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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

endoscopic ultrasonography-guided fine needle aspiration:Relatively low sensitivity in the endosonographer population

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World Journal of Gastroenterology 2012年第19期18卷 2357-2363页

作者： Jean-marc Dumonceau Thibaud Koessler Jeanin e van Hooft Paul Fockens Division of Gastroenterology and Hepatology Geneva University Hospital1211 GenevaSwitzerland Division of General Internal Medicine Geneva University Hospital1211 GenevaSwitzerland Gastrointestinal endoscopy Academic Medical Center University of Amsterdam1012 WXAmsterdamThe Netherlands

AIM： To assess the characteristics and quality of endoscopic ultrasonography-guided fine needle aspiration （eUS-FNA） in a large panel of endosonographers.MeTHODS： A survey was conducted during the 13th annual live course of endoscopic ultrasonography （eUS） held in Amsterdam, Netherlands. A 2-page question- naire was developed for the study. Content validity of the questionnaire was determined based on input by experts in the field and a review of the relevant literature. It contained 30 questions that pertained to demographics and the current practice for eUS-FNA of responders, including sampling technique, sample processing, cytopathological diagnosis and sensitivity of eUS-FNA for the diagnosis of solid mass lesions. One hundred and sixty-one endosonographers whoattended the course were asked to answer the survey. This allowed assessing the current practice of eUS-FNA as well as the self-reported sensitivity of eUS-FNA for the diagnosis of solid mass lesions. We also examined which factors were associated with a self-reported sensitivity of eUS-FNA for the diagnosis of solid mass lesions 〉 80%.ReSULTS： Completed surveys were collected from 92 （57.1%） of 161 endosonographers who attended the conference. The endosonographers had been practio ing endoscopy and eUS for 22.5 4. 7.8 years and 4.8 4- 4.1 years, respectively; one third of them worked in a hospital with an annual caseload 〉 100 eUS-FNA. endoscopy practices were located in 29 countries, in- cluding 13 countries in Western europe that totaled 75.3% of the responses. Only one third of endosonog raphers reported a sensitivity for the diagnosis of solid mass lesions 〉 80% （interquartile range of sensitivities, 25.0%-75.0%）. Factors independently associated with a sensitivity 〉 80% were （1）〉 7 needle passes for pancreatic lesions or rapid on-site cytopathological evaluation （ROSe）（P 〈 0.0001）, （2） a high annual hospital caseload （P = 0.024） and （3） routine isolation of microcores from eUS-FNA samples （P =

关键词： Caseload Community surveys Cytopa- thology endoscopic ultrasonography Histopathology Quality improvement

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GReCC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

Prediction of Shear Bond Strength of Asphalt Concrete Pavement Using Machine Learning Models and Grid Search Optimization Technique

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Computer Modeling in engineering & Sciences 2025年第1期142卷 691-712页

作者： Quynh-Anh Thi Bui Dam Duc Nguyen Hiep van Le Indra Prakash Binh Thai Pham Civil engineering Department University of Transport Technology54 Trieu KhucThanh XuanHanoi100000Vietnam DDG(R)Geological Survey of India Gandhinagar382010India

Determination of Shear Bond strength(SBS)at interlayer of double-layer asphalt concrete is crucial in flexible pavement *** study used three Machine Learning(ML)models,including K-Nearest Neighbors(KNN),extra Trees(eT),and Light Gradient Boosting Machine(LGBM),to predict SBS based on easily determinable input ***,the Grid Search technique was employed for hyper-parameter tuning of the ML models,and cross-validation and learning curve analysis were used for training the *** models were built on a database of 240 experimental results and three input variables:temperature,normal pressure,and tack coat *** validation was performed using three statistical criteria:the coefficient of determination(R2),the Root Mean Square error(RMSe),and the mean absolute error(MAe).Additionally,SHAP analysis was also used to validate the importance of the input variables in the prediction of the *** show that these models accurately predict SBS,with LGBM providing outstanding ***(Shapley Additive explanation)analysis for LGBM indicates that temperature is the most influential factor on ***,the proposed ML models can quickly and accurately predict SBS between two layers of asphalt concrete,serving practical applications in flexible pavement structure design.

关键词： Shear bond asphalt pavement grid search optimization machine learning

Reverse cholesterol transport: From classical view to new insights

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World Journal of Gastroenterology 2010年第47期16卷 5908-5915页

作者： Astrid e van der Velde Academic Medical Center AMC Liver Center Department of education and Development Gelderse Vallei Hospital

Cholesterol is of vital importance for the human body. It is a constituent for most biological membranes, it is needed for the formation of bile salts, and it is the pre- cursor for steroid hormones and vitamin D. However, the presence of excess cholesterol in cells, and in particular in macrophages in the arterial vessel wall, might be harmful. The accumulation of cholesterol in arteries can lead to atherosclerosis, and in turn, to other cardiovascular diseases. The route that is primarily thought to be responsible for the disposal of cholesterol is called reverse cholesterol transport (RCT). Therefore, RCT is seen as an interesting target for the development of drugs aimed at the prevention of atherosclerosis. Research on RCT has taken off in recent years. In this review, the classical concepts about RCT are discussed, together with new insights about this topic.

