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World Journal of Gastroenterology 2018年第31期24卷 3469-3471页

作者： Quirino Lai Michele di martino Pierleone Lucatelli Gianluca Mennini Department of General Surgery and Organ Transplantation Sapienza University of Rome Department of Radiology Sapienza University of Rome

Locoregional treatments(LRT) represent a broad strategy used for reducing the risk of drop-off and contextually improving the survivals in patients with hepatocellular cancer receiving a liver transplantation(LT). However, it is not sufficiently clear if LRT are only a surrogate of tumor aggressiveness or if they consent a real benefit in terms of tumor stabilization. A recent study by Pommergaard et al reported the results from the European Liver Transplant Registry. Patients receiving LRT before LT had better 5-year survival rates respect to no-LRT cases(69.7% vs 65.8%; P discordance with other analyses showing a detrimental effect of LRT. The main problem in the interpretation of these results is connected with the possible initial selection biases present in the studies. The most recent guidelines suggest to perform LRT before the transplant, but the level of evidence is typically low due to the absence of prospectively designed studies.

关键词： Allocation Recurrence Trans-arterial chemo-embolization Radiofrequency ablation Model for end-stage liver disease

Therapeutic implications of colon cancer stem cells

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World Journal of Gastroenterology 2010年第31期16卷 3871-3877页

作者： Eros Fabrizi Simona di martino Federica Pelacchi Lucia Ricci-Vitiani Department of Hematology Oncology and Mo-lecular MedicineIstituto Superiore di SanitàViale Regina Elena 299Rome 00161Italy

Colorectal cancer is the second most common cause of cancer-related death in many industrialized countries and is characterized by a heterogenic pool of cells with distinct differentiation patterns. Recently, the concept that cancer might arise from a rare population of cells with stem cell-like properties has received support with regard to several solid tumors, including colorectal cancer. According to the cancer stem cell hypothesis, cancer can be considered a disease in which mutations either convert normal stem cells into aberrant counterparts or cause a more differentiated cell to revert toward a stem cell-like behaviour; either way these cells are thought to be responsible for tumor generation and propagation. The statement that only a subset of cells drives tumor formation has major implications for the development of new targeted therapeutic strategies aimed at eradicating the tumor stem cell population. This review will focus on the biology of normal and malignant colonic stem cells, which might contribute to our understanding of the mechanisms responsible for tumor development and resistance to therapy.

关键词： Colon cancer initiating cells Colon carcinogenesis Target therapy

Effect of a Hybrid Zinc Stearate-Silver System on the Properties of Polylactide and Its Abiotic and the Biotic Degradation and Antimicrobial Activity Thereof

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Chinese Journal of Polymer Science 2018年第8期36卷 925-933页

作者： Gabriela Jandikova Petra Stoplova Antonio di martino Petr Stloukal Pavel Kucharczyk Michal Machovsky Vladimir Sedlarik Centre of Polymer Systems University Institute Tomas Bata University in Zlin tr. Tomas Bati 5678 760 O1 Zlin Czech Republic

This work investigates the degradation and properties of a thermoplastically prepared composite comprising a polylactide/ hybrid zinc stearate-silver system. The influence of the zinc stearate-silver system on the properties of the composite is investigated by electron microscopy, differential scanning calorimetry and tensile tests. Furthermore, the antimicrobial activities of the systems are examined. The degradation behaviour of the composites is studied in both abiotic and biotic （composting） environments at an elevated temperature of 58 ℃. The results reveal good dispersion of the additive in the PLA matrix, a stabilizing effect exerted by the same on the polylactide matrix during processing, and slight reduction in glass transition temperature. The zinc stearate-silver component also reduces brittleness and extends elongation of the composite. Abiotic hydrolysis is not significantly affected, which is in contrast with pure PLA, although mineralization during the early stage of biodegradation increases noticeably. The composite exhibits antimicrobial activity, even at the lowest dosage of the zinc stearate/silver component （1 wt%）. Moreover, Ag and Zn contents were found to be present in the composite during abiotic hydrolysis, which was demonstrated by minimal diffusion of Ag ions from the matrix and very extensive washing of compounds that contained Zn.

关键词： Polylactide Composite Biodegradation Zinc stearate Silver Antimicrobial

Evaluation of thermal water in patients with functional dyspepsia and irritable bowel syndrome accompanying constipation

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World Journal of Gastroenterology 2006年第16期12卷 2556-2562页

作者： Giovanni Gasbarrini marcello Candelli RiccardoGiuseppe Graziosetto Sergio Coccheri Ferdinando di Iorio Giuseppe Nappi Department of Internal medicine Catholic University of RomeItaly Department of Angiology University of BolognaItaly Department of Statistical Science and Biometry University of L'AquilaItaly Department of Thermal Medicine University of MilanItaly

