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Long-term response to avelumab and management of oligoprogression in Merkel cell carcinoma:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4829-4836页

作者： Inês Leão Joana Marinho Telma costa Department of Oncology Centro Hospitalar Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal

BACKGROUND Merkel cell carcinoma(MCC)is a rare and aggressive cutaneous neuroendocrine neoplasia,with high risk of recurrence and metastasis and poor *** checkpoint inhibitors,like the anti-programmed death-ligand 1 agent avelumab,were recently approved for the treatment of advanced ***,herein,report the first case of advanced MCC with oligoprogression managed with avelumab and local radical *** SUMMARY A 61-year-old man was presented to the hospital with sporadic fever and an exudative malodorous mass(10 cm of diameter),located on the right gluteal *** final diagnosis was MCC,cT4N3M1c(AJCC,TNM staging 8th edition,2017),with invasion of adjacent muscle,in-transit metastasis,and bone *** started chemotherapy(cisplatin and etoposide),and after six cycles,the main tumor increased,evidencing disease *** months later,the patient started second line treatment with avelumab(under an early access program).After two cycles of treatment,the lesion started to decrease,achieving a major *** progression was documented after 16 ***,as the tumor became resectable,salvage surgery was performed,while keeping the systemic treatment with *** the patient developed bilateral pneumonia,immunotherapy was *** than 2.5 years after surgery(last 19 mo without systemic therapy),the patient maintains complete local response and stable bone *** This report highlights the efficacy and long-term response of avelumab on the management of a chemotherapy resistant advanced MCC,with evidence of oligoprogression,in combination with local radical treatment.

关键词： Merkel cell carcinoma Unresectable tumor Avelumab Oligoprogression Surgery Chemotherapy Case report

Cognitive training in neurodegenerative diseases: a way to boost neuroprotective molecules?

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Neural Regeneration Research 2015年第11期10卷 1754-1755页

作者： Francesco Angelucci Carlo Caltagirone Alberto costa IRCCS Santa Lucia Foundation Department of Clinical and Behavioural Neurology Department of Systemic Medicine Rome University Tor Vergata Niccolò Cusano University

Neurotrophins,and growth factors in general,are proteins which exert many actions in central nervous system *** promote the survival and neuronal function of neurons and exert neuroprotective effects in pathological models of neurodegenerative *** humans several clinical trials based on the use of these proteins have been carried out. Among them, it is worth to mention gene ther- apy especially in Parkinson＇s disease （PD）（Kordower and Bjorklund, 2013）, and a series of experiments using vectors capable of carrying neurotrophins in the selected target re- gion where they can exert their beneficial action （Ghosh et al., 2014）.

关键词： BDNF a way to boost neuroprotective molecules Cognitive training in neurodegenerative diseases

Breeding next generation tree fruits: technical and legal challenges

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Horticulture Research 2017年第1期4卷 42-52页

作者： Lorenza Dalla costa Mickael Malnoy Ivana Gribaudo Research and Innovation Centre Fondazione Edmund Machvia E Mach 1San Michele a/Adige38010Italy IPSP-CNR Institute for Sustainable Plant ProtectionNational Research CouncilStrada delle Cacce 73TorinoI-10135Italy

The new plant breeding technologies(NPBTs)have recently emerged as powerful tools in the context of‘green’*** have wide potential compared to classical genetic engineering and they are attracting the interest of politicians,stakeholders and citizens due to the revolutionary impact they may have on *** and genome editing potentially allow to obtain pathogen-resistant plants or plants with enhanced qualitative traits by introducing or disrupting specific genes in shorter times compared to traditional breeding programs and by means of minimal modifications in the plant ***,the most important fruit crop in the world from an economical point of view,is a peculiar case for NPBTs because of the load of cultural aspects,varietal traditions and consumer demands,which hinder the use of classical breeding techniques and,furthermore,the application of genetic engineering to wine grape *** we explore the technical challenges which may hamper the application of cisgenesis and genome editing to this perennial plant,in particular focusing on the bottlenecks of the Agrobacterium-mediated gene *** addition,strategies to eliminate undesired sequences from the genome and to choose proper target sites are discussed in light of peculiar features of this *** is reported an update of the international legislative frameworks regulating NPBT products which shows conflicting positions and,in the case of the European Union,a prolonged lack of regulation.

