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The WRKY46–MYc2 module plays a critical role in E-2-hexenal-induced anti-herbivore responses by promoting flavonoid accumulation

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Plant communications 2024年第2期5卷 228-242页

作者： Xin Hao Shuyao Wang Yu Fu Yahui Liu Hongyu Shen Libo Jiang eric SMcLamore Yingbai Shen National Engineering Research center of Tree Breeding and Ecological Restoration College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China State Key Laboratory of Animal Biotech Breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China University of Illinois at Urbana-champaign ChampaignIL 61820USA Department of Agricultural Sciences Clemson UniversityClemsonSC 29634USA

Volatile organic compounds(VOcs)play key roles in plant–plant communication,especially in response to pest attack.E-2-hexenal is an important component of VOcs,but it is unclear whether it can induce endog-enous plant resistance to ***,we show that E-2-hexenal activates early signaling events in Ara-bidopsis(Arabidopsis thaliana)mesophyll cells,including an H2O2 burst at the plasma membrane,the directedflow of calcium ions,and an increase in cytosolic calcium *** of wild-type Arabidopsis plants with E-2-hexenal increases their resistance when challenged with the diamond-back moth Plutella xylostella L.,and this phenomenon is largely lost in the wrky46 ***,E-2-hexenal induces the expression of WRKY46 and MYc2,and the physical interaction of their encoded proteins was verified by yeast two-hybrid,firefly luciferase complementation imaging,and in vitro pull-down *** WRKY46–MYc2 complex directly binds to the promoter of RBOHD to promote its expres-sion,as demonstrated by luciferase reporter,yeast one-hybrid,chromatin immunoprecipitation,and electrophoretic mobility shift *** module also positively regulates the expression of E-2-hexenal-induced naringenin biosynthesis genes(TT4 and cHIL)and the accumulation of totalflavonoids,thereby modulating plant tolerance to ***,our results highlight an important role for the WRKY46–MYc2 module in the E-2-hexenal-induced defense response of Arabidopsis,providing new in-sights into the mechanisms by which VOcs trigger plant defense responses.

关键词： E-2-hexenal early signaling events WRKY46–MYc2 RBOHD naringenin

Hf元素添加对cuZr基非晶合金动态弛豫的影响

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力学学报 2024年第8期56卷 2282-2293页

作者：朱凡邢光辉 Jean-marc.Pelletier 乔吉超西北工业大学力学与土木建筑学院西安710072 东莞市三航军民融合创新研究院广东东莞523808 INSA-Lyon MATEIS UMR5510F-69621 VilleurbanneFrance

考虑到非晶合金具有独特的无序微观结构,其表现出极为复杂的弛豫动力学特性.动态弛豫行为在非晶合金中普遍存在,深刻理解其机制对于解构非晶合金固有的非均匀微观结构至关重要.少量元素的添加是调控非晶合金微观结构有效手段之一.本研... 详细信息

考虑到非晶合金具有独特的无序微观结构,其表现出极为复杂的弛豫动力学特性.动态弛豫行为在非晶合金中普遍存在,深刻理解其机制对于解构非晶合金固有的非均匀微观结构至关重要.少量元素的添加是调控非晶合金微观结构有效手段之一.本研究以玻璃形成能力良好的cu_(46)Zr_(47-x)Hf_(x)Al_(7)(x=0,8)非晶合金为模型合金,运用动态力学分析方法研究复模量随频率和温度的变化,进而探究Hf元素取代Zr元素对动态弛豫的影响.在动态力学频率谱中,借助准点缺陷理论阐明非晶合金在玻璃转变温度T_(g)以下处于等构型状态,准点缺陷浓度保持恒定;而在T_(g)以上,准点缺陷浓度随温度的上升呈线性增加.Hf元素的添加会降低玻璃体系等构型状态下的准点缺陷浓度,并抑制原子迁移能力.通过获取连续和离散的弛豫时间分布,直观展示了非晶合金的动力学非均匀性特征.在动态力学温度谱中,Hf元素的引入增加了玻璃体系的混合焓,抑制了β弛豫强度.进一步从内耗角度表明,Hf元素的引入不仅提高了与β弛豫相关的基本结构单元的激活难度,还增加了整个β弛豫过程的激活能.

