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Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy

World Journal of Gastroenterology 2015年第30期21卷 9118-9125页

作者： Gijs HK Berkelmans ewout A Kouwenhoven Boudewijn JJ Smeets Teus J Weijs Luis C Silva Corten marc J van Det Grard AP Nieuwenhuijzen Misha DP Luyer Department of Surgery Catharina Hospital Department of Surgery ZGT Hospital group Twente

AIM:To investigate the value of elevated drain amylase concentrations for detecting anastomotic leakage(AL) after minimally invasive Ivor-Lewis esophagectomy(MIILe).MeTHODS:This was a retrospective analysis of prospectively collected data in two hospitals in the Netherlands. Consecutive patients undergoing MI-ILe were included. A Jackson-Pratt drain next to the dorsal side of the anastomosis and bilateral chest drains were placed at the end of the thoracoscopic procedure. Amylase levels in drain fluid were determined in all patients during at least the first four postoperative days. Contrast computed tomography scans and/or endoscopic imaging were performed in cases of a clinically suspected AL. Anastomotic leakage was defined as any sign of leakage of the esophago-gastric anastomosis on endoscopy,re-operation,radiographic investigations,post mortal examination or when gastro-intestinal contents were found in drain fluid. Receiver operator characteristic curves were used to determine the cut-off values. Sensitivity,specificity,positive predictive value,negative predictive value,risk ratio and overall test accuracy were calculated for elevated drain amylase ***:A t o t a l o f 8 9 p a t ie n t s w e re in c lu d e d between march 2013 and August 2014. No differences in group characteristics were observed between patients with and without AL,except for age. Patients with AL were older than were patients without AL(P = 0.01). One patient(1.1%) without AL died within 30 d after surgery due to pneumonia and acute respiratory distress syndrome. Anastomotic leakage that required any intervention occurred in 15 patients(16.9%). Patients with proven anastomotic leakage had higher drain amylase levels than patients without anastomotic leakage [median 384 IU/L(IQR 34-6263) vs median 37 IU/L(IQR 26-66),P = 0.003]. Optimal cut-off values on postoperative days 1,2,and 3 were 350 IU/L,200 IU/L and 160 IU/L,respectively. An elevated amylase level was found in 9 o

关键词： esophageal cancer esophageal surgery Anastomotic leakage Amylase Drain fluid

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early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study

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World Journal of Gastroenterology 2013年第21期19卷 3249-3254页

作者： Stephane Supiot Wilfried Gouraud Loc Campion Pascal Jezéquel Bruno Buecher Josiane Charrier Marie-Francoise Heymann marc-Andre Mahé emmanuel Rio Michel Chérel Department of Radiation Oncology Institut de Cancérologie de l'Ouest René Gauducheau44800 Nantes-St-HerblainFrance INSeRM U892 Centre de Recherche en Cancérologie Nantes-AngersUniversity of Nantes44000 NantesFrance Centre Hospitalier Universitaire 44000 NantesFrance Department of Nuclear Medicine Institut de Cancérologie de l'Ouest René Gauducheau44800 Nantes-Saint HerblainFrance

AIM: To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. MeTHODS: Six patients presenting with a locally advanced rectal cancer (T>T2, N0/Nx, M0) eligible for preoperative radiotherapy (45 Gy in 25 fractions) were selected in a pilot study. Six tumor and 3 normal tissues biopsies were taken before and during radiotherapy,after a dose of 7.2 Gy at a median time of 1 h following irradiation (0:27-2:12). Tumor or normal tissue purity was assessed by a pathologist prior to RNA extraction. Mean RNA content was 23 μg/biopsy (14-37) before radiotherapy and 22.7 μg/biopsy (12-35) during radiotherapy. After RNA amplification, biopsies were analysed with 54K HG-U133A Plus 2.0 Affymetrix expression micro-arrays. Data were normalized according to MAS5 algorithm. A gene expression ratio was calculated as: (gene expression during radiotherapy-gene expression before radiotherapy)/gene expression before radiotherapy. Were selected genes that showed a ratio higher than ± 0.5 in all 6 patients. ReSULTS: Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes. According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDeC1 ; AKAP7 ; CAPN5 ; CLIC5 ; CPe ; CReB3L1 ; NeDD4L ; RAB27A), ion transport (AKAP7 ; ATP2A3 ; CCL28 ; CLIC5 ; F2RL2 ; NeDD4L ; SLC6A8), transcription (AKAP7 ; CReB3L1 ; ISX ; PAB-PC1L ; TXNIP), signal transduction (CAPN5 ; F2RL2 ; RA- B27A ; TNFRSF11A), cell adhesion (ADAMDeC1 ; PXDN ; SPON1 ; S100A2), immune response (CCL28 ; PXDN ; TNFRSF11A) and apoptosis (ITM2C ; PDCD4 ; PVT1). Up-regulation of 3 genes (CCL28 ; CLIC5 ; PDCD4) was detected by 2 different probes and up-regulation of 2 genes (RAB27A ; TXNIP) by 3 probes. CONCLUSION: Micro-arrays can efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer, and may he

