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CSEE Journal of Power and Energy Systems 2024年第1期10卷 292-301页

作者： Qing-Chang Zhong marcio Stefanello Department of Electrical and Computer Engineering Illinois Institute of TechnologyChicagoIL 60616USA Syndem LLC USA.M.Stefanello is with the Fundacao Universidade Federal do Pampa at AlegreteRS97546-550Brazil

In this paper,a compact mathematical model having an elegant structure,together with a generic control framework,are proposed for generic power systems dominated by power converters that are interconnected through a passive transmission and distribution(T&D)grid,by adopting the port-Hamiltonian(pH)systems theory and the fundamental circuit *** models of generic T&D lines are developed and then the model of a generic T&D grid is *** the proposed control framework,the controlled converters are proven to be passive and Input-to-State Stable(ISS).The compact mathematical model is scalable and can be applied to power systems with multiple power electronic converters with generic passive controllers,passive local loads,and different types of passive T&D lines connected in a meshed configuration without self-loops,so it is very ***,the resulting power system is proven to be ISS as *** analysis is carried out without assumptions on constant frequency/voltage,constant loads,and/or lossless networks,except the need of passivity for all parts involved,and without using the Clarke/Park transformations or the graph *** simplify the presentation,three-phase balanced systems are adopted but the results can be easily adapted for single-phase or unbalanced three-phase systems.

关键词： Input-to-State Stable(ISS) passivity,portHamiltonian(pH)systems Power electronic converters dominated power systems Synchronized and Democratized(SYNDEm)grid architecture

Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples

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Journal of Pharmaceutical Analysis 2018年第2期8卷 103-108页

作者： Luciana F.A.Romani maria I.Yoshida Elionai C.L.Gomes Renes R.machado Felipe F.Rodrigues marcio m.coelho marcelo A.Oliveira maria B.Freitas-marques Rosane A.S.San Gil Wagner N.mussel Department of Chemistry Institute of Exact Sciences Federal University of Minas Gerais Department of Pharmaceutical Products Faculty of Pharmacy Federal University of Minas Gerais Health Science Department Federal University of Espírito Santo Campus Sao Mateus Institute of Chemistry Federal University of Rio de Janeiro Campus Fundao

meloxicam(mLX) is an anti-inflammatory drug susceptible to variations and crystalline transitions. In compounding pharmacies, the complete crystallographic evaluation of the raw material is not a routine procedure. We performed a complete crystallographic characterization of aleatory raw mLX samples from compounding pharmacies. X-ray diffraction indicated the presence of two crystalline forms in one sample. DSC experiments suggested that crystallization, or a crystal transition, occurred differently between samples. The FTIR and ~1H NmR spectra showed characteristic assignments.^(13)C solid-state NmR spectroscopy indicated the presence of more than one phase in a sample from pharmacy B. The Hirshfeld surface analysis, with electrostatic potential projection, allowed complete assignment of the UV spectra in ethanol solution. The polymorph I of meloxicam was more active than polymorph III in an experimental model of acute inflammation in mice. Our results highlighted the need for complete crystallographic characterization and the separation of freely used raw materials in compounding pharmacies,as a routine procedure, to ensure the desired dose/effect.

关键词： meloxicam Polymorphism Hirshfeld surface Anti-inflammatory activity

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 97-104页

作者： mihai A.Bentan Evan R.Reiter Richard m.Costanzo Daniel H.coelho Department of Otolaryngology-Head&Neck Surgery Virginia Commonwealth University School of MedicineRichmondVirginiaUSA

Objective:The aim of this study was to review findings from a large prospective national database of chemosensory disturbances associated with coronavirus disease 2019(COVID-19)*** Sources:The Virginia Commonwealth University Smell and Taste Center national database of COVID-19 chemosensory ***:A series of online surveys,first opened on April 10,2020,was made accessible nationwide to any adult with sudden chemosensory dysfunction since January *** received subsequent follow-up surveys 14 days,1 month,3 months,and 6 months after *** additional survey was sent to all participants on may 28,2022 to assess long-term *** pertaining to demographics,symptoms,comorbidities,treatments,and life impact was ***:Of 363 participants who reported complete smell recovery,51.2%recovered within 1 month,70%within 3 months,and 79%within 6 months,while 8.8%took over 1 year to completely *** all participants,7.5%had no smell *** predictors of recovery included agemale gender,and the presence of nasal *** predictors included difficulty breathing and prior head *** participants reported a decrease in quality of life and the presence of potential safety hazards associated with decreased smell ***:most subjects with COVID-19-related chemosensory dysfunction recover,with the majority noting complete recovery within weeks of *** aged over 40 years and female gender were associated with lower rates of recovery.A considerable number of participants reported significant impact on quality of life and safety.