关键词：非晶合金动态弛豫微合金化准点缺陷微观结构非均匀性

维普期刊数据库

The sense of play lies at the roots of learning

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新兴科学和技术趋势

新兴科学和技术趋势 2024年第2期 146-157页

作者： eric Westhof Wenzhou Institute University of Chinese Academy of Sciences

In a famous book, Johann Huizinga referred to Homo sapiens （“thinkers”） as Homo ludens （“players”）. Here I try to foster an appreciation of the importance of play in the learning process, not only during childhood but continuously afterwards. Play is a major biological incentive for generating pleasure during learning and helps to accept the challenges and to overcome the difficulties attached to any intellectual effort or work. Play is rooted in the randomness of interactions between participants, with chance channeled by the rules of the game. Parallels with Darwinian evolution based on chance(randomness of mutations and changes in conditions) and necessity(the physico-chemical rules) are made. The development of science-based challenges or computer games and their roles in citizen-oriented science are also described. Some basic concepts of RNA structural biology illustrating the text are explained.“Play is the work of childhood”, Jean Piaget.“Every game has its rules”, Johann Huizinga.

关键词：科学教学游戏核糖核酸进化结构序列排列

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High rate of clinically relevant improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis

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World Journal of Orthopedics 2024年第2期15卷 156-162页

作者： marc.Randall Kristensen Nyring Bo Sanderhoff Olsen Alexander Amundsen Jeppe Vejlgaard Rasmussen Section for Shoulder and Elbow Surgery Department of Orthopaedic SurgeryHerlev and Gentofte University HospitalHellerup 2900Denmark

BAcKGROUND The minimal clinically important difference(McID)is defined as the smallest meaningful change in a health domain that a patient would identify as ***,an improvement that exceeds the McID can be used to define a successful treatment for the individual *** To quantify the rate of clinical improvement following anatomical total shoulder arthroplasty for glenohumeral *** Patients were treated with the Global Unite total shoulder platform arthroplasty between marc. 2017 and February 2019 at Herlev and Gentofte Hospital,*** patients were evaluated preoperatively and 3 months,6 months,12 months,and 24 months postoperatively using the Western Ontario Osteoarthritis of the Shoulder index(WOOS),Oxford Shoulder Score(OSS)and constant-Murley Score(cMS).The rate of clinically relevant improvement was defined as the proportion of patients who had an improvement 24 months postoperatively that exceeded the *** on previous literature,McID for WOOS,OSS,and cMS were defined as 12.3,4.3,and 12.8 *** Forty-nine patients with a Global Unite total shoulder platform arthroplasty were included for the final *** age at the time of surgery was 66 years(range 49.0-79.0,SD:8.3)and 65%were *** patient was revised within the two years *** mean improvement from the preoperative assessment to the two-year follow-up was 46.1 points[95%confidence interval(95%cI):39.7-53.3,PcI:15.5-21.0,PcI:31.5-44.0,Pceeded the McID,45 patients(94%)had an improvement in OSS that exceeded the McID,and 42 patients(88%)had an improvement in cMS that exceeded the *** Based on three shoulder-specific outcome measures we find that approximately 90%of patients has a clinically relevant *** is a clear message when informing patients about the

关键词： Minimal clinically important difference Patient reported outcome measures Glenohumeral osteoarthritis Anatomical total shoulder arthroplasty clinically relevant improvement

Late Mesozoic Exhumation of the Huangling Massif:constraints on the Evolution of the Middle Yangtze River

