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An international survey of classification and treatment choices for group D retinoblastoma

International Journal of Ophthalmology(English edition) 2017年第6期10卷 961-967页

作者： Christina Scelfo Jasmine H Francis Vikas Khetan Thomas Jenkins Brian Marr David H Abramson Carol L Shields Jacob Pe’er Francis Munier Jesse Berry J.William Harbour Andrey Yarovoy Evandro Lucena Timothy G Murray Pooja Bhagia Evelyn Paysse Samuray Tuncer Guillermo L Chantada Annette C Moll Tatiana Ushakova David A Plager Islamov Ziyovuddin Carlos A Leal Miguel A Materin Xun-Da Ji Jose W Cursino Rodrigo Polania Hayyam Kiratli Charlotta All-Ericsson Rejin Kebudi Santosh G Honavar Vicktoria Vishnevskia-Dai Sidnel Epelman Anthony B Daniels Jeanie D Ling Fousseyni Traore marco a ramirez-ortiz Ophthalmic Oncology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York 10065 USA Department of Ophthalmology Weill-Cornell Medical Center New York 10065 USA Department of Vitreoretinal and Ocular Oncology Sankara Nathralaya Chennai 600066 India Ocular Ontology Service Wills Eye Hospital Thomas Jefferson University Pennsylvania 19107 USA Hadassah - Hebrew University Medical Center Jerusalem 91120 Israel jules-Gonin Eye Hospital Lausanne 1004 Switzerland USC Roski Eye Institute Children＇s Hospital of Los Angeles California 90033 USA Ocular Oncology Service Bascom Palmer Eye Institute University of Miami Miller School of Medicine Florida 33136 USA Ocular Oncology Department S.N. Fyodorov Eye Microsurgery Federal State Institution Moscow 127486 Russia Department of Ocular Oncology Instituto Nacional de Cancer Rio de Janeiro 1122 Brazil Murray Ocular Oncology and Retina Miami Children＇s Hospital Florida 33143 USA St. Joseph＇s Children＇s Hospital New Jersey 07504 USA Department of Ophthalmology Baylor College of Medicine Texas 77030 USA Department of Ophthalmology Ocular Oncology Istanbul Medical Faculty Istanbul University Istanbul 34452 Turkey Oncology Department Hospital JP Garrahan Buenos Aires 1245 Argentina Department of Ophthalmology VU University Medical Center Amsterdam 1081 the Netherlands Department of Head and Neck Tumors Science Research Institute of Pediatric Oncology and Hematology N.N. Blokhin Russian Cancer Research Center Moscow 115478 Russia Pediatric Ophthalmology and Adult Strabismus Riley Hospital for Children Indiana University Medical Center Indiana 46202 USA National Oncology Center of Uzbekistan Tashkent 110508 Uzbekistan nstituto Nacional de Pediatria Coyoacan 04530 Mexico Department of Ophthalmology and Visual Science Smilow Cancer Hospital at Yale New Haven CT 06520 USA Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Ophthalmology Santa Casa Mi

AIM： To determine which IIRC scheme was used by retinoblastoma centers worldwide and the percentage of D eyes treated primarily with enucleation versus globe salvaging therapies as well as to correlate trends in treatment choice to IIRC version used and geographic region. METHODS： An anonymized electronic survey was offered to 115 physicians at 39 retinoblastoma centers worldwide asking about IIRC classification schemes and treatment patterns used between 2008 and 2012. Participants were asked to record which version of the IIRC was used for classification, how many group D eyes were diagnosed, and how many eyes were treated with enucleation versus globe salvaging therapies. Averages of eyes per treatment modality were calculated and stratified by both IIRC version and geographic region. Statistical significance was determined by Chi-square, ANOVA and Kruskal-Wallis tests using Prism. RESULTS： The survey was completed by 29% of physicians invited to participate. Totally 1807 D eyes were diagnosed. Regarding IIRC system, 27% of centers used the Children＇s Hospital of Los Angeles （CHLA） version, 33% used the Children＇s Oncology Group （COG） version, 23% used the Philadelphia version, and 17% were unsure. The rate for primary enucleation varied between 0 and 100% and the mean was 29%. By IIRC version, primary enucleation rates were： Philadelphia, 8%; COG, 34%; and CHLA, 37%. By geographic region, primary enucleation rates were： Latin America, 57%; Asia, 40%; Europe, 36%; Africa, 10%, US, 8%; and Middle East, 8%. However, systemic chemoreduction was used more often than enucleation in all regions except Latin America with a mean of 57% per center （P〈0.0001）. CONCLUSION： Worldwide there is no consensus on which IIRC version is used, systemic chemoreduction was the most frequently used initial treatment during the study period followed by enucleation and primary treatment modality, especially enucleation, varied greatly with regards to IIRC version used and geographic r

