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Hepatic ischemic preconditioning increases portal vein flow in experimental liver ischemia reperfusion injury

Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 40-47页

作者： Estela RR Figueira Joel A Rocha-Filho Mauro Nakatani marcelo fs buto Eduardo R Tatebe Vitor O Andre Ivan Cecconello Luiz AC D'Albuquerque Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestinal Transplantation Hospital das ClinicasUniversity of So Paulo Brazil Discipline of Anesthesiology Hospital das ClinicasUniversity of So Paulo Brazil School of Medicine Medical Student and Scientific Research in Medicine FAPESP Hospital das Clinicas University of So Paulo Brazil

BACKGROUND: Ischemic preconditioning(IPC) has been shown to decrease liver injury and to increase hepatic microvascular perfusion after liver ischemia reperfusion. This study aimed to evaluate the effects of IPC on hemodynamics of the portal venous system. METHODS: Thirty-two rats were randomized into two groups: IPC group and control group. The rats of the IPC group underwent IPC by 10 minutes of liver ischemia followed by 10 minutes of reperfusion before liver ischemia, and the rats of the control group were subjected to 60 minutes of partial liver ischemia. Non-ischemic lobes were resected immediately after reperfusion. The animals were studied at 4 hours and 12 hours after reperfusion. Mean arterial pressure, heart rate, portal vein flow and pressure were analyzed. Blood was collected for the determination of the levels of aspartate aminotransferase, alanine aminotransferase, calcium, lactate, pH, bicarbonate, and base excess. RESULTS: IPC increased the mean portal vein flow at 4 hours and 12 hours after reperfusion. IPC recovered 78% of the meanportal vein flow at 12 hours after reperfusion. IPC decreased the levels of aspartate aminotransferase, alanine aminotransferase and lactate, and increased the levels of ionized calcium, bicarbonate and base excess at 12 hours after reperfusion. CONCLUSIONS: This study demonstrated that IPC increases portal vein flow and enhances hepatoprotective effects in liver ischemia reperfusion. The better recovery of portal vein flow after IPC may be correlated with the lower levels of transaminases and with the better metabolic profile.

关键词： ischemic preconditioning portal vein flow liver ischemia

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MANNICH REACTION ON 1,2-DIHYDRO-1-PYRROLIZINONE

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Chinese Chemical Letters 1996年第1期7卷 9-10页

作者： Wang, SJ Liu, fs Zhang, SF SHENYANG PHARMACEUT UNIV SHENYANG 110015PEOPLES R CHINA

The aminomethylation of the title compound can occur at 2-C or 5-C when it undergoes Mannich reaction with different amines. With aliphatic secondary amines, the reaction occurs at 2-C of the ketone, whereas with arom...

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CARBON MATERIALS FOR LITHIUM ION BATTERIES

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Chinese Chemical Letters 1996年第4期7卷 389-390页

作者： Ma, SH Li, J Jing, XB Wang, fs ACAD SINICA CHANGCHUN INST APPL CHEMPOLYMER PHYS LABCHANGCHUN 130022PEOPLES R CHINA

The preliminary work indicated that passive film is the most important factor influencing cell performance of carbon anode, and the carbon and solvent used govern cell performance by forming the passive film of differ... 详细信息

关键词： ION CARBON MATERIALS FOR LITHIUM ION BATTERIES

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Effects on the Surface Passive Film of Carbon Anode on Cell Behavior

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Chinese Chemical Letters 1997年第2期8卷 175-176页

作者： Ma, SH Li, J Jing, XB Wang, fs ACAD SINICA CHANGCHUN INST APPL CHEMPOLYMER PHYS LABCHANGCHUN 130022PEOPLES R CHINA

The properties of the films formed in the electrolyte of PC/DME LiClO4 on two kinds of carbon materials were examined by cathodic polarization measurements. The result suggested that the films on both carbon electrode... 详细信息

关键词： DME Effects on the Surface Passive Film of Carbon Anode on Cell Behavior Cell

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STUDY ON COMBLIKE POLYMER ELECTROLYTE

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Chinese Chemical Letters 1995年第4期6卷 329-332页

作者： Ding, LM Lin, YQ Liang, HZ Wang, fs Acad Sinica Changchun Inst Appl Chem Changchun 130022 Peoples R China

New comblike polymers(CP) have been synthesized by reacting monomethyl ether of polyethylene glycol(PEGME) with poly(methyl vinyl ether-alt-maleic anhydride)(MA) and endcapping the residual carboxylic acid with methanol. Butanone was selected as a solvent for the esterification reaction in order to obtain a completely soluble product. They were characterized by IR, C-13 NMR and elemental analysis.

