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Cretaceous Antarctic plesiosaurs:stratigraphy,systematics and paleobiogeography

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Advances in Polar Science 2019年第3期30卷 210-227页

作者： Jose Patricio O’GORMAN Rodrigo OTERO marcelo REGUERO Zulma GASPARINI División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataPaseo del Bosque s/n.B1900FWALa PlataArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) ArgentinaGodoy Cruz 2290C1425FQBCABAArgentina Red Paleontológica U-Chile Laboratorio de Ontogenia y FilogeniaDepartamento de BiologíaFacultad de CienciasUniversidad de ChileLas Palmeras 3425SantiagoChile Instituto Antártico Argentino 25 de Mayo 1143B1650HMKSan MartínBuenos AiresArgentina

The last twenty million years(Maastrichtian–Santonian)of Southern Hemisphere plesiosaur history is especially well recorded in the Weddellian Province(Patagonia;Western Antarctica and New Zealand).The oldest Late Cretaceous plesiosaurs,two specimens referred to Polycotylidae indet.,come from the Santonian levels of the Santa Marta Formation,while the oldest elasmosaurids come from the lower Campanian of the same *** the lower Maastrichtian of the Snow Hill Island Formation the non-aristonectine elasmosaurid Vegasaurus molyi is recorded together with other non-diagnosable elasmosaurid specimens,but no aristonectines are *** appears in the Antarctic record in the upper Maastrichtian of the López de Bertodano Formation and are represented by Morturneria and *** specimens from the upper Campanian previously referred to Aristonectinae *** referred to Elasmosauridae indet.,shortening the temporal record of Aristonectinae in *** aristonectines appears in the Antarctic record in the upper Maastrichtian of the López de Bertodano Formation and are represented by Morturneria and *** Antarctic Cretaceous elasmosaurids show a paleobiogeographic connection with South America and New Zealand(Weddellian Province).This connection is indicated by the shared presence of the Aristonectinae Kaiwhekea katiki(New Zealand)and Aristonectes(Argentina and Chile).Recent phylogenetic analysis recovered the aristonectines within the Weddellonectia clade,which includes the aristonectines and the non-aristonectines Vegasaurus molyi(Isla Vega,Antarctica);Kawanectes lafquenianum(Argentina);Morenosaurus stocki and Aphrosaurus furlongi(California).Among the Weddellonectia,the aristonectines show a relatively large body size and extremely derived features and probably occupied a trophic niche that differed from the trophic niche of other *** way of contrast Kawanectes lafquenianum is an extremely small body-

关键词： Elasmosauridae Aristonectinae Polycotylidae Santa Marta Formation Snow Hill Island Formation López de Bertodano Formation Weddellonectia

Thermal Behavior of Sr（ll） and Ba（ll）-Diclofenac Complexes in Solid State： Study of the Dehydration and Thermal Decomposition

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Chinese Journal of Chemistry 2011年第11期29卷 2271-2277页

作者： Kobelnik, marcelo Cassimiro, Douglas Lopes Santos, Diogenesdos Dos Ribeiro, Clovis Augusto Crespi, Marisa Spirandelic Centro Universitdrio do Norte Paulista-UNORP Rua Ipiranga 3460 Sao Jose do Rio Preto SP Brazil Instituto de Quimica Sao Paulo State University C.P. 355 14800-900 Araraquara SP Brazil

Solid state compounds of general formula Sr（Diclof）2 ·5.7H2O and Ba（Diclof）2·4.8H2O were obtained. Thermo- gravimetry （TG）, differential scanning calorimetry （DSC）, X-ray diffraction powder patterns and microscopy analysis were used to characterize these compounds. Details concerning the dehydration and thermal decomposition as well as data of kinetic parameters have been described here. The kinetic behaviors of these stages were evaluated from several heating rates with samples masses of 2 and 5 mg in open crucibles under a nitrogen atmosphere. The results of the present study improve the knowledge on these compounds including their dehydration and thermal stability. The obtained data depend on the mass of the sample which results in two kinetic behavior patterns.

关键词： diclofenac divalent metal ions thermal behavior kinetic parameters

Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?

