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A technical and socioeconomic approach to estimate forest residues as a feedstock for bioenergy in northern Mexico

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Forest Ecosystems 2019年第4期6卷 312-322页

作者： Guadalupe Carrasco-Diaz Gustavo Perez-Verdin Jonathan Escobar-Flores marco antonio marquez-linares Instituto Politecnico Nacional CIIDIR Dgo.

Background: Forest residues can be a feasible alternative for converting energy into fuels, electricity, or *** to other second-generation bioenergy sources, they do not compete for food, are relatively cheap,abundant in forest-rich areas, and more importantly their energy balance is close to zero. Biomass estimations can help design energy strategies to reduce fossil fuels dependency. Because of the land property distribution in Mexico,biomass estimations should consider not only the physical availability, but also the willingness of landowners to extract such raw ***: This study presents a methodological approach for evaluating the potential use of forest residues as a feedstock to generate bioenergy in northern Mexico. Remote sensing and field forest inventory were used to estimate the quantity and distribution of forest residues. In addition, a discrete choice analysis evaluated landowners’ preferences towards bioenergy development, including the most important factors that influence their willingness to extract their products and the expected *** and conclusions: Considering both physical and socio-economic aspects, results showed that about59,000 metric tons per year could be available in the study area. The vast majority of landowners surveyed are willing to extract forest residues, as long as they are presented with extraction plans with the highest income. However, many showed concerns about the environmental impacts this activity can have on soils,plants, and fauna. These results can help evaluate the potential of these resources for bioenergy development.

关键词： Bioenergy Choice experiments Forest landowners Forest residues Remote sensing

Gene expression and physiological responses to salinity and water stress of contrasting durum wheat genotypes

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Journal of Integrative Plant Biology 2016年第1期58卷 48-66页

作者： Salima Yousfi antonio J.marquez marco Betti Jose Luis Araus Maria Dolores Serret Unit of Plant Physiology Department of Plant BiologyFaculty of BiologyUniversity of Barcelona08028Spain Department of Plant Biochemistry and Molecular Biology Faculty of ChemistryUniversity of SevilleSevilla 41012Spain

Elucidating the relationships between gene expression and the physiological mechanisms remains a bottleneck in breeding for resistance to salinity and drought. This study related the expression of key target genes with the physiological performance of durum wheat under different combinations of salinity and irrigation. The candidate genes assayed included two encoding for the DREB（dehydration responsive element binding） transcription factors Ta DREB1 A and Ta DREB2 B, another two for the cytosolic and plastidic glutamine synthetase（Ta GS1 and Ta GS2）, and one for the specific Na^＋/H^＋ vacuolar antiporter（Ta NHX1）. Expression of these genes was related to growth and different trait indicators of nitrogen metabolism（nitrogen content, stable nitrogen isotope composition, and glutamine synthetase and nitrate reductase activities）, photosynthetic carbon metabolism（stable carbon isotope composition and different gas exchange traits） and ion accumulation. Significant interaction between genotype and growing conditions occurred for growth, nitrogen content, and the expression of most *** general terms, higher expression of Ta GS1, Ta GS2,Ta DREB2 B, and to a lesser extent of Ta NHX1 were associated with a better genotypic performance in growth, nitrogen, and carbon photosynthetic metabolism under salinity and water stress. However, Ta DREB1 A was increased in expression under stress compared with control conditions, with tolerant genotypes exhibiting lower expression than susceptible ones.

关键词： Durum wheat (Triticum turgidum ssp. durum) geneexpression nitrogen metabolism salinity stable isotope

Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

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Cellular & Molecular Immunology 2021年第4期18卷 905-918页

作者： Cristina Tecchio marco antonio Cassatella Department of Medicine Section of Hem atology and Bone Marrow Transplant UnitUniversity of VeronaVeronaItaly Department of Medicine Section of General PathologyUniversity of VeronaVeronaItaly

Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow *** role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against ***,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered ***,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation ***,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC *** also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)***,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also *** on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial ***,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.

