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Lattice Boltzmann Modeling of Viscous Elementary Flows

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Advances in Applied Mathematics and Mechanics 2010年第4期2卷 467-482页

作者： Mohammed A.Boraey marcelo Epstein Mechanical and Manufacturing Engineering Department University of Calgary2500 University Drive NWCalgaryAlbertaT2N 1N4Canada

A lattice Boltzmann method is developed for modeling viscous elementary *** adjustable source term is added to the lattice Boltzmann equation,which can be tuned to model different elementary flow features like a doublet or a point source of any strength,including a negative source(sink).The added source term is dimensionally consistent with the lattice Boltzmann *** proposed model has many practical applications,as it can be used in the framework of the potential flow theory of viscous and viscoelastic *** model can be easily extended to the three dimensional *** model is verified by comparing its results with the analytical solution for some benchmark *** results are in good agreement with the analytical solution of the potential flow theory.

关键词： The Lattice Boltzmann method Chapman-Enskog expansion source term point source point sink doublet viscous elementary flows potential flow theory symmetry

Germination strategies under climate change scenarios along an aridity gradient

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Journal of Plant Ecology 2020年第4期13卷 470-477页

作者： Alexander Zogas Evsey Kosman marcelo Sternberg Porter School of Environmental Studies Tel Aviv UniversityTel AvivIsrael School of Plant Sciences and Food Security George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute for Cereal Crops Improvement School of Plant Sciences and Food SecurityGeorge S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Aims Climate change in the eastern Mediterranean region will have a strong impact on ecosystem functioning and plant community dynamics due to a reduction in annual rainfall and increased *** aim to understand the role of seed banks as potential buffers against climatic uncertainty determined by climate *** We examined germination strategies of 18 common species present along an aridity *** were obtained from soil seed banks germinated during nine consecutive years from arid,semi-arid,Mediterranean and mesic Mediterranean *** the semi-arid and Mediterranean sites,rainfall manipulations simulating 30%drought and 30%rainfall increase were *** strategies were tested under optimal irrigation conditions during three consecutive germination seasons to determine overall seed germinability in each soil *** in germination strategy were examined using a novel statistical approach that considers the climatic and biotic factors that may affect seed *** Findings The results showed that dominant species controlled their germination fractions by producing seeds with a different yearly germination fraction *** amount of rainfall under which the seeds were produced led to two major seed types with respect to germinability:high germinability,seeds leading to transient seed banks,and low germinability,seeds leading to persistent seed *** conclude that differential seed production among wet and dry years of both seed types creates a stable balance along the aridity gradient,enabling the soil seed bank to serve as a stabilizing mechanism buffering against rainfall ***,we present a general model of germination strategies of dominant annual species in Mediterranean and arid ecosystems that strengthens the notion of soil seed banks as buffers against climatic uncertainty induced by climate change in the region.

关键词： climate change desert drought Mediterranean rainfall manipulations seed bank

Prospects for bone marrow cell therapy in amyotrophic lateral sclerosis：how far are we from a clinical treatment？

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Neural Regeneration Research 2016年第8期11卷 1216-1219页

作者： Fernanda Gubert marcelo F.Satiago Instituto de Biofisica Carlos Chagas Filho Universidade Federal do Rio de Janeiro Rio de Ianeiro RJ Brasil

Amyotrophic lateral sclerosis（ALS） is a fatal neurodegenerative disease that causes progressive muscular atrophy and death within 3–5 years after its *** the significant advances in knowledge of ALS pathology,no effective treatment is ***,it is imperative to search for new alternatives to treat *** therapy,especially using bone-marrow cells,has showed to be very useful to protect the neural tissue in different brain disease or traumatic *** ALS,most published results show beneficial effects of the use bone marrow cells,especially mesenchymal stromal ***,until now,the best outcome extends animal＇s lifespan by only a few *** is essential to continue the search for a really effective therapy,testing different cells,routes and time-windows of *** the mechanisms that initiate and spread the degenerative process is also important to find out an effective ***,we discussed here some progresses that have been made using bone-marrow cell therapy as a therapeutic tool for ALS.

