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Fluidization and Transport of Vibrated Granular Matter:A Review of Landmark and Recent Contributions

Fluid Dynamics & Materials Processing 2024年第1期20卷 1-29页

作者： Peter Watson Sebastien Vincent Bonnieu marcello Lappa Department of Mechanical and Aerospace Engineering University of StrathclydeGlasgowUK European Space Agency European Space Research and Technology CentreNoordwijkNetherland

We present a short retrospective review of the existing literature about the dynamics of(dry)granular matter under the effect of *** main objective is the development of an integrated resource where vital information about past findings and recent discoveries is provided in a single *** attention is paid to those works where successful synthetic routes to as-yet unknown phenomena were *** landmark results are analyzed,while smoothly blending them with a history of the field and introducing possible categorizations of the prevalent *** no classification is perfect,and it is hard to distillate general properties out of specific observations or realizations,two possible ways to interpret the existing results are defined according to the type of forcing or the emerging(ensuing)regime of *** particular,first results concerning the case where vibrations and gravity are concurrent(vertical shaking)are examined,then the companion situation with vibrations perpendicular to gravity(horizontal shaking)is *** classes are introduced as follows:(1)Regimes where sand self-organizes leading to highly regular geometrical“pulsating”patterns(thin layer case);(2)Regimes where the material undergoes“fluidization”and develops an internal multicellular convective state(tick layers case);(3)Regimes where the free interface separating the sand from the overlying gas changes inclination or develops a kind a patterned configuration consisting of stable valleys and mountains or travelling waves;(4)Regimes where segregation is produced,i.e.,particles of a given size tend to be separated from the other grains(deep containers).Where possible,an analogy or parallelism is drawn with respect to the companion field of fluid-dynamics for which the assumption of“continuum”can be applied.

关键词： Granular materials vibrations fluidization flowability symmetry breaking

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Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans:an overview of recent findings

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Neural Regeneration Research 2024年第9期19卷 1908-1918页

作者： marcello Serra Nicola Simola Alexia E.Pollack Giulia Costa Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic *** toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and *** present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and *** elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.

关键词： 3,4-methylenedioxymethamphetamine amphetamine caffeine cell cultures cocaine methamphetamine methylphenidate neurotoxicity nicotine

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Forcing in Christian Events: The Turin Shroud Case

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Open Journal of Applied Sciences 2024年第9期14卷 2351-2359页

作者： Giovanni Fazio marcello Leonello Francesca Riotto Department of Mathematical and Computer Sciences Physical Sciences and Earth Sciences University of Messina Messina Italy Diocese of Oppido Mamertina-Palmi Palmi Italy

In its totality and complexity, the theme of forcing in Christian events is almost impossible to investigate. In fact, a lot of scholars and a very long time would be necessary to analyse the numerous events. Thus, we decided to investigate such events only in the study of the Shroud of Turin, an archaeological find known worldwide. The above topic is essential for Christianity. Furthermore, we must take into account that also among the followers of other religions, atheists and agnostics, there is a considerable interest. We think this is due to the unexpected characteristics that the Body Image, which appears on the Burial Linen of the Nazarene, shows. In this article, we would like to demonstrate that the practice of forcing is still in use. These actions, which are also present on the other side, in the non-Christian world, are the result of conflicts of religious interests. To confirm the presence of the Almighty is not necessarily the forcing. Finding a solution to these problems is not our job. However, we want to highlight them through scientific literature.

关键词： Shroud of Turin Forcing Sindonology Aromas Pollens Radiative Hypothesis

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What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

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Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： marcello Henrique Araujo Da Silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada Francisco Jose Barcellos Sampaio Diogo Benchimol de Souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when P<*** concentration,motility,and viability showed no difference between the ***,testicular weight and volume,seminiferous tubule diameter,tunica propria surface density,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

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Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic Dysfunction-Associated Steatotic Liver Disease-induced cirrhosis

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World Journal of Gastroenterology 2024年第7期30卷 685-704页

