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Open abdomen in gastrointestinal surgery:Which technique is the best for temporary closure during damage control?

World Journal of Gastrointestinal Surgery 2016年第8期8卷 590-597页

作者： marcelo a f ribeiro junior Emily Alves Barros Sabrina Marques de Carvalho Vinicius Pereira Nascimento José Cruvinel Neto Alexandre Zanchenko fonseca Department of Surgery University of Santo Amaro

AIM To compare the 3 main techniques of temporary closure of the abdominal cavity,vacuum assisted closure(vacuum-assisted closure therapy- VAC),Bogota bag and Barker technique,in damage control *** After systematic review of the literature,33 articles were selected to compare the efficiency of the three *** such as cost,infections,capacity of reconstruction of the abdominal wall,diseases associated with the technique,among others were *** The Bogota bag and Barker techniques present as advantage the availability of material and low cost,what is not observed in the VAC *** VAC technique is the most efficient,not only because it reduces the tension on the boarders of the lesion,but also removes stagnant fluids and debris and acts at cellular level increasing cell proliferation and *** bag presents the higher rates of skin laceration and evisceration,greater need for a stent for draining fluids and wash-ups,higher rates of intestinal adhesion to the abdominal *** Barker technique presents lack of efficiency in closing the abdominal wall and difficulty on maintaining pressure on the *** VAC dressing can generate irritation and dermatitis when the drape is applied,in addition to pain,infection and bleeding,as well as toxic shock syndrome,anaerobic sepsis and *** The VAC technique,showed to be superior allowing a better control of liquid on the third space,avoiding complications such as fistula with small mortality,low infection rate,and easier capability on primary closure of the abdominal cavity.

关键词： Trauma Damage control Abdominal compartment syndrome Temporary abdominal closure

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Current role of extracorporeal membrane oxygenation for the management of trauma patients:Indications and results

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World Journal of Critical Care Medicine 2025年第1期14卷 42-48页

作者： Mohammed Abdulrahman Maryam Makki Malak Bentaleb Dana Khamis Altamimi marcelo Af ribeiro junior Department of Surgery College of Medicine and Health SciencesKhalifa UniversityAbu Dhabi 11001United Arab Emirates Department of Surgery Division of TraumaCritical Care and Acute Care SurgerySheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Surgery Sheikh Shakhbout Medical CityAbu Dhabi 91888ADUnited Arab Emirates Department of Surgery R Adams Cowley Shock Trauma CenterUniversity of MarylandBaltimoreMD 21201United States

Extracorporeal membrane oxygenation(ECMO)has emerged as a vital circulatory life support measure for patients with critical cardiac or pulmonary conditions unresponsive to conventional *** allows blood to be extracted from a patient and introduced to a machine that oxygenates blood and removes carbon *** blood is then reintroduced into the patient’s circulatory *** process makes ECMO essential for treating various medical conditions,both as a standalone therapy and as adjuvant ***-venous(VV)ECMO primarily supports respiratory function and indicates respiratory ***,veno-arterial(VA)ECMO provides hemodynamic and respiratory support and is suitable for cardiac-related *** study reviews recent literature to elucidate the evolving role of ECMO in trauma care,considering its procedural intricacies,indications,contraindications,and associated ***,the use of ECMO in trauma patients,particularly for acute respiratory distress syndrome and cardiogenic shock,has demonstrated promising outcomes despite challenges such as anticoagulation management and complications such as acute kidney injury,bleeding,thrombosis,and *** studies have shown that VV ECMO was associated with significantly higher survival rates than conventional mechanical ventilation,whereas other studies have reported that VA ECMO was associated with lower survival rates than VV *** plays a critical role in managing trauma patients,particularly those with acute respiratory *** research is necessary to explore the full potential of ECMO in trauma *** should have a clear understanding of the indications and contraindications for the use of ECMO to maximize its benefits in treating trauma patients.