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World Journal of Stem Cells 2015年第2期7卷 408-417页

作者： Martha L Arango-Rodriguez Fernando Ezquer marcelo Ezquer Paulette Conget Center for Regenerative Medicine School of Medicine Clínica Alemana Universidad del Desarrollo

Multipotent mesenchymal stromal cells [also referred to as mesenchymal stem cells(MSCs)] are a heterogeneous subset of stromal cells. They can be isolated from bone marrow and many other types of tissue. MSCs are currently being tested for therapeutic purposes(i.e., improving hematopoietic stem cell engraftment, managing inflammatory diseases and regenerating damaged organs). Their tropism for tumors and inflamed sites and their context-dependent potential for producing trophic and immunomodulatory factors raises the question as to whether MSCs promote cancer and/or infection. Thisarticle reviews the effect of MSCs on tumor establishment, growth and metastasis and also susceptibility to infection and its progression. Data published to date shows a paradoxical effect regarding MSCs, which seems to depend on isolation and expansion, cells source and dose and the route and timing of administration. Cancer and infection may thus be adverse or therapeutic effects arising form MSC administration.

关键词： Cancer Infection Mesenchymal stem cells Therapy Biosafety

Exosomes:Small vesicles with big roles in cancer,vaccine development,and therapeutics

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Bioactive Materials 2022年第4期7卷 281-294页

作者： Abhimanyu Thakur Diana Carolina Parra Pedram Motallebnejad marcelo Brocchi Huanhuan Joyce Chen Pritzker School of Molecular Engineering The University of ChicagoUnited States Ben May Department for Cancer Research The University of ChicagoUnited States Tropical Disease Laboratory Department of GeneticsEvolutionMicrobiology and ImmunologyInstitute of BiologyUniversity of Campinas(UNICAMP)S˜ao PauloBrazil

Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every *** the availability of chemotherapy,radiotherapy,immunotherapy,and surgery,a cure for cancer has not been ***,exosomes have gained significant attention due to the therapeutic potential of their various components including proteins,lipids,nucleic acids,miRNAs,and *** constitute a set of tiny extracellular vesicles with an approximate diameter of 30-100 *** are released from different cells and are present in biofluids including blood,cerebrospinal fluid(CSF),and *** perform crucial multifaceted functions in the malignant progression of cancer via autocrine,paracrine,and endocrine *** ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer *** this review,we discuss the major components of exosomes and their role in cancer *** also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics.

关键词： Cancer Exosome Therapeutics Extracellular vesicles Exosomal vaccine Exosomal delivery system

Clinical features of AIDS patients with Hodgkin's lymphoma with isolated bone marrow involvement:report of 12 cases at a single institution

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Cancer Biology & Medicine 2015年第1期12卷 41-45页

作者： marcelo Corti Maria Villafa?e Gonzalo Minue Ana Campitelli Marina Narbaitz Leonardo Gilardi HIV/AIDS Department F.J.Mu?iz Hospital Hematology Unit F.J.Mu?iz Hospital Histopathology Laboratory F.J.Mu?iz Hospital National Academy of Medicine Histopathology Laboratory Sociedad Iberoamericana de Informacion Cientifica Scientific Coordination

Objective： To study the main clinical and histopathological features of 12 patients with Hodgkin＇s lymphoma （HL） diagnosed primarily from bone marrow （BM） involvement. Methods： We included 12 acquired immunodeficiency syndrome （AIDS） patients with HL assisted in the F. J. Mufiiz Infectious Diseases Hospital since January 2002 to December 2013. The diagnosis of ilL with primary BM involvement in patients was confirmed by clinical, histopathological, and immunohistochemical findings. Results： All patients presented ＂B＂ symptoms and pancytopenia. All of them had stage IV neoplasm disease because of BM infiltration. The median of CD4＋ T-cell counts was 114 cells/μL, and mixed cellularity （MC） was the most frequent histopathological subtype of 92% cases. Conclusion： When other causes are excluded, BM biopsy should be performed in AIDS patients with ＂B＂ symptoms and pancytopenia to evaluate BM infiltration by atypical lymphocytes.

