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Clinical outcomes for men with positive surgical margins after radical prostatectomy—results from the South Australian Prostate Cancer Clinical Outcomes Collaborative community-based registry

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Asian Journal of Urology 2023年第4期10卷 502-511页

作者： Kerri R.beckmann Michael E.O'Callaghan Andrew D.Vincent Kim L.Moretti Nicholas R.Brook Cancer Epidemiology and Population Health Research University of South AustraliaAdelaideAustralia Translational Oncology and Urology Research Division of Pharmaceutical and Cancer StudiesKings College LondonLondonUK South Australian Prostate Cancer Clinical Outcomes Collaborative Flinders Medical CentreAdelaideAustralia The Freemason's Foundation Centre for Men's Health Adelaide Medical SchoolUniversity of AdelaideAdelaideAustralia Discipline of Surgery University of AdelaideAdelaideAustralia Department of Urology Royal Adelaide HospitalAdelaideAustralia

Objective Positive surgical margins(PSMs)after radical prostatectomy(RP)indicate failure of surgery to completely clear *** confer an increased risk of biochemical recurrence(BCR),but how more robust outcomes are affected is *** study investigated factors associated with PSMs following RP and determined their impact on clinical outcomes(BCR,second treatment[radiotherapy and/or androgen deprivation therapy],and prostate cancer-specific mortality[PCSM]).Methods The study cohort included men diagnosed with prostate cancer(pT2-3b/N0/M0)between January 1998 and June 2016 who underwent RP from the South Australian Prostate Cancer Clinical Outcomes Collaborative *** associated with risk of PSMs were identified using Poisson *** impact of PSMs on clinical outcomes(BCR,second treatment,and PCSM)was assessed using competing risk *** Of the 2827 eligible participants,28%had PSMs—10%apical,6%bladder neck,17%posterolateral,and 5%at multiple *** follow-up was 9.6 years with 81 deaths from prostate cancer *** of PSM increased with higher pathological grade and pathological tumor stage,and greater tumour volume,but decreased with increasing surgeon volume(odds ratio[OR]:0.93;95%confidence interval[CI]:0.88-0.98,per 100 previous prostatectomies).PSMs were associated with increased risk of BCR(adjusted sub-distribution hazard ratio[sHR]2.5;95%CI 2.1-3.1)and second treatment(sHR 2.9;95%CI 2.4-3.5).Risk of BCR was increased similarly for each PSM location,but was higher for multiple margin *** found no association between PSMs and *** Our findings support previous research suggesting that PSMs are not independently associated with PCSM despite strong association with *** PSM rates remains an important objective,given the higher likelihood of secondary treatment with associated comorbidities.

关键词： Prostate cancer Positive surgical margin Biochemical recurrence Radical

On the material dependency of peri-implant morphology and stability in healing bone

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Bioactive Materials 2023年第10期28卷 155-166页

作者： Stefan Bruns Diana Krüger Silvia Galli D.C.Florian Wieland Jorg U.Hammel Felix beckmann Ann Wennerberg Regine Willumeit-Romer Berit Zeller-Plumhoff Julian Moosmann Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.121502GeesthachtGermany University of Malmo Faculty of OdontologyDepartment of ProsthodonticsCarl Gustafs Vag 34Klerken20506MalmoSweden Institute of Materials Physics Helmholtz-Zentrum HereonMax-Planck-Str.121502GeesthachtGermany University of Gothenburg Institute of OdontologyDepartment of ProsthodonticsMedicinaregatan 12 f41390GoteborgSweden

The microstructural architecture of remodeled bone in the peri-implant region of screw implants plays a vital role in the distribution of strain energy and implant *** present a study in which screw implants made from titanium,polyetheretherketone and biodegradable magnesium-gadolinium alloys were implanted into rat tibia and subjected to a push-out test four,eight and twelve weeks after *** were 4 mm in length and with an M2 *** loading experiment was accompanied by simultaneous three-dimensional imaging using synchrotron-radiation microcomputed tomography at 5μm *** deformation and strains were tracked by applying optical flow-based digital volume correlation to the recorded image *** stabilities measured for screws of biodegradable alloys were comparable to pins whereas non-degradable biomaterials experienced additional mechanical ***-implant bone morphology and strain transfer from the loaded implant site depended heavily on the biomaterial *** implants stimulated rapid callus formation displaying a consistent monomodal strain profile whereas the bone volume fraction in the vicinity of magnesium-gadolinium alloys exhibited a minimum close to the interface of the implant and less ordered strain *** in our data suggest that implant stability benefits from disparate bone morphological properties depending on the biomaterial *** leaves the choice of biomaterial as situational depending on local tissue properties.