关键词： breeding legal furthermore

Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations

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Journal of Pharmaceutical Analysis 2018年第3期8卷 168-175页

作者： Sara da Silva Anacleto Marcella Matos Cordeiro Borges Hanna Leijoto de Oliveira Andressa Reis Vicente Eduardo costa de Figueiredo Marcone Augusto Leal de Oliveira Barbara Juliana Pinheiro Borges marcelo Antonio de Oliveira Warley de Souza Borges Keyller Bastos Borges Departamento de Ciencias Naturals Universidade Federal de Sao Joao del-Rei Campus Dom Bosco Praca Dora Helvecio 74 Fabricas 36301-160 Sao Joao del-Rei Minas Gerais Brazil Departamento de Quimica Universidade Federal do Espirito Santo Avenida Fernando Ferrari 514 Goiabeiras 29075-910 Vitdria Espirito Santo Brazil Laboratorio de Analise de Toxicantes e Farmacos Faculdade de Ciencias Farmaceuticas Universidade Federal de Alfenas Rua Gabriel Monteiro da Silva 700 Centro 37130-000 Alfenas Minas Gerais Brazil Departamento de Quimica Universidade Federal de Juiz de Fora Rua Jose Lourenco Kelmer s/n 36036-330 Juiz de Fora Minas Gerais Brazil Centro de Ciencias da Saude Universidade Federal do Espirito Santo Avenida Marechal Campos 1468 Maruipe 29.043-900 Vitori Espirito Santo Brazil Centro Universitario Norte do Espirito Santo Universidade Federal do Espirito Santo Br 101 Norte Km 67 Sao Mateus Espirito Santo Brazil

This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy （FTIR）, thermogravimetry （TG）, and scanning electronic microscopy （SEM） can be useful tools for evaluating the quality of active pharmaceutical ingredients （APIs） and pharmaceutical products. In addition, a simple, sensitive, and efficient method employing HPLC-DAD was developed for simulta- neous determination of lidocaine （LID）, ciprofloxacin （CFX） and enrofloxacin （EFX） in raw materials and in veterinary pharmaceutical formulations. Compounds were separated using a Gemini Cm （250 mm×4.6 mm, 5μm） Phenomenex column, at a temperature of 25℃, with a mobile phase containing 10 mM of phosphoric acid （pH 3.29）： acetonitrile （85.7：14.3, v/v） and a flow rate of 1.5 mL/min. Physicochemical characterization by TG, FTIR, and SEM of raw materials of LID, CFX, and EFX provided information useful for the evaluation, differentiation, and qualification of raw materials. Finally, the HPLC method was proved to be useful for evaluation of raw material and finished products, besides satisfying the need for an analytical method that allows simultaneous determination of EFX, CFX, and LID, which can also be extended to other matrices and applications.

关键词： HPLC Physicochemical characterization Quality control Veterinary pharmaceutical formulation Raw material

Open data in spatial data infrastructure:the practices and experiences of Poland

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International Journal of Digital Earth 2021年第11期14卷 1547-1560页

作者： Waldemar Izdebski Agnieszka Zwirowicz-Rutkowska Joanna Nowak da costa Warsaw University of Technology WarsawPoland Military University of Technology WarsawPoland

As an important facilitator in e-government and society in general,Open SDI merits an assessment of its characteristics and the monitoring of its *** aim of the study was the proposal of the SDI openness assessment approach based on existing openness assessment frameworks,as well as the presentation of the Polish Spatial Data Infrastructure(PSDI)development towards *** results indicated that ten geodetic and cartographic databases fulfilled ten out of eleven criteria of data openness,according to the methodological assumptions,and reached a 3-star level of *** need for further development of the infrastructure towards sharing public administration data is recognized,as well as non-governmental data that meet the open data criteria,thus contributing to the openness of the *** proposed assessment method,referenced to a five-level data openness system and providing clear scoring benchmarking for assessing SDI openness,may be used for comparative analysis of SDI openness in different countries,including EU Member States that draw on the experience of the implementation of the INSPIRE Directive.

关键词： Open government data(OGD) openness assessment geospatial data information society open spatial data infrastructure(open SDI)impact

Cell membrane and bioactive factors derived from mesenchymal stromal cells: Cell-free based therapy for inflammatory bowel diseases

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World Journal of Stem Cells 2019年第9期11卷 618-633页

作者： Fabiany da costa Goncalves Ana Helena Paz Nephrology and Transplantation Internal MedicineErasmus Medical CenterRotterdamGD 3015Netherlands Experimental Research Center Hospital de Clínicas de Porto AlegrePorto AlegreRS 90035-903Brazil

Inflammatory bowel diseases(IBD)are chronic inflammatory disorders of the gastrointestinal tract associated with multifactorial conditions such as ulcerative colitis and Crohn’s *** the underlying mechanisms of IBD remain unclear,growing evidence has shown that dysregulated immune system reactions in genetically susceptible individuals contribute to mucosal ***,conventional treatments have been effective in inducing remission of IBD but not in preventing the relapse of *** this way,mesenchymal stromal cells(MSC)therapy has been recognized as a promising treatment for IBD due to their immunomodulatory properties,ability to differentiate into several tissues,and homing to inflammatory *** so,literature is conflicted regarding the location and persistence of MSC in the body after *** this reason,recent studies have focused on the paracrine effect of the biofactors secreted by MSC,especially in relation to the immunomodulatory potential of soluble factors(cytokines,chemokines,and growth factors)and extracellular vehicles that are involved in cell communication and in the transfer of cellular material,such as proteins,lipids,and nucleic ***,treatment with interferon-γ,tumor necrosis factor-α,and interleukin-1βcauses MSC to express immunomodulatory molecules that mediate the suppression via cell-contact dependent *** together,we present an overview of the role of bioactive factors and cell membrane proteins derived from MSC as a cell-free therapy that can improve IBD treatment.

