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Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa

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world Journal of Gastroenterology 2001年第4期7卷 496-499页

作者： Xi-Zhong Shen marcel w.l. koo Chi-Hin Cho Department of Gastroenterology,Zhongshan Hospital,Fudan University,136 Yixueyuan Road,Shanghai 200032,ChinaDepartment of Pharmacology.Faculty of Medicine,University of Hong Kong,5 Sassoon Road,Pokfulam,Hong Kong,ChinaSupported by .Dr.marcel w.l.koo,Department of Pharmacology,Faculty of Medicine,the University of Hong Kong,5 Sassoon Road,Hong Kong,China.wlkoo@hkusua.hku.hk Department of Pharmacology Faculty of Medicine The University of Hong Kong 5 Sassoon Road Hong Kong China.

AIM: To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense. METHODS: Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7d sleep deprivation. RT-PCR, immunohistochemistry and western blotting were used to determine the expression of heat shock protein 70. Ethanol (500ml.l(-1), i.g.) was used to induce gastric mucosa damage. RESUlTS: RT-PCR, western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500ml.l(-1) ethanol challenge, the ulcer area found in the rats with 7d sleep deprivation (19.15 +/- 4.2)mm(2) was significantly lower (P<0.01) than the corresponding control (53.7 +/- 8.1) mm(2). CONClUSION: Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection.

关键词： Animals Central Nervous System Depressants Ethanol Gastric Mucosa Gene Expression HSP70 Heat-Shock Proteins Immunohistochemistry Male RNA, Messenger Rats Rats, Sprague-Dawley Research Support, Non-U.S. Gov't Sleep Deprivation Stomach Ulcer control

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia Mouselight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Influence of alloying elements on microstructure and microhardness of Mg-Sn-Zn-based alloys

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Transactions of Nonferrous Metals Society of China 2010年第12期20卷 2246-2252页

作者： w. l. CHENG S. PARK w. N. TANG B. S. YOU B. H. koo School of Nano ＆ Advanced Materials Engineering Changwon National University Changwon 641-773 South Korea light Metals Research Group Korea Institute of Materials Science （KIMS） Changwon 641-831 South Korea

The phase evolution in （88%-91%）Mg-8%Sn-l%Zn-X （X=A1, Mn and/or Ce） system was analyzed via CAlPHAD method and simulations were used in precise selection of the chemical composition. The influence of the addition of different alloying elements such as A1, Mn and Ce on the microstructure and microhardness of Mg-8%Sn-l%Zn-based alloys was investigated. Combined addition of A1 and Mn shows features distinct from separate addition of A1 or Mn. Additions of l%AI and l%Mn to base alloy result in the formation of massive A1-Mn phase in a-Mg matrix grains. Addition of Ce element can refme the second eutectic precipitates and form intermetallic compounds with Sn. Fine rod-like Sn-Ce phase presents mainly on the grain boundaries and plays a role in inhibiting grain growth. The effects of alloying elements on Vickers microhardness and indentation size effect of base alloy were examined.

关键词： magnesium alloys alloying elements CAlPHAD method hardness indentation size effect

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Jasmonates differentially affect interconnected signal-transduction pathways of Pieris rapae-induced defenses in Arabidopsis thaliana

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Insect Science 2011年第3期18卷 249-258页

作者： Tjeerd A.l. Snoeren Colette Broekgaarden marcel Dicke laboratory of Entomology Wageningen UniversityWageningen University and Research Centre 6708PB Wageningen the Netherlands Plant Research International Wageningen University and Research Centre 6708PB Wageningen the Netherlands

The jasmonic acid （JA） pathway is the main signal-transduction pathway induced by insect folivory. Mutant plants affected in the jasmonate pathway （18：0 and/or 16：0-oxylipin routes） were studied to assess the effects of JA and its oxylipin intermediates 12-oxophytodienoic acid （OPDA） and dinor-OPDA （dnOPDA） on interconnected signal- transduction pathways that underlie induced defenses in Arabidopsis. Our data show that the oxylipin jasmonates dnOPDA, OPDA and JA have different roles in defense signaling induced after feeding by the chewing-biting caterpillar Pieris rapae. Jasmonic acid, and not OPDA or dnOPDA, is the major signaling compound required for the induction of the defense-related genes lOX2 （lipo：~vgenase 2）, OPR3 （12-Oxophytodienoate reductase 3）, ACX1 （Acyl-CoA oxidase 1） and PAl1 （Phenvlalanine ammonia-lyase 1）. Monitoring PAl1 transcript levels clearly showed that accumulation of JA upon P rapae feeding results in the induction of the salicylic acid pathway. Furthermore, JA is the major signaling compound required for the P rapae-induced expression of the defense-related gene HPl1 （Hydroperoxide lyase 1）. The jasmonate dnOPDA influences the induction of the HPk- branch as well, yet its effect is antagonistic to the effect of JA. Our data show that these jasmonates may be used to fine-tune Arabidopsis＇ herbivore-induced responses in terms of the HPl-branch from the oxylipin pathway.

关键词： gene transcript level herbivory lepidoptera mutants oxylipin qRT-PCR

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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Break-up Characteristics of Gelled Propellant Simulants with Various Gelling Agent Contents

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Journal of Thermal Science 2010年第6期19卷 545-552页

作者： Inchul lee Jaye koo Graduate Student Korea Aerospace University School of Aerospace and Mechanical Engineering Korea Aerospace University

Gel propulsion systems have many advantages with respect to high performance, the energy management of liquid propulsion systems, storability, high density impulse, and low leakage of liquid propellants. The atomization process provides sufficient contact surface area between the gelled fuel and oxidizer jets. It is important to study how injection characteristics of gelled propellants are related with break-up and spray distribution. The break-up and mixing processes are very important in achieving maximum efficiency and necessitate the careful study of combustion instability. Gelled propellants are non-Newtonian fluids in which the viscosity is a function of the shear rate, and they have a high dynamic shear viscosity which depends on the amount of gelling agent contents. The present study has focused on the break-up process, wave development of ligament and liquid sheets formed by impinging jets with various gelling agent contents. Especially, the break-up processes of the impinging jets at the initial conditions are studied. The break-up process of like-on-like doublet impinging jets are experimentally characterized using non-Newtonian liquids which are mixed by ionized water 98.5 wt%, Carbopol 941 0.5wt% or 1.0wt%, and NaOH(concentration 10%) 1.0wt%. For the like-on-like doublet injector, the generation of a liquid sheet at the impinging point of two jets was observed. The spray shape with elliptical pattern is distributed in a perpendicular direction to the momentum vectors of the jets. Gelled propellant simulants with high viscosity jets are more stable and produce less pronounced surface waves than low viscosity jets. Generally, the break-up length decreased due to the increasing Reynolds number. However, surface waves and atomized droplets increased. Gelled propellant simulants from like-on-like doublet impinging jets have the spray shape of closed rim patterns at low pressure. Also, the rim patterns of spray have no disturbances on the spray sheet. As the

关键词： gelled propellant simulants storability low leakage impinging injector rimless pattern wave-like structure