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Immediate and late effects of chronic stress in the testes of prepubertal and adult rats

Asian Journal of Andrology 2018年第4期20卷 385-390页

作者： Carina T Ribeiro Diogo B De Souza Waldemar S Costa Francisco J B sampaio marco a pereira-sampaio Urogenital Research Unit State University of Rio de Janeiro Rio de Janeiro RJ 20551-030 Brazil Department of Morphology Fluminense Federal University Niteroi RJ 24210-150 Brazil

The objective of this study was to investigate the effects of chronic stress on the testes of prepubertal and adult rats and to evaluate whether any alterations could be reversed when stress induction is ended. Seventy-six male rats were assigned to eight groups depending on the type of treatment （control or stressed）, the age at which stress was initiated （prepubertal or adult）, and the time of evaluation （immediate or late）. Stress stimuli were applied for 6 weeks. Stressed prepubertal and adult rats evaluated immediately after the last stress stimulus were included in SP-I and SA-I groups, respectively. The late prepubertal （SP-L） and adult （SA-L） groups of stressed rats were evaluated 6 weeks after the last stress stimulus. Age-matched rats were used as controls （CP-I, CA-I, CP-L, and CA-L groups）. Application of stress stimuli to rats in the SP-I group resulted in body weight and seminiferous tubule diameter reduction. The rats in the SA-I group also showed several functional （testosterone level and sperm parameter） and morphological （testicular weight and seminiferous tubule diameter） reductions. The rats in the SP-L group showed increased body weight and intertubular compartment volumetric and absolute densities and reduced tubular compartment volumetric density. The rats in the SA-L group presented only reduced sperm viability. Stress stimuli promoted changes in the rats in all the study groups. The testes of the adult rats were the most affected by chronic stress. However, the stressed adult rats recovered well from the testicular alterations.

关键词： chronic stress morphometry rat testis

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Disentangling the role of wave function overlap, exciton–exciton interaction, carrier confinement and shape in the properties of spherical quantum wells

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Nano Research 2025年第2期18卷 949-957页

作者： marco Califano Pollard Institute School of Electronic and Electrical EngineeringUniversity of LeedsLeeds LS29JTUK Bragg Centre for Materials Research University of LeedsLeeds LS29JTUK

There is a widespread conviction,fuelled by simple effective mass theoretical modelling,that the enhanced optical properties of quantum shells(i.e.,CdS/CdSe/CdS core/shell in a shell structures)derive from a combination of relaxed carrier confinement,decreased overlap between electron and hole wave functions,reduced Coulomb interaction between photoinduced charge carriers and exciton-exciton repulsion,achieved in these nanoscopic spherical quantum wells(SQWs)by shape *** the origins of such properties by means of a more sophisticated theoretical framework is however important to ensure that future efforts at further improvement do not pursue the wrong *** the atomistic semiempirical pseudopotential method,we show that most of the assumptions behind such effects are incorrect,and that the origins of the peculiar optical properties of quantum shells are to be found elsewhere.

关键词： semiconductor nanocrystals quantum shells optical properties electronic structure pseudopotential method

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli marco Cerini marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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From mice to humans:a need for comparable results in mammalian neuroplasticity

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Neural Regeneration Research 2025年第2期20卷 464-466页

作者： marco Ghibaudi Enrica Boda Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi OrbassanoItaly Department of Veterinary Sciences University of TurinTurinItaly Department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

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Tailoring sub-5 nm Fe-doped CeO2 nanocrystals within confined spaces to boost photocatalytic hydrogen evolution under visible light

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Journal of Energy Chemistry 2025年第2期101卷 263-277页

作者： Giuseppina Iervolino Olimpia Tammaro marco Fontana Bruno Masenelli Anne D.Lamirand Vincenzo Vaiano Serena Esposito Department of Industrial Engineering University of Salerno Department of Applied Science and Technology and INSTM Unit of Torino-Politecnico Politecnico di Torino Center for Sustainable Future Technologies POLITO Istituto Italiano di Tecnologia INSA Lyon Ecole Centrale de Lyon CNRS Universite Claude Bernard Lyon 1 CPE LyonINL