关键词： amyotrophic lateral sclerosis cell therapy bone-marrow mononuclear cells mesenchymal stromal cells neuroinflammation motor neurons

Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors

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World Journal of Gastroenterology 2020年第16期26卷 1888-1900页

作者： Federico Pinero marcelo Silva Massimo Iavarone Hospital Universitario Austral Facultad de Ciencias BiomédicasUniversidad AustralBuenos Aires B1629HJArgentina Latin American Liver Research Educational and Awareness Network Buenos Aires B1629HJArgentina Division of Gastroenterology and Hepatology CRC“A.M.e A.Migliavacca”Center for the Study of Liver DiseaseUniversity of MilanFondazione IRCCS Ca’Granda Maggiore HospitalMilan 20121Italy

During the last decades,further knowledge of hepatocellular carcinoma(HCC)molecular mechanisms has led to development of effective systemic treatments including tyrosine kinase inhibitors(TKIs)and *** this review,we describe first and second line systemic treatment options for advanced *** trials have evaluated new drugs for the treatment of HCC patients:In first line,lenvatinib resulted non-inferior to sorafenib and it can be used as alternative,even in the lack of evidence for sequential treatment options in second line after ***,atezolizumab plus bevacizumab have shown superiority over sorafenib in ***-regorafenib sequential administration in selected patients has opened a new paradigm of treatment in advanced HCC with a life expectancy exceeding two *** TKIs for second line treatment include cabozantinib and ramucirumab(specifically for patients with Alpha-fetoprotein values≥400 ng/mL).The combination of TKIs with immunotherapy may represent a big step forward for these patients in the near future.

关键词： Hepatocellular carcinoma Systemic Options Sequencing Advanced Future

Extreme liver resections with preservation of segment 4 only

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World Journal of Gastroenterology 2017年第26期23卷 4815-4822页

作者： Silvio Marcio Pegoraro Balzan Vinícius Grando Gava marcelo Arbo Magalhaes marcelo Luiz Dotto Department of Pharmacy and Biology University of Santa Cruz do Sul Department of Surgery Hospital Moinhos de Vento

To evaluate safety and outcomes of a new technique for extreme hepatic resections with preservation of segment 4 only. METHODSThe new method of extreme liver resection consists of a two-stage hepatectomy. The first stage involves a right hepatectomy with middle hepatic vein preservation and induction of left lobe congestion; the second stage involves a left lobectomy. Thus, the remnant liver is represented by the segment 4 only (with or without segment 1, ± S1). Five patients underwent the new two-stage hepatectomy (congestion group). Data from volumetric assessment made before the second stage was compared with that of 10 matched patients (comparison group) that underwent a single-stage right hepatectomy with middle hepatic vein preservation. RESULTSThe two stages of the procedure were successfully carried out on all 5 patients. For the congestion group, the overall volume of the left hemiliver had increased 103% (mean increase from 438 mL to 890 mL) at 4 wk after the first stage of the procedure. Hypertrophy of the future liver remnant (i.e., segment 4 ± S1) was higher than that of segments 2 and 3 (144% vs 54%, respectively, P 0.05) were proportional. The mean preoperative volume of segments 2 and 3 was 256 ± 64 cc and increased to 572 ± 257 cc after right hepatectomy. Mean preoperative volume of segment 4 increased from 211 ± 75 cc to 439 ± 180 cc after surgery. CONCLUSIONThe proposed method for extreme hepatectomy with preservation of segment 4 only represents a technique that could allow complete resection of multiple bilateral liver metastases.

关键词： Hepatectomy Colorectal liver metastases Hepatic congestion Liver regeneration Liver resection Liver failure

Periodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions?

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World Journal of Gastroenterology 2016年第35期22卷 7963-7972页

作者： Ronaldo Lira-Junior Carlos marcelo Figueredo Department of Periodontology Faculty of Odontology Rio de Janeiro State University Rio de Janeiro RJ 20551-030 Brazil

Periodontal disease and inflammatory bowel disease(IBD) are both chronic inflammatory diseases. Their pathogenesis is mediated by a complex interplay between a dysbiotic microbiota and the host immuneinflammatory response, and both are influenced by genetic and environmental factors. This review aimed to provide an overview of the evidence dealing with a possible pathogenic interaction between periodontal disease and IBD. There seems to be an increased prevalence of periodontal disease in patients with IBD when compared to healthy controls, probably due to changes in the oral microbiota and a higher inflammatory response. Moreover, the induction of periodontitis seems to result in gut dysbiosis and altered gut epithelial cell barrier function, which might contribute to the pathogenesis of IBD. Considering the complexity of both periodontal disease and IBD, it is very challenging to understand the possible pathways involved in their coexistence. In conclusion, this review points to a complex pathogenic interaction between periodontal disease and IBD, in which one disease might alter the composition of the microbiota and increase the inflammatory response related to the other. However, we still need more data derived from human studies to confirm results from murine models. Thus, mechanistic studies are definitely warranted to clarify this possible bidirectional association.