关键词： Acquired immunodeficiency syndrome (AIDS) Hodgkin's lymphoma (HL) bone marrow (BM)

Spatial distribution of morphometric parameters of glacial cirques in the Central Pyrenees(Aran and Boí valleys)

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Journal of Mountain Science 2018年第10期15卷 2103-2119页

作者： Luis LOPES Marc OLIVA marcelo FERNANDES Paulo PEREIRA Pedro PALMA Jesús RUIZ-FERNáNDEZ Centre for Geographical Studies – IGOT Universidade de Lisboa Department of Geography University of Barcelona Environmental Management Center Mykolas Romeris University Department of Geography University of Oviedo

Glacial cirques are typical landscape features of mid-latitude mountain environments like the Central Pyrenees. Their morphology as well as their spatial distribution provides insights about past glaciers and climates. In this study, we examine the distribution, morphometrical and topographical characteristics of glacial cirques in two U-shaped glacial valleys located in the Central Pyrenees – the Aran and the Boí valleys. They are located in different aspects of this mountain range(north vs south) under different climatic influences that promoted distinct glaciation patterns during the late Pleistocene. The spatial mapping of these landforms was carried out using high-resolution imagery and field observations. We analysed the data of the morphometrical and topographical variables of the glacial cirques by using different statistical and geospatial methods in order tounveil the factors controlling their formation and development. A total of 186 glacial cirques were mapped in the study area, including 119 in the Aran and 67 in the Boí valleys. The local topography and microclimate conditions lead to substantial differences in both areas in terms of the morphology and dimensions of the cirques. Glacial cirques in Boí are distributed at slightly higher elevations than in Aran and they are also larger, though their dimensions decrease with elevation in both valleys. Aran cirques are mostly oriented NE, while Boí landforms do not show any prevailing aspect. Even though lithology does not control the distribution of the glacial cirques, some specific lithological settings may favour the development of larger cirques. In general, glacial cirques in the Aran and the Boí valleys show morphometrical properties similar to those reported in other mid-latitude mountain ranges.

关键词： Central Pyrenees Aran and Boi valleys glacial cirques topography morphometry.

Soil attributes structure plant assemblages across an Atlantic forest mosaic

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Journal of Plant Ecology 2018年第4期11卷 613-622页

作者： Maria Fabíola Barros Bruno X.Pinho Tarciso Leão marcelo Tabarelli Programa de Pós-Graduação em Biologia Vegetal Departamento de BotânicaUniversidade Federal de PernambucoPE 50670-901Brazil Department of Forest Resources University of MinnesotaSt.PaulMN 55108USA

Aims Community assembly persists as a key topic in ecology due to the complex variation in the relative importance of assembly forces and mechanisms across spatio-temporal scales and *** we address a forest-savanna vegetation mosaic in the Brazilian Atlantic forest to examine the role played by soil attributes as determinants of community assembly and organiza-tion at a landscape spatial *** We examined soil and plant assemblage attributes across 23 plots of forest and savanna in a 1600 km2 landscape exposed to the same climatic conditions in the Atlantic forest region of northeast *** attributes included species richness,taxonomic and functional composition(community weighted mean,CWM)and functional diversity(quadratic diversity;Rao’s quadratic entropy index)relative to plant leaf area,specific leaf area,leaf dry matter content,thickness and *** Findings Our results suggest that forest and savanna patches exposed to the same climatic conditions clearly differ in terms of soil attributes,plant assemblage structure,taxonomic and functional *** selecting particular plant strategies relative to resource economy,soil potentially affects community structure,with forest assemblages bear-ing more acquisitive resource-use strategies,while conservative plant strategies are more frequent in ***,savanna-forest mosaics in the Atlantic forest region represent spatially organized plant assemblages in terms of taxonomic and functional features,with a sig-nal of trait convergence in both vegetation ***-mediated filter-ing thus emerges as a potential deterministic assembly force affecting the spatial organization of savanna-forest boundaries and mosaics.