关键词： CCL28 CLIC5 PDCD4 RAB27A TXNIP Protein metabolism Cell adhesion Cell migration SPON1 Carboxypeptidase e

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外周阻滞对炎症导致的大鼠前列腺素e2和环氧合酶表达的影响

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麻醉与镇痛 2011年第1期7卷 49-57页

作者： Helene Beloeil marc Gentili Dan Benhamou Jean-Xavier Mazoit 罗小会(译) 杜金(校) Univ Paris-Sub laboratoire d'Anesthesie UPRES EA3540 F-94276 Le Kremlin Bicatre France 不详

背景外周炎性疼痛与脊髓COX-2（环氧合酶-2）上调及随之而来的中枢前列腺素e2（PGe2）水平升高和痛觉超敏的发生有关。本研究中，我们评估了布比卡因经神经阻滞和全身应用对PGe2和COX在外周炎症大鼠模型脊髓表达的影响。方法所有大鼠随... 详细信息

背景外周炎性疼痛与脊髓COX-2（环氧合酶-2）上调及随之而来的中枢前列腺素e2（PGe2）水平升高和痛觉超敏的发生有关。本研究中，我们评估了布比卡因经神经阻滞和全身应用对PGe2和COX在外周炎症大鼠模型脊髓表达的影响。方法所有大鼠随机接受3种注射：①左后爪皮下注射（0．2ml2％w／v角又聚糖或盐水），②左坐骨神经阻滞（0．2ml0．5％布比卡因或盐水），③全身注射（肩胛间皮下0．2ml0．5％布比卡因或盐水）。测量局部水肿、发热、机械性痛觉超敏、脑脊液PGe2浓度和脊髓背根神经节COX-1、COX-2表达。结果证实布比卡因阻滞可以自0弱炎性疼痛模型的痛觉超敏和局部炎症，这一效果可能与抑制外周炎症导致脊髓和背根神经节的COX-2表达增强有关。脑脊液PGe2的生成也被削弱。全身应用布比卡因没有减轻痛觉超敏和局部炎症或COX表达。结论本研究结果强烈提示，局部麻醉药全身用药或神经阻滞，是在不同水平起作用的。

关键词：坐骨神经阻滞前列腺素e2 大鼠模型外周炎症环氧合酶脊髓背根神经节 COX-2表达酶表达

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X-ray focusing with efficient high-NA multilayer Laue lenses

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Light(Science & Applications) 2017年第1期6卷 95-103页

作者： Saša Bajt Mauro Prasciolu Holger Fleckenstein Martin Domaracký Henry N Chapman Andrew J Morgan Oleksandr Yefanov marc Messerschmidt Yang Du Kevin T Murray Valerio Mariani Manuela Kuhn Steven Aplin Kanupriya Pande Pablo Villanueva-Perez Karolina Stachnik Joe PJ Chen Andrzej Andrejczuk Alke Meents Anja Burkhardt David Pennicard Xiaojing Huang Hanfei Yan evgeny Nazaretski Yong S Chu Christian e Hamm Photon Science DESYNotkestrasse 85Hamburg 22607Germany Center for Free-electron Laser Science DESYNotkestrasse 85Hamburg 22607Germany Department of Physics University of HamburgLuruper Chaussee 149Hamburg 22607Germany Centre for Ultrafast Imaging Luruper Chaussee 149Hamburg 22607Germany National Science Foundation BioXFeL Science and Technology Center 700 Ellicott StreetBuffaloNY 14203USA Department of Physics Arizona State UniversityTempeAZ 85287USA Faculty of Physics University of BialystokCiolkowskiego 1L Str.Bialystok 15-245Poland National Synchrotron Light Source II Brookhaven National LaboratoryUptonNY 11973USA Alfred-Wegener Institute Helmholtz Center for Polar and Marine ResearchBussestr.27Bremerhaven 27570Germany

