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Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy

World Journal of Gastroenterology 2013年第44期19卷 8056-8064页

作者： Rossana C Soletti Kelly Z Alves marcelo ap de britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado Biomedical Engineering Program COPPE Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-972 Brazil Post-Graduation Program in Surgical Sciences Department of Surgery School of Medicine Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-972 Brazil Biomedical Science Institute Federal University of Rio de Janeiro Rio de JaneiroRJ 21941-972 Brazil Division of Gastroenterology Endoscopy UnitClementino Fraga Filho University Hospital Federal University of Rio de Janeiro RJ 21941-972 Brazil

AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic ***:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon *** was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM *** ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM *** image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall *** the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon *** the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and *** images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion ***:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and t

关键词： Ultrasound biomicroscopy Animal model Diagnostic imaging Colonic neoplasm Longitudinal study

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Voice Recognition by Neuro-Heuristic Method

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Tsinghua Science and Technology 2019年第1期24卷 9-17页

作者： Dawid Po?ap Marcin Wozniak Institute of Mathematics Silesian University of Technology

The amount of digital data is increasing every day. At every step of our daily lives, we deal with technologies in which our data are stored(e.g., mobile phones and laptops), and this is one of the main reasons for the design of various types of encryption and user identity verification algorithms. These algorithms are meant not only to fulfill the desire of protecting data but also to address the possibility of granting access of specific digital data to selected individuals. This process brings with it the problem of identity verification. This paper discusses the problem of voice verification and presents a voice verification method based on artificial intelligence *** tests are performed herein to demonstrate the effectiveness of the presented solution. The research results are shown and discussed in terms of the advantages and disadvantages of the solution.

关键词： neural network heuristic algorithms Discrete Fourier Transform(DFT) image processing

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Caustic Failure of Thermal Insulated Tubing in Steam Flooding

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Journal of Materials Science & Technology 1997年第1期13卷 27-36页

作者： Xian, ap San, YY Zhang, D Wang, YK Sun, HP LIAOHE OIL FIELD MACHINERY PLANT PANJIN 124209PEOPLES R CHINA

The coupling of the pre-stressed thermal insulated tubing string broke down inside the steam flooding welts, after the tubing were used in high temperature and high pressure steam for about two years. With further check, it was found that most of the weld joints between the inner and outer tubing also cracked. The failure analysis for the accidents has been carried out by the analysis of chemical composition for the steels, microstructure observation, mechanical property tests, and the investigation of the service environment etc.. The results show that the early damage of the pre-stressed thermal insulated tubing string is mainly induced by the caustic stress corrosion, which can be strengthened by an unstable microstructure of the coupling serviced at high temperature for a long time. Moreover, the high pre-stress design on the thermal insulated pipe for the cyclic steam injection may be not suitable to the situation of steam flooding, which would result in the weld joint cracking.

关键词： Steel pipe

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Propylthiouracyl-induced severe liver toxicity:An indication for alanine aminotransferase monitoring?

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World Journal of Gastroenterology 2006年第38期12卷 6232-6234页

作者： M Benyounes C Sempoux C Daumerie J Rahier ap Geubel departments of Gastroenterology Endocrinology and Pathology St Luc University Hospital Université Catholique de Louvain Brussels 1200 Belgium

Propylthiouracyl (PTU)-related liver toxicity is likely to oc- cur in about 1% of treated patients. In case of acute or subacute hepatitis, liver failure may occur in about one third. We report two further cases of PTU-induced sub- acute hepatitis, in whom the delay between occurrence of liver damage after the initiation of treatment, the un- derestimation of its severity and the delayed withdrawal of the drug were all likely responsible for liver failure. The high incidence of liver toxicity related to PTU, its potential severity and delayed occurrence after initiation of treatment are in favor of monthly alanine aminotrans- ferase monitoring, at least during the first six months of therapy.

关键词： Hepatitis Drug-induced liver toxicity Propylthiouracil Alanine aminotransferase

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俄罗斯阿尔泰-Sayan地区Aksug斑岩Cu-Mo体系的地质与地球化学特征(英文)

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岩石学报 2008年第12期24卷 2657-2668页

作者： Berzina AN Berzina ap Institute of Geology and Mineralogy Koptyug Avenue 3 Novosibirsk 630090 Russia