关键词： Periodontal disease Inflammatory bowel disease Crohn’s disease Ulcerative colitis Inflammation

Impacts of increased α-synuclein on clathrin-mediated endocytosis at synapses:implications for neurodegenerative diseases

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Neural Regeneration Research 2018年第4期13卷 647-648页

作者： Audrey T.medeiros Luigi Bubacco Jennifer R.Morgan The Eugene Bell Center for Regenerative Biology and Tissue Engineering Marine Biological Laboratory Department of Biology University of Padova

α-Synuclein causes synaptic pathologies in several neurodegenerative diseases：Parkinson’s disease（PD）is a neurodegenerative disease that impacts the lives of millions of people worldwide.A pathological hallmark of PD,as well as dementia with Lewy bodies（DLB）and several Alzheimer’s disease variants,is the appearanceof intracellular inclusions called Lewy bodies, which contain high levels of aggregated α-synuclein,

关键词： synuclein on clathrin-mediated endocytosis at synapses:implications for neurodegenerative diseases Impacts of increased

Dynamic localization of hepatocellular transporters in health and disease

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World Journal of Gastroenterology 2008年第44期14卷 6786-6801页

作者： marcelo G Roma Fernando A Crocenzi Aldo D Mottino Instituto de Fisiología Experimental (IFISE)-Facultad de Ciencias Bioquímicasy Farmacéuticas (CONICET-U.N.R.) S2002LRLRosarioArgentina

Vesicle-based traffi cking of hepatocellular transporters involves delivery of the newly-synthesized carriers from the rough endoplasmic reticulum to either the plasma membrane domain or to an endosomal,submembrane compartment,followed by exocytic targeting to the plasma membrane. Once delivered to the plasma membrane,the transporters usually undergo recycling between the plasma membrane and the endosomal compartment,which usually serves as a reservoir of pre-existing transporters available on demand. The balance between exocytic targeting and endocytic internalization from/to this recycling compartment is therefore a chief determinant of the overall capability of the liver epithelium to secrete bile and to detoxify endo and xenobiotics. Hence,it is a highly regulated process. Impaired regulation of this balance may lead to abnormal localization of these transporters,which results in bile secretory failure due to endocytic internalization of key transporters involved in bile formation. This occurs in several experimental models of hepatocellular cholestasis,and in most human cholestatic liver diseases. This review describes the molecular bases involved in the biology of the dynamic localization of hepatocellular transporters and its regulation,with a focus on the involvement of signaling pathways in this process. Their alterations in different experimental models of cholestasis and in human cholestatic liver disease are reviewed. In addition,the causes explaining the pathological condition (e.g. disorganization of actin or actin-transporter linkers) and the mediators involved (e.g. activation of cholestatic signaling transduction pathways) are also discussed. Finally,several experimental therapeutic approaches based upon the administration of compounds known to stimulate exocytic insertion of canalicular transporters (e.g. cAMP,tauroursodeoxycholate) are described.

关键词： Hepatocellular transporters Cholestasis cAMP Bile salts Vesicular trafficking Endocytosis Signaling pathways

Effect of Poly(ε-caprolactone-b-tetrahydrofuran)Triblock Copolymer Concentration on Morphological,Thermal and Mechanical Properties of Immiscible PLA/PCL Blends

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Journal of Renewable Materials 2019年第2期7卷 129-138页

作者： Paula do Patrocínio Dias marcelo Aparecido Chinelatto Department of Materials Engineering-Campus II São Carlos School of Engineering-EESCUniversity of São Paulo-USPAv.João Dagnone1100-Jd.Sta AngelinaSão Carlos-SP-Brazil

In this study a low molecular weight triblock copolymer derived fromε-caprolactone and tetrahydrofuran was used as a non-reactive compatibilizer of immiscible PLA/PCL *** blends with 0,1.5 wt%,3 wt%and 5 wt% copolymer and about 75 wt%PLA were prepared by single screw extrusion and characterized by scanning electron microscopy(SEM),differential scanning calorimetry(DSC),dynamic mechanical analysis(DMA),tensile and Izod impact *** micrographs showed that the size of the dispersed PCL domains was practically constant regardless of copolymer *** result can be explained by the low shear rate employed during processing step and a decrease of PCL viscosity by presence of the triblock ***,when the copolymer concentration increased,strain at break of PLA/PCL blends also ***/PCL blend with 0 wt% copolymer presented 2%strain at break,whereas PLA/PCL blend with 5 wt%copolymer exhibited 90%.

关键词： Blends non-reactive compatibilization poly(lactic acid) poly(ε-caprolactone) triblock copolymer