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Effects of endothelin ETA receptor blocker LU 135252 on cardiac remod-eling and survival in a hypertensive rat model of chronic heart failure

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Acta Pharmacologica Sinica 2006年第11期27卷 1417-1422页

作者： Alexander REINECKE marc dorenkamp Mat Jap DAEMEN Reichiger SIMON Thomas UNGER Clinic of Cardiology Christian-Albrechts-University of Kiel24105 KielGermany Institute of Pharmacology Christian-Albrechts University of Kiel24105 KielGermany Department of Pathology University of MaastrichtMaastrichtthe Netherlands

Aim:To investigate whether the endothelin ETAreceptor blocker provides similarbenefit on cardiac remodeling and survival in a hypertensive rat model of chronicheart failure（CHF）.Methods:Male stroke-prone spontaneously hypertensive（SHR-SP）rats were subjected to permanent ligation of the left coronary artery andwere treated for 6 weeks with the endothelin ETAreceptor blocker LU 135252(***-1.d-1)starting 24 h after ligation or ***-operated rats servedas normal *** mean arterial blood pressure（MAP）,heart rate（HR）,leftventricular end-diastolic pressure（LVEDP）,left ventricular contractility(LVdp/dtmax),left ventricular inner diameter（LVD）and circumference（LVC）,septalthickness,left ventricular interstitial collagen content（ICC）and heart weight（HW）were measured at the end of the ***:Compared with the untreatedgroup,LU 135252 tended to increase HW（1.43±0.03 vs 1.38±0.04 g;P>0.05）,increased LVD（7.65±0.24 mm vs 6.58±0.14 mm;P0.05）,reduced LVEDP（144mmHg vs 27±4 mmHg;P<0.05）andimproved LV dp/dtmax（4230±450 mmHg/s vs 1950±400 mmHg/s;P<0.05）;survivalwas not prolonged significantly（13% vs 11%;P=NS）.Conclusion:In this hyper-tensive rat model of CHF,chronic endothelin ETA receptor blockade with LU 135252improves cardiac hemodynamics,however,it does not affect long-term survivaland worsens cardiac ***,endothelin ETAreceptor antagonists areunlikely to have an important role in the management of patients with CHF.

关键词： myocardial infarction heart failure endothelin ET_A receptor antagonism LU 135252 cardiac remodeling ventricular function SHR-SP rats

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Comparison of cardioprotective effects of mibefradil and ramipril in stroke-prone spontaneously hypertensive rats

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Acta Pharmacologica Sinica 2004年第6期 61-66页

作者： Alexander REINECKE,marc dorenkamp,Christain STORZ,Havvo BITTERLING,Susanne PENZ,Jack CLEUTJENS,Mat JAP DAEMEN,Reichiger SIMON,Thomas UNGER Institute of Pharmacology University of Kiel 24105 Kiel Germany Institute of Pharmacology University of Kiel 24105 Kiel Germany Clinic of Cardiology Institute of Pharmacology University of Kiel 24105 Kiel Germany Institute of Pharmacology University of Kiel 24105 Kiel Germany University of Kiel Department of Pathology University ofMaastricht Maastricht The Netherlands Clinic of Cardiology University of Kiel 24105 Kiel Germany 24105 Kiel Institute of Pharmacology University of Kiel 24105 Kiel Germany Germany Institute of Pharmacology University of Kiel 24105 Kiel Germany

AIM: To elucidate the cardioprotective effects of T-type calcium channel blocker mibefradil and compare with that of the angiotensin-converting enzyme inhibitor ramipril in a stroke-prone spontaneously hypertensive rats (SHR- SP) model of congestive heart failure (CHF) after myocardial infarction (MI). METHODS: SHR-SP rats were subjected to permanent ligation of the left anterior decending coronary artery. Treatment with mibefradil (10 mg·kg-1·d-1), ramipril (10 mg·kg-1·d-1), or placebo was initiated 4 weeks before surgery and continued up to 6 weeks after induction of MI. Sham-operated rats served as controls. RESULTS: In placebo-treated MI rats, six weeks after MI, left ventricular circumference, inner diameter, and left ventricular end-diastolic pressure (LVEDP) were increased, whereas mean arterial blood pressure (MAP) and maximum rate of rise of left ventricular pressure (dp/ dtmax) were decreased compared with sham-operated controls (P05), and dp/dtmax was improved (P<0.01) compared with placebo-treated MI rats. In contrast, in mibefradil-treated MI rats, heart weight, heart weight to body weight ratio were slightly but not signifi- cantly reduced, LVEDP was slightly elevated compared with placebo-treated MI rats, and was elevated (P<0.05) compared with ramipril-treated MI rats, although interstitial collagen content were reduced (P<0.01) compared with placebo-treated MI ***: Chronic treatment with ramipril diminishes cardiac remodeling of heart failure after MI to a greater extent than mibefradil. Moreover, 6 weeks after MI, mibefradil treatment results in a slight rise in LVEDP compared with placebo-treated rats. Therefore, treatment with mibefradil might be deleterious rather than beneficial compared with ramipril or even placebo treatment in experim