The Aksug deposit,located in Altay-Sayan region of Russia,is one of the largest porphyry Cu-Mo deposits in *** ore-bearing porphyries of the Aksug porphyry Cu-Mo system were formed in post-collisional *** belong to calk-alkaline and high K-calk-alkaline *** are characterized by enrichment of LILE and depletion of HSFE andHREE,showing the importance of subduction-related components in magma *** plutonic intrusions that host porphyrysystems have been formed during *** origin of porphyritic rocks is dominantly the mantle with lower crustal *** economically important Cu-Mo mineralization is closely related to a porphyry series in time and space,being emplaced towardsthe end of magmatic *** the emplacement of plutonic and ore-bearing porphyry complexes took place in differentgeodynamic environments,both complexes are characterized by certain similarity in geochemical composition,alkalinity,trace elementcontent,Sr isotopic *** fact evidently indicates a common deep-seated magmatic source(at the lower crust-uppermantle level).Low initial ^(87)Sr/^(86)St,sulfur isotopic characteristics and presence of PGE-Co-Ni mineralization in associated pyrite-chalcopyrite ores suggest that mantle source of chalcophile elements was of high importance in porphyry Cu-Mo mineralization of theAksug deposit.

关键词：斑岩铜钼矿床岩石化学分析微量元素碱度

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Characterization of atmospheric aerosol (PM10 and PM2.5) from a medium sized city in S?o Paulo state,Brazil

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Journal of Environmental Sciences 2020年第3期32卷 238-251页

作者： Bruno T.Franzin Filipe C.Guizellini Diego V.de Babos Ossamu Hojo Ieda ap.Pastre Mary R.R.Marchi Fernando L.Fertonani Cristina M.R.R.Oliveira Sao Paulo State University(Unesp) Chemistry InstituteAnalytical Chemistry DepartmentAraraquaraSP14800-060Brazil Federal University of Sao Carlos-UFSCAr Chemistry DepartmentSao CarlosSP13565-905Brazil Chemistry and Environmental Sciences department BiosciencesLanguages and Exact Sciences InstituteIbilceSaoPaulo State University(Unesp)Sao Jose do Rio PretoSP15054-000Brazil Centro de Quimica Estrutural-Faculdade de Ciencias da Universidade de Lisboa Edif.C8Campo Grande1749-016 LisboaPortugal

Air pollution causes deleterious effects on human health with aerosols being among the most polluting *** objective of this work is the characterization of the PM2.5 and PM10 aerosol mass in the *** methods of analysis include WD-XRF and *** were correlated with meteorological information and air mass trajectories(model HYSPLIT)by multivariate analysis.A morphological structural analysis was also carried out to identify the probable sources of atmospheric aerosols in the city of Sao Jose do Rio Preto,*** mean mass concentration values obtained were 24.54 μg/m^3 for PM10,above the WHO annual standard value of 20 μg/m^3 and 10.88 μg/m^3 for PM2.5 whose WHO recommended limit is10 μg/m^***-XRF analysis of the samples revealed Si and Al as major components of the coarse *** the fine fraction,the major elements were Al and *** SEM-FEG characterization allowed identifying the morphology of the particles in agglomerates,ellipsoids and filaments in the PM10,besides spherical in the *** analysis by EDS corroborated WD-XRF results,identifying the crustal elements,aluminosilicates and elements of anthropogenic origin in the coarse *** the fine fraction crustal elements were also identified;aluminosilicates,black carbon and spherical particles(C and O) originating from combustion processes were *** use of multivariate analysis to correlate air mass trajectories with the results of the morpho-structural characterization of the particulate matter allowed confirmation of the complex composition of the particles resulting from the combination of both local and long-distance sources.

关键词： Urban aerosol PM10 PM2.5 WD-XRF SEM-EDS

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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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World Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H W M Lemlijn-Slenter Karolina ap Wijnands Gijs van der Hamsvoort Luuk P van Iperen Nico Wolter Angelique E de Rijk Ad AM Masclee department of Social Medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social Medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients with chronic GI-HPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient department of the Maastricht University Medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with McDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P valuedered *** The GI-HPB patients scored significantly worse in all dimensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

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Analysis of Growth and Productivity of Green Chickpea Using Nitrogen and Phosphorus Fertilization

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Phyton-International Journal of Experimental Botany 2021年第4期90卷 1193-1203页

作者： Maricela apáez-Barrios JoséAlberto Salvador Escalante-Estrada Patricio apáez-Barrios Yurixhi Atenea Raya-Montaño Juan CarlosÁlvarez-Hernández Facultad de Ciencias Agropecuarias-Universidad Michoacana de San Nicolás de Hidalgo Apatzingán60670México Colegio de Postgraduados-Campus Montecillo Texcoco56230México Facultad de Agrobiología“Presidente Juárez” Universidad Michoacana de San Nicolás de HidalgoUruapan60190México