Multilayer Laue lenses are volume diffraction elements for the efficient focusing of *** a new manufacturing technique that we introduced,it is possible to fabricate lenses of sufficiently high numerical aperture(NA)to achieve focal spot sizes below 10 *** alternating layers of the materials that form the lens must span a broad range of thicknesses on the nanometer scale to achieve the necessary range of X-ray deflection angles required to achieve a high *** poses a challenge to both the accuracy of the deposition process and the control of the materials properties,which often vary with layer *** introduced a new pair of materials—tungsten carbide and silicon carbide—to prepare layered structures with smooth and sharp interfaces and with no material phase transitions that hampered the manufacture of previous *** a pair of multilayer Laue lenses(MLLs)fabricated from this system,we achieved a two-dimensional focus of 8.4×6.8 nm2 at a photon energy of 16.3 keV with high diffraction efficiency and demonstrated scanning-based imaging of samples with a resolution well below 10 *** high NA also allowed projection holographic imaging with strong phase contrast over a large range of *** error analysis indicates the possibility of achieving 1 nm focusing.

关键词： multilayer Laue lenses multilayers ptychography X-ray holography X-ray optics

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Axillary Vessels and Brachial Plexus Traumas in Abidjan: Lesional Aspects and Surgical Difficulties

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World Journal of Cardiovascular Surgery 2023年第5期13卷 85-92页

作者： Yoboua Aimé Kirioua-Kamenan Assoumou Lucien Asseke Jean Calaire Degré Koutoua eric Katché Ibrahim Junior Yeo marc Hervé Kassi Zolé Cedrick Doh Kwadjau Anderson Amani Kouassi Antonin Souaga Kouassi Flavien Kendja Cardiovascular Surgery Department Abidjan Heart Institute Abidjan C&#244te d’Ivoire Department of Surgery and Surgical Specialties F&#233lix Houphou&#235t-Boigny University Abidjan C&#244te d’Ivoire Thoracic Surgery Department Abidjan Heart Institute Abidjan C&#244te d’Ivoire Anesthesia and Intensive Care Department Abidjan Heart Institute Abidjan C&#244te d’Ivoire

Introduction-Objectives: Through the presentation of epidemiological, anatomo-clinical and surgical aspects, we report our experience in the management of traumatic axillary lesions. Materials and Methods: A descriptive retrospective study was based on the medical records of patients who suffered vascular axillary and/or brachial plexus trauma and who underwent surgical repair at the Abidjan Cardiology Institute from January 2008 to June 2022. epidemiological, anatomo-clinical and surgical data were studied. Results: Thirty-four medical files belonging to 33 men and one woman, aged 32 on average, were collected. The circumstances of occurrence were dominated by the stab wound (n = 22). The combinations of injuries were as follows: associated involvement of the axillary artery and vein (n = 4);isolated involvement of axillary artery (n = 3);isolated involvement of the axillary vein (n = 2);associated involvement of the axillary artery and brachial plexus (n = 17);associated involvement of the axillary artery and vein and brachial plexus (n = 08). Anatomic lesions included acute arterial lesions (n = 29) and arteriovenous fistula (n = 1) and false aneurysms (n = 4). All patients were operated on under general anesthesia;vascular repair included direct suturing (n = 16), arterial and venous bypass using a long saphenous graft (n = 9), prosthetic arterial bypass (n = 5) and prosthetic flattening-graft (n = 4). Brachial plexus surgery consisted of an end-to-end anastomosis of each transected bundle in all cases (n = 25). The medium-term postoperative course was marked by success without functional sequelae in 88.24% of cases (n = 30) and by the persistence of distal paralysis of the thoracic limb after 6 months in 05.88% (n = 2) of all patients, i.e., 8% of patients who presented with brachial plexus injury. Conclusion: The concomitant surgical treatment of these axillary vascular and nerve lesions has given good results. However, if paralysis of the thoracic limb persis

