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Modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg Michael B.Morris marcela M.M.Bilek Anyu Zhang Behnam Akhavan Simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

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Microencapsulation of L-Ascorbic Acid by Spray Drying Using Sodium Alginate as Wall Material

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Journal of Encapsulation and Adsorption Sciences 2016年第1期6卷 1-8页

作者： ferrándiz marcela Capablanca Lucía Franco Esther Mira Elena Biotechnology Research Group Textile Research Institute (AITEX) Alcoy Spain Polytechnic University of Valencia (UPV) Campus de Alcoy Alcoy Spain

L-ascorbic acid is a water soluble vitamin (vitamin C) widely used as an additive in foods and cosmetics. It has high instability against certain environmental factors;the main cause of its deterioration is oxidation. Microencapsulation is an effective protection technique of L-ascorbic acid from its degradation reactions. This work is focused on the encapsulation of L-ascorbic acid by spray drying technique using sodium alginate as wall material. The microcapsules morphology was observed by scanning electron microscopy (SEM) and the encapsulation efficiency was determined by spectrophotometric analysis. Results showed that encapsulation efficiency was of 93.48% and after 30 days was of 92.55%;differences were not significant, so that the stability of L-ascorbic acid was not affected. Encapsulation yields obtained were low, at around 30%, but the microcapsules morphology obtained is spherical.

关键词： L-Ascorbic Acid Sodium Alginate Spray Drying Microencapsulation Stability

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Encapsulation of Almond Essential Oil by Co-Extrusion/Gelling Using Chitosan as Wall Material

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Journal of Encapsulation and Adsorption Sciences 2017年第1期7卷 67-74页

作者： Capablanca Lucía ferrándiz marcela López Ainhoa Biotechnology Research Group Textile Research Institute (AITEX) Alcoy Spain Universitat Politè cnica de Valencia (UPV) Campus de Alcoy Alcoy Spain

Encapsulation confers protection to substances as essential oils from processes like oxidation, evaporation or uncontrolled release. In this study almond oil capsules were obtained by co-extrusion/gelling technique. Chitosan was used as shell material and sodium triphosphate pentabasic as cross linking agent. Different encapsulation process variables were studied: cross-linker concentration, nozzles size and potential. Optical microscopy was used to determine the capsules morphology and degradability tests were performed in order to study capsules degradation over time. Results showed that nozzles size and cross linking concentration are key variables to consider in the encapsulation process. Degradability tests showed rapid weight loss.

关键词： Chitosan Almond Oil TTP Co-Extrusion/Gelling

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Assessing the impact of concurrent high-fructose and highsaturated fat diets on pediatric metabolic syndrome:A review

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World Journal of Clinical Pediatrics 2024年第2期13卷 62-79页

作者： Manuel Alejandro Vargas-Vargas marcela González-Montoya Olin Torres-Isidro Claudia Isabel García-Berumen Omar Ortiz-Avila Elizabeth Calderón-Cortés Christian Cortés-Rojo Instituto de Investigaciones Químico–Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico Facultad de Enfermería Universidad Michoacana de San Nicolás de HidalgoMorelia 58020MichoacánMexico

High-saturated fat(HF)or high-fructose(HFr)consumption in children predispose them to metabolic syndrome(MetS).In rodent models of MetS,diets containing individually HF or HFr lead to a variable degree of ***,simultaneous intake of HF plus HFr have synergistic effects,worsening MetS *** children,the effects of HF or HFr intake usually have been addressed ***,we have reviewed the outcomes of HF or HFr diets in children,and we compare them with the effects reported in *** humans,HFr intake causes increased lipogenesis,hypertriglyceridemia,obesity and insulin *** the other hand,HF diets promote low grade-inflammation,obesity,insulin *** the deleterious effects of simultaneous HF plus HFr intake on MetS development in rodents,there is little information about the combined effects of HF plus HFr intake in *** aim of this review is to warn about this issue,as individually addressing the effects produced by HF or HFr may underestimate the severity of the outcomes of Western diet intake in the pediatric *** consider that this is an alarming issue that needs to be assessed,as the simultaneous intake of HF plus HFr is common on fast food menus.

关键词： Fructose Saturated fat Metabolic syndrome Insulin resistance Type 2 diabetes Ultra processed foods Children Obesity Dyslipidemia Non-alcoholic fatty liver disease

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Exclusive breastfeeding greater than 50%, success of education in a university hospital in Bogotá: Case-control study

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World Journal of Clinical Pediatrics 2024年第1期13卷 23-30页

作者： marcela Murillo Galvis Sofia Ortegon Ochoa Clara Eugenia Plata García Maria Paula Valderrama Junca Dayanna Alejandra Inga Ceballos Daniel Mauricio Mora Gómez Claudia M Granados Martin Rondón Department of Pediatrics Hospital Universitario San IgnacioBogotá110111Colombia Department of Clinical Epidemiology and Biostatistics Pontifica Universidad JaverianaBogotá110111Colombia