关键词： anosmia COVID-19 smell

Twisted and Absolute Degrees of maps into the Projective Plane

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Acta mathematica Sinica,English Series 2024年

作者： marcio Colombo FENILLE Daciberg Lima GON?ALVES Universidade Federal de Uberlandia – Instituto de matemática e Estatística.Av.Jo?o Naves deávila 2121 Santa M?nica Universidade de S?o Paulo – Instituto de matemática e Estatística.Rua do mat?o 1010 Cidade Universitária

For each based map f : X → RP2from a closed surface into the real projective plane, we compute its absolute and twisted degrees and describe the action of the fundamental group of RP2over the based homotopy class of f. We emphasize the finding that for any nonorientable closed surface,there exists only one based homotopy class of maps from it into RP2whose maps have twisted degree zero and absolute degree nonzero – which shows that, unlike the absolute degree, the twisted degree is not able to detect the strong surjectivity in this setting. In all the other scenarios, the absolute degree of each map is either equal to the twisted degree or its absolute value – and so the twisted degree detects strong surjectivity.

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Obtaining 2D Soil Geotechnical Profiles from Cokriging Interpolation of Sample Data and Electrical Resistivity Tomography (ERT)—Applications in mass movements Studies

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International Journal of Geosciences 2024年第7期15卷 525-548页

作者： Cassiano Antonio Bortolozo Noel Howley Andy Legg Tristan Pryer Danielle Silva de Paula Tatiana Sussel Gonçalves mendes Daniel metodiev marcio Roberto magalhães de Andrade Silvio Jorge coelho Simões maiconn Vinicius de moraes marcio Augusto Ernesto de moraes Luana Albertani Pampuch Rodolfo moreda mendes Harideva marturano Egas Institute of Science and Technology So Paulo State University (UNESP) So Jos dos Campos Brazil Cemaden-National Center for monitoring and Early Warning of Natural Disasters General Coordination of Research and Development So Jos dos Campos Brazil Institute for mathematical Innovation University of Bath Bath UK Department of mathematical Sciences University of Bath Bath UK

Brazil annually faces significant challenges with mass movements, particularly in areas with poorly constructed housing, inadequate engineering, and lacking sanitation infrastructure. Campos do Jordão, in São Paulo state, is a city currently grappling with these issues. This paper details a study conducted within a pilot area in Campos do Jordão, where geophysical surveys and geotechnical borehole data were integrated. The geophysical surveys provided 2D profiles, and samples were collected to analyse soil moisture and plasticity. These datasets were combined using a Cokriging-based model to produce an accurate representation of the subsurface conditions. The enhanced modelling of subsurface variability facilitates a deeper understanding of soil behavior, which can be used to improve landslide risk assessments. This approach is innovative, particularly within the international context where similar studies often do not address the complexities associated with urban planning deficits such as those observed in some areas of Brazil. These conditions, including the lack of proper sanitation and irregular housing, significantly influence the geological stability of the region, adding layers of complexity to subsurface assessments. Adapting geotechnical evaluation methods to local challenges offers the potential to increase the efficacy and relevance of geological risk management in regions with similar socio-economic and urban characteristics.

关键词： mass movements Geophysics ERT Geotechnical Surveys Campos do Jordão Cokriging

Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J m Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo mario Reis Alvares-da-Silva Roberta C marchiori Cleber Rosito Pinto Kruel marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each HCC nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

Feasibility of performing the 3-minute step test with remote supervision in children and adolescents with cystic fibrosis: A comparative study

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Pediatric Investigation 2024年第2期8卷 83-90页

作者： Fernanda maria Vendrusculo Gisele Apolinario da Costa maria Amelia Bagatini Brenda maria Henrique maia Lemes Carolina Aguiar Faria Larissa Carvalhaes de Oliveira Evanirso da Silva Aquino marcio Vinicius Fagundes Donadio Laboratory of Pediatric Physical Activity Infant CenterPontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto AlegreBrazil Hospital Infantil Joao Paulo II-Fundacao Hospitalar do Estado de minas Gerais(FHEmIG) Belo HorizonteBrazil Departament of Physiotherapy Pontificia Universidade Catolica de Minas Gerais(PUCMG)-Campus BetimBetimBrazil Department of Physiotherapy Faculty of Medicine and Health SciencesUniversitat Internacional de Catalunya(UIC)BarcelonaSpain

