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World Journal of Clinical Cases 2016年第11期4卷 356-363页

作者： Isadora Luana Flores Alan Roger Santos-Silva Ricardo Della Coletta Adriana Franco Paes Leme marcio ajudarte lopes Oral Diagnosis Department Piracicaba Dental SchoolUniversity of Campinas(UNICAMP) Mass Spectrometry Laboratory Brazilian Biosciences National Laboratory (LNBio)

AIM To elucidate the profile of the salivary *** Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia(PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach,followed by analyses of variance and logistic regression *** A total of two hundred and eighty-three proteins were confidently identified in *** combining two low abundance proteins from the PVL group,angiotensinogen(AGT) and dipeptidyl peptidase 1(DPP1),a model for group differentiation was built with a concordance index of 94.2%,identifying both proteins as potential etiologic biomarkers for *** This study suggests that both AGT and DPP1 may be involved in developmental mechanisms of PVL.

关键词： Saliva Angiotensinogen Dipeptidyl peptidase 1 Biomarkers Proliferative verrucous leukoplakia LC-MS/MS

Clinical and radiographic features of Hutchinson-Gilford progeria syndrome: A case report

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World Journal of Clinical Cases 2014年第3期2卷 67-71页

作者： Daniel Berretta Alves Juliana Melo Silva Tatiany Oliveira Menezes Rosely Santos Cavaleiro Fabrício Mesquita Tuji marcio ajudarte lopes Alexandre Augusto Zaia Ricardo Della Coletta Department of Radiology Esperanca Institute of Higher Learning Santarém-Pará 68040-100 Brazil Department of Endodontics Federal University of Pará Belém-Pará 66055-240 Brazil Department of Dentistry for Patients with Special Needs Federal University of Pará Belém-Pará 66055-240 Brazil Department of Oral and Maxillofacial Pathology Federal University of Pará Belém-Pará 66055-240 Brazil Department of Oral Diagnosis School of Dentistry State University of Campinas Piracicaba-Sao Paulo 13083-970 Brazil Department of Restorative Dentistry School of Dentistry State University of Campinas Piracicaba-Sao Paulo 13083-970 Brazil

Hutchinson-Gilford progeria syndrome(HGPS) is a rare dysmorphic syndrome characterized by several features of premature aging with clinical involvement of the skin, bones, and cardiovascular system. HGPS has an estimated incidence of one in four million to one in eight million births. The main clinical features of HGPS include short stature, craniofacial dimorphism, alopecia, bone fragility, and cardiovascular disorders. The most frequent cause of death is myocardial infarction at a mean age of 13 years old. Dental manifestations include delayed development and eruption of teeth, discoloration, crowding and rotation of teeth, and displaced teeth. Cone beam computed tomography images revealed the absence of the sphenoid, frontal, and maxillary sinus, flattening of the condyles and glenoid fossa, and bilateral hypoplasia of the mandibular condyles. The disease is caused by mutations in lamin A/C(LMNA). Here, we present a case report of an 11-year-old boy with classical features of HGPS, which was caused by a de novo germ-line mutation(C1824T, G608G) in exon 11 of the LMNA gene. Some uncommon HGPS-associated features in our patient, such as alterations in the facial sinuses and hypoplasia of the condyles, contributed to the expansion of the phenotypic spectrum of this syndrome from a dentomaxillofacial perspective.

关键词： Cone beam computed tomography LMNA mutation Craniofacial anomalies Temporomandibular joint

Proliferative verrucous leukoplakia may initially mimic lichenoid reactions

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World Journal of Clinical Cases 2015年第10期3卷 861-863页

作者： marcio ajudarte lopes Patricia Feio Alan Roger Santos-Silva Pablo Agustin Vargas Oral Diagnosis Department Semiology and Oral PathologyPiracicaba Dental SchoolState University of Campinas(UNICAMP)PiracicabaSao Paulo 13083-970Brazil

Proliferative verrucous leukoplakia is an intriguing disease, which occurs particularly in women aged greater than 60 years, is not associated with tobacco and alcohol, and has a high risk of recurrence and malignant transformation. Although it is well known that the typical presentation is characterized by multifocal and verrucous white lesions, there is no description that its initial clinical presentation may simulate a lichenoid reaction.