关键词： Brachial Plexus Surgery Distal Paralysis of the Thoracic Limb False Aneurysms Flattening-Prosthetic Graft Traumatic Axillary Lesions

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Families of Sordariomycetes

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Fungal Diversity 2016年第4期79卷 1-317页

作者： Sajeewa S.N.Maharachchikumbura Kevin D.Hyde e.B.Gareth Jones e.H.C.McKenzie Jayarama D.Bhat Monika C.Dayarathne Shi-Ke Huang Chada Norphanphoun Indunil C.Senanayake Rekhani H.Perera Qiu-Ju Shang Yuanpin Xiao Melvina J.D’souza Sinang Hongsanan Ruvishika S.Jayawardena Dinushani A.Daranagama Sirinapa Konta Ishani D.Goonasekara Wen-Ying Zhuang Rajesh Jeewon Alan J.L.Phillips Mohamed A.Abdel-Wahab Abdullah M.Al-Sadi Ali H.Bahkali Saranyaphat Boonmee Nattawut Boonyuen Ratchadawan Cheewangkoon Asha J.Dissanayake Jichuan Kang Qi-Rui Li Jian Kui Liu Xing Zhong Liu Zuo-Yi Liu JJennifer Luangsa-ard Ka-Lai Pang Rungtiwa Phookamsak Itthayakorn Promputtha Satinee Suetrong marc Stadler Tingchi Wen Nalin N.Wijayawardene Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Center of excellence in Fungal Research and School of ScienceMae Fah Luang UniversityChiang Rai 57100Thailand Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityP.O.Box 34Al-Khod 123Oman Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Kingdom of Saudi Arabia Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha403108 GoaIndia Department of Botany Goa UniversityGoa 403206India engineering Research Center of Southwest Bio-Pharmaceutical Resources Ministry of EducationGuizhou UniversityGuiyang 550025Guizhou ProvinceChina Institute of Plant and environment Protection Beijing Academy of Agriculture and Forestry SciencesNo 9 of ShuGuangHuaYuanZhangLuHaidian District Beijing 100097China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Faculty of Sciences Biosystems and Integrative Sciences Institute(BioISI)University of LisbonCampo Grande1749-016 LisbonPortugal Department of Botany Faculty of ScienceSohag UniversitySohagEgypt Fungal Biodiversity Laboratory BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand Department of Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Pharmacy Guiyang Medical UniversityGuiyangGuizhou 550025China Microbe Interaction Laboratory BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand Institute of Marine Biology and Center of excell

Sordariomycetes is one of the largest classes of Ascomycota that comprises a highly diverse range of fungi characterized mainly by perithecial ascomata and inoperculate unitunicate *** class includes many important plant pathogens,as well as endophytes,saprobes,epiphytes,coprophilous and fungicolous,lichenized or lichenicolous *** occur in terrestrial,freshwater and marine habitats *** paper reviews the 107 families of the class Sordariomycetes and provides a modified backbone tree based on phylogenetic analysis of four combined loci,with a maximum five representative taxa from each family,where *** paper brings together for the first time,since Barrs’1990 Prodromus,descriptions,notes on the history,and plates or illustrations of type or representative taxa of each family,a list of accepted genera,including asexual genera and a key to these taxa of *** of taxa is supported where possible by molecular *** outline is based on literature to the end of 2015 and the Sordariomycetes now comprises six subclasses,32 orders,105 families and 1331 *** family Obryzaceae and Pleurotremataceae are excluded from the class.