关键词： Biodegradable implant materials Bone mechanical testing Implant stability Synchrotron micro-computed tomography imaging Digital volume correlation

Does knowledge of physical activity recommendations increase physical activity among Chinese college students？ Empirical investigations based on the transtheoretical model

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Journal of Sport and Health Science 2018年第1期7卷 77-82页

作者： Kahar Abula Peter Gropel Kai Chen Jürgen beckmann Technical University of Munich Munchen 80992 Germany South West Jiao Tong University Chengdu 611756 China

Background: Based on the transtheoretical model, the current study investigated whether awareness of physical activity(PA) recommendations had an impact on the stages of PA behavior change and levels of PA among Chinese college ***: In Study 1, with a cross-sectional study design, 9826 students were recruited, and their knowledge of international PA recommendations,PA stage distribution, and self-reported PA level were surveyed. Pearson's χ2 test was used to test whether those participants who were aware and not aware of PA guidelines were equally distributed across the stages of PA behavior, and independent t test was conducted to test the group difference in the actual levels of PA. In Study 2, 279 students who were not aware of the PA recommendations were randomly allocated to either an intervention group or a control group, and only those in the intervention group were presented with international PA guidelines. In both groups,students' PA stages and PA level were examined before the test and then 4 months post-test. Mc Nemar's test for correlated proportions and repeated-measures analysis of variance were conducted to examine the changes in PA stage membership and PA level after the ***: Study 1 results revealed that only 4.4% of the surveyed students had correct knowledge of PA recommendations. Those who were aware of the recommendations were in later stages of PA behavior(χ~2(4) = 167.19, p < 0.001). They were also significantly more physically active than those who were not aware of the recommendations(t(443.71) = 9.00, p < 0.001, Cohen's d = 0.53). Study 2 results demonstrated that the intervention group participants who were at the precontemplation and contemplation stages at the pre-test each progressed further in the PA stages in the post-test(χ~2(1) = 112.06, p < 0.001; χ~2(1) = 118.76, p = 0.03, respectively), although no significant change in PA level was observed(t(139) < 1, p = 0.89).Conclusion: The results showed that

关键词：大学生中国物理知识模特儿实验公共健康 PA

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RAPID DETECTION OF ONCOGENE AMPLIFICATION IN PARAFFIN SECTIONS OF BREAST CARCINOMAS USING QUANTITATIVE DIFFERENTIAL PCR AND FLUORESCENT DNA TECHNOLOGY

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Chinese Medical Journal 1995年第3期 68-69页

作者： An Hanxing Niederacher D beckmann MW Molekulargenetisches Labor der Frauenklinik Heinrich-Heine-Universitat Dusseldorf GermanyMolekulargenetisches Labor der Frauenklinik Heinrich-Heine-Universitat Dusseldorf GermanyMolekulargenetisches Labor der Frauenklinik Heinrich-Heine-Universitat Dusseldorf Germany

Gene amplification is a common mechanism of oncogene activation and contributes to tumor progression. Analysis of such genetic alterations are relevant to the understanding of tumor genetics and could provide prognostic information for the individual patient. Standard analytical approaches using Southern blot and slot blot require a large amount of good

关键词： PCR gene DNA RAPID DETECTION OF ONCOGENE AMPLIFICATION IN PARAFFIN SECTIONS OF BREAST CARCINOMAS USING QUANTITATIVE DIFFERENTIAL PCR AND FLUORESCENT DNA TECHNOLOGY

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Gonadal damage and options for fertility preservation in female and male cancer survivors

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Asian Journal of Andrology 2006年第5期8卷 515-533页

作者： Theodoros Maltaris Heinz Koelbl Rudolf Seufert Franklin Kiesewetter Matthias W. beckmann Andreas Mueller Ralf Dittrich Department of Obstetrics and Gynecology Johannes Gutenberg University Mainz D-55124 Germany Division of Andrology Erlangen University Hospital University of Erlangen-Nuremberg Erlangen Germany Department of Obstetrics and Gynecology Erlangen University Hospital University of Erlangen-Nuremberg Erlangen Germany

