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Myocardial Protection during Cardiac Surgery: Warm Blood versus Crystalloid Cardioplegia

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World Journal of Cardiovascular Diseases 2014年第9期4卷 422-431页

作者： Helene De Bruyn France Gelders Tine Gregoir Valerie Waelbers Pascal Starinieri Jean-Louis Pauwels Jeroen Lehaen Boris Robic Alaaddin Yilmaz Urbain Mees marc hendrikx Department of Cardiothoracic Surgery Jessa Hospital Hasselt Belgium Faculty of Medicine and Life Sciences Hasselt University Hasselt Belgium

Purpose: Prevention of myocardial injury is essential during cardiac surgery. Both crystalloid and blood cardioplegia are popular methods for myocardial protection. Most experimental studies have been in favor of blood cardioplegia. The objective of this study is to determine whether the use of warm blood cardioplegia (BCP) is superior to crystalloid cardioplegia (CCP) by means of myocardial injury markers and clinical outcome parameters. Materials and Methods: In a consecutive series of 293 patients, the first 150 received crystalloid cardioplegia, whereas the next 143 patients received blood cardioplegia. Postoperative myocardial injury was assessed by CTnI and CK-MB. Perioperative morbidity and mortality and clinical outcome parameters (need for inotropic support, ICU and hospital stay) were recorded. An unpaired student t-test was performed to analyse continuous postoperative variables relating to myocardial damage. The presence of possible confounders influencing the CTnI or CK-MB concentrations was tested using a student t-test for continuous variables, for categorical variables ANOVA was used. A final longitudinal model was created for CTnI and CK-MB. CTnI was analyzed by a mixed model with random intercept and slope. For all tests performed, statistical significance was 5%. Results: Both groups were well matched with respect to preoperative variables. No significant difference could be found in maximum postoperative levels of CTnI (8.8 ± 18.4 μg/l in BCP vs 9.6 ± 16.5 μg/l in CCP, p = 0.6455) or CK-MB (19.2 ± 31.0 μg/l in BCP vs 26.4 ± 41.5 μg/l in CCP, p = 0.1209). Nor was there any significant difference in other postoperative variables. Testing treatment effect over time proved only significant influence of the surgical intervention type on CTnI levels in time (p < 0.001). Conclusion: This study could not show significantly higher myocardial injury in the group of patients receiving crystalloid cardioplegia versus warm blood cardioplegia. This suggests th

关键词： Myocardium Protection Ischemia/Reperfusion Myocardial Infarction Cardiac Surgery

Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease

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Genes & Diseases 2023年第1期10卷 18-21页

作者： Eva Gijbels Kevin De Muynck Bart Vanderborght Tim Meese Filip Van Nieuwerburgh Aude Vanlander Frederik Berrevoet Bart hendrikx Anne Hoorens Hans Van Vlierberghe Mathieu Vinken Lindsey Devisscher Department of Pharmaceutical and Pharmacological Sciences Vrije Universiteit Brussel1090 BrusselsBelgium Gut-Liver Immunopharmacology Unit Basic and Applied Medical SciencesLiver Research Centre GhentFaculty of Medicine and Health SciencesGhent University9000 GhentBelgium Hepatology Research Unit Internal Medicine and PaediatricsLiver Research Centre GhentFaculty of Medicine and Health SciencesGhent University9000 GhentBelgiumd Lab of Pharmaceutical Biotechnology Ghent University9000 GhentBelgium NXTGNT Ghent University9000 GhentBelgium Department of HPB Surgery and Liver Transplantation Ghent University Hospital9000 GhentBelgium Department of Pathology Ghent University Hospital9000 GhentBelgium Hepatology Research Unit Internal Medicine and PaediatricsLiver Research Centre GhentFaculty of Medicine and Health SciencesGhent University9000 GhentBelgium

Cholelithiasis-induced cholestasis is one of the most common causes of hospitalization due to gastrointestinal disease,yet considerable knowledge gaps exist in the pathogenesis of this *** can partially be explained by inadequate characterization of experimental cholestasis ***,we compared the transcriptional profile of commonly used mouse models for obstructive cholestasis and benchmarked them to human disease to identify the model(s)best suited for cholelithiasis-induced cholestasis research and to uncover conserved mechanisms involved in human and murine cholestasis.

关键词： cholestasis obstructive pathogenesis

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SiP技术在晶圆级生产中的应用

今日电子 2005年第10期 61-62页

作者： Fred van Roosmalen Caroline Beelen-hendrikx 飞利浦半导体公司

系统芯片(SoC)旨在采用单一的半导体工艺技术实现完整的系统.系统封装(SiP)则是将各种不同的工艺技术整合到一个小型的芯片封装中.尽管SoC和SiP通常被认为是相互竞争的技术,但两者的共同之处在于:在集成密度、价位和大规模制造方面要和... 详细信息

系统芯片(SoC)旨在采用单一的半导体工艺技术实现完整的系统.系统封装(SiP)则是将各种不同的工艺技术整合到一个小型的芯片封装中.尽管SoC和SiP通常被认为是相互竞争的技术,但两者的共同之处在于:在集成密度、价位和大规模制造方面要和晶圆生产达到平衡点.