关键词： community assembly habitat filtering plant functional traits savanna vegetation tropical forest

Oxidative stress in Microcystis aeruginosa as a consequence of global climate change

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BIOCELL 2016年第1期40卷 23-25页

作者： marcelo HERNANDO CHRISTIAN HOUGHTON LEDA GIANNUZZI BERND KROCK DARIO ANDRINOLO GABRIELA MALANGA Departamento de Radiobiología Comisión Nacional de Energía AtómicaBuenos AiresArgentina Area de Toxicología Dpto.de Cs BiológicasFacultad de Ciencias Exactas.UNLP Alfred Wegener Institute BremerhavenGermany Instituto de Bioquímica y Medicina Molecular(IBIMOL)-Universidad de Buenos Aires(UBA) CONICETFisicoquímicaFacultad de Farmacia y BioquímicaJunín 956(C1113AAD)Buenos Aires.Argentina

Cyanobacteria are phototrophic organisms with great ecological and economical *** of the genus Microcystis are known for their potential ability to synthesize toxins,notably *** is a growing interest in the evaluation of oxidative stress in relation to the impact of global climate change on natural ecosystems in different trophic *** studies have focused on the analysis of organismal responses to mitigate the damage by controlling the generation of reactive oxygen *** in environ-mental factors caused by climate change generate a situation of oxidative damage in Microcystis aeruginosa as a direct or indirect *** this study we evaluate the effects of ultraviolet radiation and temperature on physiological and biochemical responses of a native ***(strain CAAT 2005-3).The results from the exposure to ultraviolet radiation doses and temperature changes suggest a high ability of *** to detect a potential stress situation as a consequence of reactive species production and to rapidly initiate antioxidant *** catalase activity is an antioxidant protection mechanism in *** for short and long term exposure to different changes in environmental ***,we found a ultraviolet-B radiation threshold dose above which oxidative stress exceeds the antioxidant protection and damage *** addition our results are in agreement with recent findings suggesting that microcystins may act as protein-modulating metabolites and protection against reactive oxygen *** is concluded that cyanobacteria have adaptative mechanisms that could lead to the replacement of species highly susceptible to oxidative stress by others with a higher system of antioxidant protection.

关键词： oxidative stress Cyanobacteria UVR temperature

Assessment of hybrid geoids in Chile and Spain,combining GGM and GNSS/Leveling observations

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Geodesy and Geodynamics 2021年第2期12卷 65-92页

作者： Jose Antonio Tarrio Mosquera marcelo Caverlotti Silva Fernando Isla Carlos Prado University of Santiago of Chile(USACH) Faculty of EngineeringGeographical Engineering DepartmentChile Geographic Military Institute Chile

This research presents the results for analyses done to five geopotential global models(GGM),comparing them with ground data from GNSS and leveling in heterogenic zones from the geodetic perspective,in Chile and *** the official and complete implementation of the International Height Reference Frame(IHRF)has not yet been established,the vertical geodetic system of many countries is not calculated on a global scale;instead,it is calculated by the variation of relative heights between one or more local tide gauges,such as in the case of Spain and *** aspect creates regional and specific altimetry data,which disables the use of GGM to directly obtain the orthometric height of the vertical reference system(VRS)from the GNSS *** models currently reach centimetric precision due to their high resolution but are directly incompatible for a local *** solve this,we expose in this article the contrast between geometric geoidal undulation(ellipsoidal heights and orthometric data from the leveling networks in Spain and Chile)with the geoidal undulation in more recent models and higher resolution:Earth Gravitational Model 2008(EGM08),European Improved Gravity model of the Earth by New techniques(EIGEN6 C4),Gravity Observation Combination(GOCO05 C),Experimental Gravity Field Model(XGM2016),and Ultra-High Resolution Global Geopotential Model(SGG-UGM),adjusting the residual between both referential heights by different parametric models and polynomials of determined *** evaluated,their geoidal undulations are combined with GNSS/leveling data from the corresponding VRS to generate a correcting surface,which is also known as a hybrid geoid,resulting in a model of optimal adjustment for the combination of five parameters of the EIGEN-6 C4 with orthometric heights and ellipsoids of both Chile and *** results show 2-3 cm precisions,which were statistically analyzed to determine the suitability for *** final products are three grids of indep

关键词： GNSS levelling Correcting surface IHRS SIRGAS EIGEN-6C4