作者： marcello Dallio Mario Romeo Paolo Vaia Salvatore Auletta Simone Mammone Marina Cipullo Luigi Sapio Angela Ragone Marco Niosi Silvio Naviglio Alessandro Federico Department of Precision Medicine Hepatogastroenterology DivisionUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Precision Medicine Clinical Biochemistry DivisionUniversity of Campania Luigi VanvitelliNaples 80138Italy

BACKGROUND For compensated advanced chronic liver disease(cACLD)patients,the first decompensation represents a dramatically worsening prognostic *** on the first decompensation event(DE),the transition to decompensated advanced chronic liver disease(dACLD)can occur through two modalities referred to as acute decompensation(AD)and non-AD(NAD),*** Significant Portal Hypertension(CSPH)is considered the strongest predictor of decompensation in these ***,due to its invasiveness and costs,CSPH is almost never evaluated in clinical ***,recognizing noninvasively predicting tools still have more appeal across healthcare *** red cell distribution width to platelet ratio(RPR)has been reported to be an indicator of hepatic fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD).However,its predictive role for the decompensation has never been *** In this observational study,we investigated the clinical usage of RPR in predicting DEs in MASLD-related cACLD *** Fourty controls and 150 MASLD-cACLD patients were consecutively enrolled and followed up(FUP)semiannually for 3 *** baseline,biochemical,clinical,and Liver Stiffness Measurement(LSM),Child-Pugh(CP),Model for End-Stage Liver Disease(MELD),aspartate aminotransferase/platelet count ratio index(APRI),Fibrosis-4(FIB-4),Albumin-Bilirubin(ALBI),ALBI-FIB-4,and RPR were *** FUP,DEs(timing and modaities)were *** was assessed at the baseline and on DE occurrence according to the available Clinical Practice *** Of 150 MASLD-related cACLD patients,43(28.6%)progressed to dACLD at a median time of 28.9 months(29 NAD and 14 AD).Baseline RPR values were significantly higher in cACLD in comparison to controls,as well as MELD,CP,APRI,FIB-4,ALBI,ALBI-FIB-4,and LSM in dACLD-progressing compared to cACLD individuals[all P<0.0001,except for FIB-4(P:0.007)and ALBI(P:0.011)].Receiving operator curve a

关键词： Liver cirrhosis Red blood cell distribution width Red blood cell distribution width to platelet ratio Translational Medicine Prognostic biomarker

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Evaluation of ruminal methane and ammonia formation and microbiota composition as affected by supplements based on mixtures of tannins and essential oils using Rusitec

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1607-1622页

作者： Giulia Foggi Melissa Terranova Matteo Daghio Sergej L.Amelchanka Giuseppe Conte Simon Ineichen Monica Agnolucci Carlo Viti Alberto Mantino Arianna Buccioni Michael Kreuzer marcello Mele Department of Agriculture Food and Environment(DAFE)University of Pisa56124 PisaItaly AgroVet‑Strickhof ETH ZurichLindauSwitzerland Department of Agriculture FoodEnvironment and ForestryUniversity of FlorenceFlorence 50144Italy Centro Di Ricerche Agro‑Ambientali“E.Avanzi” University of PisaPisa 56122Italy School of Agricultural Forest and Food Sciences HAFLBern University of Applied SciencesZollikofenSwitzerland Institute of Agricultural Sciences ETH ZurichLindauSwitzerland

Background Dietary supplements based on tannin extracts or essential oil compounds(EOC)have been repeatedly reported as a promising feeding strategy to reduce the environmental impact of ruminant husbandry.A previous batch culture screening of various supplements identified selected mixtures with an enhanced potential to mitigate ruminal methane and ammonia *** these,Q-2(named after quebracho extract and EOC blend 2,composed of carvacrol,thymol,and eugenol)and C-10(chestnut extract and EOC blend 10,consisting of oregano and thyme essential oils and limonene)have been investigated in detail in the present study with the semi-continuous rumen simulation technique(Rusitec)in three independent *** this purpose,Q-2 and C-10,dosed according to the previous study,were compared with a non-supplemented diet(negative control,NC)and with one supplemented with the commercial EOC-based Agolin^(R) Ruminant(positive control,PC).Results From d 5 to 10 of fermentation incubation liquid was collected and analysed for pH,ammonia,protozoa count,and gas *** residues were collected for the determination of ruminal *** d 10,samples of incubation liquid were also characterised for bacterial,archaeal and fungal communities by high-throughput sequencing of 16S rRNA and 26S ribosomal large subunit gene *** of the duration of the fermentation period,Q-2 and C-10 were similarly efficient as PC in mitigating either ammonia(-37%by Q-2,-34%by PC)or methane formation(-12%by C-10,-12%by PC).The PC was also responsible for lower feed degradability and bacterial and fungal richness,whereas Q-2 and C-10 effects,particularly on microbiome diversities,were limited compared to *** All additives showed the potential to mitigate methane or ammonia formation,or both,in vitro over a period of 10 ***,several differences occurred between PC and Q-2/C-10,indicating different mechanisms of *** pronounced defaunation caused by PC a

