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Hepatic perivascular epithelioid cell tumors:Benign,malignant,and uncertain malignant potential

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World Journal of Gastroenterology 2024年第18期30卷 2374-2378页

作者： marcelo Fabián Amante División Patología Hospital General de Agudos Cosme ArgerichBuenos Aires C1155AHAArgentina División Patología Hospital Alemán de Buenos AiresBuenos Aires C1155AHAArgentina

In 2013,the World Health Organization defined perivascular epithelioid cell tumor(PEComa)as“a mesenchymal tumor which shows a local association with vessel walls and usually expresses melanocyte and smooth muscle markers.”This generic definition seems to better fit the PEComa family,which includes angiomyolipoma,clear cell sugar tumor of the lung,lymphangioleiomyomatosis,and a group of histologically and immunophenotypically similar tumors that include primary extrapulmonary sugar tumor and clear cell myomelanocytic *** cell tumors with this immunophenotypic pattern have also had their malignant variants *** localizing to the liver,preoperative radiological diagnosis has proven to be very difficult,and most patients have been diagnosed with hepatocellular carcinoma,focal nodular hyperplasia,hemangioma,or hepatic adenoma based on imaging *** of a malignant variant of the liver have been ***,reports of malignant variants of these lesions have increased in recent ***,we support the use of the Folpe criteria,which in 2005 established the criteria for categorizing a PEComa as benign,malignant,or of uncertain malignant *** they are not considered ideal,they currently seem to be the best approach and could be used for the categorization of liver tumors.

关键词： PEComas Liver Pathology Malignant Benign Uncertain malignant potential

Liver transplantation in acute liver failure:A challengingscenario

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World Journal of Gastroenterology 2016年第4期22卷 1523-1531页

作者： Manuel Mendizabal marcelo Oscar Silva Hepatology and Liver Transplant Unit Hospital Universitario AustralPilar B1629AHJArgentina

Acute liver failure is a critical medical condition defined as rapid development of hepatic dysfunction associated with encephalopathy. The prognosis in these patients is highly variable and depends on the etiology, intervalbetween jaundice and encephalopathy, age, and the degree of coagulopathy. Determining the prognosis for this population is vital. Unfortunately, prognostic models with both high sensitivity and specificity for prediction of death have not been developed. Liver transplantation has dramatically improved survival in patients with acute liver failure. Still, 25% to 45% of patients will survive with medical treatment. The identification of patients who will eventually require liver transplantation should be carefully addressed through the combination of current prognostic models and continuous medical assessment. The concerns of inaccurate selection for transplantation are significant, exposing the recipient to a complex surgery and lifelong immunosuppression. In this challenging scenario, where organ shortage remains one of the main problems, alternatives to conventional orthotopic liver transplantation, such as living-donor liver transplantation, auxiliary liver transplant, and ABO-incompatible grafts, should be explored. Although overall outcomes after liver transplantation for acute liver failure are improving, they are not yet comparable to elective transplantation.

关键词： Encephalopathy Fulminant hepatic failure Liver transplantation Outcome Prognostic score

Lattice Boltzmann Modeling of Viscous Elementary Flows

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Advances in Applied Mathematics and Mechanics 2010年第4期2卷 467-482页

作者： Mohammed A.Boraey marcelo Epstein Mechanical and Manufacturing Engineering Department University of Calgary2500 University Drive NWCalgaryAlbertaT2N 1N4Canada

A lattice Boltzmann method is developed for modeling viscous elementary *** adjustable source term is added to the lattice Boltzmann equation,which can be tuned to model different elementary flow features like a doublet or a point source of any strength,including a negative source(sink).The added source term is dimensionally consistent with the lattice Boltzmann *** proposed model has many practical applications,as it can be used in the framework of the potential flow theory of viscous and viscoelastic *** model can be easily extended to the three dimensional *** model is verified by comparing its results with the analytical solution for some benchmark *** results are in good agreement with the analytical solution of the potential flow theory.