This work aimed to study the efficiency of the reverse micelle（RM） preparation route in the syntheses of sub-5 nm Fe-doped CeO2nanocrystals for boosting the visible-light-driven photocatalytic hydrogen production from methanol aqueous *** effectiveness of confining precipitation reactions within micellar cages was evaluated through extensive physicochemical cha *** particula r,the nominal composition（0-5 mol% Fe） was preserved as ascertained by ICP-MS analysis,and the absence of separate iron-containing crystalline phases was supported by X-ray *** effective aliovalent doping and modulation of the optical properties were investigated using UV-Vis,Raman,and photoluminescence spectroscopies.2.5 mol% iron was found to be an optimal content to achieve a significant decrease in the band gap,enhance the concentration of oxygen vacancy defects,and increase the charge carrier *** photocatalytic activity of Fe-doped CeO2prepared at different Fe contents with RM preparation was studied and compared with undoped *** optimal iron load was identified to be2.5 mol%,achieving the highest hydrogen production(7566 μmol L-1after 240 min under visible light).Moreover,for comparison,the conventional precipitation（P） method was adopted to prepare iron containing CeO2at the optimal content（2.5 mol% Fe）.The Fe-doped CeO2catalyst prepared by RM showed a significantly higher hydrogen production than that obtained with the sample prepared by the P *** optimal Fe-doped CeO2,prepared by the RM method,was stable for six reuse ***,the role of water in the mechanism of photocatalytic hydrogen evolution under visible light was studied through the test in the presence of *** obtained results evidenced that hydrogen was produced from the reduction of H+by the electrons promoted in the conduction band,while methanol was preferentially oxidized by the photogenerated positive holes.

关键词： Hydrogen evolution Mesoporous CeO2 Photocatalysis Reverse micelles Sub-5 nm Fe-doped CeO2 Visible light

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Novel Methodologies for Preventing Crack Propagation in Steel Gas Pipelines Considering the Temperature Effect

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Structural Durability & Health Monitoring 2025年第1期19卷 1-23页

作者： Nurlan Zhangabay Ulzhan Ibraimova marco Bonopera Ulanbator Suleimenov Konstantin Avramov Maryna Chernobryvko Aigerim Yessengali Department of Architecture and Urban Planning Mukhtar Auezov South Kazakhstan UniversityShymkent160012Kazakhstan Department of Industrial Civil and Road Construction Mukhtar Auezov South Kazakhstan UniversityShymkent160012Kazakhstan Mechanics Sound&Vibration LaboratoryDepartment of Civil EngineeringCollege of EngineeringNational Taiwan UniversityTaipei10617Taiwan Department of Reability&Dynamic Strength A.Pidhornyi Institute of Mechanical Engineering Problems of National Academy of Sciences of UkraineKharkiv61046Ukraine

Using the software ANSYS-19.2/Explicit Dynamics,this study performedﬁnite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire *** effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also *** results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum *** analysis of the inﬂuence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire *** increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the inﬂuence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline *** analysis of the temperature effect on the pipeline material,within a range from-40℃ to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length *** such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃ and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline signiﬁcantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of *** work integrated the existing methods for crack localization along steel gas pipelines.

关键词： Crack propagation ﬁnite-element internal pressure prestressing steel gas pipeline temperature effect

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Generation,interrogation,and future applications of microglia-containing brain organoids

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Neural Regeneration Research 2025年第12期20卷 3448-3460页

