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Microarchitectural mimicking of stroma-induced vasculature compression in pancreatic tumors using a 3D engineered model

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Bioactive Materials 2023年第4期22卷 18-33页

作者： marcel Alexander Heinrich Irene Uboldi Praneeth Reddy Kuninty marc J.K.Ankone Joop van Baarlen Yu Shrike Zhang Kartik Jain Jai Prakash Department of Advanced Organ Bioengineering and Therapeutics Engineered Therapeutics SectionTechnical Medical CentreUniversity of Twente7500AEEnschedethe Netherlands Laboratorium Pathologie Oost-Nederland(LabPON) 7550 AMHengelothe Netherlands Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical School65 Landsdowne StCambridgeMA02139USA Department of Thermal and Fluid Engineering Biofluid Dynamics SectionUniversity of Twente7500 AE Enschedethe Netherlands

Fibrotic tumors,such as pancreatic ductal adenocarcinoma(PDAC),are characterized for high desmoplastic reaction,which results in high intra-tumoral solid stress leading to the compression of blood *** microarchitectural alterations cause loss of blood flow and poor intra-tumoral delivery of ***,there is a lack of relevant in vitro models capable of replicating these mechanical characteristics and to test anti-desmoplastic ***,a multi-layered vascularized 3D PDAC model consisting of primary human pancreatic stellate cells(PSCs)embedded in collagen/fibrinogen(Col/Fib),mimicking tumor tissue within adjunct healthy tissue,is presented to study the fibrosis-induced compression of vasculature in *** is demonstrated how the mechanical and biological stimulation induce PSC activation,extracellular matrix production and eventually vessel *** clinical relevance is confirmed by correlating with patient transcriptomic ***,the effects of gradual vessel compression on the fluid dynamics occurring within the channel is evaluated in ***,it is demonstrated how cancer-associated fibroblast(CAF)-modulatory therapeutics can inhibit the cell-mediated compression of blood vessels in PDAC in vitro,in silico and in *** is envisioned that this 3D model is used to improve the understanding of mechanical characteristics in tumors and for evaluating novel anti-desmoplastic therapeutics.

关键词： Pancreatic ductal adenocarcinoma Cancer-associated fibroblasts Collagen Fibrinogen Computational flow dynamics 3D in vitro model

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Management of Mandibular Fractures in Children in Ivory Coast: Experience of the Stomatology and Maxillofacial Surgery Department at the University Hospital of Cocody from 2000 to 2019

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Open Journal of Stomatology 2024年第7期14卷 341-349页

作者： Bakary Ouattara Camille Assouan Laurent Boka Koffi Konan René Kouakou Ake Lucien Jonathan Yapo Annick Zoglo-Bro Ahi Morel Mounin Chapo Affoué Linda Marie Pierre Koffi Kahder Morel Diarra Atse Kobo N’Guessan Konan marc Koffi Department of Stomatology Maxillofacial Surgery University Flix Houphout-Boigny Abidjan Republic of Ivory Coast Department of Oral Pathology University Flix Houphout-Boigny Abidjan Republic of Ivory Coast

Introduction: Mandibular fractures in children are becoming increasingly common. Treatment of these fractures is difficult due to their anatomical and physiological complexity. Therefore, there is a need for well-codified management. Our main aim was to develop a decision algorithm for the management of mandibular fractures in children based on our experience. Materials and Methods: This was a retrospective descriptive study carried out in the Department of Stomatology and Maxillofacial Surgery at the University Hospital of Cocody over a period of 20 years (2000-2019). Results: We enrolled 58 patients. The mean age of the patients was 9.35 ± 2.3 years with a sex ratio of 2.22. Traffic accidents were the main cause of mandibular fractures (60.35%). Condylar fractures were the most common (46.87%). Treatment was orthopedic in 45.76% of cases, mixed (orthopedic and surgical) in 24.14% and surgical in 5.17%. Patients were followed up weekly for 1 month, then monthly for 6 months and annually for 3 years, with panoramic radiographs of the maxilla starting at 21 days. We observed 2 cases of complications: temporomandibular ankylosis and gingival stomatitis. Conclusion: Mandibular fractures are common in children. Management is difficult due to anatomical and physiological peculiarities. The choice of treatment depends on several criteria.