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 250-264页

作者： SU Jianchao LIN Xu LI chang’an Jolivet marc.WU Lin cHENG Feng DENG Bin WU Zhonghai cHEN Xiaokang HU chengwei School of Geography and Information Engineering China University of GeosciencesWuhan 430074China college of civil Engineering and Architecture China Three Gorges UniversityYichangHubei 443002China Géosciences Rennes CNRS-UMR6118Univ RennesRennesFrance State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBejing 100029China Key Laboratory of Orogenic Belts and crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation/chengdu University of Technology Chengdu 100871China Institute of Geological Mechanics Chinese Academy of Geological ScienceBeijing 100081China

Plate subduction leads to complex exhumation processes on *** Huangling Massif lies at the northern margin of the South china *** the Huangling Massif was exhumed as a watershed of the middle reaches of the Paleo-Yangtze River during the Mesozoic remains under *** examined the exhumation history of the Huangling Massif based on six granite bedrock samples,using apatite fission track(AFT)and apatite and zircon(U-Th)/He(AHe and ZHe)*** samples yielded ages of 157–132 Ma(ZHe),119–106 Ma(AFT),and 114–72 Ma(AHe),*** modeling revealed that three phases of rapid cooling occurred during the Late Jurassic–Early cretaceous,late Early cretaceous,and Late *** exhumation processes led to the high topographic relief responsible for the emergence of the Huangling *** integrated of our new data with published sedimentological records suggests that the Huangling Massif might have been the watershed of the middle reaches of the Paleo-Yangtze River since the *** that time,the rivers flowed westward into the Sichuan Basin and eastward into the Jianghan *** subduction of the Pacific Plate beneath the Asian continent in the Mesozoic deeply influenced the geomorphic evolution of the South china Block.

关键词： apatite zircon (U-Th)/He fission track Huangling Massif Yangtze River

维普期刊数据库

A high-power electromagnetic source for disabling improvised explosive devices

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High Voltage 2024年第2期9卷 403-409页

作者： Laurent Ariztia Njomza Ibrahimi Alexey Zhabin Antoine Silvestre de Ferron marc.Rivaletto Edson Martinod Valérie Bertrand Bucur Novac Laurent Pécastaing Universite de Pau et des Pays de l’Adour E2S UPPASIAMEPauFrance XLIM UMR CNRS BriveLimogesFrance cISTEME LimogesFrance Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLeicestershireUK

Ultra-wideband(UWB)microwave sources driven by specialised pulsed power generators have experienced a considerable development in the last decade due to their wide domain of new applications such as defence or counter-terrorism *** authors present the main findings of a research dedicated to the development of a pulsed power-driven electromagnetic field source for disabling improvised explosive devices(IED).The pulsed power generator driving the source is a 13-stage compact Marx producing voltage pulses reaching an amplitude of 0.5 MV,with a pulse repetition frequency(PRF)of up to 100 *** generator is coupled to a bipolar pulse forming line,providing bipolar pulses with a dV/dt of around 1.6 MV/*** pulsed power system feeds an array composed of 16 Koshelev-type UWB antennas through an impedance matching *** resulting electromagnetic source is capable to produce pulsed electric fields(PEFs)having a figure-of-merit(FOM)of 1 ***,practical experiments were carried out to study the effects of the PEFs on *** targets used in the present study are M2B type flashbulbs,known to have the same susceptibility as the US army M6 *** configurations of wires(shielded,twisted,etc)with different lengths were used in connecting items inside these *** tests were performed by placing the flashbulbs at different distances to determine the essential parameters(i.e.,amplitude,duration,and frequency range)of the PEFs required to trigger *** overview of the experimental campaign and the main findings are also presented followed by conclusions.

