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Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation

World Journal of Gastroenterology 2015年第13期21卷 3912-3920页

作者： Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero marcello vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone Department of Medical and Surgical Sciences University of Bologna and Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’Orsola Malpighi40138 BolognaItaly Department of Gastroenterology Azienda Ospedaliero-Universitaria and University of Modena and Reggio Emilia41124 ModenaItaly Department of Hepatology and Gastroenterology Niguarda Hospital20162 MilanItaly Hepatobiliopancreatic and General Surgery Unit Regina Elena Institute00186 RomeItaly Department of General Surgery and Transplantation Niguarda Hospital20162 MilanItaly

AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic ***: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, "too sick to be treated" and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the "non-responders"(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence.

关键词： Hepatitis C Liver transplantation Hepatitis C viru

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China＇s Engagement with the Sixteen Countries of Central, East and Southeast Europe under the Belt and Road Initiative

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China & World Economy 2017年第5期25卷 101-124页

作者： Anastas vangeli Doctoral Researcher Graduate School for Social Research Polish Academy of Sciences Poland

This paper provides an overview of China＇s burgeoning relationship with Central, Eastand Southeast Europe （CESEE） in the context of the Belt and Road Initiative （BRI）.China has rapidly expanded the extent of its interactions with CESEE since 2012,and this region has subsequently become one of the focal points of the BRI. The keyfeature of China＇s engagement with CESEE is the devising of an experimental andinnovative approach, demonstrated in the establishment of an institutional mechanismfor cooperation with a particular group of16 CESEE countries （16＋1）. The case ofChina-CESEE relations offers an insight into how, in the era of the BRL China iscomplementing its economic approach with institution-building and policy *** article concludes that as the BRI progresses, these tendencies will remain central toChina＇s relations with CESEE.

关键词： Belt and Road Initiative, foreign relations, 16+1

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中国-CESEE合作的不对称关系和深化合作关系面临的障碍：理解和解决方案

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国际商务研究 2018年第4期39卷 57-66,87页

作者： Anastas vangeli Adela Gjorgjioska 郝晓琼杨晨成华沙波兰科学院汉堡ZEIT施蒂夫通机构罗马大学上海对外经贸大学

自"一带一路"倡议提出以来,中国和中东欧国家合作使双方都取得了巨大的进展和成果。本文基于该背景分析了中国和中东欧国家进一步合作的主要障碍,并为双方政府克服这些困难提供了政策建议。首先,文章回顾了"一带一路"推动双方合作的背景... 详细信息

自"一带一路"倡议提出以来,中国和中东欧国家合作使双方都取得了巨大的进展和成果。本文基于该背景分析了中国和中东欧国家进一步合作的主要障碍,并为双方政府克服这些困难提供了政策建议。首先,文章回顾了"一带一路"推动双方合作的背景,简要总结了该议题的政策艺术性。然后,基于高层官员及专家间的访谈内容和政治论坛上有关合作事项的与会观察,本文提供了对这些原始数据的分析。文章的分析模型结合了两种衡量推进合作障碍的评估标准。第一种基于对问题源头的探讨,即究竟是外生因素还是内生因素造成的;第二种基于代理—结构二分法。之后,文章为每一种障碍提供了各自的理论分析模型(源于结构的内生因素,源于代理的内生因素,源于结构的外生因素,源于代理的外生因素),并相应给出合作实践中的具体实例。本文的最后一部分对每种障碍存在的可能解决机制做出了分析,并提出了双方在未来如何提高适应力和推进合作的指导原则。

关键词： 16+1 合作障碍解决机制国际贸易

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Occult Cytomegalovirus Cholangitis and Pancreatic Adenocarcinoma: A Case Report

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Infectious Diseases & Immunity 2023年第3期3卷 140-141页

作者： Antonio Mastroianni Sonia Greco Valeria vangeli Maria Vittoria Mauro Francesca Greco Roberto Manfredi Infectious&Tropical Diseases Unit "Annunziata"Hub HospitalAzienda Ospedaliera di CosenzaCosenzaItaly Microbiology&Virology Unit "Annunziata"Hub HospitalAzienda Ospedaliera di CosenzaCosenzaItaly University of Bologna BolognaItaly

A rare case of occult cytomegalovirus(CMV)cholangitis along with an updated literature review is *** patient had not undergone solid organ-bone marrow transplantation and had no chronic autoimmune biliary tract disorder or obvious *** patient had underwent a pyloric-sparing duodenocephalopancreasectomy,and the postoperative histopathologic examination revealed multiple ulcerative lesions and an occult CMV *** copy number of CMV DNA was high(38,000 copies/μg DNA)in common bile duct surgical specimens measured by real-time quantitative polymerase chain *** was not detected in blood and urine samples from the patient after full doses of intravenous ganciclovir and full doses of oral valganciclovir antiviral *** report recapitulates the role of CMV in causing severe cholangiopathy in the absence of obvious immunosuppression or autoimmune disorder of the biliary tract.

关键词： Cholangitis Bile cytomegalovirus-DNA detection Biliary complications Cytomegalovirus

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出血性异位血管曲张:经颈静脉肝内门体分流术(TIPS)及栓塞术治疗

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 56-57页

作者： vangeli M. Patch D. Terreni N. 姜志茹

Bleeding ectopic varices due to cirrhosis can be difficult to manage. We report our experience of uncontrolled bleeding from ectopic varices treated with transjugular intrahepatic porto systemic shunt (TIPS).We selected the 21 cirrhotics who underwent TIPS for bleeding ectopic varices from our database: Child Pugh grade A(2), B (11) and C(8). Site of bleeding was rectal(11), colonic (2), ileal(1), jejunal(1), duodenal(1), and stomal(5). TIPS was performed successfully in 19/21(90%) patients. All except 1 had either a reduction in portosystemic pressure gradient ≤12 mmHg(n=12) or reduction by 25-50%of baseline(n=6). TIPS alone was used in 12/19: 7 of these 12 had no further bleeding; 5 (42%) rebled within 48 h, and had embolisation, 4 without further bleeding. In 7 of 19, TIPS and embolisation were performed together: 2 patients(28%) rebled; further embolisation stopped the bleeding. Ectopic varices do rebleed despite a reduction of porto systemic pressure gradient ≤12 mmHg or by 25-50%of baseline, following TIPS. Embolisation stopped bleeding in all but 1 patient. We recommend performing embolisation at the time of the initial TIPS to control bleeding from ectopic varices.

关键词： TIPS 经颈静脉肝内门分流术栓塞术治疗再出血门体基线水平压力梯度循环压力张行

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