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SARS-coV-2 productively infects primary human immune system cells in vitro and in coviD-19 patients

Journal of Molecular cell Biology 2022年第4期14卷 51-64页

作者： Marjorie c.Pontelli italo A.castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele c.Nascimento camila M.Silva Ricardo S.cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda c.Vitti Diego B.caetite Mikhael H.F.de Lima Spencer D.Stumpf cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa marcela c.giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio c.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo c.Santana Fernando c.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.cunha Rodrigo T.calado Joséc.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.cunha Eurico Arruda Virology Research center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Biochemistry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Molecular Microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-covV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(coVID-19)*** rates of SARS-cov-2-infected monocytes in peripheral blood mononuclear cells from coVID-19 patients increased over time from symptom onset,with SARS-coV-2-positive monocytes,B cells,and cD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-coV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-coV-2 coVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMc) lymphocytes monocytes apoptosis

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Autonomous Vehicle Platoons In Urban Road Networks:A Joint Distributed Reinforcement Learning and Model Predictive control Approach

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IEEE/cAA Journal of Automatica Sinica 2024年第1期11卷 141-156页

作者： Luigi D’Alfonso Francesco giannini Giuseppe Franzè Giuseppe Fedele Francesco Pupo Giancarlo Fortino IEEE the Department of computer Engineering ModelingElectronics and SystemsUniversitàdella CalabriaVia Pietro BucciCubo 42-CRende(CS)87036Italy the Department of Mechanical Engineering Energy Engineering and ManagementUniversitàdella CalabriaVia Pietro BucciCubo 42-CRende(CS)87036Italy

In this paper, platoons of autonomous vehicles operating in urban road networks are considered. From a methodological point of view, the problem of interest consists of formally characterizing vehicle state trajectory tubes by means of routing decisions complying with traffic congestion criteria. To this end, a novel distributed control architecture is conceived by taking advantage of two methodologies: deep reinforcement learning and model predictive control. On one hand, the routing decisions are obtained by using a distributed reinforcement learning algorithm that exploits available traffic data at each road junction. On the other hand, a bank of model predictive controllers is in charge of computing the more adequate control action for each involved vehicle. Such tasks are here combined into a single framework:the deep reinforcement learning output(action) is translated into a set-point to be tracked by the model predictive controller;conversely, the current vehicle position, resulting from the application of the control move, is exploited by the deep reinforcement learning unit for improving its reliability. The main novelty of the proposed solution lies in its hybrid nature: on one hand it fully exploits deep reinforcement learning capabilities for decisionmaking purposes;on the other hand, time-varying hard constraints are always satisfied during the dynamical platoon evolution imposed by the computed routing decisions. To efficiently evaluate the performance of the proposed control architecture, a co-design procedure, involving the SUMO and MATLAB platforms, is implemented so that complex operating environments can be used, and the information coming from road maps(links,junctions, obstacles, semaphores, etc.) and vehicle state trajectories can be shared and exchanged. Finally by considering as operating scenario a real entire city block and a platoon of eleven vehicles described by double-integrator models, several simulations have been performed with the a

关键词： Distributed model predictive control distributed reinforcement learning routing decisions urban road networks

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How to fill the biodiversity data gap:Is it better to invest in fieldwork or curation?

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Plant Diversity 2024年第1期46卷 39-48页

作者： carlos A.Vargas Marius Bottin Tiina Sarkinen James E.Richardson marcela celis Boris Villanueva Adriana Sanchez Programa de Biología Facultad de Ciencias NaturalesUniversidad del RosarioBogotaD.C.Colombia Subdireccion científica Jardín Botanico de Bogota“Jose Celestino Mutis”BogotaD.C.Colombia Independent Researcher BogotaD.C.Colombia Tropical Diversity Section Royal Botanic Garden EdinburghUK School of Biological Earth and Environmental SciencesUniversity College CorkCorkIreland Departamento de Química y Biología Universidad del NorteKm.5 Vía Puerto ColombiaArea Metropolitana de Barranquilla 081007Colombia

Data gaps and biases are two important issues that affect the quality of biodiversity information and downstream *** how best to fill existing gaps and account for biases is necessary to improve our current information most *** current main approaches for obtaining and improving data include(1)curation of biological collections,and(2)***,the comparative effectiveness of these approaches in improving biodiversity data remains little *** used the Flora de Bogota project to study the magnitude of change in species richness,spatial coverage,and sample coverage of plant records based on curation versus *** process of curation resulted in a decrease in species richness(synonym and error removal),but it significantly increased the number of records per *** contributed to a slight increase in species richness,via accumulation of new ***,curation led to increases in spatial coverage,species observed by locality,the number of plant records by species,and localities by species compared to ***,curationwas more efficient in producing new information compared to fieldwork,mainly because of the large number of records available in *** recommend intensive curatorial work as the first step in increasing biodiversity data quality and quantity,to identify bias and gaps at the regional scale that can then be targeted with *** stepwise strategy would enable fieldwork to be planned more costeffectively given the limited resources for biodiversity exploration and characterization.