关键词： Extracorporeal membrane oxygenation treatments Multiple trauma Respiratory distress syndrome Cardiogenic shock Contraindications Anticoagulants

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Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita O.Teodoro Mafalda ribeiro Ramos Lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and franze,2024).

关键词： plasticity structural mechanisms

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Giant squamous cell carcinoma of the gallbladder: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2787-2793页

作者： marcelo Af ribeiro junior Murillo de Lima favaro Stephanie Santin Cintia Magalhaes Silva Ana Paula Marconi Iamarino Department of Acute Care and Trauma Surgery Hospital MoriahSao Paulo 04081000Brazil Department of Surgery University of Santo AmaroSao Paulo 04829- 300Brazil Department of Surgery Hospital MoriahUniversity of Santo AmaroSao Paulo 04829-300Brazil Medical Student University of Santo AmaroSao Paulo 04829-300Brazil Department of Surgery Hospital MoriahHospital MoriahSao Paulo 04829-300Brazil

BACKGROUND Gallbladder cancer is the most common malignant tumor of the biliary tract. The majority of cases are adenocarcinoma. Squamous cell carcinoma is the histological type present in 12% of all neoplasias accounting for approximately 12% of gallbladder neoplasms. It can occur in its pure form reaching 1%-3% of the tumors. Many patients are at an advanced stage when diagnosed and have bad therapeutic efficacy. CASE SUMMARY A 45-year-old male patient presented with left flank pain for 1 year and irradiated to the mesogastric region. He denied fever, vomiting, and any other intestinal changes. He reported a weight loss of 10 kg in a period of 7 mo. He denied alcoholism, smoking, drug use, or prior illness. Computed tomography of the abdomen showed in the gallbladder fossa a voluminous mesogastric heterogeneous collection that had a thick and irregular capsule with liquid and gaseous contents. A predominantly hypoattenuating rounded material with partially calcified margins measuring about 2.0 cm related to gallstone was also emphasized. No lymphadenomegalies or free fluid was observed in the abdominal cavity. Patient underwent laparotomy where a huge tumor was observed affecting the transverse colon and gallbladder. This mass was resected en bloc removing gallbladder and transverse colon together with corresponding mesocolon and regional lymphadenectomy. There were no complications in the postoperative period. Although oncological treatment was performed, the patient died 6 mo after surgery. CONCLUSION Squamous cell carcinoma represents a rare disease. Patients often present with large, bulky tumors with involvement of adjacent organs. In spite of progress in surgical techniques and adjuvant chemotherapy, the prognosis remains poor.

关键词： Squamous cell Carcinoma Gallbladder neoplasm Treatment Case report

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Periodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions?

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World Journal of Gastroenterology 2016年第35期22卷 7963-7972页

作者： Ronaldo Lira-junior Carlos marcelo figueredo Department of Periodontology Faculty of Odontology Rio de Janeiro State University Rio de Janeiro RJ 20551-030 Brazil

Periodontal disease and inflammatory bowel disease(IBD) are both chronic inflammatory diseases. Their pathogenesis is mediated by a complex interplay between a dysbiotic microbiota and the host immuneinflammatory response, and both are influenced by genetic and environmental factors. This review aimed to provide an overview of the evidence dealing with a possible pathogenic interaction between periodontal disease and IBD. There seems to be an increased prevalence of periodontal disease in patients with IBD when compared to healthy controls, probably due to changes in the oral microbiota and a higher inflammatory response. Moreover, the induction of periodontitis seems to result in gut dysbiosis and altered gut epithelial cell barrier function, which might contribute to the pathogenesis of IBD. Considering the complexity of both periodontal disease and IBD, it is very challenging to understand the possible pathways involved in their coexistence. In conclusion, this review points to a complex pathogenic interaction between periodontal disease and IBD, in which one disease might alter the composition of the microbiota and increase the inflammatory response related to the other. However, we still need more data derived from human studies to confirm results from murine models. Thus, mechanistic studies are definitely warranted to clarify this possible bidirectional association.