关键词： mibefradil ramipril angiotensin-converting enzyme inhibitors calcium channel blockers myocar- dial infarction heart failure cardiac remodeling ventricular function SHR-SP rats

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MDCT in the diagnostic algorithm in patients with symptomatic atrial fibrillation

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World Journal of Radiology 2011年第2期3卷 41-46页

作者： Christian Sohns Dirk Vollmann Lars Luethje marc dorenkamp Joachim Seegers Jan D Schmitto Markus Zabel Silvia Obenauer Department of Cardiology and Pneumology Heart CenterGeorg-August-University GoettingenD-37077 GoettingenGermany Division of Cardiac Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115United States Department of Diagnostic and Interventional Radiology Medical FacultyUniversity DusseldorfD-40225 DusseldorfGermany

Atrial fibrillation(AF) is the most common supraventricular arrhythmia and a major cause of *** foci originating within the pulmonary veins(PVs) are an important cause of both paroxysmal and persistent AF.A variety of endovascular and surgical techniques have been used to electrically isolate the PV from the left *** venography for localization of the PV ostium can be difficult to perform during the ablation *** the anatomy of the PV is patientspecific,non-invasive imaging techniques may provide useful diagnostic information prior to the intended *** this context,multidetector computed tomography(MDCT) visualization of the left atrial and PV anatomy prior to left atrial ablation and PV isolation is becoming increasingly *** imaging provides pre-procedural information on the left atrial anatomy,including atrial size and venous attachments,and it may identify potential post-procedural complications,such as pulmonary vein stenosis or cardiac ***,we review the relevant literature and present the current"state-of-the-art"of left atrial anatomy,PV ostia as well as the clinical aspects of refractory AF with MDCT imaging protocols and procedural aspects of PV ablation.

关键词： Atrial fibrillation Multidetector computed tomography Pulmonary veins Pulmonary vein ablation

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Bound and Resonating Multiquark Configurations

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Chinese Physics Letters 2024年第8期41卷 8-12页

作者： Jean-marc Richard Institut de Physique des 2 Infinis de Lyon Université Claude Bernard(Lyon 1) CNRS-IN2P34 rue Enrico Fermi69622 VilleurbanneFrance

We review the predictions of quark models for multiquark configurations that are bound or resonant states,and compare different methods for estimating the properties of resonances.

关键词： quark Configuration resonant

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Fibre optic distributed scattering sensing system:perspectives and challenges for high performance applications

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仪器仪表学报 2007年第8期28卷 1345-1352页

作者： marc Niklès Omnisens SA Riond-Bosson 3CH-1110 MorgesSwitzerland

As fiber optic distributed scattering sensing systems are providing innovative solutions for the monitoring of large structures,the comparison of different techniques and solutions is difficult because of the lack of standardized specifications and the difficulty associated to the characterization of such *** article presents a tentative definition of performance specifications and qualification procedures applicable to fiber optic distributed sensing systems aiming at providing clear guidelines for their design,specifications,qualification,application and selection.

关键词：纤维光学传感器分布式散射传感系统发展前景应用布里渊散射空间分辨率温度

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Computational modelling of gas–liquid–solid multiphase free surface flow with and without evaporation

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Particuology 2024年第7期90卷 218-235页

作者： Huihuang Xia marc Kamlah Institute for Applied Materials(IAM) Karlsruhe Institute of Technology(KIT)Hermann-von Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Gas–liquid–solid multiphase systems are ubiquitous in engineering applications,*** printing,spray drying and *** a numerical framework for modelling these multiphase systems is of great *** improved,resolved computational fluid dynamics-discrete element method(CFD-DEM)framework is developed to model the multiphase free surface flow with and without *** improved capillary force model is developed to compute the capillary interactions for partially floating particles at a free *** well-known benchmark cases,namely drag coefficient calculation,the single sphere settling,and drafting-kissing-tumbling of two particles are conducted to validate the resolved CFD-DEM *** turns out that the resolved CFD-DEM model developed in this paper can accurately calculate the fluid–solid interactions and predict the trajectory of solid particles interacting with the liquid *** demonstrations,namely two particles moving along a free surface when the liquid phase evaporates,and particle transport and accumulations inside an evaporating sessile droplet show the performance of the resolved model.

关键词： Capillary force Discrete element method Liquid bridge Particle transport Resolved CFD-DEM Volume of fluid

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NON SPURIOUS SPECTRAL-LIKE ELEMENT METHODS FOR MAXWELL'S EQUATIONS

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Journal of Computational Mathematics 2007年第3期25卷 282-304页

作者： Gary Cohen marc Duruflé INRIA Domaine de VoluceauRocquencourt-BP 10578153 Le Chesnay CedexFrance

In this paper, we give the state of the art for the so called “mixed spectral elements” for Maxwell＇s equations. Several families of elements, such as edge elements and discon-tinuous Galerkin methods （DGM） are presented and discussed. In particular, we show the need of introducing some numerical dissipation terms to avoid spurious modes in these methods. Such terms are classical for DGM but their use for edge element methods is novel approach described in this paper. Finally, numerical experiments show the fast and low-cost character of these elements.