AIM： To evaluate the efficacy of water supplementation treatment in patients with functional dyspepsia or irritable bowe syndrome （IBS） accompanying predominant constipation. METHODS： A total of 3872 patients with functional dyspepsia and 3609 patients with irritable bowel syndrome were enrolled in the study by 18 Italina thermal centres. Patients underwent a first cycle of thermal therapy for 21 d. A year later patients were re-evaluated at the same centre and received another cycle of thermal therapy. A questionnare to collect personal data on social and occupational status, family and pathological case history, life style, clinical records, utilisation of welfare and health structure and devices was administered to each patient at basal time and one year after each thermal treatment. Sixty patients with functional dyspepsia and 20 with IBS and 80 healthy controls received an evaluation of gastric output and oro-cecal transit time by breath test analysis. Breath test was performed at basal time and after water supplementaton therapies. Gastrointestinal symptoms were evaluated at the same time points. Breath samples were analyzed with a mass spectometer and a gascromatograph. Results were expressed as T1/2 and T-lag for octanoic add breath test and as oro-cecal transit time for lactulose breath test. RESULTS： A significant reduction of prevalence of symptoms was observed at the end of the first and second cycles of thermal therapy in dyspeptic and IBS patients, The analysis of variance showed a real and persistant improvement of symptoms in all patients. After water supplementation for 3 wk a reduction of gastric output was observed in 49 （87.5%） of 56 dyspepUc patients. Both T1/2 and T-lag were significantly reduced after the therapy compared to basal values [91 ± 12 （T1/2） and 53± 11 （T-lag）, Tables 1 and 2] with results of octanoic acid breath test similar to healthy subjects. After water supplementation for 3 wk oro-cecal transit time was shorter than that at t

关键词： Mineral water Constipation dispepsia Thermal therapy

贺兰山东麓产区非酿酒酵母筛选及发酵特性研究

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食品与发酵工业 2025年第1期51卷 72-80,I0001-I0007页

作者：周迪卢玲王岚宁夏大学食品科学与工程学院宁夏银川750021 宁夏大学葡萄酒与园艺学院宁夏银川750021 葡萄与葡萄酒教育部工程研究中心宁夏银川750021

该研究对112株宁夏本土非酿酒酵母进行高糖、乙醇、pH、SO_(2)耐受性筛选及生长曲线的测定,筛选出耐受性强的本土非酿酒酵母进行赤霞珠葡萄酒发酵试验,通过理化指标测定、感官评价和挥发性物质测定,研究菌株发酵特性。结果表明,筛选出的... 详细信息

该研究对112株宁夏本土非酿酒酵母进行高糖、乙醇、pH、SO_(2)耐受性筛选及生长曲线的测定,筛选出耐受性强的本土非酿酒酵母进行赤霞珠葡萄酒发酵试验,通过理化指标测定、感官评价和挥发性物质测定,研究菌株发酵特性。结果表明,筛选出的4株本土非酿酒酵母YC-A13、YC-B10、YC-C13、YQY-B12均可耐受葡萄糖质量浓度450 g/L、乙醇含量13%、pH 1.0、SO_(2)质量浓度250 mg/L,优于商业酿酒酵母F33、CECA、XR。与商业酿酒酵母发酵酒样相比,4株本土非酿酒酵母发酵酒样产生了独有的香气物质癸酸乙酯、2-糠酸乙酯,质量浓度分别在17.63~19.85μg/L、4.04~20.42μg/L,癸酸甲酯的OAV>1可作为葡萄酒的主要香气成分;YC-B10、YC-C13、YQY-B12发酵酒样中产生了具有草本香、蔷薇花香的香茅醇,质量浓度在5.82~8.43μg/L。非酿酒酵母菌株发酵酒样之间产生的香气物质也存在明显差异,葡萄汁有孢汉逊酵母YC-B10和YQY-B12发酵酒样中产生了该种属独有的香气物质己酸丁酯,质量浓度分别为69.31和69.06μg/L,还分别产生了具有奶酪香气的己酸(质量浓度为536.25μg/L)和具有杏仁、菠萝香气的丙酸异戊酯(质量浓度为1.71μg/L)。美极梅奇酵母YC-A13和泽普林假丝酵母YC-C13发酵酒样中产生了具有脂香、黄油香气的2,3-丁二酮,质量浓度分别为69.31和69.06μg/L。美极梅奇酵母YC-A13中检测出具有扁桃仁、脂香气的1-戊醇,含量为280.15μg/L,OAV>0.1可作为潜在香气成分。综上所述,筛选出的4株优良本土非酿酒酵母具有不同的发酵特性,在提升葡萄酒香气品质和丰富度方面都有着独特的贡献与优势,为酿造具有产区特色的葡萄酒提供了理论依据。

关键词：本土非酿酒酵母耐受性发酵特性挥发性化合物

Comparison of magnetic resonance spectroscopy, proton density fat fraction and histological analysis in the quantification of liver steatosis in children and adolescents

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World Journal of Gastroenterology 2016年第39期22卷 8812-8819页

作者： Michele di martino Lucia Pacifico Mario Bezzi Rossella di Miscio Beatrice Sacconi Claudio Chiesa Carlo Catalano Department of Radiological Sciences Oncology and Anatomical Pathology "Sapienza" University of Rome Department of Pediatrics and Child Neuropsychiatry "Sapienza" University of Rome Institute of Translational Pharmacology National Research Council