作者： Julia Di Stefano Federica Di marco Ilaria Cicalini Una FitzGerald Damiana Pieragostino Marleen Verhoye Peter Ponsaerts Elise Van Breedam Laboratory of Experimental Hematology Vaccine and Infectious Disease Institute(Vaxinfectio)University of AntwerpWilrijkBelgium Bio-Imaging Lab University of AntwerpWilrijkBelgium Center for Advanced Studies and Technology(CAST) G.d’Annunzio University of Chieti-PescaraChietiItaly Department of Innovative Technologies in Medicine and Dentistry University“G.d’Annunzio”of Chieti-PescaraChietiItaly CÚRAM Center for Research in Medical DevicesBiomedical EngineeringUniversity of GalwayIreland Galway Neuroscience Center University of GalwayIreland μNEURO Research Center of Excellence University of AntwerpWilrijkBelgium

Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and ***,this review provides a brief introduction to the current state-of-the-art for neuroectoderm brain organoid development,emphasizing their biggest advantages in comparison with classical two-dimensional cell cultures and animal ***,despite their usefulness for developmental studies,a major limitation for most brain organoid models is the absence of contributing cell types from endodermal and mesodermal *** such,current research is highly investing towards the incorporation of a functional vasculature and the microglial immune *** this review,we will specifically focus on the development of immune-competent brain *** summarizing the different approaches applied to incorporate microglia,it is highlighted that immune-competent brain organoids are not only important for studying neuronal network formation,but also offer a clear future as a new tool to study inflammatory responses in vitro in 3D in a brainlike ***,our main focus here is to provide a comprehensive overview of assays to measure microglial phenotype and function within brain organoids,with an outlook on how these findings could better understand neuronal network development or restoration,as well as the influence of physical stress on microglia-containing brain ***,we would like to stress that even though the development of immune-competent brain organoids has largely evolved over the past decade,their full potential as a pre-clinical tool to study novel therapeutic approaches to halt or reduce inflammation-mediated neurodegeneration still needs to be explored and validated.

关键词： 3D cell culture brain organoids immune response immunocompetent model in vitro model microglia neural organoids neuroimmunology neuroinflammation

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Long-term monitoring of active large-scale landslides for non-structural risk mitigation-integrated sensors and web-based platform

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Journal of Mountain Science 2025年第1期22卷 1-15页

作者： CATELAN Filippo Tommaso BOSSI Giulia SCHENATO Luca TONDO Melissa CRITELLI Vincenzo MULAS marco CICCARESE Giuseppe CORSINI Alessandro TONIDANDEL David MAIR Volkmar MARCATO Gianluca Research Institute for Geo-Hydrological Protection(IRPI) National Research Council(CNR)Padova 35127Italy Department of Chemical and Geological Sciences University of Modena and Reggio EmiliaModena 41125Italy Department of Information Engineering University of PadovaPadova 35131Italy Department of Biological Geological and Environmental SciencesUniversity of BolognaBologna 67-40126Italy Office for Geology and Building Materials Testing Autonomous Province of BolzanoCardano 39053Italy

Large-scale deep-seated landslides pose a significant threat to human life and ***,closely monitoring these landslides is crucial for assessing and mitigating their associated *** this paper,the authors introduce the So Lo Mon framework,a comprehensive monitoring system developed for three large-scale landslides in the Autonomous Province of Bolzano,Italy.A web-based platform integrates various monitoring data(GNSS,topographic data,in-place inclinometer),providing a user-friendly interface for visualizing and analyzing the collected *** facilitates the identification of trends and patterns in landslide behaviour,enabling the triggering of warnings and the implementation of appropriate mitigation *** So Lo Mon platform has proven to be an invaluable tool for managing the risks associated with large-scale landslides through non-structural measures and driving countermeasure works *** serves as a centralized data repository,offering visualization and analysis *** information empowers decisionmakers to make informed choices regarding risk mitigation,ultimately ensuring the safety of communities and infrastructures.