关键词： Periodontal disease Inflammatory bowel disease Crohn’s disease Ulcerative colitis Inflammation

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Epigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesis

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World Journal of Gastroenterology 2015年第30期21卷 9021-9037页

作者： Juliana Carvalho Santos marcelo Lima ribeiro Sao francisco University Medical School Clinical Pharmacology and Gastroenterology Unit Laboratory of Microbiology and Molecular Biology UNICAMP Universidade Estadual de CampinasGenetics and Molecular Biology

Although thousands of DNA damaging events occur in each cell every day,efficient DNA repair pathways have evolved to counteract them. The DNA repair machinery plays a key role in maintaining genomic stability by avoiding the maintenance of mutations. The DNA repair enzymes continuously monitor the chromosomes to correct any damage that is caused by exogenous and endogenous mutagens. If DNA damage in proliferating cells is not repaired because of an inadequate expression of DNA repair genes,it might increase the risk of cancer. In addition to mutations,which can be either inherited or somatically acquired,epigenetic silencing of DNA repair genes has been associated with carcinogenesis. Gastric cancer represents the second highest cause of cancer mortality worldwide. The disease develops from the accumulation of several genetic and epigenetic changes during the lifetime. Among the risk factors,Helicobacter pylori(H. pylori) infection is considered the main driving factor to gastric cancer development. Thus,in this review,we summarize the current knowledge of the role of H. pylori infection on the epigenetic regulation of DNA repair machinery in gastric carcinogenesis.

关键词： Helicobacter pylori DNA repair Epigenetic DNA methylation Gastric cancer Histone modification

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Impacted Lower Third Molar fused with a Supernumerary Tooth—Diagnosis and Treatment Planning Using Cone-Beam Computed Tomography

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International Journal of Oral Science 2009年第4期1卷 224-228页

作者： Osny ferreira-junior Luciana Dorigatti de .＆.Aila marcelo Bonifacio da Silva Sampieri Eduardo Dias- ribeiro Wei-liang Chen Song fan Department of Stomatology Dental School of Bauru University of Sao Paulo Bauru Sao Paulo Brazil Department of Stomatology the Second Affiliated Hospital Sun Yat-Sen University Guangzhou China

This paper reported a case of fusion between an impacted third molar and a supernumerary tooth, in which a surgical intervention was carried out, with the objective of removing the dental elements. The panoramic radiography was complemented by the Donovan＇s radiographic technique; but because of the proximity of the dental element to the mandibular ramus, it was not possible to have a final fusion diagnosis. Hence, the Cone-Beam Computed Tomography--which provides precise three- dimensional information--was used to determinate the fusion diagnosis and also to help in the surgical planning. In this case report we observed that the periapical, occlusal and panoramic were not able to show details which could only be examined through the cone-beam computed tomo- graphy.

关键词： third molar supernumerary tooth oral surgery,cone-beam computed tomography

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Comment on"Reversible 3D optical data storage and information encryption in photo-modulated transparent glass medium"

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Light(Science & Applications) 2022年第8期11卷 1933-1934页

作者： Gael Poirier marcelo Nalin Sidney J.L ribeiro Younes Messaddeq Institute of Science and Technology Federal University of AlfenasCampus Poços de CaldasPoços de CaldasMGBrazil Institute of Chemistry São Paulo State University UNESPAraraquaraSPBrazil

Dear Editor,The development of reversible photochromic materials combining efficient writing/erasing properties, low-cost and environmentally friendly compositions is a breakthrough challenge and a subject of many research works in the last decades. In this perspective, transparent oxide glasses are promising since their production is ensured by a simple melt-quenching technique and a proper laser writing setup is able to give rise to a localized photochromic effect, opening opportunities for 3D optical data storage.

