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The influence of porosity on tablet subdivision

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Particuology 2020年第6期18卷 192-196页

作者： Maira T.Teixeira Livia L.Sa-Barreto Izabel C.Silva Tais Gratieri Guilherme M.Gelfuso Ricardo N.Marreto Mariana Landin marcilio cunha-filho Laboratory of Food Drugs and Cosmetics(LTMAC)University of Brasilia(UnB)70910-900 BrasiliaDFBrazil Laboratory of Nanosystems and Drug Delivery Devices(NanoSYS) Federal University of GoiasGoianiaGO.Brazil Departamento de Farmacologia Farmacia y Tecnologia Farmaceutica1+D Farma Group(Gl-1645)Universidade de Santiago de CompostelaSpain

A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical ***,tablet subdivisions were studied as a functi on of tablet *** tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose ***,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of *** assays were corre lated to the subdivision performs *** increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the *** all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision *** in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision *** trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

关键词： Tablet subdivision Porosity Mass variation Mass loss Friability Hardness

A new heparin fragment decreases liver ischemia-reperfusion injury

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 190-192页

作者： Enio R Vasques Estela RR Figueira Joel A Rocha-filho Cinthia Lanchotte Jorge LS Ximenes Helena B Nader Ivarne LS Tersariol Marcelo A Lima Tiago Rodrigues JoséEM cunha Eleazar Chaib Luiz AC D’Albuquerque Flávio HF Galvão Laboratorio de Investigaçao Medica 37 Departamento de GastroenterologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246-903Brazil Departamento de Gastroenterologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil Disciplina de Anestesiologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil Departamento de Bioquimica Universidade Federal de São PauloSão PauloBrazil Universidade Federal do ABC Santo AndreSão PauloBrazil Serviço de Transplante de Figado e Orgaos do Aparelho Digestivo Departamento de GastroenterologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão PauloBrazil

To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan *** calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (TD),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca^(2+),showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1].

关键词： irreversible heparin injury

Effects of a 12-Week Recreational Soccer Program on Resting Metabolic Rate Among Adolescents with Obesity

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Journal of Science in Sport and Exercise 2023年第3期5卷 218-225页

作者： Isabela F.Soares Felipe A.cunha Fabrício Vasconcellos Graduate Program in Exercise Science and Sports University of Rio de Janeiro StateRio de JaneiroBrazil Laboratory of Physical Activity and Health Promotion Institute of Physical Education and SportsUniversity of Rio de Janeiro StateRua São Francisco Xavier 524/sala 8121F-MaracanãRio de JaneiroRJ CEP:20550-013Brazil

Objectives The purpose of this study was to investigate the chronic effects of a 12-week recreational soccer program(RSP)on resting metabolic rate(RMR)in adolescents with *** Eighteen adolescents with obesity were assigned to RSP[n=10,age=13.8±1.5 years,body mass index(BMI)=30.7±5 kg/m^(2)]and control(n=8,age=14.9±1.4 years,BMI=32.5±4.1 kg/m^(2))*** underwent anthropometric,body composition,cardiorespiratory fitness and RMR assessments at baseline and *** 12-week RSP consisted of small-sided games with 60-min performed 3 times per *** Post-intervention,between-group differences due to RSP emerged for body mass(Δ:−15.1 kg,P=0.043),BMI(Δ:−4.7 kg,P=0.05),waist and hip circumferences(Δ:−14.6 and−16.6 cm,P=0.015 and P=0.017,respectively),fat mass(Δ:−8.7 kg,P=0.049)and VO2max(Δ:5.5 mL/kg/min,P=0.013).No significant differences were detected for the absolute and adjusted RMR for fat mass and fat-free mass at baseline and after 12 weeks for both RSP and control groups,although a marked downward trend of 27.6%for adjusted RMR was observed post-control(1915 vs.1386 kcal/day;Δ:−529 kcal/day).Conclusion A 12-week RSP was effective for improving anthropometric,body composition and cardiorespiratory fitness health markers in adolescents with obesity,but not for RMR.