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STRUCTURE　OF　GANODERIC　ACID　DM，A　NEW　TRITERPENOID　FROM　THE　FRUITING　BODY　OF　GANODERMA　LUCIDUM

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Chinese Chemical Letters 1995年第12期6卷 1051-1052页

作者： Cai, H Wang, fs Yang, JS Zhang, YM Univ Agr & Anim Sci PLA Changchun 130062 Peoples R China Chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China

A new lanostane-type triterpenoid, ganoderic acid DM was isolated from the cultured fruiting body of G. lucidum. The structure of ganoderic acid DM (1) was determined by spectral data. It was ldentifled as 3. 7-dioxo-... 详细信息

关键词： ACID BODY DM

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Resolution of 3,3'-Dioxo-1,1'(3H,3(H)spirobi[isobenzofuran] -5,6,5'6'-tetracarboxylic acid and Optically active Polyimides thereof

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Chinese Chemical Letters 2000年第12期11卷 1077-1080页

作者： Han, fs Qu, JQ Zhang, X Ding, MX Gao, LX Chinese Acad Sci Changchun Inst Appl Chem PCLCC State Key Lab Polymer Phys & Chem Changchun 130022 Peoples R China

3,3`-Dioxo-1,1'(3H,3'H)spirobi[isobenzofuran]-5,6,5',6'-tetracarboxylic acid 1 was resolved successfully and the corresponding optically active polyimides PI were synthesized. The properties of the optically active PI and the racemic one were investigated. The results showed that the specific rotation of (-)-PI was about two times to that of the (+)-PI, and the regularity of the optically active PI was higher than that of the racemic one.

关键词： Resolution spirodilactone tetracarboxylic acid optically active polyimide.

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Redox Reaction of Disulfide/Polyaniline in Aqueous Solution

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Chinese Chemical Letters 1998年第6期9卷 523-526页

作者： Yu, L Wang, XH Li, J Jing, XB Wang, fs Chinese Acad Sci Changchun Inst Appl Chem Polymer Chem Lab Changchun 130022 Peoples R China

The cleavage and formation of the di sulfide bond of 2,5-dimercapto-1,3,4-thiadiazole (DMcT) were examined in an aqueous solution of pH value from 0 to 14 with and without polyaniline (PAn), The redox reaction of DMcT was accelerated by PAn in acidic condition. The cell using this anodic material was set-up and characterized in aqueous electrolyte.

关键词： polyaniline disulfide redox reaction

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A NEW TRITERPENOID FROM THE FUNGUS GANODERMA LUCIDUM

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Chinese Chemical Letters 1995年第12期6卷 1049-1050页

作者： Wang, fs Cai, H Jing, ZX Yang, JS Zhang, YM Univ Agr & Anim Sci PLA Changchun 130062 Peoples R China Chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China

The structure of a new triterpenoid, named gonolactone A, isolated from the fruiting body of Ganoderma lucidum,was determined by spectroscopic methods. This compound was identified as 7 beta -hydroxy-3. 11,15-trioxo-l...

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Influence of peptide bond on photosensitized oxidation of tryptophan, tyrosine and histidine dipeptides

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Chinese Science Bulletin 1997年第19期42卷 1624-1628页

作者： Liu, JB Zhang, fs Zhao, Y Zhao, FQ Tang, YW Song, XQ TSING HUA UNIV DEPT CHEMBEIJING 100084PEOPLES R CHINA

IN photodynamic therapy, the damage of protein results from the photooxidation of one ormore of only five amino acid residues (tryptophanyl, tyrosyl, histidyl, methionyl and cys-teinyl). These five amino acids are also readily photooxidized in their monomeric states. How-ever, the reaction kinetics and mechanisms of free amino acids and bound amino acid residuesin proteins are somewhat different. For example, Tassin found that the incorporation of tryp-tophan into a peptide linkage dramatically altered its susceptibility to photooxidation as well

关键词： amino acid dipeptide photosensitized oxidation.

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