关键词： Additive Bacteria Continuous culture Degradability Fermentation Fungi Greenhouse gas In vitro Microbiome Rumen

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Linking 24-h Movement Behavior Guidelines to Cognitive Difficulties,Internalizing and Externalizing Problems in Preterm Youth

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International Journal of Mental Health Promotion 2024年第8期26卷 651-662页

作者： Zhihui Cheng Ailikute Aikeremu Yanping Gao Zhihao Zhang Anthony G.Delli Paoli Paolo marcello Cunha Alyx Taylor Fabian Herold Liye Zou Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen518060China Department of Kinesiology and Health Rutgers UniversityNew BrunswickNJ 08901USA Metropolitan University Center of Maringá Maringá87020Brazil School of Health and Rehabilitation Sciences AECC University CollegeBournemouthBH52DFUK Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam14476Germany

Background:Given the heightened risk of developmental challenges associated with preterm birth,it is crucial to explore interventions that may ameliorate potential adverse *** study aimed to examine whether meeting the 24-h movement behavior(24-HMB)guidelines,which include recommendations on physical activity(PA),screen time(ST),and sleep(SL),is related to indicators of cognitive difficulties,internalizing problems(e.g.,depression and anxiety),and externalizing problems(e.g.,difficulties in making friends and arguing)in a sample of preterm youth(children and adolescents born preterm).Methods:In this cross-sectional study,data from 3410 preterm youth(aged 6 to 17 years)were included for data *** logistic regression was used to investigate associations between meeting the 24-HMB guidelines and the above-mentioned health outcomes,while controlling for sociodemographic and health-related ***:The prevalence of meeting 24-HMB guidelines varied across independent and integrated components of the 24-HMB *** the ST guideline alone(p<0.05)and integrated guidelines(i.e.,ST+SL and ST+SL+PA)were associated with fewer cognitive difficulties and reduced internalizing and externalizing problems(p<0.05).Specifically,meeting the SL guideline alone and integrated guidelines(i.e.,SL+ST)were associated with lower odds of depression and anxiety(p<0.01).Additionally,meeting independent,and integrated(PA and/or ST)guidelines were associated with less pronounced difficulties in making friends and arguing(p<0.05).Meeting 24-HMB guidelines in an isolated and integrated manner are linked to better cognitive performance and fewer internalizing and externalizing problems in preterm ***:Results suggest that advocating for the implementation of the 24-HMB guidelines may reduce cognitive challenges and behavioral issues,which is of high relevance for improving public *** longitudinal studies in preterm youth should inves

关键词： Cognitive difficulties externalizing problems internalizing problems physical activity preterm youth

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如何利用历史数据更好地做好投资决策

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中华纸业 2024年第3期45卷 19-20页

作者： ResourceWise marcello Collares ResourceWise

对于各大造纸企业来说,具有战略性的决定何时何地投资的能力对于业务增长和保持竞争优势至关重要,而利用好历史数据可以作为解决这一关键问题的指导力量。历史数据提供了对过去趋势、市场行为和客户偏好的宝贵见解。这些信息使企业能够... 详细信息

对于各大造纸企业来说,具有战略性的决定何时何地投资的能力对于业务增长和保持竞争优势至关重要,而利用好历史数据可以作为解决这一关键问题的指导力量。历史数据提供了对过去趋势、市场行为和客户偏好的宝贵见解。这些信息使企业能够根据具体数据做出明智的决策。