关键词： Proliferative verrucous leukoplakia Lichenoid reactions Diagnosis

Evaluation of the regional distribution of the pediatric surgery workforce and surgical load in Brazil

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World Journal of Pediatric Surgery 2023年第2期6卷 85-91页

作者： Joaquim Bustorff-Silva marcio lopes Miranda Amanda Rosendo Ayla Gerk Antonio Goncalves Oliveira-filho Pediatric Surgery State University of Campinas Medical SchoolCampinasBrazilPediatric SurgeryState University of Campinas Medical SchoolCampinasBrazil Medicine Pontificia Universidad Católica ArgentinaBuenos AiresArgentina

Objective The purpose of this study is to examine the regional distribution of the pediatric surgery workforce and the expected local demand for pediatric surgical procedures in *** We collected data on the pediatric surgical workforce,surgical volume,Gross Domestic Product per capita,and mortality for gastrointestinal tract malformations(MGITM)across the different regions of Brazil for *** Data from the Federal Medical Council reported 1515 pediatric surgery registries in Brazil,corresponding to 1414 pediatric surgeons(some pediatric surgeons are registered in more than one state),or 2.4 pediatric surgeons per 100000 children 14 years of age and *** were 828 men and 586 *** mean age was 51.5±12.8 years,and the mean time from graduation was 3.4±5.7 *** is a higher concentration of pediatric surgeons in the wealthier Central-West,South,and Southeast *** surgical volume ranged from 88 to 245 operations/year(average 146 operations/year)depending on the *** these,only nine(6.1%)were high-complexity(including neonatal)*** tended to be higher in the poorer North and Northeast regions than in other regions of *** Our findings suggest significant disparities in the surgical workforce and workload across Brazil related to socioeconomic *** with an increased surgical workforce were associated with lower *** average number of complex operations performed annually by each pediatric surgeon was considerably *** investment and well-defined health policies are imperative to enhance the quality of surgical care in the different regions of Brazil.

关键词： pediatric operations distribution

The Role of Natural and Human-Mediated Pathways for Invasive Agricultural Pests:A Historical Analysis of Cases from Brazil

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Agricultural Sciences 2014年第7期5卷 634-646页

作者： Marcelo lopes-da-Silva marcio Martinello Sanches Andrea Ramos Stancioli Giliardi Alves Regina Sugayama Plant Quarantine Laboratory Embrapa Genetic Resources and BiotechnologyBrazilian Agricultural Research Corporation(Embrapa)BrasiliaBrazil Agropec Pesquisa Extensao e ConsultoriaBelo HorizonteBrazil

Information about the geographic distribution of agricultural pests is the basis for all pest-related agricultural and environmental protection policies. However, often the pest’s records are incomplete and uncertain. Even with limitations, the pest records are needed for any country to organize a system for agriculture protection and to mobilize surveillance efforts. The first point is to identify the imminence of biological invasions, which can be accomplished through the collection of data on pest distribution. The basic information to evaluate the predictability of an invasion is geographic distribution and the identification of pathway types associated with the potential invader. Thus, the level of the risk of introduction is assessed more objectively. In this article, cases of introduction of pests were analyzed from published reports in Brazil in terms of their geographic distribution at the time of their introduction. Taking into consideration the country’s extensive terrestrial borders, this study attempts to elucidate the role played by different pathways in each bioinvasion. This analysis recognized the limitations of the historical method and underlying uncertainties of each invasion event. Human-mediated pathways were the main source of agricultural pest invasions in Brazil and the country was more a disperser than a receptor of exotic agricultural pests and diseases in South America. A new geographical hotspot (Northern South America and Caribbean Region) for possible invasions was identified.

