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Partial gastric pull-up in the treatment of patients with long-gap esophageal atresia

World Journal of Pediatrics 2015年第3期11卷 267-271页

作者： marc reismann Tina Granholm Henrik Ehrén Department of Pediatric Surgery and Urology Astrid Lindgren Children's HospitalKarolinska University HospitalStockholmSweden

Background:This study was to analyze outcomes of long-gap esophageal atresia(LGEA)treated with partial gastric pull-up(PGP)into the ***:The medical records of all children who had undergone PGP for LGEA from 1999 to 2012 were *** data,initial postoperative course,complications,time to full oral nutrition,follow-up diagnostics and nutritional status were ***:Nine children who had undergone PGP were followed up for a mean period of 6.2±3.1 *** median gestational age was 37+2 weeks,and mean birth weight 2462±658 *** children were primarily treated with a gastrostomy,their mean age at PGP was 11.4+10.9 weeks and mean weight was 4484+1966 *** mean operation time was 199+51 *** was an early postoperative complication in three children,one of whom had a consecutive stricture *** complications were stenosis(n=7)and gastro-esophageal reflux(n=5).The general status of the children was judged as"good"or"very good"on the last *** median percentile of the body-mass-index was *** at 3.7±3.2 years after the operation revealed a grade I esophagitis in two *** was no death in this group of ***:Because of its high complication rate,partial gastric pull-up cannot be recommended as an alternative for the treatment of LGEA at present.A final judgment could be made on the basis of a comparative study.

关键词： early childhood esophageal atresia gastric pull-up

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Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts

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World Journal of Pediatrics 2018年第5期14卷 504-509页

作者： Maximiliane I.Minderjahn Dag Schadlich Josephine Radtke Karin Rothe marc reismann Department of Pediatric Surgery Charité–Universitatsmedizin BerlinAugustenburger Platz 113353 BerlinGermany

Background Phlegmonous and complicated appendicitis represent independent entities depending on hereditary immuno-logical mechanisms. However, clinically there are no means to distinguish uncomplicated phlegmonous from complicated appendicitis. The ability to distinguish these two forms of appendicitis is relevant as current attempts are to treat both forms of the disease differently. The aim of the present study was to investigate differences in white blood cell counts (WBCs) in these conditions to identify areas of interest for future molecular studies. Methods White blood cell counts of patients aged between 7 and 14 years who underwent appendectomy from January 2008 to June 2016 were investigated with special reference to particular cellular subpopulations. Results A total of 647 children were included in the study. Within distinct inflammatory patterns, significant eosinophilia and basophilia were found in phlegmonous inflammation compared with complicated inflammation (0.11±0.19×109/L vs. 0.046±0.104×109/L, P<0.0001, and 0.033±0.031×109/L vs. 0.028±0.024×109/L, P<0.001). Conclusions Compared with complicated disease, phlegmonous appendicitis seems to depend primarily on eosinophil inflam-mation. This observation is stable over time and indicates a direction for investigation of underlying genetic prerequisites.

关键词： Appendicitis Children Eosinophil granulocytes Immunology

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Correspondence

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世界儿科杂志:英文版 2016年第2期12卷 251-251页

作者： marc reismann Department of Pediatric Surgery Astrid Lindgren Children's HospitalKarolinska HospitalStockholmSweden

We are very grateful to Karabulut et al for their interest in our paper reporting the method of partial gastric pull-up(PGP)in the treatment of long-gap esophageal atresia(LGEA).We agree to the view that the central problem in treatment of esophageal atresia is at present lack of generally accepted defi nitions,for instance,the defi nition of LGEA as mentioned in their letter.

关键词： treatment mentioned

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Toll样受体4(TLR4)基因多态性与脑缺血无关

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 13-13页

作者： reismann P. Lichy C. Rudofsky G. 江山 Department of Neurology University of Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Germany Dr

Toll-like receptor-4 (TLR4), an important mediator of the innate immune response, is expressed in atherosclerotic lesions. The common single nucleotide exchange (Asp299Gly) of the TLR4 gene has been previously reported to impair TLR4 function and to be associated with a decreased risk of carotid atherosclerosis. Therefore, we aimed to detect the potential impact of TLR4 genotypes on the risk of cerebral ischemia. We studied the prevalence of two common polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) in 3 independent study populations: (1.) in a cross sectional study including 769 patients either with type 1 or type 2 diabetes mellitus, of whom 56 (7.2% ) had a history of cerebral ischemia (stuyg 1), (2.) a case control study (study 2) including 128 consecutive patients with cerebral ischemia, mean age 60± 10.9 years and 139 control subjects, and(3.) a case control study (study 3) including 171 young adults aged < 50 years with cerebral ischemia and 204 control individuals. In all subjects, Asp299Gly and Thr399Ile were detected by restriction length analysis. The prevalence of the TLR4 genotypes was essentially the same between patients with cerebral ischemia and control subjects in all 3 study populations. Furthermore, there was also no association with the subgroup of atherosclerotic stroke in both case control studies populations. Although TLR4 polymorphisms are associated with a decreased risk of carotid atherosclerotic lesions, our findings indicate that they do not influence the prevalence of cerebral ischemia. This implies that the Asp299Gly TLR4 allele might have a protective role in carotid atherosclerosis, but not in cerebral ischemia.

关键词：脑缺血 TLR4 Toll样受体4 基因多态性核苷酸置换粥样硬化性受试人群片断长度病例对照研究横断面研究

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