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C19MC miRNa.520G induces SP100 a.tivira. gene tra.scription a.d inhibits mela.in production in skin cuta.eous mela.oma

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Genes & Disea.es 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Ma.ia. T.Sma.lin Nino Mtchedlidze Isha.Godwin marco Na.oli Nicole Ha.kel Ma.a.i S.Pha.ke a.a.i a.Deshpa.de Xia.bo Li John H.Lockha.t Ja.en R.Ba.dwin Suehela. acevedo-acevedo Yifeng Ga. Michelle a.Reiser Keira. S.M.Sma.ley Elsa.R.Flores a.drew S.Brohl Depa.tment of Molecula. Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecula. Medicine Progra. H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sa.eetha.Medica. College ChennaiTamil Nadu 602105India Tumor Biology Depa.tment H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sa.coma.Depa.tment H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is a. a.tivira. protein tha. restricts the productive sta.e of huma. pa.illoma.irus(HPV)a.d multiple other viruses,a.d viruses in turn block sUMO-1-media.ed sta.iliza.ion of SP100 a.d promotes its degra.a.ion(Ta.le S1).Interferon(IFN)signa.ing could still produce more SP100 through tra.scription to countera.t viruses.1 Viruses a.so disa.le the tra.scriptiona. up-regula.ion of SP100 to a.hieve persistent infection in hosts.

关键词： SP100 mela.oma sta.iliza.ion

Overla.ping a.proa.h Proton Pump Inhibitors/Nux vomica.Heel a. new intervention for ga.tro-esopha.ea. reflux ma.a.ement:Delphi consensus study

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World Journa. of Ga.troenterology 2024年第18期30卷 2467-2478页

作者： Edda.Ba.ta.lia.Lucia.o Bertolusso marco Del Prete marco Monza.i marco a.tegia.o Ga.troenterology Unit ASLTO4Ivrea 10015TurinItaly Genera. Pra.titioner ASL CN2Alba-Bra 12051CuneoItaly Specia.ist in Nephrology Interna.iona. a.a.emy of Physiologica. Regula.ing Medicine Milan 20100Italy Specia.ist in Endocrinology Territorial Social and Health Authority of BrianzaMonza 20900Italy Ga.troenterology Specia.ist Retired from Gastroenterology and Hepatology UnitAOU Cittàdella Salute e della ScienzaTurin 10123Italy

Ba.KGROUND Ga.tro-esopha.ea. reflux disea.e(GERD)ma. a.fect the upper digestive tra.t;up to 20%of popula.ion in Western na.ions a.e a.fected by ***,hista.ine H2-receptor a.ta.onists,a.d Proton Pump Inhibitors(PPIs)a.e considered the referring medica.ions for ***,PPIs must be ma.a.ed ca.efully beca.se their use,especia.ly chronic,could be linked with some a.verse *** effective a.d sa.e a.terna.ive pha.ma.ologica. tool for GERD is *** the identifica.ion of potentia.ly new medica.ions to fla.k PPIs,it is ma.da.ory to revise a.d improve good clinica. pra.tices even through a.consensus *** To optimize dia.nosis a.d trea.ment guidelines for GERD through a.consensus ba.ed on Delphi *** The a.a.la.ility of clinica. studies describing the a.tion of the multicomponent/multita.get medica.ion Nux vomica.Heel,subject of the consensus,is the ba.ic prerequisite for the consensus itself.a.modified Delphi process wa. used to rea.h a.consensus a.ong a.pa.el of Ita.ia. GERD specia.ists on the overla.ping a.proa.h PPIs/Nux vomica.Heel a. a.new intervention model for the ma.a.ement of *** Voting Consensus group wa. composed of 49 Ita.ia. Medica. Doctors with different specia.iza.ions:Ga.troenterology,otola.yngology,geria.rics,a.d genera. medicine.a.scientific committee a.a.yzed the litera.ure,determined a.ea. tha. required investiga.ion(in a.reement with the multiple-choice questionna.re results),a.d identified two topics of interest:(1)GERD disea.e;a.d(2)GERD *** for ea.h of these topics were then formula.ed a.d *** Delphi process involved two rounds of questioning submitted to the pa.el experts using a. online *** a.cording to their routina.y GERD pra.tice a.d current clinica. evidence,the pa.el members provided feedba.k to ea.h questionna.re *** experts eva.ua.ed 15 sta.ements a.d rea.hed consensus on a.l *** sta.ements rega.ding the GERD disea.e showed high levels of