关键词： Amplistromatales Annulatascales Boliniales Calosphaeriales Chaetosphaeriales Coniochaetales Conioscyphales Cordanales Coronophorales Diaporthales Falcocladiales Glomerellales Hypocreales Jobellisiales Koralionastetales Lulworthiales Magnaporthales Melanosporales Meliolales Microascales Ophiostomatales Phylogeny Phyllachorales Pisorisporiales Pleurotheciales Sordariales Savoryellales Tirisporellales Togniniales Torpedosporales Trichosphaeriales Taxonomy Trichosphaeriales Type species Xylariales

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速生材的新型盘磨机械法制浆工艺及其在中国制浆造纸工业中的发展潜力

速生材的新型盘磨机械法制浆工艺及其在中国制浆造纸工业中的发展...

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1999中国造纸学会学术报告会

作者： eric C．Xu marc J．Sabourin 孙来鸿 Andritz Inc．R＆D Lab and Pilot Plant Springfield Ohio USA Andritz Inc．R＆D Lab and Pilot Plant Springfield Ohio USA

本文介绍了三种新开发的盘磨机械法制浆工艺:P-RC、RT-螺旋挤碾和RTS2。研究了中国产两种按木——蓝桉和赤桉的P-RC过氧化物机械浆,结果发现,这两种桉木化机浆手抄纸页的松厚性能均优于杨木BCTMP和巨桉化学浆,而松厚性能对薄页纸、纸张...

本文介绍了三种新开发的盘磨机械法制浆工艺:P-RC、RT-螺旋挤碾和RTS2。研究了中国产两种按木——蓝桉和赤桉的P-RC过氧化物机械浆,结果发现,这两种桉木化机浆手抄纸页的松厚性能均优于杨木BCTMP和巨桉化学浆,而松厚性能对薄页纸、纸张和纸板的质量则又非常重要。采用螺旋挤碾处理流程（在120℃以上汽蒸10-25秒后进行高压缩比挤碾）可在维持或改善浆料性能的前提下显著降低磨浆能耗。RTS2,采用RTS处理条件进行第一、二道磨浆,可进一步降低磨浆能耗而不会损害浆料的强度性能。RT-螺旋挤碾处理和RTS2工艺流程配合使用则可使磨浆能耗降至最低,并且非常适合用于高密度速生针叶材（如南方松）的机械法制浆。

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Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols

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Horticulture Research 2019年第1期6卷 444-455页

作者： Kendra AMcClure YuiHui Gong Jun Song Melinda Vinqvist-Tymchuk Leslie Campbell Palmer Lihua Fan Karen Burgher-MacLellan ZhaoQi Zhang Jean-marc Celton Charles FForney ZoëMigicovsky Sean Myles Department of Plant and Animal Sciences Faculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada Agriculture and Agri-Food Canada Kentville Research and Development CentreKentvilleNS B4N 1J5Canada College of Horticulture South China Agriculture UniversityGuangzhou 510642China IRHS Agrocampus-OuestINRAUniversitéd’AngersSFR 4207 QuaSaVBeaucouzéFrance

Apples are a nutritious food source with significant amounts of polyphenols that contribute to human health and wellbeing,primarily as dietary *** numerous pre-and post-harvest factors can affect the composition of polyphenols in apples,genetics is presumed to play a major role because polyphenol concentration varies dramatically among apple *** we investigated the genetic architecture of apple polyphenols by combining high performance liquid chromatography(HPLC)data with~100,000 single nucleotide polymorphisms(SNPs)from two diverse apple *** found that polyphenols can vary in concentration by up to two orders of magnitude across cultivars,and that this dramatic variation was often predictable using genetic markers and frequently controlled by a small number of large effect genetic *** GWAS,we identified candidate genes for the production of quercitrin,epicatechin,catechin,chlorogenic acid,4-O-caffeoylquinic acid and procyanidins B1,B2,and *** observation that a relatively simple genetic architecture underlies the dramatic variation of key polyphenols in apples suggests that breeders may be able to improve the nutritional value of apples through markerassisted breeding or gene editing.