关键词： retinoblastoma oncology retina enucleation chemotherapy intra-arterial chemotherapy ophthalmic arterychemosurgery cancer

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli marco Cerini marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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From mice to humans:a need for comparable results in mammalian neuroplasticity

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Neural Regeneration Research 2025年第2期20卷 464-466页

作者： marco Ghibaudi Enrica Boda Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi OrbassanoItaly Department of Veterinary Sciences University of TurinTurinItaly Department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

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First record of Odontaster penicillatus populations(Philippi,1870)(Echinodermata:Asteroidea)in the Atacama and Antofagasta regions,Chile(Southeast Pacific)

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Acta Oceanologica Sinica 2022年第12期41卷 152-155页

作者： Leonardo Campos Fernando Berrios Brenda BHermosillo-Núñez marco ortiz Departamento de Ciencias Acuáticas y Ambientales Universidad de Antofagasta ChileAntofagasta 1240000Chile Centro de Investigaciones Costeras Universidad de Atacama(CIC-UDA) Avenida Copayapu 485Copiapó1530000Chile Laboratorio de Modelamiento de Sistemas Ecológicos Complejos(LAMSEC) Instituto AntofagastaUniversidad de AntofagastaAntofagasta 1240000Chile Instituto de Ciencias Naturales AvH Facultad de Ciencias del Mar y Recursos BiológicosUniversidad de AntofagastaAntofagasta 1240000Chile Centro de Investigación y Estudios Avanzados del Maule Vicerrectoría de Investigación y PosgradoUniversidad Católica Del MauleCampus San MiguelTalca 3480094Chile

We report for the first time the presence of local populations of the starfish Odontaster penicillatus in the regions of Atacama and Antofagasta,*** finding indicates an extension of the distribution limit of 500 km with respect to the last observation made in 2007 in Isla Grande de Atacama.A total of 121 specimens of *** were recorded at depths of between 8 m and 24 *** were associated with rocky substrate and with different species of barnacles,sponges and *** presence of *** expands the knowledge of the benthic biodiversity of the region,and the development of studies on its ecological importance will be promoted.

关键词： Odontaster penicillatus new record Antofagasta Atacama South Pacific Ocean

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Novel Methodologies for Preventing Crack Propagation in Steel Gas Pipelines Considering the Temperature Effect

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Structural Durability & Health Monitoring 2025年第1期19卷 1-23页

作者： Nurlan Zhangabay Ulzhan Ibraimova marco Bonopera Ulanbator Suleimenov Konstantin Avramov Maryna Chernobryvko Aigerim Yessengali Department of Architecture and Urban Planning Mukhtar Auezov South Kazakhstan UniversityShymkent160012Kazakhstan Department of Industrial Civil and Road Construction Mukhtar Auezov South Kazakhstan UniversityShymkent160012Kazakhstan Mechanics Sound&Vibration LaboratoryDepartment of Civil EngineeringCollege of EngineeringNational Taiwan UniversityTaipei10617Taiwan Department of Reability&Dynamic Strength A.Pidhornyi Institute of Mechanical Engineering Problems of National Academy of Sciences of UkraineKharkiv61046Ukraine

Using the software ANSYS-19.2/Explicit Dynamics,this study performedﬁnite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire *** effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also *** results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum *** analysis of the inﬂuence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire *** increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the inﬂuence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline *** analysis of the temperature effect on the pipeline material,within a range from-40℃ to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length *** such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃ and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline signiﬁcantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of *** work integrated the existing methods for crack localization along steel gas pipelines.