AIM To establish a threshold value for liver fat content between healthy children and those with nonalcoholic fatty liver disease(NAFLD) by using magnetic resonance imaging(MRI), with liver biopsy serving as a reference standard. METHODS The study was approved by the local ethics committee, and written informed consent was obtained from all participants and their legal guardians before the study began. Twenty-seven children with NAFLD underwent liver biopsy to assess the presence of nonalcoholic steatohepatitis. The assessment of liver fat fraction was performed using MRI, with a high field magnet and 2D gradient-echo and multiple-echo T1-weighted sequence with low flip angle and single-voxel pointresolved 1H MR-Spectroscopy(1H-MRS), corrected for T1 and T2* decays. Receiver operating characteristic curve analysis was used to determine the best cutoff value. Lin coefficient test was used to evaluate thecorrelation between histology, MRS and MRI-PDFF. A Mann-Whitney U-test and multivariate analysis were performed to analyze the continuous variables. RESULTS According to MRS, the threshold value between healthy children and those with NAFLD is 6%; using MRI-PDFF, a cut-off value of 3.5% is suggested. The Lin analysis revealed a good fit between the histology and MRS as well as *** MRS is an accurate and precise method for detecting NAFLD in children.

关键词： Magnetic resonance spectroscopy Magnetic resonance imaging-PDFF Obesity Non-alcoholic fatty liver disease Children

Carbon sequestration capability of Fagus sylvatica forests developing in the Majella National Park (Central Apennines,Italy)

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Journal of Forestry Research 2018年第6期29卷 1627-1634页

作者： Loretta Gratani Luciano di martino Anna Rita Frattaroli ANDrea Bonito Valter di Cecco Walter De Simone Giorgia Ferella Rosangela Catoni Department of Environmental Biology Sapienza University of Rome Majella Seed Bank Majella National Park Department of Life Health and Environmental Sciences University of L'Aquila

Terrestrial ecosystems represent a major sink for atmospheric carbon(C) and temperate forests play an important role in global C cycling, contributing to lower atmospheric carbon dioxide(CO2) concentration through photosynthesis. The Intergovernmental Panel of Climate Change highlights that the forestry sector has great potential to decrease atmospheric CO2concentration compared to other sectoral mitigation activities. The aim of this study was to evaluate CO2sequestration(CO2S)capability of Fag us sylvatica(beech) growing in the Orfento Valley within Majella National Park(Abruzzo,Italy). We compared F. sylvatica areas subjected to thinning(one high-forest and one coppice) and no-management areas(two high-forests and two coppices). The results show a mean CO2S of 44.3 ± 2.6 Mg CO2ha-1a-1,corresponding to 12.1 ± 0.7 Mg C ha-1a-1the no-managed areas having a 28% higher value than the managed areas. The results highlight that thinning that allows seed regeneration can support traditional management practices such as civic use in some areas while no management should be carried out in the reserve in order to give priority to the objective of conservation and naturalistic improvement of the forest heritage.

关键词： Beech Carbon sequestration Coppice High-forest Leaf area index

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

T1-weighted dual-echo MRI for fat quantification in pediatric nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2011年第25期17卷 3012-3019页

作者： Lucia Pacifico Michele di martino Carlo Catalano Valeria Panebianco Mario Bezzi Caterina Anania Claudio Chiesa Department of Pediatrics Sapienza University of Rome Department of Radiological Sciences Sapienza University of Rome Institute of Translational Pharmacology National Research Council

AIM： To determine in obese children with nonalcoholic fatty liver disease （NAFLD） the accuracy of magnetic resonance imaging （MRI） in assessing liver fat concentration. METHODS： A case-control study was performed. Cases were 25 obese children with biopsy-proven NAFLD. Controls were 25 obese children matched for age and gender, without NAFLD at ultrasonography and with normal levels of aminotransferases and insulin. Hepatic fat fraction （HFF） by MRI was obtained using a modification of the dixon ***： HFF ranged from 2% to 44% [mean, 19.0% （95% CI, 15.1-27.4）] in children with NAFLD, while in the controls this value ranged from 0.08% to 4.69% [2.0% （1.3-2.5）, P 〈 0.0001]. HFF was highly correlated with histological steatosis （r = 0.883, P 〈 0.0001） in the NAFLD children. According to the histological grade of steatosis, the mean HFF was 8.7% （95% CI, 6.0-11.6） for mild, 21.6% （15.3-27.0） for moderate, and 39.7% （34.4-45.0） for severe fatty liver infiltration. With a cutoff of 4.85%, HFF had a sensitivity of 95.8% for the diagnosis of histological steato- sis ≥ 5%. All control children had HFF lower than 4.85%; thus, the specificity was 100%. Alter 12 mo, children with weight loss displayed a significant decrease in HFF. CONCLUSION： MRI is an accurate methodology for liver fat quantification in pediatric NAFLD.

关键词： Nonalcoholic fatty liver disease Children Obesity Fast-magnetic resonance imaging Liver fatquantification

Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-Min Zeng di-Wei Zheng Ting Pan Xing-Lan ding Yun Zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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