It is estimated that in 2010, 1 in every 250 adults will be a childhood cancer survivor. Today, oncological surgery, radiotherapy and chemotherapy achieve relatively high rates of remission and long-term survival, yet are often detrimental to fertility. Quality of life is increasingly important to long-term survivors of cancer, and one of the major quality-of-life issues is the ability to produce and raise normal children. Developments in the near future in the emerging field of fertility preservation in cancer survivors promise to be very exciting. This article reviews the published literature, discusses the effects of cancer treatment on fertility and presents the options available today thanks to advances in assisted-reproduction technology for maintaining fertility in male and female patients undergoing this type of treatment. The various diagnostic methods of assessing the fertility potential and the efficacy of in vitro fertilization （IVF） after cancer treatment are also presented.

关键词： reproduction cryopreservation male infertility semen preservation fertility preservation cancer treatment ovarian tissue

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Resisting the Violences of ＂Market Normalisation＂： The Importance of Critical Pedagogies for Critical Criminology

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Journal of Sociology Study 2012年第7期2卷 483-495页

作者： Andrea beckmann University of Lincoln UK

The neo‐liberal re‐positioning of the educational‐explorative realm to a vocational market‐confinement has already impacted quite heavily on the educational sector in England and Wales and is now being imposed on a European wide scale. However, global as well as European students’ protests illustrate that resistance to this ideology is gathering pace, and not only involves students and academics but also reaches wider parts of societies. This paper seeks to demonstrate the need for critical pedagogical practices that seek to sensitise students to the modes of current "conditions of domination". It further suggests critical criminologists to foster and engage in a process of public, intellectual, and intercultural exchange of ideas about education and educational institutions away from merely rationalistic, one‐dimensional and profit‐orientated ambitions toward a multitude of exchanges about meanings and purposes of such important socio‐cultural and political institutions and processes that shape "subjectivities", inter‐subjectivities and thus entire socio‐cultural and political spheres. Such processes and active engagements are crucial to the agenda of critical criminologists, and perhaps most importantly, vital to the continued existence of a critical criminology that understands itself as proper ideology critique.

关键词：新自由主义批判性犯罪市场教学法正常化社会文化意识形态

Obstetrics and gynecology

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Prevalence and classification of equinus foot in bilateral spastic cerebral palsy

2006年

作者： Charles R.B. beckmann ... [et al.]

来源：畅想之星图书光盘版（南... 评论

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World Journal of Pediatrics 2019年第3期15卷 276-280页

作者： Axel Horsch Marco G(o)tze Andreas Geisbüsch Nicholas beckmann Stefanos Tsitlakidis Gregor Berrsche Matthias Klotz Heidelberg University Hospital Clinic for Orthopedics and Trauma SurgerySchlierbacher Landstr.200a69118 HeidelbergGermany

Background Equinus is a common deformity in children with bilateral spastic cerebral palsy (BSCP).While dynamic equinus usually is treated by conservative therapy,fixed contractures need surgical *** choose the appropriate surgical method,it is important to discriminate between isolated gastrocnemius shortening and combined gastrosoleus complex *** In a retrospective study 938 patients with BSCP were *** underwent gait analysis and clinical examination.248 patients (496 limbs) met the inclusion *** from motion analysis and clinical examination were used to calculate the prevalence and to further classify fixed equinus *** The prevalence of equinus was 83.3%.During clinical exam 246 (59.6%) limbs showed combined gastrosoleus complex contracture and 167 (40.4%) isolated gastrocnemius *** at stance and mean DF at initial contact were significantly reduced in combined contracture,while *** was increased (P < 0.05).Conclusions Corroborating the results of previous studies,in this study there was a high prevalence of fixed equinus in patients with *** prevalence of equinus correlated with increasing *** half of the patients with fixed equinus show a different involvement of gastrocnemius and soleus muscle,we recommend to apply Silfverski(o)ld's test to discriminate between those two types to choose the appropriate surgical therapy.

关键词： Cerebral palsy Classification Equinus foot Equinus prevalence Gait analysis

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犯罪现场的科学

英语学习 2004年第3期 62-64页

作者： Roger beckmann 水青

一名五十多岁的男子死在卧室里:他躺在地上,身旁有一个破碎的玻璃杯,墙上和地毯上有红褐色的血迹,浴室的窗户也被砸碎了。这一切是意外,还是谋杀?

关键词：犯罪现场 DNA 发光氨