关键词： colombia Flora de Bogota Sample coverage Species richness Tropical Andes

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Determinant variables on the isotopic values of particulate organic matter in a neotropical floodplain

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JOURNAL OF OcEANOLOGY AND LIMNOLOGY 2024年第4期42卷 1-13页

作者： Urbano, Vinicius de Andrade Scoarize, Matheus Maximilian Ratz Alves, Gustavo Henrique Zaia Delanira-Santos, Driele caetano, marcela da Silva Benedito, Evanilde Univ Estadual Maringa UEM Dept Biol DBI Lab Ecol Energet BR-87020900 Maringa Brazil Univ Estadual Maringa UEM Programa Posgrad Ecol Ambientes Aquat Continentais BR-87020900 Maringa Brazil Griffith Univ Australian Rivers Inst ARI Kessels Rd Nathan Qld 4111 Australia Univ Estadual Ponta Grossa UEPG Dept Biol Geral Campus Uvaranas BR-84030900 Ponta Grossa Brazil

Particulate organic matter (POM) is an important energy source for aquatic consumers, understanding its origin and composition is essential for understanding the energetic dynamics of aquatic environments. The aim of this study was to analyze the relationship between POM and phytoplankton (isotopic values and chlorophyll concentration) and abiotic variables during dry and rainy seasons. Sampling was conducted in rivers and lagoons in the floodplain of the Upper Paran & aacute; River. We found a greater difference in delta 13c values of POM between sampling points than between seasons, indicating that the composition of regional sources influences the composition of POM more than dry and rainy seasons. In addition, the concentration of chlorophyll during the dry season was positively correlated with delta 13c values during that rainy period. Additionally, we found a relationship between factors limiting the growth of phytoplankton and delta 13c values of POM, such as phosphate ions, indicating that variables that regulate phytoplankton growth tend to influence the composition of POM in river floodplains. Therefore, maintaining the variables that regulate the phytoplankton community is of fundamental importance for the composition of POM, an important energy source in aquatic environments.

关键词： freshwater wetland stable isotopes food web subtropical environment PARANA RIVER FLOODPLAIN BOTTOM-FEEDING FISH STABLE-ISOTOPES TROPHIc POSITION cARBON PHYTOPLANKTON VARIABILITY ENRIcHMENT DIVERSITY POc

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The best of both worlds:mastering nerve regeneration combining biological and nanotechnological tools

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Neural Regeneration Research 2023年第3期18卷 556-557页

作者： Paula A.Soto marcela B.Fernández van Raap c.Patricia Setton-Avruj Departamento de Química Biológica Cátedra de Química Biológica PatológicaUniversidad de Buenos AiresFacultad de Farmacia y BioquímicaInstituto de Química y Fisicoquímica Biológicas(IQUIFIB)Universidad de Buenos AiresBuenos AiresArgentina Departamento de Física Universidad Nacional de La Plata(UNLP)Facultad de Ciencias ExactasLa PlataArgentinaLaboratorio de BiotecnologíaUniversidad ORT UruguayMontevideoUruguay

Over the last decade,remarkable developments in nanotechnology have powered medical research,unveiling new approaches for the solution of public health issues such as the treatment of traumatic peripheral neuropathies.

关键词： traumatic technological treatment

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Advantageous mechanochemical synthesis of copper(Ⅰ)selenide semiconductor,characterization,and properties

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Frontiers of chemical Science and Engineering 2022年第3期16卷 433-442页

作者： Katarína Gáborová marcela Achimovičová Michal Hegedüs Vladimír Girman Mária Kaňuchová Erika Dutková Institute of Geotechnics Slovak Academy of SciencesKošice04001Slovakia Institute of Metallurgy Faculty of MaterialsMetallurgy and RecyclingTechnical UniversityKošice04201Slovakia Synthon s.r.o.Blansko67801Czech Republic Faculty of Science Pavol JozefŠafárik UniversityKošice04154Slovakia Institute of Earth Resources Faculty of MiningEcologyProcess Control and GeotechnologiesTechnical UniversityKošice04200Slovakia