关键词： Maxwell's equations Discontinuous Galerkin methods Edge elements Masslumping.

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Precision Measurement of Complex Optics Using a Scanning‑Point Multiwavelength Interferometer Operating in the Visible Domain

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Nanomanufacturing and Metrology 2023年第2期6卷 19-26页

作者： marc Wendel Ametek GmbH/BU Taylor Hobson Rudolf-Diesel-Str.1664331 WeiterstadtGermany

The growing demands of optical systems have led to increasingly complex aspheres and *** this paper,an established measurement system in asphere production,which is also a promising approach in high-precision freeform metrology,is *** is based on a scanning-point multiwavelength interferometer *** scanning principle enables great fexibility,reduces setup time and costs,and has almost no limitations in spherical *** to the absolute measurement capability,the utilized multiwavelength approach is benefcial for segmented,annular,and discrete surfaces,which are common designs of modern applications’optical *** metrology system enables measurements on a nanometer scale on a great variety of apertures—from 1 to 1000 ***,a new short-coherence multiwavelength interferometer operating in the visible domain has been *** enables the high-precision measurement on silicon-coated surfaces,which can be found in space applications and are also commonly used for extreme-ultraviolet(EUV)lithographic setups,which will be used as an example throughout this *** to the large absolute measurement capability,applied grating structures for suppressing infrared light in the EUV process can easily be *** paper summarizes the basic working principles of the proposed metrology system,explains the special requirements for diferent felds of application,highlights the capabilities of the visible multiwavelength approach,and shows the measurement results.

关键词： Multiwavelength interferometer Scanning-point sensor Metrology Short coherence interferometry

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An integrated hard- and soft-ware triboelectrochemical test rig for tribocorrosion experiments

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Friction 2015年第3期3卷 256-258页

作者： marc BELLANTONIO TRIBOtechnic 4 rue ValitonF-92110 ClichyFrance

Tribocorrosion is a degradation mechanism resulting from the interaction of mechanical(wear)and chemical(corrosion)*** interaction leads to surface damage that does not correspond to the simple sum of wear and corrosion taken *** tribocorrosion of material pairings thus requires the capability not only to control the mechanical and chemical test parameters but also to identify the relative contribution of corrosion and wear in the overall material *** paper describes a novel laboratory tribocorrosion test set-up combining in one experiment the control of mechanical input(load,velocity,and frequency)and output(friction and wear)parameters as well as the control of corrosion phenomena through a series of dedicated electrochemical methods(open circuit,potentiostatic and potentiodynamic measurements).The possibilities offered by this set-up are illustrated by selected case studies.

关键词： tribocorrosion friction and corrosion tribotechnic

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Congenital left ventricular aneurysms and diverticula： an entity in search of an identity

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Journal of Geriatric Cardiology 2017年第12期14卷 750-762页

作者： marc-Alexander Ohlow Heart Center Department of Cardiology Zentralklinik Bad Berka Germany

Congenital left ventricular aneurysm or diverticulum are rare cardiac malformations described in 809 cases since the first description in 1816, being associated with other cardiac, vascular or thoraco-abdominal abnormalities in about 70%. It appears to be a developmental anomaly, starting in the 4th embryonic week. In an experimental study, targeted knockdown of cardiac troponin T in the chick was performed at day 3, after the heart tube has formed. Morpholino treatment of gene TNNT2 at this stage led to the development of left ventricular diver- ticula （LVD） in the primitive left ventricular wall. Diagnosis of left ventricular aneurysms （LVA）/LVD can be made after exclusion of coro- nary artery disease, local or systemic inflammation or traumatic causes as well as cardiomyopathies. Clinically, most of LVA and LVD are asymptomatic or may cause systemic embolization, congestive heart failure, valvular regurgitation, ventricular wall rupture, ventricular tachycardia or sudden cardiac death. Diagnosis is established by imaging studies （echocardiography, magnetic resonance imaging or left ventricular angiography） visualizing the structural changes and accompanying abnormalities. Mode of treatment has to be individually tai- lored and depends on clinical presentation, accompanying abnormalities and possible complications, options include surgical resection （espe- cially in symptomatic patients）, anticoagulation after systemic embolization, radiofrequency ablation or implantation of an implantable car- dioverter defibrillator （ICD） in case of symptomatic ventricular tachycardias, and occasionally combined with class I- or III-antiarrhythmic drugs. Cardiac death occurs usually in childhood, is significantly more frequent in LVA patients and caused by congestive heart failure in most of the cases, whereas patients diagnosed with LVD died more frequently from rupture of the LVD.

关键词： Aneurysm Congenital Diverticulum Left ventricular Prognosis Therapy

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