BACKGROUND Maintenance rates of exclusive breastfeeding(EBF)worldwide are low,thus,one of the objectives of the summary of policies on breastfeeding(BF)in world nutrition goals for 2025 are that at least 50%of infants under six months of age receive EBF that *** Objective of this study is to document the rates of EBF in children born in San Ignacio University Hospital(HUSI)and identify factors associated with *** To document the percentages of EBF in those that were born at HUSI and identify factors associated to their *** This is a study of cases and controls in an analytic,retrospective cohort that took children born alive between January 2016 and January 2019 at HUSI located in the city of Bogotá,*** Receiving information about BF at HUSI was able to maintain EBF up until 4 mo(OR=1.65;95%CI:1.02-2.66).The presence of gynecologic and obstetric comorbidities(OR=0.32;95%CI:0.12-0.83),having mastitis(OR=0.56;95%CI:0.33-0.94),and receiving information from mass media(OR=0.52;95%CI:0.31-0.84)are factors associated with not maintaining *** Receiving education at a Women-and Child-Friendly Institution was the only significant factor to achieve EBF until 4 mo,with a frequency greater than the one reported in the country,which matches multiple studies where counseling and individualized support on BF achieve this *** about BF and early detection of obstetric/gynecologic complications must be strengthened among the healthcare staff in charge of mothers during ***,strategies must be promoted to continue BF such as creating milk banks with the objective of increasing BF rates even when mothers return to work.

关键词： Breastfeeding Women-and Child-Friendly Institutional Strategy Strategies Adherence Education

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Microencapsulation of Lipase and Savinase Enzymes by Spray Drying Using Arabic Gum as Wall Material

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Journal of Encapsulation and Adsorption Sciences 2016年第4期6卷 161-173页

作者： Torres Andrea ferrándiz marcela Capablanca Lucía Franco Esther Mira Elena Moldovan Simona Biotechnology Research Group Textile Research Institute (AITEX) Alcoy Spain

Enzymes have been used in detergents over the years. They can improve the detergent’s efficiency due to their activities against hard stains. Nevertheless, enzymes cannot maintain their properties indefinitely, since they are exposed to stress factors, like temperature, pH, mechanical processes and others. Consequently, enzymes lose their structure and they are not functional. For this reason, microencapsulating these proteins is a feasible solution to improve their use in industrial processes and commercial products. Spray drying technology has been selected because a lot of scientific literature proved its useful application in a variety of industries. In particular, savinase and lipase are the two encapsulated enzymes in this work. Savinase attacks proteins and lipase removes fats, so they are suitable enzymes for detergent industry. Arabic gum has been used as wall material. Morphology, size and activity of the obtained microcapsules have been analyzed in order to find the best conditions to produce them. In conclusion, useful microcapsules of lipase and savinase can be obtained with the mentioned technology.

关键词： Savinase Lipase Arabic Gum Spray Drying Microencapsulation

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The Use of Insulin Negatively Impacts the Mortality of Severe COVID-19 in Patients with Type 2 Diabetes—A Systematic Review

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Journal of Diabetes Mellitus 2024年第3期14卷 166-176页

作者： Caio F. Biolcatti marcela R. Simoes Thais P. Prado Milena Monfort-Pires Licio A. Velloso Obesity and Comorbidities Research Center Campinas Brazil Turku PET Centre University of Turku Turku Finland National Institute of Science and Technology on Neuroimmunomodulation Campinas Brazil

Obesity and type 2 diabetes are among the most important risk factors for severe coronavirus disease-19. Some studies have suggested that the use of insulin as a therapeutic agent to treat hyperglycemia and the metabolic abnormalities associated with type 2 diabetes during the acute phase of severe coronavirus disease-19 could have a negative impact on the disease’s progression;however, there is no consensus on this issue. Here, we performed a systematic review in an attempt to answer this important question. We included 29 articles published from December 2019 to August 2023, which reported the outcomes of 3,070,657 patients with severe coronavirus disease-19 that had the diagnosis of diabetes and were treated with either insulin or other glucose-reducing agents. The results show that using insulin as a pharmacological intervention to treat type 2 diabetes in patients with severe coronavirus disease-19 increases the likelihood of mortality by 193%.

关键词： SARS-CoV2 Obesity Inflammation Metabolism Glucose

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Microencapsulation of Essential Oils by Interfacial Polimerization Using Polyurea as a Wall Material

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Journal of Encapsulation and Adsorption Sciences 2015年第4期5卷 165-177页

作者： ferrándiz marcela Capablanca Lucía Bou Eva García David Bonet Ma ángeles Bartolome Luis Biotechnology Research Group Textile Research Institute (AITEX) Alcoy Spain Campus de Alcoy Universitat Politècnica de València (UPV) Alcoy Spain Faculty of Science and Technology Central Analysis Service (SGIker) University of the Basque Country (UPV/EHU) Bilbao Spain

An essential oil is the volatile lipophilic component extracted from plants. Microencapsulation systems protect the essential oil from degradation and evaporation, and, at the same time, allow a sustained release. This work analyses and characterizes the oregano and sage essential oil microcapsules prepared by interfacial polymerization technique, using polyurea as wall material. Several instrumental techniques are used: optical microscopy, size particle, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), Termo gravimetric analysis (TGA), spectrophotometry, antimicrobial test and chromatography. Results show that oregano and sage oil have antimicrobial properties, and their microencapsulation allows knowing that these properties remain inside the microcapsules.

