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Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome

World Journal of Critical Care Medicine 2017年第1期6卷 74-78页

作者： Martin Albert Daniel Corsilli David R Williamson marc brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin Departments of Intensive Care and Medicine Hopital du Sacré-Coeur de Montréal Research Center Université de Montréal Department of Intensive Care Centre Hospitalier Universitaire de Montréal Université de Montréal Department of Pharmacy Université de Montréal Hopital du Sacré-Coeur de Montréal Research Center Department of Respiratory Care Hopital du Sacré-Coeur de Hopital du Sacré-Coeur de Montréal Research Center Université de Montréal

AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled *** The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milr

关键词： Inhaled milrinone Nitric oxide Pulmonary hypertension Hypoxemia Acute respiratory distress syndrome Prostacyclin

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Studies on the Molecular Mechanism Underlying Resistance to Potato Virus X Conferred by Plant Argonaute2

Studies on the Molecular Mechanism Underlying Resistance to ...

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中国植物病理学会2021年学术年会

作者： ZHAO Zhenxing MARTINS Guilherme Silva JIAO Zhiyuan brosseau Chantal FAN Zaifeng MOFFETT Peter Department of Plant Pathology China Agricultural University Centre SèVE Département de BiologieUniversité de Sherbrooke Institute of Plant Inspection and Quarantine Chinese Academy of Inspection and Quarantine

RNA silencing is one of the important mechanisms of plant antiviral innate immunity（Calil and Fontes,2017;Li and Wang,2019）.Arabidopsis is usually not considered a host of PVX and is immune to its *** certain circumstances,PVX can break this non-host *** combined with another virus,PVX can infect Arabidopsis ecotype *** previous studies,it was shown that PVX can achieve systemic infection after inoculation in the dcl2/dcl3/dcl4 triple mutant,indicating that RNA silencing may be the cause of Arabidopsis immunity to PVX（Jaubert et al.,2011）.It has also been shown that the AtCol-0-AGO2 allele confers resistance to PVX,whereas the AG02 allele from the C24 ecotype（AtC24-AG02） does *** reason for this difference may be the longer RGR repeat motif and D33 sites located in the N-terminus of *** variants are not located in the known functional domain of AG02（brosseau et al.,2019）.The molecular role of these two sites involved in antiviral resistance is still *** study aims to use the tobacco leaf transient overexpression system and transgenic overexpression Arabidopsis lines to explore the function of the Nterminal region of the AGO2 protein and its effect on the relationship between PVX and P25.

关键词： RNA silencing ARGONAUTE 2 viral suppressor of RNA silencing Potato virus X

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混合边界条件下绕旋成体的势流——横向流

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系统工程与电子技术 1983年第11期 19-31页

作者： J.V.Rattayya ,J.A.brosseau ,M.A.Chisholm ,郝文彬

本文系统地阐述了平面运动中作用在带有拖尾空泡的轴对称体上的流体动力和力矩的计算方法,计算中考虑了空泡表面的横向偏转。对不大的空泡偏转情况,所用的基本假设是,认为物体-空泡外形无偏转,并规定空泡偏转与相应的物体-空泡表面上的... 详细信息

本文系统地阐述了平面运动中作用在带有拖尾空泡的轴对称体上的流体动力和力矩的计算方法,计算中考虑了空泡表面的横向偏转。对不大的空泡偏转情况,所用的基本假设是,认为物体-空泡外形无偏转,并规定空泡偏转与相应的物体-空泡表面上的源强分布有关,借此我们可以计算与非轴对称物体-空泡外形相应的势流,以满足恰当的混合边界条件。然后,使用类似于轴向流情况时所用的迭代法,分别求解与刚体平移和旋转有关的势流解。接下来计算作用在运动物体上的压力分布,并与模拟自由飞行时所测得的压力数据进行比较。我们将计算出的流体动力系数作为Froude数和空泡数的函数给了出来。

关键词：空泡偏转角流体动力系数轴对称体旋转体横向流源强混合边界边界条件平面运动势流流体流动

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