关键词：投资决策历史数据造纸企业客户偏好保持竞争优势关键问题战略性

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γ氨基丁酸转运体1在大脑皮质小胶质细胞中的表达

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神经损伤与功能重建 2020年第12期15卷 F0003-F0003页

作者： Giorgia Fattorini Myriam Catalano marcello melone Carmela Serpe Silvia Bassi Cristina Limatola Fiorenzo Conti 杜一星(编译) Department of Experimental and Clinical Medicine Section of Neuroscience and Cell BiologyUniversitàPolitecnica delle MarcheAnconaItaly Center for Neurobiology of Aging IRCCS INRCAAnconaItaly Department of Physiology and Pharmacology Sapienza University of RomeLaboratory Affiliated to Istituto Pasteur ItaliaRomeItaly IRCCS Neuromed Via AtinensePozzilliItaly 不详

小胶质细胞是脑的免疫细胞。通过感知微环境,小胶质细胞可以使大脑正常发育和发挥功能。它们与其他神经胶质细胞和神经元通讯,释放能对周围细胞产生影响的许多分子,并且能对这些分子做出反应。其中,神经递质,尤其是γ-氨基丁酸(GABA)最... 详细信息

小胶质细胞是脑的免疫细胞。通过感知微环境,小胶质细胞可以使大脑正常发育和发挥功能。它们与其他神经胶质细胞和神经元通讯,释放能对周围细胞产生影响的许多分子,并且能对这些分子做出反应。其中,神经递质,尤其是γ-氨基丁酸(GABA)最近引起了研究者对这一过程的兴趣。我们证明了GABA转运体1(GAT-1)在小胶质细胞的胞体和突起均有表达。我们发现,用强效的和选择性的GAT-1抑制剂NNC-711处理小胶质细胞,可显着降低其钠离子依赖性GABA的摄取。另一方面,用GAT-2/3抑制剂SNAP-5114处理细胞能显著增加其对GABA的摄取。该作用可被肉毒杆菌毒素Bo NT/C1完全阻断,该毒素特异性切割和灭活突触融合蛋白1A(STX1A)。总而言之,这些发现表明小胶质细胞表达GAT-1,且STX1A在小胶质细胞中GAT-1依赖的GABA摄取调控中起着重要作用。

关键词： γ氨基丁酸 γ氨基丁酸转运体1 小胶质细胞

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Statistical Analysis of Abilities to Give Consent to Health Data Processing

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Applied Mathematics 2024年第8期15卷 508-542页

作者： Antonella Massari Biagio Solarino Paola Perchinunno Angela Maria D’Uggento marcello Benevento Viviana D’Addosio Vittoria Claudia De Nicolò Samuela L’Abbate Department of Economics Management and Business Law University of Bari Aldo Moro Bari Italy Institute of Legal Medicine Department of Interdisciplinary Medicine University of Bari Aldo Moro Bari Italy Department of Economics and Finance University of Bari Aldo Moro Bari Italy

The recent pandemic crisis has highlighted the importance of the availability and management of health data to respond quickly and effectively to health emergencies, while respecting the fundamental rights of every individual. In this context, it is essential to find a balance between the protection of privacy and the safeguarding of public health, using tools that guarantee transparency and consent to the processing of data by the population. This work, starting from a pilot investigation conducted in the Polyclinic of Bari as part of the Horizon Europe Seeds project entitled “Multidisciplinary analysis of technological tracing models of contagion: the protection of rights in the management of health data”, has the objective of promoting greater patient awareness regarding the processing of their health data and the protection of privacy. The methodology used the PHICAT (Personal Health Information Competence Assessment Tool) as a tool and, through the administration of a questionnaire, the aim was to evaluate the patients’ ability to express their consent to the release and processing of health data. The results that emerged were analyzed in relation to the 4 domains in which the process is divided which allows evaluating the patients’ ability to express a conscious choice and, also, in relation to the socio-demographic and clinical characteristics of the patients themselves. This study can contribute to understanding patients’ ability to give their consent and improve information regarding the management of health data by increasing confidence in granting the use of their data for research and clinical management.

关键词： Privacy Health Data Consent Cluster Analysis Logit

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