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Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 194-200页

作者： Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella marcel cc machado Luiz AC D'Albuquerque Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestinal Transplantation Hospital das Clinicas University of Sao Paulo School of Medicine Discipline of Anesthesiology Hospital das Clinicas University of Sao Paulo School of Medicine Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestina Hospital das Clinicas University of Sao Paulo School of Medicinel Transplantation

BACKGROUND：Liver ischemia reperfusion（IR）injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver ***（PTX）and hypertonic saline solution（HTS）have been identified to have beneficial effects against IR *** study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR ***： Male Wistar rats were allocated into three groups. Control rats underwent 60 minutes of partial liver ischemia, HTS rats were treated with 0.4 mL/kg of intravenous 7.5% NaCl 15 minutes before reperfusion, and HPTX group were treated with 7.5% NaC1 plus 25 mg/kg of PTX 15 minutes before reperfusion. Samples were collected after reperfusion for determination of ALT, AST, TNF-α, IL-6, IL-10, mitochondrial respiration, lipid peroxidation, pulmonary permeability and myeloperoxidase. RESULTS： HPTX significantly decreased TNF-α 30 minutes after reperfusion. HPTX and HTS significantly decreased ALT,AST, IL-6, mitochondrial dysfunction and pulmonary myelo- peroxidase 4 hours after reperfusion. Compared with HTS only, HPTX significantly decreased hepatic oxidative stress 4 hours after reperfusion and pulmonary permeability 4 and 12 hours after reperfusion. CONCLUSION： This study showed that PTX added the beneficial effects of HTS on liver IR injury through decreases of hepatic oxidative stress and pulmonary permeability.

关键词： pentoxifylline hypertonic saline solution hepatic oxidative stress ischemia reperfusion injury pulmonary permeability

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Numerical and Experimental Investigation of Aerodynamic Performance of Vertical-Axis Wind Turbine Models with Various Blade Designs

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Journal of Power and Energy Engineering 2018年第5期6卷 26-63页

作者： Mosfequr Rahman Travis E. Salyers Adel El-Shahat marcel Ilie Mahbub Ahmed Valentin Soloiu Mechanical Engineering Department Georgia Southern University Statesboro USA Electrical Engineering Department Georgia Southern University Statesboro USA Engineering & Physics Department Southern Arkansas University Magnolia USA

Due to the importance and advantages of Vertical-axis wind turbines (VAWTs) over traditional horizontal-axis wind turbines (HAWTs), this paper is implemented. Savonius turbines with drag-based rotors are adopted from the two more extensive arrangements of vertical wind turbines because of their advantages. In this paper, six diverse rotor plans with measure up to cleared regions are analyzed with exploratory wind burrow testing and numerical reenactments. These proposed models incorporate a conventional Savonius with two different edges criteria and 90 degree helical bend models with two, three and four sharp edges. The models were designed using SolidWorks software then the physical models were 3D printed for testing. A subsonic open-sort wind burrow was utilized for Revolution per Minute (RPM) and torque estimation over a scope of wind speeds. ANSYS Fluent reenactments were utilized for dissecting streamlined execution by using moving reference outline and sliding lattice display methods. A 3-dimensional and transient strategy was utilized for precisely tackling torque and power coefficients. The five new rotor geometries have important advantages such as making a focal point of weight advance from the hub of revolution and causing more noteworthy torque on the turbine shaft contrasted with the customary Savonius turbine. Our new models with the names of cc model and QM model display cross-areas lessen the aggregate scope of negative torque on the edges by 20 degrees, contrasted with the customary Savonius demonstrate. Helical plans are better spread the connected torque over a total transformation resulting in positive torque over every single operational point. Moreover, helical models with 2 and 3 cutting edges have the best self-starting ability in low wind speeds. Helical VAWT with 3 edges starts revolution of 35 RPM at only 1.4 m/s wind speed under no generator stacking. The most noteworthy power coefficient is accomplished, both tentatively and numerically,

关键词： Vertical-Axis Wind Turbine VAWT Savonius Helical Wind Tunnel Computational Fluid Dynamics (CFD) ANSYS Fluent

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