关键词： The Lattice Boltzmann method Chapman-Enskog expansion source term point source point sink doublet viscous elementary flows potential flow theory symmetry

Going beyond 1000000 resolved points in a Brillouin distributed fiber sensor: theoretical analysis and experimental demonstration

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Light(Science & Applications) 2016年第1期5卷 788-795页

作者： Andrey Denisov marcelo A Soto Luc Thévenaz EPFL Swiss Federal Institute of Technology Group for Fiber Optics(GFO)SCI-STI-LTStation 11CH-1015 LausanneSwitzerland

Distributed fiber sensing possesses the unique ability to measure the distributed profile of an environmental quantity along many tens of kilometers with spatial resolutions in the meter or even centimeter *** feature enables distributed sensors to provide a large number of resolved points using a single optical ***,in current systems,this number has remained constrained to a few hundreds of thousands due to the finite signal-to-noise ratio(SNR)of the measurements,which imposes significant challenges in the development of more performing ***,we propose and experimentally demonstrate an ultimately optimized distributed fiber sensor capable of resolving 2100000 independent points,which corresponds to a one-orderof-magnitude improvement compared to the *** a Brillouin distributed fiber sensor based on phase-modulation correlation-domain analysis combined with temporal gating of the pump and time-domain acquisition,a spatial resolution of 8.3 mm is demonstrated over a distance of 17.5 *** sensor design addresses the most relevant factors impacting the SNR and the performance of medium-to-long range sensors as well as of sub-meter spatial resolution *** step record in the number of resolved points could be reached due to two theoretical models proposed and experimentally validated in this study:one model describes the spatial resolution of the system and its relation with the sampling interval,and the other describes the amplitude response of the sensor,providing an accurate estimation of the SNR of the measurements.

关键词： distributed fiber sensors optical fibers stimulated Brillouin scattering

Arabidopsis photoperiodic regulator CONSTANS feeds back to control the circadian clock

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Molecular Plant 2024年第9期17卷 1338-1340页

作者： Abril San Martin marcelo Javier Yanovsky Instituto de Investigaciones Bioquimicas de Buenos Aires(Fundacion Instituto Leloir-CONICET) Av.Patricias Argentinas 435Buenos Aires C1405BWEAraentina

Human beings live in a world defined by daily cycles of light and darkness caused by the Earth’s rotation around its ***,like most living organisms,have evolved internal circadian clocks that time biological processes in anticipation of these daily environmental changes(Young and Kay,2001).The plant clock relies on core genes encoding transcription factors(TFs),which regulate each other’s expression through intricate networks of interlocking transcriptional-translational feedback loops(Nohales and Kay,2016).These loops ultimately control the expression of thousands of genes,allowing plants to adapt to daily fluctuations in light,temperature,and humidity(Covington et al.,2008).In addition to daily rhythms,the Earth experiences yearly seasonal cycles marked by longer,warmer days in spring and summer,followed by shorter,cooler days in autumn and *** changes in day length and temperature intensify with distance from the ***,the ability of plants to adjust their growth and development in anticipation of seasonal changes determines their latitudinal distribution(McMillan,1960).

关键词： circadian seasonal Arabidopsis

Germination strategies under climate change scenarios along an aridity gradient

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Journal of Plant Ecology 2020年第4期13卷 470-477页

作者： Alexander Zogas Evsey Kosman marcelo Sternberg Porter School of Environmental Studies Tel Aviv UniversityTel AvivIsrael School of Plant Sciences and Food Security George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute for Cereal Crops Improvement School of Plant Sciences and Food SecurityGeorge S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Aims Climate change in the eastern Mediterranean region will have a strong impact on ecosystem functioning and plant community dynamics due to a reduction in annual rainfall and increased *** aim to understand the role of seed banks as potential buffers against climatic uncertainty determined by climate *** We examined germination strategies of 18 common species present along an aridity *** were obtained from soil seed banks germinated during nine consecutive years from arid,semi-arid,Mediterranean and mesic Mediterranean *** the semi-arid and Mediterranean sites,rainfall manipulations simulating 30%drought and 30%rainfall increase were *** strategies were tested under optimal irrigation conditions during three consecutive germination seasons to determine overall seed germinability in each soil *** in germination strategy were examined using a novel statistical approach that considers the climatic and biotic factors that may affect seed *** Findings The results showed that dominant species controlled their germination fractions by producing seeds with a different yearly germination fraction *** amount of rainfall under which the seeds were produced led to two major seed types with respect to germinability:high germinability,seeds leading to transient seed banks,and low germinability,seeds leading to persistent seed *** conclude that differential seed production among wet and dry years of both seed types creates a stable balance along the aridity gradient,enabling the soil seed bank to serve as a stabilizing mechanism buffering against rainfall ***,we present a general model of germination strategies of dominant annual species in Mediterranean and arid ecosystems that strengthens the notion of soil seed banks as buffers against climatic uncertainty induced by climate change in the region.