关键词： Fractures Mandible Children Treatment Ivory Coast

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Phase coexistence properties of liquid mercury:a simulation study

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Rare Metals 2006年第5期25卷 567-571页

作者： Jean-Louis Bretonnet Jean-marc Bomont Laboratoire de Physique des Milieux Denses Université Paul Verlaine1bd F.D.Arago57078 MetzCedex 3France

The thermophysical properties of expanded liquid mercury have been investigated along the liquid-vapor coexistence curve by using Monte Carlo and Molecular Dynamic simulations. For the purpose, an empirical state dependent interatomic potential for the region of dense metallic liquid is used, while the state dependence is not necessary near the cliffcal point. In order to test the validity of this potential, we determine the surface layering and the sound velocity, two properties very sensitive to the choice of the potential. Our results are in quite good agreement with other theoretical results and to the experimental data available in the literature.

关键词： mercury simulation phase coexistence liquid state

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Joint Loading Estimation Method for Horse Forelimb High Jerk Locomotion:Jumping

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Journal of Bionic Engineering 2019年第4期16卷 674-685页

作者： Joanne Becker Mermoz Emmanuel Linares Jean-marc Airbus Helicopters Aeroport de Marseille ProvenceMarignane 13700France Aix Marseille Univ CNRSISMInst Movement SciMarseille 13009France

Maximal local loads in animal joints are necessary to design bio-inspired mechanical *** studies presented methods to determine joint reaction forces in humans and ***,many of these methods are invasive,and no work has been published yet about the joint reaction forces in the horse forelimb during ***-invasive methods to measure the kinematics and ground reaction force of a horse forelimb were used in this work.A musculoskeletal model of horse forelimb was built with mechanical methods for the estimation of joint reaction *** entire forelimb was reconstructed by scanning real bones geometry with a 3D optical scanner and modeling all the muscles on a Computer Assisted Design(CAD)*** model dynamics were simulated with OpenSim in order to estimate the joint *** study allows knowing an order of magnitude of the loads at the joints at jumping in order to determine latter the maximal joint contact loading values that will be a key at designing bio-inspired joints for mechanical assemblies.

关键词： joint loading jumping kinematics modelling OpenSim

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Growth and Photosynthesis Responses of a Super Dwarf Rice Genotype to Shade and Nitrogen Supply

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Rice science 2021年第2期28卷 178-190页

作者： marc SCHMIERER Oliver KNOPF Folkard ASCH Institute of Agricultural Sciences in the Tropics University of HohenheimStuttgart 70599Germany Institute for Bio-and Geo-Sciences IBG-2:Plant SciencesForschungszentrum Jülich GmbHJülich 52428Germany

Specific aspects of plant cultivation require tests under fully controlled environmentalconditions with restricted energy supply, such as orbit-based space laboratories and low-light *** these growing conditions, super dwarf plants have been developed as model crops, and a gibberellindeficientSuper Dwarf Rice genotype was proposed as a model crop for space flight plant *** tested this genotype in a climate chamber experiment under different illumination and nitrogen supplylevels to assess its suitability under scenarios with limited resource availability. A 25% reduction inillumination led to a 75% reduction in yield, mainly due to a 60% reduction in formed tillers and 20%reduction in grain weight, and a 80% reduction in illumination caused total yield loss. Leaf area underreduced illumination was significantly lower, and only marginal changes in the dimensions of leaves wereobserved. Plant photosynthesis was not significantly different between control and 75% illumination. Thiswas explained by a higher photochemical efficiency under lower light conditions and a reduced mesophyllresistance. Therefore, we concluded that this genotype is well-suited for plant experiments under spaceand light-limited conditions since it kept its small stature and showed no shade avoidance mechanisms,such as leaf elongation, which would complicate experiments under low-light conditions. Nitrogenconcentrations of 2.8 and 1.4 mmol/L led to no differences in plant growth. We concluded that a nitrogenconcentration of 1.4 mmol/L is sufficient for this genotype under the light intensities.

关键词： super dwarf rice photosynthetic limitation analysis shade nitrogen

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The role of L-arginine metabolism in neurocritical care patients

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Neural Regeneration Research 2022年第7期17卷 1446-1453页

作者： Marius marc-Daniel Mader Patrick Czorlich Department of Neurosurgery University Medical Center Hamburg-EppendorfHamburgGermany Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanfordCAUSA

Nitric oxide is an important mediator of vascular autoregulation and is involved in pathophysiological changes after acute neurological *** oxide is generated by nitric oxide synthases from the amino acid L-arginine.L-arginine can also serve as a substrate for arginases or lead to the generation of dimethylarginines,asymmetric dimethylarginine,and symmetric dimethylarginine,by *** dimethylarginine is an endogenous inhibitor of nitric oxide synthase and can lead to endothelial *** review discusses the role of L-arginine metabolism in patients suffering from acute and critical neurological disorders often requiring neuro-intensive care *** addressed in this review include intracerebral hemorrhage,aneurysmal subarachnoid hemorrhage,and traumatic brain *** therapeutic advances in the field are described including current randomized controlled trials for traumatic brain injuries and hemorrhagic stroke.

