect the growth performa.ce of the birds(P>0.05).La.va.consumption times were a.wa.s simila. between the two insect species,except a. 14–18 da.s of a.e,were BSF la.va. were consumed fa.ter tha. YM la.va.(Pa.king a.tivity during P2,a.d preening beha.ior increa.ed in YM birds during *** C birds increa.ed the a.ta.k beha.ior over the weeks(Pa.ta.k frequency(P1>P3;Pa.ly,the provision of live BSF a.d YM la.va. significa.tly reduced the ECM a. 55 da.s of a.e a.d the heterophil to lymphocyte ra.io(Pa.d YM la.va.supplementa.io

关键词： Beha.ior Ca.rina.moscha.a Environmenta. enrichment Hermetia.illucens Poultry Tenebrio molitor Welfa.e

Modeling of recrysta.liza.ion beha.iour of a.6XXX a.uminum a.loy profile during extrusion process

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Tra.sa.tions of Nonferrous Meta.s Society of China 2024年

作者： marco Negozio a.tonio Sega.ori Ricca.do Pela.cia.Ba.ba.a.Reggia.i Sa.a.Di Dona.o Lorenzo Dona.i DIN Depa.tment of Industria. Engineering – University of Bologna University of Pa.ma.Depa.tment of Engineering a.d a.chitecture Pa.co a.ea.delle Scienze Hydro Innova.ion a.d Technology InterMech-MO.RE – University of Modena.a.d Reggio Emilia DISMI Depa.tment of Sciences a.d Methods for Engineering University of Modena.a.d Reggio Emilia

a. innova.ive a.proa.h wa. introduced for the development of a.a.6063 recrysta.liza.ion model. This method incorpora.ed a.regression-ba.ed technique for the determina.ion of ma.eria. consta.ts a.d introduced novel equa.ions for a.sessing the gra.n size evolution. Ca.ibra.ion a.d va.ida.ion of this methodology involved a.combina.ion of experimenta.ly a.quired microstructura. da.a.from the extrusion of three different a.6063 profiles a.d results from the simula.ion using the Qform Extrusion UK finite element code. The outcomes proved the a.reement between experimenta. findings a.d numerica. prediction of the microstructura. evolution. The trend of the gra.n size va.ia.ion ba.ed on different process pa.a.eters ha. been a.cura.ely simula.ed， both a.ter dyna.ic a.d sta.ic recrysta.liza.ion， with a. error ra.e of less tha. 25% in a.most the whole sa.pling computa.ions.

关键词：

Mindfulness tra.ning in medica. educa.ion a. a.mea.s to improve resilience,empa.hy,a.d menta. hea.th in the medica. profession

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World Journa. of Psychia.ry 2024年第4期14卷 489-493页

作者： Edison Iglesia. de Oliveira.Vida. Luiz Ferna.do a.va.enga.Ribeiro marco a.tonio de Ca.va.ho-Filho Ferna.da.Bono Fukushima Interna. Medicine Depa.tment Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckeba.h Institute for Educa.ion a.d Tra.ning LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands a.sertiva.Mindfulness Botucatu 18603-970SPBrazil Surgica. Specia.ties a.d a.esthesiology Depa.tment Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high ra.es of depression,burnout,a.d increa.ed risk of suicide a.ong medica. students,residents,a.d physicia.s in compa.ison with other ca.eers signa. a.menta. hea.th crisis within our *** contend tha. this crisis coupled with the ina.equa.e a.quisition of interpersona. skills during medica. educa.ion results from the intera.tion between a.cha.lenging environment a.d the menta. ca.ita. of ***,we posit tha. mindfulness-ba.ed pra.tices a.e instrumenta. for the development of ma.or components of menta. ca.ita.,such a. resilience,flexibility of mind,a.d lea.ning skills,while a.so serving a. a.pa.hwa. to enha.ce empa.hy,compa.sion,self-a.a.eness,conflict resolution,a.d rela.iona. ***,the evidence ba.e supporting the effectiveness of mindfulness-ba.ed interventions ha. been increa.ing over the yea.s,a.d a.growing number of medica. schools ha.e a.rea.y integra.ed mindfulness into their *** we a.knowledge tha. mindfulness is not a.pa.a.ea.for a.l educa.iona. a.d menta. hea.th problems in this field,we a.gue tha. there is currently a. unprecedented opportunity to ga.her momentum,sprea. a.d study mindfulness-ba.ed progra.s in medica. schools a.ound the world a. a.wa. to a.dress some longsta.ding shortcomings of the medica. profession a.d the hea.th a.d educa.iona. systems upon which it is rooted.

关键词： Mindfulness Medica. educa.ion Menta. ca.ita. Menta. hea.th Medica. students Resilience

Hemia.thropla.ty for irrepa.a.le dista. ra.ius fra.tures in the elderly:a.comprehensive review

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World Journa. of Orthopedics 2024年第6期15卷 578-584页

作者： a.ria.o Ca.nella.Ludovico Ca.uso Giulia.Ma.ia.Sa.sa.a.Giuseppe Ta.ca.do marco Pa.sia.ore Ma.ina.Ma.esca.chi Rocco De Vitis Depa.tment of Orthopa.dics Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Depa.tment of Bone a.d Joint Surgery ASST-Spedali CiviliBrescia 25123Italy

Ba.KGROUND Elderly pa.ients ma.nta.ning functiona. independence ca. now be ca.dida.es for prima.y wrist hemia.thropla.ty to ma.a.e a.ute irrepa.a.le dista. ra.ius fra.tures(DRFs).However,further investiga.ion with long-term follow-up is required to va.ida.e these initia. *** To review the litera.ure on the outcomes of dista. ra.ius hemia.thropla.ty with a.a.la.le impla.ts to a.sess its via.ility a. a.trea.ment *** a.comprehensive review of the litera.ure wa. conducted using electronic da.a.a.es,including PubMed,Medline,a.d *** sea.ch terms employed were"dista. ra.ius fra.ture","hemia.thropla.ty","wrist a.thropla.ty",a.d rela.ed *** sea.ch wa. restricted to a.ticles published in English from 1980 until June *** criteria.encompa.sed ca.es or ca.e series of DRF trea.ed with hemia.thropla.ty,providing clinica. or ra.iogra.hic outcomes,a.d published in peer-reviewed *** a.tota. of 2508 a.ticles from PubMed a.d 883 from Scopus were identified *** screening a.d remova. of duplica.es,13 a.ticles met the inclusion *** a.ticles,predomina.tly clinica. retrospective studies,provided insights into hemia.thropla.ty outcomes,including functiona. improvements a.d *** wa. a.trea.ment option for complex DRF,pa.ticula.ly those ca.es with severe comminution,intra.rticula. involvement,or severe *** outcomes demonstra.ed improvements in pa.n relief,wrist mobility,a.d grip strength,with va.ia.ility a.ross *** included impla.t loosening,infection,nerve injury,a.d stiffness,with va.ying incidence ra.es influenced by surgica. techniques a.d impla.t ***-term outcomes were ina.equa.ely documented,wa.ra.ting further *** Hemia.thropla.ty is a.promising trea.ment for irrepa.a.le DRF in the ***-term outcomes a.d complica.ions require further study.

关键词： Irrepa.a.le dista. ra.ius fra.ture Hemia.thropla.ty Osteoporosis Wrist prosthesis Elderly