关键词： power bipolar source

如何负责任地回应他人痛苦?——对中国缓和医疗的再思考

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协和医学杂志 2024年第1期15卷 7-11页

作者： eric L.Krakauer 哈佛大学医学院美国马萨诸塞州波士顿MA02138 波士顿总医院缓和医疗与老年医学部美国马萨诸塞州波士顿MA02138

笛卡尔医学模式导致过度医疗已成为全球普遍现象。现代缓和医疗的兴起正是源于对笛卡尔医学模式的反思,其主要目的是缓解重病患者的痛苦,同时关注医学技术本身带来的不必要伤害。本文结合相关病例提出问题,围绕解除痛苦的历史溯源、笛... 详细信息

笛卡尔医学模式导致过度医疗已成为全球普遍现象。现代缓和医疗的兴起正是源于对笛卡尔医学模式的反思,其主要目的是缓解重病患者的痛苦,同时关注医学技术本身带来的不必要伤害。本文结合相关病例提出问题,围绕解除痛苦的历史溯源、笛卡尔医学模式的观点与弊端、维持生命技术的应用与善终等方面展开讨论,启发对中国缓和医疗发展的进一步思考与深刻理解。

关键词：笛卡尔医学模式过度医疗缓和医疗善终

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Uncovering the epidemiology of bladder cancer in the Arab world: A review of risk factors, molecular mechanisms, and clinical features

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Asian Journal of Urology 2024年第3期11卷 406-422页

作者： Noura F.Abbas marc.R.Aoude Hampig R.Kourie Humaid OAl-Shamsi Department of Hematology-Oncology Hotel Dieu De France HospitalSaint Joseph University of BeirutRiad El SolhLebanon Department of Oncology Burjeel Cancer InstituteBurjeel Medical CityAbu DhabiUnited Arab Emirates Innovation and Research center Burjeel Cancer InstituteBurjeel Medical CityAbu DhabiUnited Arab Emirates college of Medicine University of SharjahSharjahUnited Arab Emirates Emirates Oncology Society DubaiUnited Arab Emirates college of Medicine Gulf Medical UniversityAjmanUnited Arab Emirates

Objective:Bladder cancer(Bc)is a significant public health concern in the Middle East and North Africa,but the epidemiology and clinicopathology of the disease and contributors to high mortality in this region remain poorly *** aim of this systematic review was to investigate the epidemiological features of Bc in the Arab world and compare them to those in Western countries in order to improve the management of this ***:An extensive electronic search of the PubMed/PMc and cochrane Library databases was conducted to identify all articles published until May 2022,following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.A total of 95 articles were included in the final analysis after title,abstract,and full-text screening,with additional data obtained from the GLOBOcAN and WHO 2020 databases.

关键词： Bladder cancer Epidemiology Risk factor Biomarker Schistosomiasis Arab world Urology

Association of congenital Heart Defects (cHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

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congenital Heart Disease 2024年第1期19卷 19-31页

作者： Yamixa Delgado caliani Gaytan Naydi Perez eric Miranda Bryan colón Morales Mónica Santos Biochemistry&Pharmacology Department San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for clinical and Translational Research University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Department of Internal Medicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Background:Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States,there is a compelling need to investigate the intricate interplay among body mass index(BMI),pregesta-tional,and gestational maternal diabetes,and their potential impact on the occurrence of congenital heart defects(cHD)during neonatal ***:Using the comprehensive System of Vigilance and Surveillance of congenital Defects in Puerto Rico,we conducted a focused analysis on neonates diagnosed with cHD between 2016 and *** assessment encompassed a range of variables,including maternal age,gestational age,BMI,pregestational diabetes,gestational diabetes,hypertension,history of abortion,and presence of ***:A cohort of 673 patients was included in our *** average maternal age was 26 years,within a range of 22 to 32 *** mean gestational age measured 39 weeks,with a median span of 38 to 39 *** the 673 patients,274(41%)mothers gave birth to neonates diagnosed with *** this group,22 cases were linked to pre-gestational diabetes,while 202 were not;20 instances were associated with gestational diabetes,compared to 200 without;and 148 cases exhibited an overweight or obese BMI,whereas 126 displayed a normal ***:We identiﬁed a statistically signiﬁcant correlation between pre-gestational diabetes mellitus and the occurrence of ***,our analysis did not show a statistically signiﬁcant association between maternal BMI and the likelihood of *** results may aid in developing effective strategies to prevent and manage cHD in neonates.

关键词： congenital heart defects(cHD) obesisty maternal health diabetes body mass index(BMI)