关键词： transparent since glasses

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Thermal Behavior of Sr（ll） and Ba（ll）-Diclofenac Complexes in Solid State： Study of the Dehydration and Thermal Decomposition

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Chinese Journal of Chemistry 2011年第11期29卷 2271-2277页

作者： Kobelnik, marcelo Cassimiro, Douglas Lopes Santos, Diogenesdos Dos ribeiro, Clovis Augusto Crespi, Marisa Spirandelic Centro Universitdrio do Norte Paulista-UNORP Rua Ipiranga 3460 Sao Jose do Rio Preto SP Brazil Instituto de Quimica Sao Paulo State University C.P. 355 14800-900 Araraquara SP Brazil

Solid state compounds of general formula Sr（Diclof）2 ·5.7H2O and Ba（Diclof）2·4.8H2O were obtained. Thermo- gravimetry （TG）, differential scanning calorimetry （DSC）, X-ray diffraction powder patterns and microscopy analysis were used to characterize these compounds. Details concerning the dehydration and thermal decomposition as well as data of kinetic parameters have been described here. The kinetic behaviors of these stages were evaluated from several heating rates with samples masses of 2 and 5 mg in open crucibles under a nitrogen atmosphere. The results of the present study improve the knowledge on these compounds including their dehydration and thermal stability. The obtained data depend on the mass of the sample which results in two kinetic behavior patterns.

关键词： diclofenac divalent metal ions thermal behavior kinetic parameters

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Progeny selections of coffee cultivar'Mundo Novo'with potential for the specialty coffee market

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Beverage Plant Research 2023年第1期3卷 1-11页

作者： Gabriela Ester ferraz Marlon Enrique López flávia Maria Avelar Gonçalves marcelo ribeiro Malta Renato ribeiro de Lima Gladyston Rodrigues de Carvalho Lyndel WMeinhardt Dapeng Zhang Antonio Chalfun-junior Institute of Natural Sciences Department of BiologyFederal University of LavrasLavrasMinas Gerais 37200900Brazil Honduran foundation for Agricultural Research(fHIA) La LimaCortés 2067Honduras Empresa de Pesquisa Agropecuária de Minas Gerais(EPAMIG) Laboratory of Coffee QualityFederal University of Lavras CampusLavrasMinas Gerais 37200000Brazil Department of Statistics Federal University of LavrasLavrasMinas Gerais 37200900Brazil Empresa de Pesquisa Agropecuária de Minas Gerais(EPAMIG) Federal University of Lavras CampusLavrasMinas Gerais 37200900Brazil Sustainable Perennial Crops Laboratory United States Department of AgricultureAgricultural Research ServiceUSDAWest BeltsvilleMD 20705USA Institute of Natural Sciences Laboratory of Plant Molecular PhysiologyDepartment of BiologyFederal University of LavrasLavrasMinas Gerais 37200900Brazil

Coffee is one of the most popular beverages in the world with a global market worth over$USD 100 *** Brazil,the Arabica coffee(Coffea arabica)cultivar'Mundo Novo'is one of the most planted cultivars due to its high yield,growth vigor and ***,this traditional cultivar is generally not considered a good production source for specialty *** intra-cultivar variation and selecting'Mundo Novo'progenies with superior sensory quality may provide a viable option for coffee producers targeting the rapidly expanding specialty coffee *** present study analyzed cup quality attributes,agronomic characteristics and genetic identities of 14 genotypes selected from the putative progenies of'Mundo Novo'and assessed their potential as specialty coffee in *** quality was assessed using chemical and sensory analysis according to the methodology proposed by the Specialty Coffee Association(SCA)in six selected *** sensory quality,with sensory scores above 80 points was observed which qualified them in the very good and excellent quality *** identities of the 14 selections were verified using 96 SNP markers,based on 57 reference cultivars from the coffee collection of EPAMIG(Empresa de Pesquisa Agropecuária de Minas Gerais),*** and Bayesian clustering analysis generated consistent results and confirmed that all the 14 selections were progenies of'Mundo Novo'.Among them,the top three genotypes(SGAB 1,SGAB 7 and SGAB 8)were selected as promising genotypes,either for future genetic improvement or for direct use in the production of specialty coffee.

关键词： market potential Brazil

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