关键词： Bioinvasions Biosecurity Surveillance Borders Dispersion Invasion Biology Risk Analysis

Stable Isotopes Studies in the Urucu Oil Province, Amazon Region, Brazil

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Journal of Water Resource and Protection 2015年第3期7卷 131-142页

作者： Eliene lopes de Souza Paulo Galvao Roseli de Almeida Cleane Pinheiro Marcus Baessa marcio Cabral Institute of Geosciences Federal University of Pará (UFPA) Belém Brazil Institute of Geosciences University of Sao Paulo Sao Paulo Brazil Institute of Environment and Spatial Planning of the State of Amapá (IMAP) Macapá Brazil Leopoldo Américo Miguez de Mello Center for Research and Development (CENPES) Rio de Janeiro Brazil

The study area is the Urucu Oil Province, Municipality of Coari, State of Amazonas, Brazil. This research represents a contribution to the hydrogeological knowledge in the northern region of Brazil, particularly in the central part of the Amazon rainforest, where researches on isotopic are still incipient. The primary goal was to determine, by stable isotopes 18O and 2H measurements, interrelationships between surface water and groundwater, in order to understand the origin and mechanisms of groundwater recharge and discharge. For this, samples of rainwater, superficial water and groundwater were collected between June 2008 and May 2009 for stable isotopic analyzes. This understanding is important in cases of eventual contaminations of the area, which could degrade the water resources. The results show that the superficial waters are typically light waters and have meteoric origin, and the groundwater recharge is by direct rainfall infiltration with primary evaporation before reaching the groundwater table in the Icá-Solimoes Aquifer System. The isotopic signatures similarities between groundwater and superficial waters indicate both waters’ contributions in the streams and, therefore, in the Urucu river.

关键词： Stable Isotopes Hydrogeology Water Management Surface Water Groundwater

Predictors of surgical complications in boys with hypospadias:data from an international registry

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World Journal of Pediatric Surgery 2023年第4期6卷 217-223页

作者： Kathryn Scougall Jillian Bryce Federico Baronio Rachel L Boal Jose Roberto Castera Sebastián Castro Tim Cheetham Eduardo Correa Costa Feyza Darendeliler Justin H Davies Mirjam Dirlewanger Gabriella Gazdagh Evgenia Globa Gil Guerra-Junior Tulay Guran Gloria Herrmann Paul-Martin Holterhus Ahsen KaragözlüAkgül Renata Markosyan Kenneth McElreavey marcio lopes Miranda Anna Nordenstrom Stuart O’Toole Sukran Poyrazoglu Gianni Russo Valerie Schwitzgebel Marianna Stancampiano Michael Steigert S Faisal Ahmed Angela K Lucas-Herald University of Glasgow GlasgowUK IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola BolognaItaly Great North Children's Hospital Newcastle Upon TyneUK Hospital de Ninos Ricardo Gutiérrez Buenos AiresArgentina Hospital de Clinicas de Porto Alegre Porto AlegreBrazil Istanbul University IstanbulTurkey Southampton Children's Hospital SouthamptonUK University Hospital of Geneva GenevaSwitzerland Ukrainian Research Center of Endocrine Surgery Endocrine Organs and Tissue Transplantation KyivUkraine State University of Campinas CampinasBrazil Marmara University IstanbulTurkey University Medical Centre UlmGermany University Hospital of Schleswig-Holstein Campus Kiel/Christian-Albrechts-University of Kiel KielGermany Marmara University Faculty of Medicine IstanbulTurkey Yerevan State Medical University Endocrinology Clinic YerevanArmenia Institut Pasteur ParisFrance Karolinska University Hospital StockholmSweden Royal Hospital for Children GlasgowUK IRCCS Ospedale San Raffaele MilanoItaly Graubunden Cantonal Hospital ChurSwitzerland

Background Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their *** Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development(l-DSD)*** regressions,fisher's exact tests and spearman's correlation tests were performed on the data to assess associations between clinical factors and complication *** Of the 551 eligible boys,data were available on 160(29%).Within the cohort,the median(range)External Masculinization Score(EMS)was 6(2,9).All presented with one or more additional genital malformation and 61(38%)presented with additional extragenital *** of androgen action,androgen synthesis and gonadal development were diagnosed in 28(18%),22(14%)and 9(6%)boys,*** remaining 101(62%)patients were diagnosedas having non-specific 46,XY Disorders of Sex ***(50%)boys had evidence of abnormal biochemistry,and gene variants were identified in 42(26%).Median age at first hypospadias surgery was 2 years(0,9),and median length of follow-up was 5 years(0,17).Postsurgical complications were noted in 102(64%)*** were no significant associations with postsurgical *** Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative *** clinical factors were significantly associated with complication *** complication rates with no observable cause suggest the involvement of other factors which need investigation.

关键词： complications surgical involvement