关键词： climate change desert drought Mediterranean rainfall manipulations seed bank

Prospects for bone marrow cell therapy in amyotrophic lateral sclerosis：how far are we from a clinical treatment？

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Neural Regeneration Research 2016年第8期11卷 1216-1219页

作者： Fernanda Gubert marcelo F.Satiago Instituto de Biofisica Carlos Chagas Filho Universidade Federal do Rio de Janeiro Rio de Ianeiro RJ Brasil

Amyotrophic lateral sclerosis（ALS） is a fatal neurodegenerative disease that causes progressive muscular atrophy and death within 3–5 years after its *** the significant advances in knowledge of ALS pathology,no effective treatment is ***,it is imperative to search for new alternatives to treat *** therapy,especially using bone-marrow cells,has showed to be very useful to protect the neural tissue in different brain disease or traumatic *** ALS,most published results show beneficial effects of the use bone marrow cells,especially mesenchymal stromal ***,until now,the best outcome extends animal＇s lifespan by only a few *** is essential to continue the search for a really effective therapy,testing different cells,routes and time-windows of *** the mechanisms that initiate and spread the degenerative process is also important to find out an effective ***,we discussed here some progresses that have been made using bone-marrow cell therapy as a therapeutic tool for ALS.

关键词： amyotrophic lateral sclerosis cell therapy bone-marrow mononuclear cells mesenchymal stromal cells neuroinflammation motor neurons

Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors

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World Journal of Gastroenterology 2020年第16期26卷 1888-1900页

作者： Federico Pinero marcelo Silva Massimo Iavarone Hospital Universitario Austral Facultad de Ciencias BiomédicasUniversidad AustralBuenos Aires B1629HJArgentina Latin American Liver Research Educational and Awareness Network Buenos Aires B1629HJArgentina Division of Gastroenterology and Hepatology CRC“A.M.e A.Migliavacca”Center for the Study of Liver DiseaseUniversity of MilanFondazione IRCCS Ca’Granda Maggiore HospitalMilan 20121Italy

During the last decades,further knowledge of hepatocellular carcinoma(HCC)molecular mechanisms has led to development of effective systemic treatments including tyrosine kinase inhibitors(TKIs)and *** this review,we describe first and second line systemic treatment options for advanced *** trials have evaluated new drugs for the treatment of HCC patients:In first line,lenvatinib resulted non-inferior to sorafenib and it can be used as alternative,even in the lack of evidence for sequential treatment options in second line after ***,atezolizumab plus bevacizumab have shown superiority over sorafenib in ***-regorafenib sequential administration in selected patients has opened a new paradigm of treatment in advanced HCC with a life expectancy exceeding two *** TKIs for second line treatment include cabozantinib and ramucirumab(specifically for patients with Alpha-fetoprotein values≥400 ng/mL).The combination of TKIs with immunotherapy may represent a big step forward for these patients in the near future.

关键词： Hepatocellular carcinoma Systemic Options Sequencing Advanced Future

Epigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesis

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World Journal of Gastroenterology 2015年第30期21卷 9021-9037页

作者： Juliana Carvalho Santos marcelo Lima Ribeiro Sao Francisco University Medical School Clinical Pharmacology and Gastroenterology Unit Laboratory of Microbiology and Molecular Biology UNICAMP Universidade Estadual de CampinasGenetics and Molecular Biology

Although thousands of DNA damaging events occur in each cell every day,efficient DNA repair pathways have evolved to counteract them. The DNA repair machinery plays a key role in maintaining genomic stability by avoiding the maintenance of mutations. The DNA repair enzymes continuously monitor the chromosomes to correct any damage that is caused by exogenous and endogenous mutagens. If DNA damage in proliferating cells is not repaired because of an inadequate expression of DNA repair genes,it might increase the risk of cancer. In addition to mutations,which can be either inherited or somatically acquired,epigenetic silencing of DNA repair genes has been associated with carcinogenesis. Gastric cancer represents the second highest cause of cancer mortality worldwide. The disease develops from the accumulation of several genetic and epigenetic changes during the lifetime. Among the risk factors,Helicobacter pylori(H. pylori) infection is considered the main driving factor to gastric cancer development. Thus,in this review,we summarize the current knowledge of the role of H. pylori infection on the epigenetic regulation of DNA repair machinery in gastric carcinogenesis.

关键词： Helicobacter pylori DNA repair Epigenetic DNA methylation Gastric cancer Histone modification