关键词： neutrophils allogeneic hematopoietic stem cell transplantation(alloHSCT) alloHSCT-associated complications lowdensity neutrophils(LDNs) normal-density neutrophils(NDNs)

Influence of manufacturing process-induced geometrical defects on the energy absorption capacity of polymer lattice structures

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Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： Alexandre Riot Enrico Panettieri antonio Cosculluela marco Montemurro Universite de Bordeaux Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance French Atomic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern additive manufacturing processes enable fabricating architected cellular materials of complex shape,which can be used for different *** them,lattice structures are increasingly used in applications requiring a compromise among lightness and suited mechanical properties,like improved energy absorption capacity and specific stiffness-to-weight and strength-to-weight ratios.A dedicated modeling strategy to assess the energy absorption capacity of lattice structures under uni-axial compression loading is presented in this *** numerical model is developed in a non-linear framework accounting for the strain rate effect on the mechanical responses of the lattice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodecahedron and truncated cuboctahedron 2+,are ***,the influence of the relative density of the representative volume element of each geometry,the strain-rate dependency of the bulk material and of the presence of the manufacturing process-induced geometrical imperfections on the energy absorption capacity of the lattice structure is *** main outcome of this study points out the importance of correctly integrating geometrical imperfections into the modeling strategy when shock absorption applications are aimed for.

关键词： Lattice structures Architected cellular materials Dynamic simulation Energy absorption Geometrical imperfection Additive manufacturing

Nervous and Neuroendocrine regulation of the pathophysiology of cholestasis and of biliary carcinogenesis

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World Journal of Gastroenterology 2006年第22期12卷 3471-3480页

作者： marco Marzioni Giammarco Fava antonio Benedetti Department of Gastroenterology Universita Politecnica delle Marche via Tronto 1060020 AnconaItaly

Cholangiocytes, the epithelial cells lining the biliary ducts, are the target cells in several liver diseases. Cholangiopathies and cholangiocarcinoma generate interest in many scientists since the genesis. The developing mechanisms, and the therapeutic tools of these diseases are still undefined. Several studies demonstrate that many hormones, neuropeptides and neurotransmitters regulate malignant and non-malignant cholangiocyte pathophysiology in the course of chronic biliary diseases. The aim of this review is to present the findings of several studies published in the recent years that contributed to clarifying the role of nervous and neuroendocrine regulation of the pathophysiologic events associated with cholestasis and cholangiocarcinoma development. This manuscript is organized into two parts. The first part offers an overview of the innervation of the liver and the origin of neuroendocrine hormones, neurotransmitters and neuropeptides affecting cholangiocyte function and metabolism. The first section also reviews the effects played by several neuroendocrine hormones and nervous system on cholangiocyte growth, survival and functional activity in the course of cholestasis. In the second section, we summarize the results of some studies describing the role of nervous system and neuroendocrine hormones in the regulation of malignant cholangiocyte growth.

关键词： Cholangiocyte Neuroendocrine hormones Neurotransmitters Neuropeptides Cholestasis Nervous System Biliary carcinogenesis Pathophysiology Cholangiocarcinoma Proliferation

Biomarkers in colorectal cancer: Current clinical utility and future perspectives

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World Journal of Clinical Cases 2018年第15期6卷 869-881页

作者： marco Vacante antonio Maria Borzì Francesco Basile antonio Biondi Department of General Surgery and Medical-Surgical Specialties University of Catania

Colorectal cancer(CRC) is a major cause of cancer death worldwide. CRC has poor prognosis and there is a crucial need for new diagnostic and prognostic biomarkers to avoid CRC-related deaths. CRC can be considered a sporadic disease in most cases(75%-80%), but it has been suggested that crosstalk between gene mutations(i.e., mutations of BRAF, KRAS, and p53 as well as microsatellite instability) and epigenetic alterations(i.e., DNA methylation of Cp G island promoter regions) could play a pivotal role in cancer development. A number of studies have focused on molecular testing to guide targeted and conventional treatments for patients with CRC, sometimes with contrasting results. Some of the most useful innovations in the management of CRC include the possibility to detect the absence of KRAS, BRAF, NRAS and PIK3 CA gene mutations with the subsequent choice to administer targeted adjuvant therapy with anti-epidermal growth factor receptor antibodies. Moreover, CRC patients can benefit from tests for microsatellite instability and for the detection of loss of heterozygosity of chromosome 18 q that can be helpful in guiding therapeutic decisions as regards the administration of 5-FU. The aim of this review was to summarize the most recent evidence on the possible use of genetic or epigenetic biomarkers for diagnosis, prognosis and response to therapy in CRC patients.