关键词： Crack propagation ﬁnite-element internal pressure prestressing steel gas pipeline temperature effect

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In vitro Evaluation with 5SBF of Alloy ASTM F75 Thermally Treated with Wollastonite

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Journal of Wuhan University of Technology(Materials Science) 2016年第3期31卷 487-490页

作者： MUNIZ Rodrigo ortiz Juan LUNA Jesus MARTINEZ Jesus RODRIGEZ Nelly HERNANDEZ marco OROZCO Pilar EQUIHUA Fabian Faculty of Engineering Autonomous University of CoahuilaCUSaltilloMexico Department of Metal Mechanics Technological Institute of SaltilloMexico Faculty of Engineering Mechanical and Electrical Autonomous University of Nuevo LeonMexico Faculty of Engineering Autonomous University of Zacatecas Faculty of Mechanical and Electrical Engineering Autonomous University of Coahuila North UnitMonclovaMexico

Samples of a cobalt-based alloy that underwent a surface treatment were evaluated. The samples, which were obtained by casting alloy ASTM F 75, were ground and polished on one side until a mirror finish was obtained. The samples were encapsulated in wollastonite （W） using uniaxial pressure, treated at 1 220 ~C for 1 h and subsequently tempered in water. The characterisation of the sample indicated that part of the ceramic encapsulating material was mechanically incorporated on the metallic surface by growth of the oxide layer of the alloy. After thermal treatment, a series of specimens were submerged in a solution with 5-fold simulated body fluid （5SBF） for 3, 5 and 21 days. Characterisation by scanning electron microscopy （SEM）, energy dispersive spectroscopy （EDS） and X-ray diffraction （XRD） indicated nucleation and growth of a homogenous layer of apatite, beginning on the third day when the sample was submerged.

关键词： cobalt-based alloy wollastonite 5SBF apatite.

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Measurement of vibration frequencies of ties in masonry arches by means of a robotic total station

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 489-500页

作者： marco Gatti Dipartimento di Ingegneria University of Ferraravia Saragat 144123 FerraraItaly

Measurement of the vibration frequencies of eight ties set in masonry arches of a church by means of a robotic total station is *** instrument made continuous recordings(up to ten per second)of the three-dimensional positions of a reflector situated at 1/2 or 1/4 of the length of the tie during vertical oscillation induced by an impulsive *** recording slips,vibration amplitudes(and their accuracy),hourly diagram and experimental spectra of vibrations,and the corresponding frequencies were *** results were verified by comparing them with the vibration frequencies and indirectly the tension and fixed support constraint calculated from accelerometric *** study provides interesting information on the accuracies of the reflector′s three-dimensional coordinates,but highlighted certain limits in the application of robotized total stations for measuring vibration frequencies of ties in masonry arches.

关键词： RTS frequency vibrations ties arches

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Dynamics of ^(14)C-labelled Glucose and NH_4^+ in a Regularly Flooded Extremely Alkaline Saline Soil

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Pedosphere 2015年第2期25卷 230-239页

作者： Luc DENDOOVEN Eustacio ramirez-FUENTES Rocio ALCANTARA-HERNDEZ Cesar VALENZUELA-ENCINAS Katia Berenice SANCHEZ-LOPEZ marco LUNA-GUIDO Victor Manuel RUIZ-VALDIVIEZO Laboratory of Soil Ecology ABACUSCinvestavAvenida Instituto Politecnico Nacional 2508CP 07360Mexico Mexico