关键词： iP技术生产晶圆半导体工艺应用系统封装芯片封装技术整合技术实现

直接心肌内自体骨髓细胞移植术可使收缩功能局部恢复而非整体恢复:一项随机对照临床试验的结果

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 21-22页

作者： hendrikx M. Clijsters C. 徐永城 Department of Cardiothoracic Surgery Virga Jessehospital Stadsomvaart 11 B-3500 Hasselt BelgiumDr

背景:近来研究发现,急性心肌梗死后给予冠状动脉内注射骨髓细胞(BMC)可以改善功能恢复。然而,对于作为机化梗死后重构结果的心力衰竭,这种治疗是否有效尚不清楚。在本项随机试验中,作者通过4个月随访评估了这样的假设:在冠状动脉搭桥术(... 详细信息

背景:近来研究发现,急性心肌梗死后给予冠状动脉内注射骨髓细胞(BMC)可以改善功能恢复。然而,对于作为机化梗死后重构结果的心力衰竭,这种治疗是否有效尚不清楚。在本项随机试验中,作者通过4个月随访评估了这样的假设:在冠状动脉搭桥术(CABG)过程中直接心肌内注射自体单核骨髓细胞,可以改善整体和局部左心室射血分数(LVEF)。

关键词：自体骨髓细胞移植术收缩功能冠状动脉搭桥术随访评估左心室射血分数肌内注射急性心肌梗死核

Anti-Inflammatory Pre-Treatment to Reduce Mobilization-Induced Liver Inflammation in Mice: Novel Model to Study Liver Injury

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Modern Research in Inflammation 2015年第1期4卷 1-7页

作者： T. hendrikx C. Piersma D. K. Dhar L. Mpabanzi J. J. W. Schreurs M. Malagó R. Shiri-Sverdlov S. W. M. Olde Damink Department of Molecular Genetics Maastricht University Maastricht The Netherlands Nutrition and Toxicology Research Institute Maastricht Maastricht University Maastricht The Netherlands Department of Surgery Maastricht University Medical Centre Maastricht The Netherlands Department of HPB Surgery and Liver Transplantation Royal Free Hospital University College London London UK Comparative Medicine Department Organ Transplantation Center King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia

Background: Liver surgery requires mobilization of the liver resulting in injury. Mobilization is the predominant cause of hepatocyte damage during liver surgery and jeopardizes post-operative liver function. Previously, mobilization-induced liver injury was found to be associated with inflammation. So far, anti-inflammatory drugs to potentially prevent liver inflammation following liver mobilization were not tested. In this study, we aimed to establish an in vivo mouse model of mobilization-induced liver injury and to evaluate the effect of anti-inflammatory pre-treatment before liver mobilization on liver inflammation. Methods: To develop a mouse model for mobilization-induced liver injury, C57BL/6 mice (n = 8) underwent surgery during which the liver was mobilized by gentle manipulation of the lobes with cotton-wool applicators for 15 minutes. In two control groups, the liver was left alone or was subjected to laparotomy only. An additional group was added that received anti-TNF treatment (Infliximab) 2 days prior to surgery. Liver samples were obtained 2 hours after mobilization and liver inflammation was analyzed by histology and inflammatory gene expression. Results: Gentle liver mobilization resulted in acute liver inflammation as indicated by increased recruitment of inflammatory cells and elevated inflammatory gene expression compared to controls. Infliximab pre-treatment had no effect on the inflammatory response in the liver. Conclusion: Our current model provides an excellent opportunity to study the effects of pre-treatment with anti-inflammatory drugs on mobilization-induced liver inflammation. Further studies are needed to investigate whether anti-inflammatory mediators can be used to prevent liver inflammation.

关键词： Liver Surgery Hepatocellular Damage Inflammation Translational Model Post-Resectional Liver Failure

扩散加权成像与常规MR成像在新生儿缺氧缺血中的应用:2年的随访研究

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国际医学放射学杂志 2009年第1期32卷 67-68页

作者： R.J. Vermeulen P.E. van Schie L. hendrikx F. Barkhof M. van Weissenbruch D.L. Knol 李志明 Department of Child Neurology VU University Medical Center Amsterdam the Netherlands

目的通过对缺血缺氧的新生儿2年后临床预后的评估，明确扩散加权成像（DWI）对于常规MR成像的信息补充价值。材料和方法 46例缺血缺氧新生儿作为本项前瞻性研究对象．年龄在出生后1～45d不等。这项研究经过了当地伦理委员会的认可，... 详细信息

目的通过对缺血缺氧的新生儿2年后临床预后的评估，明确扩散加权成像（DWI）对于常规MR成像的信息补充价值。材料和方法 46例缺血缺氧新生儿作为本项前瞻性研究对象．年龄在出生后1～45d不等。这项研究经过了当地伦理委员会的认可，告知患儿家属并获得同意。在大脑14个不同的区域测定表观扩散系数（ADC）。

关键词：新生儿缺氧缺血扩散加权成像 MR成像随访研究表观扩散系数缺血缺氧伦理委员会临床预后