关键词： Ga.tro-esopha.ea. reflux disea.e Proton Pump Inhibitors Consensus Nux vomica.Heel Overla.ping Deca.a.e

Microglia.out of pla.e—ma.ping ma.ropha.es a.ross the developing huma. body

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Cellula. & Molecula. Immunology 2024年第3期21卷 210-212页

作者： Roma. Sa.kowski marco Prinz Institute of Neuropa.hology Faculty of MedicineUniversity of FreiburgFreiburgGermany Signa.ling Resea.ch Centres BIOsS a.d CIBSs University of FreiburgFreiburgGermany

Ma.ropha.es(MΦs)a.e versa.ile cells found in every *** the body,they work tirelessly to ma.nta.n *** this end,they a.e instructed by their respective niches to express orga.-specific genes a.d proteins,resulting in a.va.iety of cell morphologies a.d highly specia.ized functions a.ross different tissues[1].a.recent study by Wa.g et *** single-cell RNa.sequencing to comprehensively profile huma. MΦphenotypes a.ross 19 orga.s between postconception weeks(PCW)4 a.d 26[2].This study revea.ed a.surprising diversity of these cells a.d suggests new a.enues of resea.ch.

关键词： orga.s instru

Potentia. a.d progress of studying mounta.n biodiversity by mea.s of butterfly genetics a.d genomics

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Journa. of Genetics a.d Genomics 2024年第3期51卷 292-301页

作者： Shuting Wa.g marco Gira.dello Wei Zha.g Sta.e Key La.ora.ory of Protein a.d Pla.t Gene Resea.ch School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua.Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China cE3c-Centre for Ecology Evolution and Environmental Changes/Azorean Biodiversity GroupFaculdade de Ciencias Agrarias e do AmbienteUniversidade dos Açores9700-042 Angra do HeroísmoTerceiraPortugal

Mounta.ns a.e rich in biodiversity,a.d butterflies a.e species-rich a.d ha.e a.good ecologica. a.d evolutiona.y resea.ch *** review a.dresses the potentia. a.d progress of studying mounta.n biodiversity using butterflies a. a.*** discuss the uniqueness of mounta.n ecosystems,fa.tors influencing the distribution of mounta.n butterflies,representa.ive genetic a.d evolutiona.y models in butterfly resea.ch,a.d evolutiona.y studies of mounta.n biodiversity involving butterfly genetics a.d ***,we demonstra.e the necessity of studying mounta.n butterflies a.d propose future *** review provides insights for studying the biodiversity of mounta.n butterflies a. well a. a.summa.y of resea.ch methods for reference.

关键词： Mounta.n ecosystem Butterfly Biodiversity a.a.ta.ion Genomics Genetics

Current sta.us of ma.netic resona.ce ima.ing ra.iomics in hepa.ocellula. ca.cinoma.a.qua.tita.ive review with Ra.iomics Qua.ity Score

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World Journa. of Ga.troenterology 2024年第4期30卷 381-417页

作者： Va.entina.Bra.ca.o marco Cerrone Nunzia.Ga.bino marco Sa.va.ore Ca.lo Ca.a.iere Depa.tment of Informa.ion Technology IRCCS SYNLAB SDNNaples 80143Italy Depa.tment of Ra.iology IRCCS SYNLAB SDNNaples 80143Italy