Flooding an extremely alkaline(pH 10.6) saline soil of the former Lake Texcoco to reduce salinity will affect the soil carbon(C)and nitrogen(N) dynamics.A laboratory incubation experiment was done to investigate how decreasing soil salt content affected dynamics of C and N in an extremely alkaline saline *** soil with electrical conductivity(EC) of 59.2 dS m^(-1) was packed in columns,and then flooded with tap water,drained freely and conditioned aerobically at 50%water holding capacity for a *** process of flooding-drainage-conditioning was repeated eight *** original soil and the soil that had undergone one,two,four and eight flooding-drainage-conditioning cycles were amended with 1000 mg glucose-^(14)C kg^(-1) soil and 200 mg NH_4^+-N kg^(-1)soil,and then incubated for 28 *** CO_2 emissions,soil microbial biomass,and soil ammonium(NE_4^+),nitrite(NO_2^-) and nitrate(NO_3^-) were monitored in the aerobic incubation of 28 *** soil EC decreased from 59.2 to 1.0 dS m^(_1) after eight floodings,and soil pH decreased from 10.6 to *** the added ^(14)C-labelled glucose,only 8%was mineralized in the original soil,while 24%in the soil flooded eight times during the 28-d *** priming effect was on average 278 mg C kg^(-1) soil after the 28-d *** microbial biomass C(mean 66 mg C kg^(-1) soil) did not change with flooding times in the unamended soil,and increased 1.4 times in the glucose-NH_4^+-amended *** immobilization and NO_2^- concentration in the aerobically incubated soil decreased with increasing flooding times,while NO_3^- concentration *** was found that flooding the Texcoco soil decreased the EC sharply,increased mineralization of glucose,stimulated nitrification,and reduced immobilization of inorganic N,but did not affect soil microbial biomass C.

关键词： C mineralization CO2 emission microbial biomass C mineral N nitrification

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σ-Phase in Lean Duplex Stainless Steel Sheets

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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 331-337页

作者： marco Breda Massimo Pellizzari marco Frigo Industrial Engineering Department(DII) University of PadovaVia Marzolo 9Int.435131 PaduaItaly Industrial Engineering Department(DII) University of TrentoVia Mesiano 7738123 TrentoItaly Outokumpu S.p.A. Piazza Piccapietra 916121 GenoaItaly

The precipitation kinetics of secondary phases in two austeno-ferritic lean duplex stainless steels（lean DSS）were examined after aging the materials at 800 ℃.Owing to the instability of ferrite,all DSS are known to be sensitive to solid-state phase transformations in the critical temperature range 600-1,000 ℃ and different secondary phases may form,depending on composition and *** performed thermodynamic simulations revealed the proneness to the precipitation of such phases also have been done in lean DSS,but only information on the equilibrium microstructures were ***,the materials were aged at various times,in order to verify the simulations and determine the precipitation *** occurred structural modifications were observed and quantified by scanning electron microscope and X-ray diffraction measurements,determining phase type,composition and volumetric *** 800 ℃,grade 2101 was found to be only affected by Cr_2N nitrides precipitation,whereas a significant amount of σ-phase was found to form in LDX 2404 for treatment longer than 1 h,almost totally replacing ferrite after 50 *** to now,the intermetallic σ-phase has been observed only in the high alloyed DSS,and the unexpected precipitation in grade 2404 highlighted that the increased content of molybdenum in this steel might be considered as determinant for the formation.

关键词： Lean duplex stainless steels Isothermal heat treatments σ-Phase Chromium nitrides Precipitation kinetics

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Elastic period of vibration calculated experimentally in buildings hosting permanent GPS stations

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Earthquake Engineering and Engineering Vibration 2018年第3期17卷 607-625页

作者： marco Gatti Department of Engineering University of Ferrara

During the earthquake in Emilia（Italy） of 2012,ca.30 permanent GPS stations were in operation within a radius of about 100 km from the epicenter,each equipped with an antenna rigidly fixed to the host building and sampling the GPS signal at a high rate（〉 1 Hz）.From the recording of the GPS measurements,the instantaneous displacements s（t） in the NorthSouth and East-West directions of the phase centers of the single GPS antennas at each permanent station during the most important seismic sequences were calculated in kinematic ***,for each of the two displacements considered as two distinct external forces,the elastic response spectra of the building were determined and from them the two periods of vibration T along two orthogonal directions coinciding with the walls of the building were *** experimentally obtained periods of vibration were compared with those inferable from the technical *** this way,a sufficiently large sample was obtained per building type,geometry（square,rectangular,regular or irregular planimetry）,height（from a minimum of 4 to a maximum of 20 m） and materials（masonry,reinforced concrete,etc.）.From the computational point of view,the study confirmed that GPS is an emerging tool for monitoring dynamic displacements and the experimentally estimated value of T is always lower than the one estimated with the formulae reported in the *** limitations of the study lie in the impossibility to choose a priori the geometry and/or structural type of the building hosting the GPS station.

关键词： permanent GPS stations Emilia-Romagna Italy earthquake period vibrations dynamic structure

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