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WJSc 6^(th) Anniversary Special Issues(1):Hematopoietic stem cell transplantation Allogeneic hematopoietic cell transplant for acute myeloid leukemia:current state in 2013 and future directions

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World Journal of Stem cells 2014年第2期6卷 69-81页

作者： Abraham S Kanate marcelo c pasquini Parameswaran N Hari Mehdi Hamadani Osborn Hematopoietic Malignancy and Transplantation program Section of Hematology/OncologyWest Virginia University Division of Hematology and Oncology Medical College of Wisconsin

Acute myeloid leukemia(AML)represents a heterogeneous group of high-grade myeloid neoplasms of the elderly with variable *** remissioninduction is an important first step in the management of AML,additional treatment strategies are essential to ensure long-term disease-free *** pivotal advances in understanding the genetics and molecular biology of AML have allowed for a risk-adapted approach in its management based on *** hematopoietic cell transplantation(allo-HcT)represents an effective therapeutic strategy in AML providing the possibility of cure with potent graft-versus-leukemia reactions,with a demonstrable survival advantage in younger patients with intermediate-or poor-risk *** we review the published data regarding the role of allo-HcT in adults with *** searched MEDLINE/PubMed and EMBASE/*** addition,we searched reference lists of relevant articles,conference proceedings and ongoing trial *** discuss the role of allo-HcT in AML patients stratified by cytogenetic-and molecular-risk in first complete remission,as well as allo-HcT as an option in relapsed/refractory *** the conventional sibling and unrelated donor allografts,we review the available data and recent advances for alternative donor sources such as haploidentical grafts and umbilical cord *** also discuss conditioning regimens,including reduced intensity conditioning which has broadened the applicability of *** we explore recent advances and future possibilities and directions of allo-HcT in *** therapeutic recommendations have been made where possible based on available data and expert opinion.

关键词： Acute myeloid leukemia Allogeneic hematopoietic cell transplantation Reduced intensity conditioning Myeloablative conditioning Haploidentical Umbilical cord blood

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Study of the Superficial Modification of Sisal Fibres with Lignin, and Its Use As a Reinforcement Agent in cementitious composites

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Journal of Renewable Materials 2020年第8期8卷 891-903页

作者： Plínio B.Mundim Rondinele A.R.Ferreira Leila A.c.Motta Mariana A.Henrique Daniel pasquini college of civil Engineering Federal University of UberlândiaUberlândia38400-902Brazil chemistry Institute Federal University of UberlândiaUberlândia38400-902Brazil

The objective of this work was to evaluate different superficial treatments of sisal fibres employing lignin,and their use as a reinforcement agent in cementitious *** treatments consisted of superficially impregnating sisal fibres(S)with organosolv lignin(LO),organosolv lignin and glutaraldehyde(LOG),Kraft lignin(LK)and Kraft lignin and glutaraldehyde(LKG).The fibre modifications were verified by FTIR-ATR and SEM analyzes,and the presence of lignin on the surface of the fibres was evidenced,confirming the effectiveness of the *** mechanical,thermal(by TGA)and water absorption properties of the fibres before and after the modifications were also *** treatment,the modified fibres presented an expressive reduction of the water absorption and did not show significant changes in the mechanical properties when compared with the natural unmodified sisal fibre(SNAT).It was verified an increase in the thermal stability of the treated fibres which can be attributed to the insertion of lignin on the *** evaluate the performance of the fibres in the cementitious composites,cement plates(cP)were produced with different treated fibres(cP-SLOG,cP-SLO,cP-SLKG,cP-SLK)and fibres without treatment(cP-SNAT).The composites were evaluated concerning to the water absorption,porosity and mechanical *** fractured regions were also investigated by *** composites prepared showed similar values of absorption and porosity *** the mechanical properties,the composites prepared with modified fibres showed a significant increase in the modulus of rupture and modulus of elasticity compared with cP-SNAT,while toughness was similar to all *** the SEM images,it was observed that the modified fibres immersed in the cementitious plates showed no degradation,indicating that the impregnation of lignin acted as a protective agent of the ***,the treatments of the fibres with lignin led to a significant improvement in th

关键词： cementitious composites sisal lignin surface modification

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Microglia depletion as a therapeutic strategy:friend or foe in multiple sclerosis models?