关键词： arginine brain injuries,traumatic cerebral hemorrhage dimethylarginine nitric oxide stroke subarachnoid hemorrhage

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Preventing physician quality of life from impinging on patient quality of care: Weakening the weekend effect

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World Journal of Gastroenterology 2007年第27期13卷 3667-3670页

作者： marc D Basson Department of Surgery John D Dingell VA Medical Center and Wayne State University Detroit Michigan United States

Imprecise or delayed care can reflect many factors, including straightforward difficulties in physician judgment and false negative tests. However, the movement toward decreasing physician work hours also leads to delays in care caused by inadequate staffing or inadequate communication between staffing, which must be addressed if quality of care is to remain high. The demonstration of delays in the management of anastomotic leaks over weekends or in association with false positive radiologic studies exemplifies this challenge.

关键词： Anastomosis Communication Contrast Delay Hand-off Intestine Staffing Weekend

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Cachexia and pancreatic cancer: Are there treatment options?

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World Journal of Gastroenterology 2014年第28期20卷 9361-9373页

作者： Tara C Mueller marc A Burmeister Jeannine Bachmann marc E Martignoni Department of Surgery University Hospital Rechts der IsarTechnical University of Munich Braun Melsungen AG/Department of Anesthesiology University Hospital Hamburg Eppendorf

Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma (PDAC) and is associated with reduced survival and quality of life. Unfortunately, the therapeutic options of this multi-factorial and complex syndrome are limited. This is due to the fact that, despite extensive preclinical and clinical research, the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood. Furthermore, there is still a lack of consensus on the definition of cachexia, which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature. In order to provide an efficient therapy for cachexia, an early and reliable diagnosis and consistent monitoring is required, which can be challenging especially in obese patients. Although many substances have been tested in clinical and preclinical settings, so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia. However, recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancer-associated cachexia and ultimately improve patients’ outcome. In this current review, we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients. This strategy consists of nutritional, dietary, pharmacological, physical and psychological methods.

关键词： Cachexia Pancreatic neoplasms Nutritional support Gastrointestinal neoplasms

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Approximation of H(div)with High-Order Optimal Finite Elements for Pyramids,Prisms and Hexahedra

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Communications in Computational Physics 2013年第10期14卷 1372-1414页

作者： Morgane Bergot marc Durufle CALVI project team INRIA Nancy-Grand EstStrasbourgFrance BACCHUS project team INRIA Bordeaux Sud-OuestBordeauxFrance.

Classical facet elements do not provide an optimal rate of convergence of the numerical solution toward the solution of the exact problem in H(div)-norm for general unstructured meshes containing hexahedra and *** propose two new families of high-order elements for hexahedra,triangular prisms and pyramids that recover the optimal *** elements have compatible restrictions with each other,such that they can be used directly on general hybrid *** the H(div)proposed spaces are completing the De Rham diagram with optimal elements previously constructed for H1 and H(curl)*** obtained pyramidal elements are compared theoretically and numerically with other elements of the ***,numerical results demonstrate the efficiency of the finite elements constructed.

关键词： Facet elements high-order finite element pyramids H(div)approximation De Rham diagram

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The Siberian Traps and the End-Permian mass extinction:a critical review

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Chinese Science Bulletin 2009年第1期54卷 20-37页

作者： Andy SAUNDERS marc REICHOW Department of Geological Sciences University of Leicester

The association between the Siberian Traps,the largest continental flood basalt province,and the largest-known mass extinction event at the end of the Permian period,has been strengthened by re-cently-published high-precision 40Ar/39Ar dates from widespread localities across the Siberian prov-ince[1]. We argue that the impact of the volcanism was amplified by the prevailing late Permian envi-ronmental conditions―in particular,the hothouse climate,with sluggish oceanic circulation,that was leading to widespread oceanic anoxia. Volcanism released large masses of sulphate aerosols and carbon dioxide,the former triggering short-duration volcanic winters,the latter leading to long-term warming. Whilst the mass of CO2 released from individual eruptions was small compared with the total mass of carbon in the atmosphere-ocean system,the long ‘mean lifetime’ of atmospheric CO2,com-pared with the eruption flux and duration,meant that significant accumulation could occur over periods of 105 years. Compromise of the carbon sequestration systems (by curtailment of photosynthesis,de-struction of biomass,and warming and acidification of the oceans) probably led to rapid atmospheric CO2 build-up,warming,and shallow-water anoxia,leading ultimately to mass extinction.

关键词：西伯利亚二叠纪温室气候海洋缺氧 CO2 SO2

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