关键词： Bioactive factors Cell membrane Mesenchymal stem cells Cell-free therapy Inflammatory bowel diseases

Evaluation of the efficiency of urban solid waste management in Brazil by data envelopment analysis and possible variables of influence

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Waste Disposal and Sustainable Energy 2024年第2期6卷 283-295页

作者： Isabel das Merces costa Marta Ferreira Dias Margarita Robaina GOvCOPP-Research Unit on Governance Competitiveness and Public Policies and Analyst of UniversidadeEstadual de Feira de SantanaUniversidade de AveiroAveiroPortugal GOvCOPP-Research Unit on Governance Competitiveness and Public PoliciesDEGEIT-Department of EconomicsManagementIndustrial Engineering and TourismUniversidade de AveiroAveiroPortugal

This article has the general objective of estimating the efficiency of urban solid waste management in 940 Brazilian munici-palities through Data Envelopment Analysis(DEA)technique and has specific objectives:(i)to estimate efficiency scores;(ii)to compare the performance between different groups of municipalities;and(ii)to analyze the profile of efficient munici-palities from the perspective of the guidelines of Law 12,305/2010 and socio-economic and environmental *** technique used was DEA with output-oriented and variable scale to return *** results showed higher efficiency scores in the municipalities with populations above 500,000 *** score variation ranged from 0.5(municipalities with populations<10,000 inhabitants)to 0.9(municipalities with more than 500,000 inhabitants).Of the sample set,only 12.34%of the municipalities were considered efficient,and when analyzing the efficient group,it was found that adherence to legislation was not a major factor in achieving efficiency.

关键词： Urban solid waste management Data envelopment analysis Efficiency Brazil Municipalities

Variation of parental and chick diet in opportunistic insectivorous European Bee-eaters

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Avian Research 2024年第4期15卷 473-481页

作者： Joana S.costa Steffen Hahn José A.Alves Department of Biology and CESAM-Centre for Environmental and Marine Studies University of AveiroPortugal Department of Biodiversity Ecology and EvolutionFaculty of Biological SciencesComplutense University of MadridMadridSpain Laboratory of Ornithology University of LatviaInstitute of BiologyRigaLatvia South Iceland Research Centre University of IcelandLaugarvatnIceland

Insectivorous Palaearctic bird species associated with open habitats rely on high prey abundances,which are currently declining due to habitat loss and intensive agricultural *** European Bee-eater(Merops apiaster)is an opportunistic insectivore of open habitats,preying mainly on medium to large-sized flying *** diet composition received some attention in the past,but the current variation in diet composition of birds breeding across different habitats,and between adults and chicks remains poorly *** this study,we determine variation in bee-eaters’diet in colonies located in five common habitats at the Iberian *** also assess differences in the diet composition of chicks and adults and investigate seasonal diet selectivity of ***,we explore the variability in the size of prey provided to chicks throughout their growth *** and Coleoptera were the most important groups for bee-eaters,with adults and chicks consuming 58.8%and 64.1%of hymenopterans and 37.6%and 28.6%of coleopterans,*** proportion of Hymenoptera(42.3–55.7%)and Coleoptera(43.3–53.5%)in the diet was similar in colonies in pasture and oak habitats,but Hymenoptera dominated(83.8%and 95.7%)in meadow and mixed forest *** being a generally opportunistic predator,adult bee-eaters provide their progeny with an increasing proportion of larger insects through chick ***,they equally take Hymenoptera and Coleoptera for themselves and their chicks,even when the abundance of these insects decreases ***,these results suggest that local prey availability associated with specific habitats influences diet composition and that regional declines in certain groups may,therefore,affect insectivore species differently according to their dietary and habitat preferences.

关键词： Feeding ecology Habitat variation Merops apiaster Prey availability Prey selection

Heme as an inducer of cerebral damage in hemorrhagic stroke:potential therapeutic implications

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Neural Regeneration Research 2022年第9期17卷 1961-1962页

作者： Luiz Ricardo da costa Vasconcellos Pedro Moreno Pimentel-Coelho Cellular Signalling and Cytoskeletal Function Laboratory The Francis Crick InstituteLondonUK Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroInstituto Nacional de Ciência e Tecnologia em Medicina RegenerativaRio de JaneiroRJBrazil

Intracerebral hemorrhage(ICH)consists of the rupture of a cerebral artery leading to bleeding into the surrounding *** event has a primary phase of brain injury consisting of mechanical tissue damage due to the mass effect,followed by a secondary phase of brain injury triggered by the presence of blood components released at the site of bleeding(Bulters et al.,2018).Despite the high rates of mortality and morbidity from ICH,no effective treatment is available so far.

关键词： cerebral damage rupture