关键词： Cholesterol excretion Transport Intestine Liver

Parallel patterns and trends in functional structures in extinct island mammals

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Integrative Zoology 2014年第2期9卷 167-182页

作者： Alexandra A.e.van DeR GeeR Naturalis Netherlands Biodiversity Center LeidenNetherlands

endemic mammalian species on islands are generally known to have followed a different evolutionary pathway than their mainland relatives. General patterns, such as body size trends, have been described regularly. How-ever, most island mammal species are unique and each of them is adapted to a specific local niche as part of an equally specific ecological assemblage. Therefore, comparing island species across taxa, islands and time is in-herently dangerous without understanding the adaptational value of the studied feature in the compared taxa and without taking the ecological setting of the taxa into account. In this contribution, general and recurring patterns are described per taxon. Some features, like body mass change and sturdy limbs, are relatively general, where-as most features, like bone fusions and change of orbital axis, occur only in a very few taxa. Some features are even contradictory, such as brain size and degree of hypsodonty, with each taxon having its own particular de-sign. In conclusion, general patterns are more often than not just trends and need to be applied with caution.

关键词： body proportions fossil record island rule paleo-insular mammals Pleistocene

Self-expandable metal stents for malignant gastric outlet obstruction: A pooled analysis of prospective literature

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World Journal of Gastroenterology 2015年第43期21卷 12468-12481页

作者： emo e van Halsema erik AJ Rauws Paul Fockens Jeanin e van Hooft Department of Gastroenterology and Hepatology Academic Medical Center

AIM: To provide an overview of the clinical outcomes of self-expandable metal stent(SeMS) placement for malignant gastric outlet obstruction(MGOO).MeTHODS: A systematic literature search was performed in Pub Med of the literature published between January 2009 and march 2015. Only prospective studies that reported on the clinical success of stent placement for MGOO were included. The primary endpoint was clinical success,defined according to the definition used in the original article. Data were pooled and analyzed using descriptive statistics. Subgroup analyses were performed for partially covered SeMSs(PCSeMSs) and uncovered SeMSs(UCSeMSs) using Fisher's exact ***: A total of 19 studies,including 1281 patients,were included in the final analysis. Gastric(42%) and pancreatic(37%) cancer were the main causes of MGOO. UCSeMSs were used in 76% of patients and PCSeMSs in 24%. The overall pooled technical success rate was 97.3% and the clinical success rate was 85.7%. Stent dysfunction occurred in 19.6% of patients,mainly caused by re-obstruction(12.6%) and stent migration(4.3%),and was comparable between PCSeMSs and UCSeMSs(21.2% vs 19.1%,respectively,P = 0.412). Re-obstruction was more common with UCSeMSs(14.9% vs 5.1%,P ent migration was more frequent after PCSeMS placement(10.9% vs 2.2%,P e overall perforation rate was 1.2%. Bleeding was reported in 4.1% of patients,including major bleeding in 0.8%. The median stent patency ranged from 68 to 307 d in five studies. The median overall survival ranged from 49 to 183 d in 13 ***: The clinical outcomes in this large population showed that enteral stent placement was feasible,effective and safe. Therefore,stent placement is a valid treatment option for the palliation of MGOO.

关键词： Stents Gastric outlet obstruction Stomach neoplasm

Treatment of mesothelioma: still a long way to go!

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Chinese Journal of Cancer Research 2013年第2期25卷 132-133页

作者： Paul e. van Schil Department of Thoracic and Vascular Surgery Antwerp University Hospital

Prognosis of patients with malignant pleural mesothelioma remains very poor. Single treatment modality is clearly not effective in improving disease-free and overall survival. For this reason combined modality therapy is intensively investigated. In the well-performed and timely systematic review by Cao and colleagues, results of trimodality therapy for mesothelioma consisting of neoadjuvant or adjuvant chemotherapy, extrapleural pneumonectomy and adjuvant radiotherapy, were evaluated （1）. A total of 16 studies were included of which one was a randomized controlled trial, 5 were prospective studies and the others selected retrospective, observational studies. Although the results are inconsistent,

关键词： Treatment of mesothelioma still a long way to go

CURDIS:A template for incremental curve discretization algorithms and its application to conics

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虚拟现实与智能硬件（中英文） 2024年第5期6卷 358-382页

作者： Philippe LATOUR marc van DROOGeNBROeCK Montefiore Institute University of LiègeQuartier Polytech 1Allée de la découverte 104000 LiègeBelgium

We introduce CURDIS,a template for algorithms to discretize arcs of regular curves by incrementally producing a list of support pixels covering the *** this template,algorithms proceed by finding the tangent quadrant at each point of the arc and determining which side the curve exits the pixel according to a tailored *** two elements can be adapted for any type of curve,leading to algorithms dedicated to the shape of specific *** the calculation of the tangent quadrant for various curves,such as lines,conics,or cubics,is simple,it is more complex to analyze how pixels are traversed by the *** the case of conic arcs,we found a criterion for determining the pixel exit *** leads us to present a new algorithm,called CURDIS-C,specific to the discretization of conics,for which we provide all the ***,the criterion for conics requires between one and three sign tests and four additions per pixel,making the algorithm efficient for resource-constrained systems and feasible for fixed-point or integer arithmetic *** algorithm also perfectly handles the pathological cases in which the conic intersects a pixel twice or changes quadrants multiple times within this pixel,achieving this generality at the cost of potentially computing up to two square roots per *** illustrate the use of CURDIS for the discretization of different curves,such as ellipses,hyperbolas,and parabolas,even when they degenerate into lines or corners.

关键词： Computer graphics Curve discretization Conics Rasterization ellipse drawing Conic spline Conic pencil