关键词： Web-based platform South Tyrol landslides Long term monitoring Risk mitigation

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Effects of temperature and salinity on the seed germination of Limonium strictissimum(Salzm.)Arrigoni in the Mediterranean Basin

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Journal of Arid Land 2025年第2期17卷 259-270页

作者： Ludovica DESSÌ Alba CUENA-LOMBRAÑA Lina PODDA marco PORCEDDU Mauro FOIS Lillia FAUSTI Carole PIAZZA Gianluigi BACCHETTA Sardinian Germplasm Bank(BG-SAR) Centre for Conservation of Biodiversity(CCB)Department of Life and Environmental SciencesUniversity of CagliariCagliari 09123Italy National Botanical Conservatory of Corsica Office of the Environment of CorsicaCorte F-20250France

Salt stress might be an important factor that decreases the emergence of seedlings and reduces plants'growth,causing their endangered ***,the effects of salt stress on the germination of the Mediterranean species are less *** strictissimum(Salzm.)Arrigoni,part of the group related to Limonium articulatum(Loisel.)Kuntze,is a Cyrno-Sardinian endemism,which is included in the International Union for Conservation of Nature(IUCN)Red Lists as Endangered(EN).Fresh seeds of *** harvested from the only known population in Sardinia and a population in southeastern Corsica were used with the aims to study the effects of temperature and salinity on the seed germination and to evaluate the ability to recover their germination after exposure to salt *** both populations,empty fruits with a lower percentage were observed in Sardinia than in *** seeds showed a high germination capacity,which was not influenced by temperature and did not even differ between the two *** with non-saline condition,the presence of salt in the substrate,independently of the concentration tested,inhibited seed germination in both populations,with germination percentages never exceeding 40%.The Sardinian population showed a recovery capacity after exposure to high salt stress,always above 50%regardless of the salt concentration and incubation temperature *** seeds previously exposed to 125 mM NaCl at 30℃ had the lowest recovery percentage(56%),while the highest recovery percentage(84%)was recorded at 25℃ with a concentration of 250 mM ***,the Corsican population recorded a higher recovery percentage(54%)in seeds previously exposed to 500 mM NaCl at 20℃,while for the concentration of 125 mM NaCl,the best recovery percentage(11%)was recorded at 30℃.The ability of *** to recover germination after salt exposure can be interpreted as an adaptation to the coastal habitats in which it *** study provides n

关键词： Limonium Mill. Mediterranean vascular flora NaCl recovery phase salt stress endemic species threatened species

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Significance of the neutrophil-to-lymphocyte ratio and the platelet-tolymphocyte ratio as prognostic predictors after liver transplantation

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World Journal of Transplantation 2025年第2期15卷 237-244页

作者： marco Maria Pascale Francesco Frongillo Pierangelo Vasta Giuseppe Massimiani Erida Nure Salvatore Agnes General Surgery and Liver Transplantation Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Surgery Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND The use of biomarkers,such as the neutrophil-to-lymphocyte ratio(NLR)and the neutrophil-to-platelet ratio(NPR),has shown promise in evaluating early outcomes after medical,interventional,and surgical *** has emer-ged as an indicator of systemic inflammation and physiological *** has emerged as a potential indicator of inflammation and thrombotic risk in the context of surgical and radiological *** To analyze the correlation of NLR and NPR with the development of post-liver transplantation(LT)early complications after stratification for hepatocellular carcinoma *** Consecutive patients undergone LT between January 2019 and December 2023 were *** regarding the concentration of hemoglobin and the differ-ential leukocyte count on postoperative days(POD)0,1,3,and 5 were *** The dataset included 161 consecutive patients undergone ***-Dindo IV-V complications had a good correlation with NLR POD 1(P=0.05),NLR POD 3(P<0.001),NLR POD 7(P<0.001),NPR POD 3(P<0.001).In addition,the NPR ratio on POD 3 correlated with the onset of 30-day hemorrhage(P=0.009).Finally,30-day mortality had a significant association with the NLR POD 1(P=0.03)and with NLR POD 7(P=0.004),while NPR had a significant correlation with 30-day mortality in NPR POD 7(P=0.004).CONCLUSION The analysis of NLR and NPR are strictly correlated with Clavien-Dindo IV-V complications and 30-day post-LT death.

关键词： Liver transplantation Immunobiomarkers Neutrophil-to-lymphocyte ratio Neutrophil-to-platelet ratio Postoperative complications

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