Chickpea contains high levels of protein,vitamins and *** chickpea yield is the result of meeting nitrogen and phosphorus *** effect of appropriately meeting such requirements reflects on growth and can easily be evaluated using growth *** research determined:(a)The effect of nitrogen and phosphorus fertilization on phenology,net assimilation rate,number of green leaves,leaf area,leaf area index and leaf area duration;(b)Green chickpea yield and number of pods due to fertilization;and(c)The combination of nitrogen and phosphorus fertilization that yields the most net *** and phosphorus fertilization was evaluated;each at the doses of 0,75 and 150 kg ha–1(N0,N75,N150;P0,P75 and P150,respectively).The combination of the levels of both nutrients generated nine combinations of treatments which were distributed in the field in a randomized complete block design in an arrangement of divided plots with four *** of phenological phases were similar among *** and phosphorus fertilization increased number of leaves,leaf area index,and leaf area duration that translated into increased green chickpea yield(GCY).Combinations N150-P75 and N150-P150 produced the highest *** highest net revenue and revenue per peso invested was obtained with N150-P75.

关键词： Cicer arietinum economic analysis leaf area number of leaves yield

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ap生物学导学与应考指南

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丛书名：美国ap课程

2013年

作者：安生ap课程专家组

本书是安生国际教育研究院出版的ap系列丛书的第4本，生物学系列。作为ap考试的重要科目，生物学于2012年5月进行了大幅度改革，本书即是按照改革以后的考纲和命题思路编写。全书从生物学引论开始，分10个部分分别讲述了细胞、生物化学... 详细信息

ISBN: (纸本)9787564144784

本书是安生国际教育研究院出版的ap系列丛书的第4本，生物学系列。作为ap考试的重要科目，生物学于2012年5月进行了大幅度改革，本书即是按照改革以后的考纲和命题思路编写。全书从生物学引论开始，分10个部分分别讲述了细胞、生物化学、基因等方面的原理和考点、难点，在对于中国学生感到困难的地方还特别加上了中文注解，目的是帮助母语非英语的学习者尽快掌握生物学的主要内容和命题规律。

关键词：生物课高中教学参考资料

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Relaxin prevents the development of severe acute pancreatitis

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World Journal of Gastroenterology 2006年第10期12卷 1558-1568页

作者： Laura Iris Cosen-Binker marcelo Gustavo Binker Rodica Cosen Gustavo Negri Osvaldo Tiscornia RHC-LICB Medical Research Institute-Buenos Aires Argentina Programa de Estudios Pancreáticos-Hospital de Clinicas Universidad de Buenos AiresArgentina Cátedra de Gastroenterologia y Enzimologia Clinica-Departamento de Bioquimica ClinicaFacultad de Farmacia y BioquimicaUniversidad de Buenos AiresArgentina RHC-LICB Medical Research Institute-Buenos Aires Argentina Programa de Estudios Pancreáticos-Hospital de Clínicas Universidad de Buenos AiresArgentina RHC-LICB Medical Research Institute-Buenos Aires Argentina Cátedra de Gastroenterología y Enzimología Clínica-departamento de Bioquímica Clínica Facultad de Farmacia y Bioquimica Universidad de Buenos AiresArgentina Programa de Estudios Pancreáticos-Hospital de Clínicas Universidad de Buenos Aires Argentina

AIM： TO investigate the severity of acute pancreatitis （ap） is associated to the intensity of leukocyte activation, inflammatory up-regulation and microcirculatory disruption associated to ischernia-reperfusion injury. Hicrovascular integrity and inhibition of pro-inflammatory mediators are key-factors in the evolution of ap. Relaxin is an insulin-like hormone that has been attributed vasorelaxant properties via the nitric oxide pathway while behaving as a glucocorticoid receptor agonist. METHODS： ap was induced by the bilio-pancreatic duct-outlet-exclusion closed-duodenal-loops model. Treatment with relaxin was done at different timepoints. Nitric oxide synthase inhibition by L-NAME and glucocorticoid receptor （GR） blockage by mifepristone was considered. ap severity was assessed by biochemical and histopathological analyses. RESULTS： Treatment with relaxin reduced serum amylase, lipase, C-reactive protein, IL-6, IL-10, hsp72, LDH and 8-isoprostane as well as pancreatic and lung myeloperoxidase. Acinar and fat necrosis, hemorrhage and neutrophil infiltrate were also decreased. ATP depletion and ADP/ATP ratio were reduced while caspases 2-3-8 and 9 activities were increased. L-NAME and mifepristone decreased the efficiency of relaxin. CONCLUSION： Relaxin resulted beneficial in the treatment of ap combining the properties of a GR agonist while preserving the microcirculation and favoring apoptosis over necrosis.

关键词： Acute pancreatitis Relaxin Nitric oxide Glucocorticoid receptor Necrosis apoptosis

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