Importance:The 3-min step test is a simple option to monitor submaximal exercise capacity,although its use via remote video monitoring has not been investigated in children with cystic fibrosis(CF).Objective:This study aimed to assess the feasibility and reproducibility of performing the 3-min step test with remote ***:A cross-sectional study including CF patients(6-18 years)from two CF services were ***,anthropometric,clinical,and lung function data were collected and two 3-min step tests were performed:(i)in-person supervision,and(ii)remotely supervised by video *** and after the tests,heart rate(HR),oxygen saturation(SpO2),and the Borg score for dyspnea and lower limb fatigue were ***:Twenty-three patients(10.7±3.7 years)with a mean FEV1 of 89.5%±23.2%were *** were no significant differences between tests,with mean differences(95%confidence intervals)in final HR of-3.3(-8.9,2.4),change in HR of-1.9(-6.1,2.1),final SpO2 of 0.3(-0.4,1.0),and final dyspnea of 0.1(-0.8,0.9).The intraclass correlation coefficient was 0.852(final HR),0.762(final SpO2),and 0.775(final lower limb fatigue).Significant and moderate correlations were found between tests for final HR(r=0.75),change in HR(r=0.61),and final SpO2(r=0.61).The Bland-Altman analysis showed a mean difference in final SpO2 between tests of 0.3%(limit of agreement-3.0%,3.5%).Interpretation:Physiological responses between tests were similar,indicating it was feasible to perform the 3-min step test with remote supervision in CF children.

关键词： Children Cystic fibrosis Exercise test Telehealth

The effect of non-pharmaceutical interventions on COVID-19 outcomes:A heterogeneous age-related generalisation of the SEIR model

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Infectious Disease modelling 2023年第3期8卷 742-768页

作者： Jorge m.mendes Pedro S.coelho NOVA Information management School(NOVAImS) Universidade Nova de LisboaCampus de Campolide1070-312LisbonPortugal NOVA Cairo at the Knowledge Hub Universities New Admnistrative CapitalCairoEgypt

Successive generalisations of the basic SEIR model have been proposed to accommodate the different needs of the organisations handling the SARS-CoV-2 epidemic and the assessment of the public health measures adopted and named under the common um-brella of Non-Pharmaceutical Interventions(NPIs).So far,these generalisations have not been able to assess the ability of these measures to avoid infection by the SARS-CoV-2 and thus their contribution to contain the spread of the *** work proposes a new generalisation of SEIR model and includes a heterogeneous and age-related generation of infections that depends both on a probability that a contact generates the transmission of the disease and a contact *** results show(1)thanks to the universal wearing of facial coverings,the probability that a contact provokes the transmission of the disease was reduced by at least 50%and(2)the impact of the other NPI is so significant that otherwise Portugal would have gone into a non-sustainable situation of having 80%of its population infected in the first 300 days of the *** situation would have led to a number of deaths almost twenty times higher than the number that was actually recorded by December 26th,***,the results suggest that even if the requirement of universal wearing of facial coverings was adopted sooner jointly with closing workplaces and resorting to teleworking would have postponed the peak of the incidence,altought the epidemic path would have result in a number of infections hardly managed by the National Health ***,results confirm that(3)the health authorities adopted a conservative approach on the criteria to consider an infected individual not infective any longer;and(4)the most effective NPIs and stringency levels either impacting on self-protection against infection or reducing the contacts that would eventually result in infection are,in decreasing order of importance,the use of Facial coverings,Workplace clos

关键词： eventually otherwise string

Recycling of spent lithium-ion batteries as a sustainable solution to obtain raw materials for different applications

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Journal of Energy Chemistry 2023年第4期79卷 118-134页

作者： V.m.Leal J.S.Ribeiro E.L.D.coelho m.B.J.G.Freitas Federal University of Espírito Santo Department of ChemistryLaboratory of Electrochemistry and ElectrochemistryAv.Fernando Ferrari514VitóriaES 29075-910Brazil

Lithium-ion batteries(LIBs)containing graphite as anode material and LiCoO_(2),Limn_(2)O_(4),and LiNi_(x)mn_(y)Co_(z)O_(2) as cathode materials are the most used worldwide because of their high energy density,capacitance,durability,and ***,such widespread use implies the generation of large amounts of electronic *** is estimated that more than 11 million ton of LIBs waste will have been generated by *** recycling can contribute to minimizing environmental contamination and reducing production costs through the recovery of high-value raw materials such as lithium,cobalt,and *** most common processes used to recycle spent LIBs are pyrometallurgical,biometallurgical,and *** the current scenario,it is necessary to develop environmentally friendly methods to recycle batteries and synthesize materials with multiple technological *** study presents a review of industrial and laboratory processes for recycling spent LIBs and producing materials that can be used in new batteries,energy storage devices,electrochemical sensors,and photocatalytic reactions.

关键词： Li-ion batteries Recycling Cathode Battery Hydrometallurgical Pyrometallurgical

Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： Joana menino Pedro Camacho Andrécoelho Escola Superior de Tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TRC-Health&Technology Research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama Pinto Lisbon 1150-255Portugal

AIm:To determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:This retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:This study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence