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Initial scalar lithospheric magnetic anomaly map of China and surrounding regions derived from CSES satellite data

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Science China(Technological Sciences) 2021年第5期64卷 1118-1126页

作者： WANG Jie SHEN XuHui YANG YanYan ZEREN ZhiMa HULOT gauthier OLSEN Nils ZHOU Bin MAGNES Werner DE SANTIS Angelo HUANG JianPing GUO Feng LIU WenLong YU JingBo National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China School of Space and Environment Beihang UniversityBeijing 100191China Universitéde Paris Institut de physique du globe de ParisCNRSParis F-75005France DTU Space National Space InstituteTechnical University of DenmarkKongens Lyngby 2800Denmark National Space Science Center Chinese Academy of SciencesBeijing 100190China Space Research Institute Austrian Academy of SciencesGraz 8042Austria Istituto Nazionale di Geofisica e Vulcanologia Via di Vigna MurataRome 605Italy School of Earth Sciences Hebei GEO UniversityShijiazhuang 050031China

The China Seismo-Electromagnetic Satellite(CSES),China’s first satellite to measure geophysical fields with scientific goals in both space and solid earth physics,was launched successfully in February *** carries high-precision magnetometers to measure the geomagnetic *** this study,the CSES magnetic data were used to extract the signal of the lithospheric magnetic field caused by magnetized rocks in the crust and uppermost ***,an along-track analysis of the CSES magnetic data was undertaken near the Bangui magnetic anomaly in central Africa and the Tarim magnetic anomaly in China,demonstrating that the CSES magnetic data are indeed sensitive to the lithospheric magnetic anomaly *** a lithospheric magnetic anomaly map over China and surrounding regions was *** map is consistent with the lithospheric part of the CHAOS-7 *** particular,it clearly reveals four major magnetic anomalies containing long-wavelength signals at the altitude of lowearth-orbiting *** magnetic highs are located over the Tarim,Sichuan and Songliao basin,the origins of which could be related to large-scale tectonic-magmatic activities during geological history.A prominent magnetic low is otherwise found in the southern Himalayan-Tibetan plateau,possibly caused by the shallow Curie depth in this *** further improve the precision of the lithospheric magnetic field model,more detailed data processing and multi-source data merging are needed.

关键词： anomaly lithospheric Himalayan

Measuring organ shift and deformation for port placement in robotassisted minimally invasive surgery

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Laparoscopic, Endoscopic and Robotic Surgery 2020年第4期3卷 99-106页

作者： Mohammad R.Maddah Cedric Dumas Olivier gauthier Marion Fusellier Caroline G.L.Cao Department of Biomedical Industrialand Human Factors EngineeringWright State UniversityDayton OHUSA IMT Atlantique NantesFrance Laboratoire des Sciences du Numerique de Nantes(LS2N) NantesFrance ONIRIS Nantes-Atlantic College of Veterinary MedicineFood Science and EngineeringNantesFrance

Objective:Port placement is a crucial pre-operative task in robot-assisted minimally invasive *** to the insufflation process,the abdominal shape is deformed while the internal organs are shifted in *** changes need to be considered when determining the optimal port locations for the robotic ***,intra-operative medical image acquisition systems are not always *** this study,we aim to estimate the shift extent of the abdominal organs in humans by measuring the changed volume and position of the abdominal organs before and after insufflation in three ***:A 3D model of the abdomen and abdominal organs was reconstructed from 3D images of the pigs taken by an MRI scanner before and after *** shift and shape changes of the abdominal organs after insufflation were *** corresponding shift in port location for the robotic manipulators was determined based on the abdominal ***:Organ movements as a result of insufflation ranged from 6.37±0.10 cm for the spleen,to 1.64±0.22 cm for the *** a slight planar motion of the target organ(e.g.,1.33±0.06 cm,2.38±0.21 cm in X-Y plane for the left kidney)can shift the access port for the robot manipulator by about 1.6 cm on the abdominal ***:The target organs’motion due to insufflation is a critical factor in determining port locations in robot-assisted minimally invasive surgery.

关键词： Insufflation 3D abdominal model Organ shift Volume changes

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树形聚合物及功能化结构设计研究新进展

高分子材料科学与工程 2003年第2期19卷 6-10页

作者：游秀东向安高建平于九皋 Mario gauthier 天津大学化学系天津300072 Dept.of Chem.Uni.Of Waterloo

综述了树形聚合物的最新研究进展 ,重点介绍了近年来树形聚合物功能化结构设计及其在光、电信息及生物技术等新领域中的应用研究、发展趋势和应用前景。

关键词：树形聚合物功能化结构设计研究进展光开头发色基团光获体系生物探针

Mathematical Analysis of a Large Scale Vector SIS Malaria Model in a Patchy Environment

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Applied Mathematics 2014年第13期5卷 1913-1926页

作者： Josephine Wairimu Sallet gauthier Wandera Ogana INRIA Metz and University of Lorraine Lorraine France School of Mathematics University of Nairobi Nairobi Kenya

We answer the stability question of the large scale SIS model describing transmission of highland malaria in Western Kenya in a patchy environment, formulated in [1]. There are two equilibrium states and their stability depends on the basic reproduction number, Ro?[2]. If Ro ≤1, the disease-free steady solution is globally asymptotically stable and the disease always dies out. If Ro >1, there exists a unique endemic equilibrium which is globally stable and the disease persists. Application is done on data from Western Kenya. The age structure reduces the level of infection and the populations settle to the equilibrium faster than in the model without age structure.

关键词： Highland Malaria Differentiated Susceptibility and Infectivity Monotone Dynamical Systems

Cerebrospinal fluid phosphorylated tau,visinin-like protein-1,and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease

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Translational Neurodegeneration 2018年第1期7卷 221-232页

作者： Hua Zhang Kok Pin Ng Joseph Therriault Min Su Kang Tharick APascoal Pedro Rosa-Neto Serge gauthier the Alzheimer’s Disease Neuroimaging Initiative Department of Neurology the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Neurology National Neuroscience InstituteSingaporeSingapore The McGill University Research Centre for Studies in Aging McGill UniversityMontrealCanada 不详

Background:Visinin-like protein-1(VILIP-1)and chitinase-3-like protein 1(CHI3L1 or YKL-40)in cerebrospinal fluid(CSF)are newly discovered markers indicating neuronal damage and microglial activation,*** tau(p-tau)reflects the neuropathology of Alzheimer’s disease(AD)and is useful as diagnostic markers for ***,it is unknown whether these biomarkers have similar or complementary information in ***:We stratified 121 participants from the Alzheimer’s Disease Neuroimaging Initiative(ADNI)database into cognitively normal(CN),stable mild cognitive impairment(sMCI),progressive MCI(pMCI),and dementia due to *** of covariance(ANOVA)and chi-square analyses,Spearman correlation,and logistic regression models were performed to test the demographic,associations between biomarkers,and diagnostic accuracies,*** mixed-effects models were used to evaluate the effects of CSF amyloid-β(Aβ)on above biomarkers within diagnostic groups,the combination of diagnostic group and Aβstatus as predictor,and CSF biomarkers as predictors of AD features,including cognition measured by Mini–Mental State Examination(MMSE)and brain structure and white matter hyperintensity(WMH)measured by magnetic resonance imaging(MRI).Results:P-tau,VILIP-1,and YKL-40 were all predictors of AD diagnosis,but combinations of biomarkers did not improve the diagnostic accuracy(AUC 0.924 for p-tau,VILIP-1,and YKL-40)compared to p-tau(AUC 0.922).P-tau and VILIP-1 were highly correlated(r=0.639,p<0.001)and strongly associated with Aβpathology across clinical stages of AD,while YKL-40 was correlated with Aβpathology in CN and AD ***-1 was associated with acceleration of cognitive decline,hippocampal atrophy,and expansion of ventricles in longitudinal ***-40 was associated with hippocampal atrophy at baseline and follow-up,while p-tau was only associated with worsening WMH at ***:CSF levels of p-tau,VILIP-1,and YKL-40 may have uti

关键词： Alzheimer’s disease Amyloid-β Chitinase-3-like protein 1 Phosphorylated tau Visinin-like protein-1

Preparation of Different Lights Irradiated ZnSe/GSH QDs and Their Interaction with BSA

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Journal of Wuhan University of Technology(Materials Science) 2019年第4期34卷 858-865页

作者： DING Ling LI Shiqian The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Wuhan 430081China Coal Conversion and New Carbon Materials Hubei Key Laboratory School of Chnemistry and Chemical EngineeringWuhan University of Science and TechnologyWuhan 430081China Key Laboratory of Measurement and Control System for Offshore Environment Fuqing Branch of Fujian Normal UniversityFuqing 350300China

Using L-glutathione(GSH) as a capping agent,Zn Se/GSH quantum dots(QDs) were prepared under microwave irradiation and irradiated under dark, ultraviolet light and incandescent light, respectively. The properties and interaction of different lights irradiated ZnSe/GSH QDs and bovine serum albumin(BSA) were studied systematically. The fluorescence(FL) spectra results reveal that the quenching mechanism are all the static quenching in nature. The quenching constant(Ksv) and binding constant(K) value of different irradiated Zn Se/GSH QDs and BSA all increased with the change of light types from dark to incandescent light and UV light. The number of binding site(n) is close to 1 at different temperatures. The lighting types influence the enthalpy and entropy changes. The Fourier transform infrared(FTIR) spectra indicate that the light induced GSH ligand will facilitate photocatalytic oxidation on the surface of ZnSe/GSH QDs. The circular dichroism(CD)results show that the α-helicity content of BSA decreases from 60.34%, 59.31%, to 58.79% under UV lighting,incandescent lighting and dark conditions. The interaction results of different lights illuminated ZnSe/GSH QDs with BSA by CD spectra method matches well with that by FL and FTIR spectra. That is, the interaction of ZnSe/GSH QDs and BSA from strong to weak is UV light, incandescent light and dark in sequence.

关键词： lights irradiated ZnSe/GSH quantum dots preparation bovine serum albumin interaction thermodynamics

Engineering homologous platelet-rich plasma,platelet-rich plasma-derived exosomes,and mesenchymal stem cell-derived exosomes-based dual-crosslinked hydrogels as bioactive diabetic wound dressings

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Bioactive Materials 2023年第10期28卷 74-94页

作者： Bianza Moise Bakadia Abeer Ahmed Qaed Ahmed Lallepak Lamboni Zhijun Shi Biampata Mutu Mukole Ruizhu Zheng Mazono Pierre Mbang Bi Zhang Mario gauthier Guang Yang Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan430074China College of Life Science and Technology Key Laboratory of Molecular Biophysics of MOEHuazhong University of Science and TechnologyWuhanChina Institut Sup´erieur des Techniques M´edicales de Lubumbashi LubumbashiCongo Department of Molecular Medicine Biochemistry UnitUniversity of Pavi127100Pavi1Italy e Institut National de Recherche Biom´edicale Minist`ere de la Sant´eCongo Department of Chemistry University of WaterlooWaterlooOntarioN2L 3G1Canada

The management of diabetic wounds remains a critical therapeutic challenge. Platelet-rich plasma (PRP) gel, PRP-derived exosomes (PRP-Exos), and mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated therapeutic potential in wound treatment. Unfortunately, their poor mechanical properties, the short half-lives of growth factors (GFs), and the burst release of GFs and exosomes have limited their clinical applications. Furthermore, proteases in diabetic wounds degrade GFs, which hampers wound repair. Silk fibroin is an enzyme-immobilization biomaterial that could protect GFs from proteases. Herein, we developed novel dual-crosslinked hydrogels based on silk protein (SP) (sericin and fibroin), including SP@PRP, SP@MSC-Exos, and SP@PRP-Exos, to promote diabetic wound healing synergistically. SP@PRP was prepared from PRP and SP using calcium gluconate/thrombin as agonist, while SP@PRP-Exos and SP@MSC-Exos were derived from exosomes and SP with genipin as crosslinker. SP provided improved mechanical properties and enabled the sustained release of GFs and exosomes, thereby overcoming the limitations of PRP and exosomes in wound healing. The dual-crosslinked hydrogels displayed shear-induced thinning, self-healing, and eradication of microbial biofilms in a bone-mimicking environment. In vivo, the dual-crosslinked hydrogels contributed to faster diabetic wound healing than PRP and SP by upregulating GFs expression, down-regulating matrix metalloproteinase-9 expression, and by promoting an anti-NETotic effect, angiogenesis, and re-epithelialization. Hence, these dual-crosslinked hydrogels have the potential to be translated into a new generation of diabetic wound dressings.

关键词： Platelet-rich plasma(PRP) Exosomes(Exos) Silk protein Dual-crosslinked hydrogel Diabetic wound

基于烟气重金属浓度在线监测的流化床蒸发动力学模型

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中国电机工程学报 2008年第11期28卷 1-5页

作者：刘晶 S.Abanades D.gauthier G.Flamant 郑楚光煤燃烧国家重点实验室(华中科技大学) 湖北省武汉市430074 CNRS-PROMES BP 50deilloFont-Romeu 66125France

应用改进的电感耦合等离子体发射光谱仪对烟气中重金属的相对浓度进行在线测量,以全面跟踪重金属的释放过程。在烟气重金属浓度实时监测基础上,发展动力学模型来研究重金属蒸发释放的动力学特性。应用矿物质基体氧化铝的实验结果来验证... 详细信息

应用改进的电感耦合等离子体发射光谱仪对烟气中重金属的相对浓度进行在线测量,以全面跟踪重金属的释放过程。在烟气重金属浓度实时监测基础上,发展动力学模型来研究重金属蒸发释放的动力学特性。应用矿物质基体氧化铝的实验结果来验证数学模型的有效性,理论模拟值与实验结果吻合较好。结果表明应用模型,将烟气重金属在线分析的实验结果作为输入参数,可用于预测重金属的蒸发率。根据重金属的蒸发率和固体颗粒中重金属浓度的关系得到其蒸发的动力学规律,对于氧化铝得到1级反应动力学规律。

关键词：重金属蒸发动力学模拟烟气流化床

Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study

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Stroke & Vascular Neurology 2024年第2期9卷 165-173,I0426,I0427页

作者： Romain Didier Lucie Garnier gauthier Duloquin Alexandre Meloux Audrey Sagnard Mathilde Graber Geoffrey Dogon Karim Benali Thibaut Pommier Gabriel Laurent Catherine Vergely Yannick Bejot Charles Guenancia Cardiology CHU Dijon BourgogneDijonFrance Dijon Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEC 2 Universitéde BourgogneDijonFrance Cardiology CHU Saint EtienneSaint EtienneFrance

Background Atrial cardiomyopathy(AC)is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation(AF).A definition based on the presence of electrical abnormality(P-wave terminal force in lead V1(PTFV1)>5000µV×ms),N-Terminal pro-B-type natriuretic peptide(NT pro BNP)>250pg/mL and/or indexed left atrial diameter(LADI)>3cm/m^(2)is currently tested in the ARCADIA(AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke)*** set out to estimate the prevalence of AC as defined in the ARCADIA trial,its determinants and its association with AF detected after stroke(AFDAS).Methods Stepwise screening for silent Atrial Fibrillation After Stroke(SAFAS)study prospectively included 240 ischaemic stroke *** markers were complete for 192 of them and 9 were not included in this analysis because AF had been diagnosed on *** A total of 183 patients were analysed,of whom 57%(104 patients)met the AC criteria(79 NT-proBNP,47 PTFV1,4 LADI).In the multivariate logistic regression,C reactive protein>3mg/L(OR(95%CI)2.60(1.30 to 5.21),p=0.007)and age(OR(95%CI)1.07(1.04 to 1.10),p34mL/m^(2),OR 2.35(CI 1.09 to 5.06)p=0029).Conclusion AC as defined in ARCADIA is mostly based on NT pro BNP elevation(76%of patients)and is associated with age and ***,AC was not independently associated with AFDAS at *** ARCADIA trial,which compares aspirin to apixaban in patients with embolic strokes of undetermined source with AC markers and must,therefore be analysed in the light of these limitations.

关键词： atrial cardiomyopathy prevention