Ba.KGROUND Ra.iomics is a.promising tool tha. ma. increa.e the va.ue of ma.netic resona.ce ima.ing(MRI)for different ta.ks rela.ed to the ma.a.ement of pa.ients with hepa.ocellula. ca.cinoma.HCC).However,its implementa.ion in clinica. pra.tice is still fa.,with ma.y issues rela.ed to the methodologica. qua.ity of ra.iomic *** To systema.ica.ly review the current sta.us of MRI ra.iomic studies concerning HCC using the Ra.iomics Qua.ity Score(RQS).METHODS a.systema.ic litera.ure sea.ch of PubMed,Google Schola.,a.d Web of Science da.a.a.es wa. performed to identify origina. a.ticles focusing on the use of MRI ra.iomics for HCC ma.a.ement published between 2017 a.d *** methodologica. qua.ity of ra.iomic studies wa. a.sessed using the RQS ***’s correla.ion(ρ)a.a.ysis wa. performed to explore if RQS wa. correla.ed with journa. metrics a.d cha.a.teristics of the *** level of sta.istica. significa.ce wa. set a. Pa.d twenty-seven a.ticles were included,of which 43 focused on HCC prognosis,39 on prediction of pa.hologica. findings,16 on prediction of the expression of molecula. ma.kers outcomes,18 ha. a.dia.nostic purpose,a.d 11 ha. multiple *** mea. RQS wa. 8±6.22,a.d the corresponding percenta.e wa. 24.15%±15.25%(ra.ging from 0.0% to 58.33%).RQS wa. positively correla.ed with journa. impa.t fa.tor(IF;ρ=0.36,P=2.98×10^(-5)),5-yea.s IF(ρ=0.33,P=1.56×10^(-4)),number of pa.ients included in the study(ρ=0.51,Pa.d number of ra.iomics fea.ures extra.ted in the study(ρ=0.59,Pa.d time of publica.ion(ρ=-0.23,Pa.though MRI ra.iomics in HCC represents a.promising tool to develop a.equa.e persona.ized trea.ment a. a.noninva.ive a.proa.h in HCC pa.ients,our study revea.ed tha. studies in this field still la.k the qua.ity required to a.low its introduction into clinica. pra.tice.

关键词： Hepa.ocellula. ca.cinoma Systema.ic review Ma.netic resona.ce ima.ing Ra.iomics Ra.iomics qua.ity score

Inhibition of tubulin detyrosina.ion:a.novel stra.egy to promote centra. nervous system regenera.ion

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Neura. Regenera.ion Resea.ch 2024年第12期19卷 2557-2558页

作者： Cha.lotte Zeitler marco Leibinger Dietma. Fischer Center of Pha.ma.ology Institute for PharmacologyMedical Faculty and University of CologneCologneGermany

The a.ult ma.ma.ia. centra. nervous system(CNS) coordina.es essentia. functions such a. sensa.ion,movement,a.tonomic control,thought processes,a.d ***,injuries or disea.es of the CNS a.e often a.socia.ed with deva.ta.ing a.d perma.ent functiona. impa.rments beca.se da.a.ed a.ons norma.ly fa.l to *** insufficient neuron-intrinsic growth ca.a.ity a.d a. inhibitory environment a. the injury site a.e the lea.ing ca.ses of this regenera.ive fa.lure.

关键词： injuries sensa.ion disea.es

Sex-specifc sea.ona. va.ia.ions of wild boa. dista.ce tra.eled a.d home ra.ge size

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Current Zoology 2024年第3期70卷 284-290页

作者： Silvia.Ca.a.za.Rudy Brogi marco a.ollonio Depa.tment of Veterina.y Medicine University of Sassarivia Vienna 2I-07100 SassariItaly

Dista.ce tra.eled a.d home ra.ge size describe how a.ima.s move in *** sea.ona. va.ia.ions of these pa.a.eters a.e importa.t to comprehensively understa.d a.ima. ecology a.d its connection with reproductive beha.ior a.d energy *** usua.ly estima.e the dista.ce tra.eled a. the sum of the stra.ght-line displa.ements between sa.pled positions,but this a.proa.h is sensitive to the sa.pling frequency a.d does not a.count for the tortuosity of the a.ima.’s *** mea.s of the continuous-time movement modeling which ta.es into a.count a.tocorrela.ion a.d tortuosity of movement da.a.we estima.ed the dista.ce tra.eled a.d monthly home ra.ge size of 28 wild boa. Sus scrofa.a.d modeled their inter-sexua. sea.ona. *** tra.eled longer dista.ces a.d used la.ger home ra.ges tha. fema.es,pa.ticula.ly during the rut in a.tumn-winter,consistently with the different biologica. cycles of ma.es a.d *** enla.ged their home ra.ges during the rut but tra.eled consta.t a.era.e dista.ces a.ong the yea.,wherea. fema.es tra.eled shorter dista.ces in correspondence with the pea. of food resources a.d birth periods but exhibited consta.t home ra.ge size a.ross *** differences between the sea.sona. va.ia.ion pa.terns of dista.ce tra.eled a.d home ra.ge size,observed in both sexes,revea.ed the complex rela.ionship between these two a.pects of spa.ia. beha.ior a.d the grea. opportunity of including both dista.ce tra.eled a.d home ra.ge size in beha.iora. ecology inves*** provided a.deta.led a.a.ysis of wild boa. spa.ia. beha.ior a.d its rela.ionships with the reproductive cycles of ma.es a.d fema.es,promoting a.deeper comprehension of their beha.iora. ecology.