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Neural Regeneration Research 2023年第2期18卷 267-272页

作者： Victoria Sofia Berenice Wies Mancini Anabella Ayelen Di Pietro Laura Andrea pasquini Universidad de Buenos Aires Facultad de Farmacia y BioquímicaDepartamento de Química BiológicaCátedra de Química Biológica PatológicaBuenos AiresArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Química y Fisicoquímica Biológicas Prof.Dr.Alejandro C.PaladiniFacultad de Farmacia y BioquímicaBuenos AiresArgentina

M ultiple sclerosis is a chro nic central nervous system demyelinating disease whose onset and progression are driven by a combination of immune dysregulation,genetic predisposition,and environmental fa *** activation of microglia and astrocytes is a key player in multiple sclerosis immunopathology,playing specific roles associated with anatomical location and phase of the disease and controlling demyelination and *** though reactive mic roglia can damage tissue and heighten deleterious effects and neurodegeneration,activated microglia also perform neuroprotective functions such as debris phagocytosis and growth fa ctor *** can be activated into pro-inflammato ry phenotype A1 through a mechanism mediated by activated neuroinflammatory microglia,which could also mediate *** A1 phenotype inhibits oligodendrocyte prolife ration and differe ntiation and is toxic to both oligodendrocytes and *** r,astroglial activation into phenotype A2 may also take place in response to neurodegeneration and as a protective mechanism.A variety of animal models mimicking specific multiple sclerosis features and the associated pathophysiological processes have helped establish the cascades of events that lead to the initiation,progression,and resolution of the *** colonystimulating facto r-1 receptor is expressed by myeloid lineage cells such as peripheral monocytes and macrophages and central nervous system ***,as microglia development and survival critically rely on colony-stimulating factor-1 receptor signaling,colony-stimulating factor-1 receptor inhibition can almost completely eliminate microglia from the *** this context,the present review discusses the impact of microglial depletion through colo ny-stimulating factor-1 receptor inhibition on demyelination,neurodegeneration,astroglial activation,and behavior in different multiple sclerosis models,highlighting the diversity of micr

关键词： astrocytes colony-stimulating factor-1 receptor inhibition cuprizone demyelnation microglia multiple sclerosis neurodegeneration

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Association between Body condition and Oxidative Status in Dogs

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Food and Nutrition Sciences 2013年第8期4卷 191-196页

作者： Anna pasquini Silvia Roberti Valentina Meucci Elena Luchetti Sergio canello Gianandrea Guidetti Giulia Biagi Department of Veterinary Science University of Pisa Pisa Italy Sanypet Bagnoli di Sopra Padova Italy

Oxidative Stress (OS) is considered an underlying mechanism by which dysfunctional metabolism occurs in obese subjects but there are still very few studies in canine species. The purpose of this study was to evaluate simultaneously the effects of diet on body weight, oxidative and inflammatory status in a group of 12 adult dogs. The dogs were fed a maintenance diet, integrated with natural antioxidants, for a period of 6 months. At the beginning and the end of the trial, Body condition Score (BcS) was evaluated and haematological (cBcs, complete Blood counts), oxidative parameters (d-ROMs, derivatives of Reactive Oxygen Metabolites;BAP, Biological Antioxidant Potential;Retinol;α-tocopherol) and inflammatory parameters (Fibrinogen;cRP, c Reactive Protein) were performed. Significant differences (p α-tocopherol, fibrinogen and cRP between the two periods of different diet. In this study, dogs showed an oxidative imbalance documented by the increase in d-ROMs and the reduction of BAP and retinol. Inflammatory parameters don’t change in relation to body weight like an alteration of the oxidative status could precede the onset of inflammation. The role of oxidative stress and of integration with antioxidants should be taken into special consideration in the dietary treatment in overweight dogs.

关键词： canine Nutrition Overweight Oxidative Stress Antioxidants Inflammation

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肿瘤基因型、病理类型以及fMRI脑肿瘤定位对脑肿瘤病人语言重构的影响

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国际医学放射学杂志 2023年第6期 746-746页

作者： L.pasquini O.Yildirim P.Silveira c.Tamer A.Napolitano M.Lucignani 齐晓莹

摘要目的肿瘤侵犯优势半球后，可能会出现语言重构。肿瘤的位置、级别和基因型会影响发音区之间的联通以及肿瘤的生长动态，而这正是语言可塑性的驱动因素。研究

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