关键词： Basal metabolism Energy expenditure Calorimetry Exercise training Body mass

Uniformity of Precipitation and Radial Profile of the Super 10 Sprinkler at Different Operating Pressures

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Journal of Water Resource and Protection 2014年第11期6卷 951-960页

作者： Paulo Eduardo S.Martins Elcides R.da Silva Juan Gabriel C.L.Ruiz Gustavo R.Barbosa Jose Renato Zanini marcilio V.Martins filho Centro Universitário de Patos de Minas Patos de MinasBrazil Instituto Taquaritinguense de Ensino Superior TaquaritingaBrazil Sao Paulo State University JaboticabalBrazil

The study aimed to evaluate the effect of operating parameters of the sprinkler Super 10, manufactured by NaanDanJain, with green, yellow and blue nozzles on the hydraulic characterization, so that this information can contribute to a better dimensioning of systems and management of irrigated areas. For the determination of UC and UD the radial method was used and with the aid of computer application CATCH 3D the overlapping of water slides with ten spacings was calculated. The results demonstrate that the mechanism used for the fractionation of the water jet of sprinkler Super 10 is efficient because it presented good uniformity of water distribution and low amplitude of precipitation. For high uniformity of distribution of water in the larger wetting radii, it is recommended to work with Super 10 sprinkler using the green nozzle, with a pressure of 40 mH2O and spacing between sprinklers and lateral lines 12 × 12 m.

关键词： Hydraulic Performance Uniformity Irrigation Water Distribution Profile

A Proof-of-Concept Assessment of the Safety and Efficacy of Intralesional Diclofenac in the Treatment of Cutaneous Neurofibromas

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International Journal of Clinical Medicine 2015年第12期6卷 975-983页

作者： Mauro Geller Aguinaldo Bonalumi filho Lisa Oliveira Allan ERubenstein Luiz Guilherme Darrigo Jr David Azulay Allan Bernacchi Marcia Goncalves Ribeiro Karin Soares Goncalves cunha Immunology Department Fundacao Educacional Serra dos Orgaos(UNIFESO)TeresopolisBrazil Clinical Immunology Instituto de Pos-Graduacao Medica Carlos Chagas(IPGMCC)Rio de JaneiroBrazil Medical Genetics Service IPPMG-Universidade Federal Rio de JaneiroRio de JaneiroBrazil Hospital Naval marcilio Dias Rio de JaneiroBrazil Sociedade Evangelica Beneficiente de Curitiba Outpatient Unit CuritibaBrazil NYU Langone Medical Center New YorkNYUSA Bone Marrow Transplant Unit Hospital das Clinicas da Faculdade de Medicina de Ribeirao PretoUniversidade de Sao Paulo(USP)Ribeirao PretoBrazil Pontifica Universidade Catolica do Rio de Janeiro(PUC-RJ) Rio de JaneiroRJBrazil Plastic Surgery Post-Graduation PUC-RJRio de JaneiroBrazil 1 Universidade Federal Fluminense(UFF) Rio de JaneiroBrazil

The objectives of this study were to assess the safety and efficacy of intralesionally administered diclofenac in the treatment of cutaneous neurofibromas in patients with NF1. This was a proof-of-concept, prospective, safety and efficacy study of the effect of intralesionally administered diclofenac 25 mg/ml given once a week to 3 target cutaneous neurofibromas for 4 consecutive weeks. Overall, there was no significant change in neurofibroma size. During the study, some treated lesions developed signs of necrosis and fell off after a few weeks, but none of the control neurofibromas fell off. There were no significant changes in patient’s vital signs. A few adverse events occurred, mostly at the injection sites. During the study, some neurofibromas developed necrosis after the diclofenac injections and eventually detached from the patient. Overall, diclofenac was well tolerated, suggesting minimal systemic exposure, which required confirmation and further studies, including bioavailability analysis.

关键词： Neurofibromatosis Type 1 Cutaneous Neurofibromas Diclofenac Sodium

Comparison of Two Protocols of Agar Gel Immunodiffusion(AGID)Used to Diagnose of Equine Infectious Anemia(EIA)

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Open Journal of Veterinary Medicine 2015年第7期5卷 169-174页

作者： Maria do Rosario Oliveira da cunha Beltrao Cid Aristoteles de Siqueira Alencar Adriana Soares Leite Leonardo Tavares Freitas Julianne Cortizo Gonzalez Vania Lucia de Assis Santana Helio Cordeiro Manso-filho Department of Veterinary Medicine Federal Rural University of PernambucoRecifeBrazil National Animal and Plant Laboratory Ministry of AgricultureLivestock and Food SupplyRecifeBrazil

The aim of the present study was to compare two protocols of Agar Gel Immunodiffusion (AGID) that can be used to diagnose Equine Infectious Anemia (EIA). Different volumes of reagents and support for agar gel were used, as recommended by the Ministry of Agriculture, Livestock and Food Supply (MAPA) and the World Organization for Animal Health (OIE). Equidae sera samples (n = 1000) were tested using a national commercial kit and different volumes (i.e. 25 μL—MAPA and 50 μL—OIE) of reagents and standard sera. Antigen was used as recommended by MAPA. The results were assessed by two operators, 48 hours after beginning the test. At the end of the experiment, a Kappa index of 1 was obtained by the operators, for the interpretation of the results and for the different volumes of reagents used. Similar results of agreement (Kappa index = 1) were obtained when using slides or Petri dishes as support for the agar gel. In both cases, an almost perfect agreement was achieved, suggesting that the use of different supports does not affect the results. These findings indicate that both protocols (MAPA and OIE) can be used to diagnose EIA.