关键词： Oregano Oil Sage Oil Interfacial Polymerization Polyurea

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Secondary rectal linitis plastica caused by prostatic adenocarcinoma-magnetic resonance imaging findings and dissemination pathways:A case report

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World Journal of Radiology 2024年第9期16卷 473-481页

作者： Andres Antonio Labra Giancarlo Schiappacasse Rolando Alfonso Cocio Jorge Tomás Torres Fernando Omar González Joaquin Alberto Cristi marcela Schultz Department of Radiology Facultad de Medicina Clínica Alemana-Universidad del DesarrolloSantiago 7650568Región MetropolitanaChile Department of Pathology Clínica Alemana de SantiagoSantiago 7650568Región MetropolitanaChile

BACKGROUND Secondary rectal linitis plastica(RLP)from prostatic adenocarcinoma is a rare and poorly understood form of metastatic spread,characterized by a desmoplastic response and concentric rectal wall infiltration with mucosal *** complicates endoscopic diagnosis and can mimic gastrointestinal *** case series underscores the critical role of magnetic resonance imaging(MRI)in identifying the distinct imaging features of RLP and highlights the importance of considering this condition in the differential diagnosis of patients with a history of prostate *** SUMMARY Three patients with secondary RLP due to prostatic adenocarcinoma presented with varied clinical *** first patient,a 76-year-old man with advanced prostate cancer,had rectal pain and *** showed diffuse prostatic invasion and significant rectal wall thickening with a characteristic"target sign"*** second,a 57-year-old asymptomatic man with elevated prostatespecific antigen levels and a history of prostate cancer exhibited rectoprostatic angle involvement and rectal wall thickening on MRI,with positron emission tomography/computed tomography PSMA confirming the prostatic origin of the metastatic *** third patient,an 80-year-old post-radical prostatectomy,presented with refractory *** revealed a neoplastic mass infiltrating the rectal *** all cases,MRI consistently showed stratified thickening,concentric signal changes,restricted diffusion,and contrast enhancement,which were essential for diagnosing secondary *** confirmed the prostatic origin of the neoplastic involvement in the *** Recognizing MRI findings of secondary RLP is essential for accurate diagnosis and management in prostate cancer patients.

关键词： Rectal linitis plastica Prostatic adenocarcinoma Signet ring cell carcinoma Metastatic spread Magnetic resonance imaging Concentric wall infiltration Case report

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Analysis of the microbial communities in soils of different ages following volcanic eruptions

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Pedosphere 2020年第1期30卷 126-134页

作者： marcela HERNáNDEZ marcela CALABI Ralf CONRAD Marc G.DUMONT Max Planck Institute for Terrestrial Microbiology Karl-von-Frisch-Str.10Marburg 35043(Germany) Scientific and Technological Bioresource Nucleus Universidad de La FronteraTemuco(Chile) School of Biological Sciences University of SouthamptonSouthampton SO171BJ(UK)

Volcanism is a primary process of land *** provides a model for understanding soil-forming processes and the role of pioneer bacteria and/or archaea as early colonizers in those new *** objective of this study was to identify the microbial communities involved in soil *** was extracted from soil samples from the Llaima volcano in Chile at sites destroyed by lava in different centuries(1640,1751,and 1957).Bacterial and archaeal 16 S r RNA genes were analyzed using quantitative polymerase chain reaction(q PCR)and Illumina Mi Seq *** showed that microbial diversity increased with soil age,particularly between the 1751 and 1640 *** archaeal communities,Thaumarchaeota was detected in similar abundances in all soils,but Euryarchaeota was rare in the older *** analysis of bacterial 16 S r RNA genes showed high abundances of Chloroflexi(37%),Planctomycetes(18%),and Verrucomicrobia(10%)in the youngest *** and Acidobacteria were highly abundant in the older soils(16%in 1640 and 15%in 1751 for Acidobacteria;38%in 1640 and 27%in 1751 for Proteobacteria).The microbial profiles in the youngest soils were unusual,with a high abundance of bacteria belonging to the order Ktedonobacterales(Chloroflexi)in the 1957 soil(37%)compared with the 1751(18%)and 1640(7%)*** this study,we show that there is a gradual establishment of the microbial community in volcanic soils following an eruption and that specific microbial groups can colonize during the early stages of recovery.

关键词： 16S rRNA gene extreme environment high-throughput sequencing Ktedonobacterales microbial diversity pioneer microbe recolonization soil formation volcanic deposit

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