关键词： effect apple cultivar

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New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers

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World Journal of Clinical Cases 2014年第12期2卷 769-786页

作者： Armel Hervé Nwabo Kamdje Paul Faustin Seke etet Lorella Vecchio Richard Simo Tagne Jeremie Mbo Amvene Jean-marc Muller Mauro Krampera Kiven erique Lukong Department of Biomedical Sciences Faculty of Sciences University of NgaoundéréPO Box 454 NgaoundéréCameroon Department of Basic Health Sciences College of Applied Medical Sciences Qassim UniversityBuraydah 52571 Saudi Arabia Université de Poitiers Faculté des Sciences P?le Biologie-Santé Bat B36 1 rue Georges Bonnet-BP633 86022 Poitiers cedex France Department of Medicine Section of Hematology Stem Cell Research Laboratory University of Verona 37129 Verona Italy Department of Biochemistry College of Medicine University of Saskatchewan Saskatoon S7N 5E5 Canada

Breast cancer is the most frequent female malignancy worldwide. Current strategies in breast cancer therapy,including classical chemotherapy, hormone therapy, and targeted therapies, are usually associated with chemoresistance and serious adverse effects. Advances in our understanding of changes affecting the interactome in advanced and chemoresistant breast tumors have provided novel therapeutic targets, including, cyclin dependent kinases, mammalian target of rapamycin,Notch, Wnt and Shh. Inhibitors of these molecules recently entered clinical trials in mono- and combination therapy in metastatic and chemo-resistant breast cancers. Anticancer epigenetic drugs, mainly histone deacetylase inhibitors and DNA methyltransferase inhibitors, also entered clinical trials. Because of the complexity and heterogeneity of breast cancer, the future in therapy lies in the application of individualized tailored regimens. emerging therapeutic targets and the implications for personalized-based therapy development in breast cancer are herein discussed.

关键词： Breast cancer Microenvironment Signaling molecule Targeted therapy Chemoresistance

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Saudi Consensus on the Usage of Sodium-Glucose Cotransporter-2 Inhibitors on the Management of Chronic Kidney Diseases

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International Journal of Clinical Medicine 2023年第12期14卷 525-539页

作者： Abdulrahman Alsheikh Ahmed Aljedai Hajer Almudaiheem Salwa Alaidarous Ali Alshehri Hussein elbadawi Saeed Alghamdi Faisal Aljehani Sami Alobaidi Talal A. Altuwaijri Khalid Almatham David Strain marc evans emad R. Issak Saud Alsifri King Abdulaziz University Hospital Jeddah Saudi Arabia Ministry of Health Riyadh Saudi Arabia Ministry of National Guards Hospital Jeddah Saudi Arabia King Fahad Medical City Riyadh Saudi Arabia My Clinic Jeddah Saudi Arabia College of Medicine University of Jeddah Jeddah Saudi Arabia College of Medicine King Saud University Riyadh Saudi Arabia College of Medicine Alfaisal University Riyadh Saudi Arabia University of exeter Medical School Exeter UK University Hospital Llandough Cardiff UK College of Medicine Ain Shams University Cairo Egypt Alhada Armed Forces Hospital Taif Saudi Arabia

According to recent epidemiological data, chronic kidney diseases (CKDs) affect approximately 10% of the global population. Like many countries, CKD is a significant public health issue in Saudi Arabia. The prevalence of CKD in Saudi Arabia is estimated to be around 4.5% of the adult population, with a higher prevalence in older age groups. Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are a class of oral medications used to treat type 2 diabetes mellitus (T2DM). In addition to their glucose-lowering effects, SGLT2i have been shown to have beneficial effects on kidney function in patients with or without T2DM. Therefore, a Saudi task force gathered to develop an explicit, evidence-based consensus on SGLT2i use in CKD Saudi patients. A panel of 14 experts made up a task force. An initial concept proposal was obtained. The proposal was divided into several topics discussed on 24 May 2023. A literature review was carried out. The literature search was completed on 3rd June 2023. A drafted report was distributed to the entire panel. Approval of the recommendations required consensus, defined as a majority approval (i.e. above 75%). The recommendations were revised to accommodate any differences of opinion until a consensus was reached. Recommendations were finally formulated on 21st June 2023. Subsequently, the panel reviewed and discussed the supporting rationale of the revised recommendations. This article presents these practical recommendations.

关键词： Chronic Kidney Disease Sodium-Glucose Cotransporter-2 Inhibitors Adverse effects Monitoring Canagliflozin Dapagliflozin empagliflozin

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