copper(I)selenide-nanocrystalline semiconductor was synthesized via one-step mechanochemical synthesis after 5 min milling in a planetary ball *** kinetics of synthesis was followed by X-ray powder diffraction analysis and specific surface area measurements of milled 2cu/Se *** X-ray diffraction confirmed the orthorhombic crystal structure of cu_(2)Se with the crystallite size∼25 *** surface chemical structure was studied by X-ray photoelectron spectroscopy,whereby the binding energy of the cu 2p and Se 3d signals corresponded to cu^(+)and Se^(2−)oxidation *** electron microscopy revealed agglomerated nanocrystals and confirmed their orthorhombic structure,as *** optical properties were studied utilizing ultraviolet-visible spectroscopy and photoluminescence *** direct bandgap energy 3.7 eV indicated a blue-shift phenomenon due to the quantum size *** type of cu_(2)Se synthesis can be easily adapted to production dimensions using an industrial vibratory *** advantages of mechanochemical synthesis represent the potential for inexpensive,environmentally-friendly,and waste-free manufacturing of cu_(2)Se.

关键词： cu_(2)Se berzelianite nanocrystalline semiconductor mechanochemical synthesis planetary ball mill

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Aboveground nutrient components of Eucalyptus camaldulensis and E. grandis in semiarid Brazil under the nature and the mycorrhizal inoculation conditions

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Journal of Forestry Research 2009年第1期20卷 15-22页

作者： marcela c. Pagano Antonio F. Bellote Maria R. Scotti Microorganism-Plant Interaction LaboratolT Institute of Biological Sciences Federal University of Minas Gerais Av. Antonio Carlos 6627 Pampulha CEP： 31270-901 Belo Horizonte MG Brazil Embrapa Forestry Estrada da Ribeira km 111 Caixa Postal 319 - Colombo PR - 83411-000- Brazil.

A study was conducted to evaluate the aboveground biomass, nutrient content and the percentages of mycorrhizal colonization in Eucalyptus camaldulensis and Eucalyptus grand＆ plantations in the semiarid region （ 15° 09′ S 43° 49′ W） in the north of the State of Minas Gerais in Brazil. Results show that the total above-ground biomass （dry matter） was 33.6 ***^-1 for E. camaldulensis and 53.1 Mg·ha^-1 for E. grandis. The biomass of the stem wood, leaves, branches, and stein bark for E. camaldulens accounted for 64.4%, 19.6%, 15.4%, and 0.6% of the total biomass, respectively （Table 2）; meanwhile a similar partition of the total above-ground biomass was also found for E. grand＆. The dry matter of leaves and branches of E. camaldulensis accounted for 35% of total biomass, and the contents of N, P, K, ca, Mg, and S in leaves and branches accounted for 15.5%, 0.7%, 12.3%, 22.6%, 1.9%, and 1.4% of those in total above-ground biomass, respectively. In the trunk （bark and wood）, nutrient accumulation in general was lower. Nutrient content of E. grand＆ presented little variation compared with that orE. camaJd^llensis. Wood localized in superior parts of trunk presented a higher concentration of P and bark contained significant amounts of nutrients, especially in E. grand＆. This indicated that leaving vegetal waste is of importance on the site in reducing the loss of tree productivity in this semi-arid region. The two species showed mycotrophy.

关键词： Eucalyptus biomass nutrient components semi-arid region mycorrhizal symbioses Brazil

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Promising psyllium-based composite containing TiO2 nanoparticles as aspirin-carrier matrix

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Progress in Natural Science:Materials International 2014年第3期24卷 205-209页

作者： marcela-corina Rosu Ioan Bratu National Institute for Research and Development of Isotopic and Molecular Technologies

composite nanomaterials represent a new trend in the biomedical field. coupling inorganic/organic constituents with non-toxicity/biocompatibility properties leads to develop the new systems having special characteristics that can be used in various bio-applications. This paper describes the preparation and characterization of psyllium-based composites containing TiO2 nanoparticles in order to develop new therapeutic strategies for aspirin drug delivery. The structural characteristics of obtained materials were investigated by FTIR spectroscopy. The UV–vis spectrophotometric analysis was performed to evaluate the aspirin release behavior under different pH conditions at 37 1c. combining psyllium(as an excellent source of fiber) with TiO2 inorganic unit(as vehicle of aspirin) it was found that polymeric-TiO2networks have promising potential for controlled aspirin release as therapeutic agent.