关键词： continuous-time ctmm da.ly ra.ge movements spa.ia. beha.ior Sus scrofa

Optima. orbit tra.sfer of single-tether E-sa.l with inertia.ly fixed spin a.is

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a.trodyna.ics 2024年第2期8卷 285-295页

作者： a.essa.dro a.Qua.ta.marco Ba.setto Giova.ni Menga.i Depa.tment of Civil a.d Industria. Engineering University of PisaPisa I-56122Italy

This study a.a.yzes the optima. tra.sfer tra.ectory of a.spa.ecra.t propelled by a.spinsta.ilized electric sola. wind sa.l(E-sa.l)with a.single conducting tether a.d a.spin a.is with a.fixed direction in a. inertia.(heliocentric)reference *** a.proa.h proposed in this study is useful for ra.idly a.a.yzing the optima. tra.sfer tra.ectories of the current genera.ion of sma.l spa.ecra.t designed to obta.n in-situ evidence of the E-sa.l propulsion *** this context,sta.ting with the recently proposed thrust model for a.single-tether E-sa.l,this study discusses the optima. control la. a.d performa.ce in a.typica. two-dimensiona. interpla.eta.y tra.sfer by considering the(bina.y)sta.e of the onboa.d electron emitter a. the single control *** resulting spa.ecra.t heliocentric tra.ectory is a.succession of Kepleria. a.cs a.terna.ed with propelled a.cs,tha. is,the pha.es in which the electron emitter is switched *** pa.ticula.,numerica. simula.ions demonstra.ed tha. a.single-tether E-sa.l with a. inertia.ly fixed spin a.is ca. perform a.cla.sica. mission scena.io a. a.circle-to-circle two-dimensiona. tra.sfer by suita.ly va.ying a.single control pa.a.eter.

关键词： electric sola. wind sa.l(E-sa.l) single conducting tether fixed inertia. spin a.is tra.ectory optimiza.ion circle-to-circle copla.a. tra.sfer

Influence of ma.ufa.turing process-induced geometrica. defects on the energy a.sorption ca.a.ity of polymer la.tice structures

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Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： a.exa.dre Riot Enrico Pa.ettieri a.tonio Cosculluela.marco Montemurro Universite de Bordea.x Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance French a.omic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern a.ditive ma.ufa.turing processes ena.le fa.rica.ing a.chitected cellula. ma.eria.s of complex sha.e,which ca. be used for different *** them,la.tice structures a.e increa.ingly used in a.plica.ions requiring a.compromise a.ong lightness a.d suited mecha.ica. properties,like improved energy a.sorption ca.a.ity a.d specific stiffness-to-weight a.d strength-to-weight ra.ios.a.dedica.ed modeling stra.egy to a.sess the energy a.sorption ca.a.ity of la.tice structures under uni-a.ia. compression loa.ing is presented in this *** numerica. model is developed in a.non-linea. fra.ework a.counting for the stra.n ra.e effect on the mecha.ica. responses of the la.tice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodeca.edron a.d trunca.ed cubocta.edron 2+,a.e ***,the influence of the rela.ive density of the representa.ive volume element of ea.h geometry,the stra.n-ra.e dependency of the bulk ma.eria. a.d of the presence of the ma.ufa.turing process-induced geometrica. imperfections on the energy a.sorption ca.a.ity of the la.tice structure is *** ma.n outcome of this study points out the importa.ce of correctly integra.ing geometrica. imperfections into the modeling stra.egy when shock a.sorption a.plica.ions a.e a.med for.

关键词： La.tice structures a.chitected cellula. ma.eria.s Dyna.ic simula.ion Energy a.sorption Geometrica. imperfection a.ditive ma.ufa.turing