关键词： Horses Equids EIA Diagnosis AGID Serology

Piezomagnetic vibration energy harvester with an amplifier

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Theoretical & Applied Mechanics Letters 2023年第6期13卷 481-483页

作者： João Pedro Norenberg Americo cunha Jr Piotr Wolszczak Grzegorz Litak Department of Mechanical Engineering São Paulo State UniversityIlha SolteiraSPBrazil Department of Applied Mathematics Rio de Janeiro State UniversityRio de JaneiroRJBrazil Department of Automation Lublin University of TechnologyLublinPoland

We study the effect of an amplification mechanism in a nonlinear vibration energy harvesting system where a ferromagnetic beam resonator is attached to the vibration source through an additional linear spring with a *** beam moves in the nonlinear double-well potential caused by interaction with two *** piezoelectric patches with electrodes attached to the electrical circuit support mechanical energy transduction into electrical *** results show that the additional spring can improve energy *** changing its stiffness,we observed various *** the point of the optimal stiffness of the additional spring,the power output is amplified a few times depending on the excitation amplitude.

关键词： Nonlinear energy harvesting Piezoelectric Displacement amplifier Bistable potential

Diabetes Mellitus and Diabetic Peripheral Neuropathy

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Open Journal of Endocrine and Metabolic Diseases 2017年第1期7卷 12-21页

作者： Lídia Karla Martinho Bruschi Dayvson Araújo da Rocha Eusínio Lavigne Gesteira filho Nathália de Moura Pancoti Barboza Poliana Aparecida Bresciane Frisanco Raquel Milanesi Callegaro Larissa Bianca Paiva cunha de Sá Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School S&atilde o Paulo Brazil Diabetology Department Malteser Krankenhaus St. Franziskus-Hospital Flensburg Germany

Diabetes mellitus (DM) is considered a major public health problem because of its high prevalence and progressive increase of incidence. DM chronic complications are major causes of morbidity and mortality, among which diabetic neuropathy (DN) stands out, affecting 30% - 50% of DM patients. An appropriate medical approach, involving anamnesis and thorough clinical examination, is extremely important for the early diagnosis of DN and, therefore, to the prevention of its complications, including the amputation of limbs. Despite of the importance of DN prevention and treatment, in order to provide improved quality of life and longevity to DM patients, current therapeutic options are very limited with respect to both symptom control and as effective disease therapies. Intensive glucose control is extremely important in order to prevent and avoid the progression of DN, as demonstrated in two large multicenter studies involving patients with type 1 DM, the DCCT (Diabetes Control and Complications Trial) and the EDIC (Epidemiology of Diabetes Interventions and Complications).

关键词： Diabetes mellitus Diabetic Peripheral Neuropathy Diabetic Foot Diabetes and Complications

Case Report: Clinical and Diagnostic Aspects of Mayer-Rokitansky-Kuster-Hauser Syndrome

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Health 2019年第10期11卷 1367-1372页

作者： Lucas Ferreira de Paula filho Guilherme Carolino Neves Laís Figueira Bandoli Lucas Caraline de Almeida Coelho Nathália de Souza Ferreira Feital Renan Vieira Murad Ana Luísa Conceiç o de Jesus Diana Aristótelis de Sá Larissa Bianca cunha de Sá Jonathan Mwambire Alberto Krayyem Arbex IPEMED Medical School/AFYA Educational Postgraduation in Endocrinology Rio de Janeiro Brazil UNIFESO Medical School Teresópolis Brazil Department of Pediatrics Medical School University of So Paulo (USP) So Paulo Brazil Medical Clinic in Endocrinology and Diabetology Schleswig-Flensburg Germany.

Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is a rare disease characterized by total or partial vagina agenesis, karyotype 46, XX with normal secondary sexual characters. Still, it is the second leading cause of primary amenorrhea. The absence of obvious signs and symptoms often causes the syndrome to be diagnosed only after puberty. The case presented here highlights exactly this difficulty of early diagnosis, which meets the objective of the study, and is precisely to provide reliable material that facilitates the diagnosis and management of patients with MRKH syndrome.

关键词： Mayer-Rokitansky-Kuster-Hauser Syndrome Primary Amenorrhea Gonadal Dysgenesis