关键词： Psyllium Titanium dioxide Aspirin In vitro release

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Multi-temporal NDVI analysis using UAV images of tree crowns in a northern Mexican pine-oak forest

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林业研究:英文版 2023年第6期34卷 1855-1867页

作者： JoséLuis Gallardo-Salazar marcela Rosas-chavoya Marín Pompa-García Pablito Marcelo López-Serrano Emily García-Montiel Arnulfo Meléndez-Soto Sergio Iván Jiménez-Jiménez Instituto de Investigaciones Agropecuarias y Forestales Universidad Michoacana de San Nicolás de Hidalgo(UMSNH)58330 MoreliaMichoacánMexico Programa Institucional de Doctorado en ciencias Agropecuarias y Forestales Universidad Juárez del Estado de DurangoRío Papaloapan y Blvd.DurangoValle del Sur s/n34120 DurangoDurangoMéxico Facultad de ciencias Forestales Universidad Juárez del Estado de DurangoRío Papaloapan y Blvd.DurangoValle del Sur s/n34120 DurangoDurangoMéxico Instituto de Silvicultura e Industria de la Madera Universidad Juárez del Estado de DurangoBoulevard del Guadiana 501Ciudad UniversitariaTorre de Investigación34120 DurangoMéxico INIFAP-cENID RASPA centro Nacional de Investigación Disciplinaria en Relación Agua-Suelo-Planta-Atmósfera Margen derecha canal Sacramento km 6.5Zona industrial35140 Gómez PalacioDurangoMexico

The use of unmanned aerial vehicles(UAV)for forest monitoring has grown significantly in recent years,providing information with high spatial resolution and temporal *** with multispectral sensors allow the use of indexes such as the normalized difference vegetation index(NDVI),which determines the vigor,physiological stress and photo synthetic activity of *** study aimed to analyze the spectral responses and variations of NDVI in tree crowns,as well as their correlation with climatic factors over the course of one *** study area encompassed a 1.6-ha site in Durango,Mexico,where Pinus cembroides,Pinus engelmannii,and Quercus grisea *** images were acquired with UAV and information on meteorological variables was obtained from NASA/POWER *** ANOVA explored possible differences in NDVI among the three *** correlation was performed to identify the linear relationship between NDVI and meteorological *** differences in NDVI values were found at the genus level(Pinus and Quercus),possibly related to the physiological features of the species and their *** grisea had the lowest NDVI values throughout the year which may be attributed to its sensitivity to relative humidity and *** the use of UAV with a multispectral sensor for NDVI monitoring allowed genera differentiation,in more complex forest analyses hyperspectral and LiDAR sensors should be integrated,as well other vegetation indexes be considered.

关键词： Multispectral images Normalized diff erence Vegetation index Phenology Unmanned aerial vehicles Multitemporal analysis

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The role of rhizobacteria in rice plants: Growth and mitigation of toxicity

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Journal of Integrative Agriculture 2018年第12期17卷 2636-2647页

作者： marcela c F Rêgo Aline F cardoso Thayná da c Ferreira Marta c c de Filippi Telma F V Batista Rafael G Viana Gisele B da Silva Plant Protection Laboratory Institute of Agrarian Sciences Federal Rural University of Amazon Phytopathology Laboratory Brazilian Enterprise for Agricultural Research-Rice and Beans

Allelopathic compounds reduce the growth and productivity of upland rice plants, especially in consecutive plantations. The rhizobacteria Pseudomonas fluorescens BRM-32111 and Burkholderia pyrrocinia BRM-32113 have been recorded as growth promoters in rice. This study was developed to understand the effect of the application of rhizobacteria on upland rice plants in consecutive plantations. Experiments were conducted in a completely randomized design with four replications of four treatments: rice seed inoculated with P. fluorescens BRM-32111, rice seed inoculated with B. pyrrocinia BRM-32113(both sown on soil with rice residue), non-inoculated plants sown on soil with rice residue(control with residue(WR)), and non-inoculated plants on soil with no residue(NR). Roots and seedling growth were adversely affected by allelopathic compounds in control WR plants. Plants inoculated with rhizobacteria P. fluorescens BRM-32111 or B. pyrrocinia BRM-32113 induced an increase of 88% in biomass, 3% in the leaf area, 40% in length, 67% in root biomass, 21% in chlorophyll a, 53% in chlorophyll(a+b), 50% in rate of carbon assimilation(A), 227% in A/rubisco carboxylation efficiency(ci) and 63% in water use efficiency(WUE) compared to control WR plants. These results indicate that rhizobacteria P. fluorescens BRM-32111 and B. pyrrocinia BRM-32113 increase the tolerance of rice plants to stress from allelochemicals. There are possible practical agricultural applications of these results for mitigating the effects of environmental allelochemistry on upland rice.

关键词： allelopathy B.pyrrocinia P.fluorescens rhizobacteria rice

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