关键词： Biomarkers Colorectal cancer Epigenetics Tumor markers DNA methylation

Study of risk factors for gastric cancer by populational databases analysis

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World Journal of Gastroenterology 2013年第48期19卷 9383-9391页

作者： Fangio Ferrari marco antonio Moura Reis Master’s Program on Health and Environment University of the Region of Joinville-Univille Joinville Santa Catarina 89219-710 Brazil

AIM:To study the association between the incidence of gastric cancer and populational exposure to risk/protective factors through an analysis of international ***:Open-access global databases concerning the incidence of gastric cancer and its risk/protective factors were identified through an extensive search on the *** its distribution was neither normal nor symmetric,the cancer incidence of each country was categorized according to ranges of percentile *** association of each risk/protective factor with exposure was measured between the extreme ranges of the incidence of gastric cancer(under the 25th percentile and above the 75th percentile)by the use of the Mann-Whitney test,considering a significance level ***:A variable amount of data omission was observed among all of the factors under study.A weak or nonexistent correlation between the incidence of gastric cancer and the study variables was shown by a visual analysis of scatterplot *** contrast,an analysis of categorized incidence revealed that the countries with the highest human development index(HDI)values had the highest rates of obesity in males and the highest consumption of alcohol,tobacco,fruits,vegetables and meat,which were associated with higher incidences of gastric *** was no significant difference for the risk factors of obesity in females and fish ***:Higher HDI values,coupled with a higher prevalence of male obesity and a higher per capita consumption of alcohol,tobacco,fruits,vegetables and meat,are associated with a higher incidence of gastric cancer based on an analysis of populational global data.

关键词： Gastric cancer Risk factors Epidemiologic factors Environment Public health

Familial adenomatous polyposis and changes in the gut microbiota: New insights into colorectal cancer carcinogenesis

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 495-508页

作者： antonio Biondi Francesco Basile marco Vacante Department of General Surgery and Medical-Surgical Specialties University of CataniaCatania 95123Italy Multidisciplinary Research Center for Rare Diseases University of CataniaCatania 95123Italy

Patients with familial adenomatous polyposis(FAP),an autosomal dominant hereditary colorectal cancer syndrome,have a lifetime risk of developing cancer of nearly 100%.Recent studies have pointed out that the gut microbiota could play a crucial role in the development of colorectal adenomas and the consequent progression to colorectal *** gut bacteria,such as Fusobacterium nucleatum,Escherichia coli,Clostridium difficile,Peptostreptococcus,and enterotoxigenic Bacteroides fragilis,could be implicated in colorectal carcinogenesis through different mechanisms,including the maintenance of a chronic inflammatory state,production of bioactive tumorigenic metabolites,and DNA *** using the adenomatous polyposis coliMin/+mouse model,which resembles FAP in most respects,have shown that specific changes in the intestinal microbial community could influence a multistep progression,the intestinal“adenoma-carcinoma sequence”,which involves mucosal barrier injury,low-grade inflammation,activation of the Wnt ***,modulation of gut microbiota might represent a novel therapeutic target for patients with *** of probiotics,prebiotics,antibiotics,and nonsteroidal anti-inflammatory drugs could potentially prevent the progression of the adenoma-carcinoma sequence in *** aim of this review was to summarize the best available knowledge on the role of gut microbiota in colorectal carcinogenesis in patients with FAP.

关键词： Familial adenomatous polyposis Microbiota Colorectal cancer Polyps Carcinogenesis Bacteria

Performance evaluation of permissioned blockchains for financial applications: The ConsenSys Quorum case study

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Blockchain(Research and Applications) 2022年第1期3卷 1-12页

作者： marco Mazzoni antonio Corradi Vincenzo Di Nicola Conio Inc. c/o The Orrick Building405 Howard StreetSan FranciscoCA94105USA Department of Computer Science and Engineering University of BolognaViale Risorgimento 2BolognaItaly

Given the availability of several blockchain technologies in permissioned contexts,blockchain application designers have to cope with the increasing complexity of choosing which technology and consensus algorithm best fit a specific use ***,the lack of a standard framework allowing to assess the scalability of permissioned blockchain platforms and to compare performances and features of consensus algorithms makes the development of a sensible evaluation a costly and difficult time-consuming *** this article,we propose a practical scalability and applicability evaluation of the Quorum blockchain and its consensus *** we apply our evaluation workflow to a financial use case,we define a methodology that can be generalized to any permissioned blockchain *** leverage Hyperledger Caliper as a benchmarking tool,and Docker as a deployment tool,making our analysis easy to be repeated,cross-platform,and cost-effective.

关键词： Blockchain Consensus Benchmark Quorum Cryptocurrency